Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B1M0_LEIMU

TriTrypDb:

LmxM.30.0690

Length:

480

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B1M0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1M0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	268	272	PF00656	0.636
CLV_NRD_NRD_1	55	57	PF00675	0.625
CLV_PCSK_KEX2_1	55	57	PF00082	0.625
CLV_PCSK_SKI1_1	276	280	PF00082	0.615
DEG_SCF_FBW7_1	185	192	PF00400	0.588
DEG_SCF_FBW7_1	444	451	PF00400	0.687
DEG_SPOP_SBC_1	178	182	PF00917	0.513
DEG_SPOP_SBC_1	464	468	PF00917	0.495
DOC_CKS1_1	196	201	PF01111	0.642
DOC_CKS1_1	445	450	PF01111	0.687
DOC_CYCLIN_yCln2_LP_2	378	384	PF00134	0.579
DOC_MAPK_DCC_7	101	110	PF00069	0.552
DOC_MAPK_gen_1	303	311	PF00069	0.462
DOC_MAPK_MEF2A_6	101	110	PF00069	0.552
DOC_MAPK_MEF2A_6	299	306	PF00069	0.443
DOC_MAPK_NFAT4_5	299	307	PF00069	0.445
DOC_PP2B_LxvP_1	378	381	PF13499	0.573
DOC_PP2B_LxvP_1	382	385	PF13499	0.590
DOC_PP4_FxxP_1	102	105	PF00568	0.419
DOC_PP4_FxxP_1	135	138	PF00568	0.743
DOC_PP4_MxPP_1	420	423	PF00568	0.726
DOC_SPAK_OSR1_1	101	105	PF12202	0.550
DOC_USP7_MATH_1	109	113	PF00917	0.493
DOC_USP7_MATH_1	178	182	PF00917	0.787
DOC_USP7_MATH_1	189	193	PF00917	0.543
DOC_USP7_MATH_1	200	204	PF00917	0.637
DOC_USP7_MATH_1	210	214	PF00917	0.770
DOC_USP7_MATH_1	222	226	PF00917	0.602
DOC_USP7_MATH_1	448	452	PF00917	0.646
DOC_USP7_MATH_1	65	69	PF00917	0.501
DOC_WW_Pin1_4	113	118	PF00397	0.682
DOC_WW_Pin1_4	119	124	PF00397	0.717
DOC_WW_Pin1_4	138	143	PF00397	0.479
DOC_WW_Pin1_4	185	190	PF00397	0.675
DOC_WW_Pin1_4	195	200	PF00397	0.598
DOC_WW_Pin1_4	316	321	PF00397	0.679
DOC_WW_Pin1_4	444	449	PF00397	0.756
DOC_WW_Pin1_4	60	65	PF00397	0.498
LIG_14-3-3_CanoR_1	251	255	PF00244	0.429
LIG_14-3-3_CanoR_1	299	303	PF00244	0.462
LIG_14-3-3_CanoR_1	55	64	PF00244	0.507
LIG_BIR_II_1	1	5	PF00653	0.655
LIG_BIR_III_4	10	14	PF00653	0.651
LIG_BRCT_BRCA1_1	179	183	PF00533	0.746
LIG_CSL_BTD_1	317	320	PF09270	0.738
LIG_deltaCOP1_diTrp_1	91	102	PF00928	0.440
LIG_EVH1_1	421	425	PF00568	0.488
LIG_FHA_1	138	144	PF00498	0.594
LIG_FHA_1	196	202	PF00498	0.640
LIG_FHA_1	251	257	PF00498	0.455
LIG_FHA_1	343	349	PF00498	0.737
LIG_FHA_1	55	61	PF00498	0.473
LIG_FHA_2	218	224	PF00498	0.541
LIG_IRF3_LxIS_1	191	197	PF10401	0.680
LIG_LIR_Apic_2	133	138	PF02991	0.638
LIG_LIR_Apic_2	253	257	PF02991	0.433
LIG_LIR_Apic_2	58	64	PF02991	0.408
LIG_LIR_Gen_1	14	24	PF02991	0.394
LIG_LIR_Gen_1	2	11	PF02991	0.647
LIG_LIR_Gen_1	42	52	PF02991	0.397
LIG_LIR_Gen_1	93	104	PF02991	0.388
LIG_LIR_Nem_3	14	19	PF02991	0.395
LIG_LIR_Nem_3	2	8	PF02991	0.662
LIG_LIR_Nem_3	228	234	PF02991	0.535
LIG_LIR_Nem_3	419	424	PF02991	0.491
LIG_LIR_Nem_3	42	48	PF02991	0.413
LIG_LIR_Nem_3	471	476	PF02991	0.744
LIG_LIR_Nem_3	98	103	PF02991	0.473
LIG_LYPXL_S_1	230	234	PF13949	0.529
LIG_LYPXL_yS_3	231	234	PF13949	0.574
LIG_NRBOX	374	380	PF00104	0.562
LIG_Pex14_1	96	100	PF04695	0.477
LIG_PTB_Apo_2	94	101	PF02174	0.466
LIG_SH2_CRK	139	143	PF00017	0.734
LIG_SH2_CRK	254	258	PF00017	0.456
LIG_SH2_CRK	364	368	PF00017	0.639
LIG_SH2_CRK	476	480	PF00017	0.749
LIG_SH2_CRK	5	9	PF00017	0.634
LIG_SH2_NCK_1	358	362	PF00017	0.746
LIG_SH2_NCK_1	5	9	PF00017	0.634
LIG_SH2_PTP2	16	19	PF00017	0.420
LIG_SH2_PTP2	45	48	PF00017	0.401
LIG_SH2_SRC	16	19	PF00017	0.420
