C2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

C2 domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B1L9_LEIMU

TriTrypDb:

LmxM.30.0680

Length:

282

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B1L9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1L9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005509	calcium ion binding	5	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.365
CLV_PCSK_KEX2_1	142	144	PF00082	0.524
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.524
CLV_PCSK_PC7_1	138	144	PF00082	0.507
DOC_CKS1_1	185	190	PF01111	0.525
DOC_CYCLIN_yCln2_LP_2	242	248	PF00134	0.515
DOC_MAPK_gen_1	104	113	PF00069	0.414
DOC_MAPK_MEF2A_6	106	115	PF00069	0.434
DOC_PP4_FxxP_1	55	58	PF00568	0.338
DOC_SPAK_OSR1_1	54	58	PF12202	0.366
DOC_USP7_MATH_1	236	240	PF00917	0.720
DOC_USP7_MATH_1	248	252	PF00917	0.546
DOC_USP7_UBL2_3	92	96	PF12436	0.366
DOC_WW_Pin1_4	184	189	PF00397	0.687
LIG_AP2alpha_2	24	26	PF02296	0.366
LIG_Clathr_ClatBox_1	115	119	PF01394	0.423
LIG_deltaCOP1_diTrp_1	46	55	PF00928	0.319
LIG_eIF4E_1	166	172	PF01652	0.528
LIG_FHA_1	36	42	PF00498	0.413
LIG_FHA_1	89	95	PF00498	0.541
LIG_FHA_2	105	111	PF00498	0.622
LIG_FHA_2	72	78	PF00498	0.366
LIG_LIR_Apic_2	239	243	PF02991	0.685
LIG_LIR_Apic_2	52	58	PF02991	0.338
LIG_LIR_Gen_1	24	31	PF02991	0.565
LIG_LIR_Nem_3	119	123	PF02991	0.455
LIG_LIR_Nem_3	24	29	PF02991	0.565
LIG_LIR_Nem_3	97	102	PF02991	0.405
LIG_MYND_1	169	173	PF01753	0.560
LIG_PCNA_yPIPBox_3	72	83	PF02747	0.351
LIG_Pex14_1	49	53	PF04695	0.469
LIG_SH2_CRK	166	170	PF00017	0.572
LIG_SH2_CRK	266	270	PF00017	0.617
LIG_SH2_NCK_1	166	170	PF00017	0.572
LIG_SH2_NCK_1	266	270	PF00017	0.579
LIG_SH2_PTP2	202	205	PF00017	0.548
LIG_SH2_SRC	202	205	PF00017	0.532
LIG_SH2_SRC	241	244	PF00017	0.543
LIG_SH2_STAT3	194	197	PF00017	0.613
LIG_SH2_STAT3	210	213	PF00017	0.817
LIG_SH2_STAT3	219	222	PF00017	0.590
LIG_SH2_STAT3	265	268	PF00017	0.566
LIG_SH2_STAT3	274	277	PF00017	0.541
LIG_SH2_STAT3	36	39	PF00017	0.366
LIG_SH2_STAT5	100	103	PF00017	0.372
LIG_SH2_STAT5	194	197	PF00017	0.645
LIG_SH2_STAT5	202	205	PF00017	0.588
LIG_SH2_STAT5	210	213	PF00017	0.612
LIG_SH2_STAT5	219	222	PF00017	0.563
LIG_SH2_STAT5	241	244	PF00017	0.574
LIG_SH2_STAT5	266	269	PF00017	0.594
LIG_SH3_1	155	161	PF00018	0.530
LIG_SH3_1	228	234	PF00018	0.726
LIG_SH3_3	155	161	PF00018	0.650
LIG_SH3_3	182	188	PF00018	0.670
LIG_SH3_3	193	199	PF00018	0.818
LIG_SH3_3	228	234	PF00018	0.745
LIG_SH3_3	242	248	PF00018	0.637
LIG_SH3_3	273	279	PF00018	0.555
LIG_SUMO_SIM_par_1	114	119	PF11976	0.574
LIG_TRAF2_1	124	127	PF00917	0.515
LIG_UBA3_1	84	92	PF00899	0.263
LIG_WW_2	233	236	PF00397	0.581
MOD_CK2_1	104	110	PF00069	0.663
MOD_N-GLC_1	49	54	PF02516	0.286
MOD_N-GLC_2	71	73	PF02516	0.338
MOD_NEK2_1	102	107	PF00069	0.664
MOD_NEK2_2	49	54	PF00069	0.366
MOD_PIKK_1	104	110	PF00454	0.448
MOD_PIKK_1	203	209	PF00454	0.513
MOD_PIKK_1	264	270	PF00454	0.579
MOD_PIKK_1	