LIG_SH2_STAP1	252	256	PF00017	0.446
LIG_SH2_STAP1	5	9	PF00017	0.634
LIG_SH2_STAT3	187	190	PF00017	0.670
LIG_SH2_STAT3	86	89	PF00017	0.668
LIG_SH2_STAT5	139	142	PF00017	0.730
LIG_SH2_STAT5	16	19	PF00017	0.420
LIG_SH2_STAT5	187	190	PF00017	0.565
LIG_SH2_STAT5	252	255	PF00017	0.453
LIG_SH2_STAT5	45	48	PF00017	0.401
LIG_SH3_3	100	106	PF00018	0.456
LIG_SH3_3	114	120	PF00018	0.646
LIG_SH3_3	338	344	PF00018	0.587
LIG_SH3_3	419	425	PF00018	0.618
LIG_SH3_3	435	441	PF00018	0.720
LIG_SH3_3	442	448	PF00018	0.683
LIG_SH3_3	469	475	PF00018	0.670
LIG_SH3_3	76	82	PF00018	0.539
LIG_SUMO_SIM_anti_2	275	282	PF11976	0.626
LIG_SUMO_SIM_par_1	275	282	PF11976	0.636
LIG_TRAF2_1	85	88	PF00917	0.605
LIG_TYR_ITIM	229	234	PF00017	0.542
MOD_CDK_SPK_2	113	118	PF00069	0.698
MOD_CK1_1	112	118	PF00069	0.644
MOD_CK1_1	122	128	PF00069	0.775
MOD_CK1_1	225	231	PF00069	0.566
MOD_CK1_1	324	330	PF00069	0.668
MOD_CK1_1	465	471	PF00069	0.725
MOD_CK2_1	217	223	PF00069	0.546
MOD_CK2_1	60	66	PF00069	0.532
MOD_GlcNHglycan	124	127	PF01048	0.782
MOD_GlcNHglycan	145	148	PF01048	0.623
MOD_GlcNHglycan	149	152	PF01048	0.624
MOD_GlcNHglycan	171	174	PF01048	0.678
MOD_GlcNHglycan	210	213	PF01048	0.690
MOD_GlcNHglycan	240	243	PF01048	0.501
MOD_GlcNHglycan	295	298	PF01048	0.456
MOD_GlcNHglycan	335	338	PF01048	0.639
MOD_GlcNHglycan	353	356	PF01048	0.600
MOD_GlcNHglycan	450	453	PF01048	0.703
MOD_GlcNHglycan	5	8	PF01048	0.571
MOD_GlcNHglycan	66	70	PF01048	0.619
MOD_GSK3_1	108	115	PF00069	0.608
MOD_GSK3_1	143	150	PF00069	0.638
MOD_GSK3_1	165	172	PF00069	0.764
MOD_GSK3_1	179	186	PF00069	0.560
MOD_GSK3_1	190	197	PF00069	0.634
MOD_GSK3_1	238	245	PF00069	0.629
MOD_GSK3_1	279	286	PF00069	0.418
MOD_GSK3_1	444	451	PF00069	0.736
MOD_GSK3_1	464	471	PF00069	0.517
MOD_GSK3_1	55	62	PF00069	0.479
MOD_GSK3_1	67	74	PF00069	0.641
MOD_N-GLC_1	225	230	PF02516	0.503
MOD_NEK2_1	143	148	PF00069	0.671
MOD_NEK2_1	194	199	PF00069	0.712
MOD_NEK2_1	201	206	PF00069	0.629
MOD_NEK2_1	238	243	PF00069	0.438
MOD_NEK2_1	348	353	PF00069	0.672
MOD_NEK2_1	72	77	PF00069	0.672
MOD_NEK2_2	416	421	PF00069	0.660
MOD_PIKK_1	465	471	PF00454	0.725
MOD_PKA_1	55	61	PF00069	0.588
MOD_PKA_2	217	223	PF00069	0.779
MOD_PKA_2	250	256	PF00069	0.421
MOD_PKA_2	298	304	PF00069	0.443
MOD_PKA_2	54	60	PF00069	0.466
MOD_Plk_1	225	231	PF00069	0.462
MOD_Plk_1	283	289	PF00069	0.422
MOD_Plk_4	225	231	PF00069	0.546
MOD_Plk_4	284	290	PF00069	0.533
MOD_Plk_4	416	422	PF00069	0.558
MOD_Plk_4	468	474	PF00069	0.644
MOD_ProDKin_1	113	119	PF00069	0.682
MOD_ProDKin_1	138	144	PF00069	0.541
MOD_ProDKin_1	185	191	PF00069	0.675
MOD_ProDKin_1	195	201	PF00069	0.598
MOD_ProDKin_1	316	322	PF00069	0.685
MOD_ProDKin_1	444	450	PF00069	0.755
MOD_ProDKin_1	60	66	PF00069	0.508
TRG_DiLeu_BaEn_1	275	280	PF01217	0.616
TRG_DiLeu_BaEn_2	97	103	PF01217	0.424
TRG_ENDOCYTIC_2	16	19	PF00928	0.377
TRG_ENDOCYTIC_2	231	234	PF00928	0.574
TRG_ENDOCYTIC_2	418	421	PF00928	0.498
TRG_ENDOCYTIC_2	45	48	PF00928	0.542
TRG_ENDOCYTIC_2	5	8	PF00928	0.648
TRG_ER_diArg_1	302	305	PF00400	0.446
TRG_ER_diArg_1	54	56	PF00400	0.642

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8K0	Leptomonas seymouri	41%	100%
A0A3Q8ISG1	Leishmania donovani	83%	100%
A4HJ47	Leishmania braziliensis	71%	100%
A4I6G3	Leishmania infantum	84%	100%
Q4Q6J4	Leishmania major	85%	100%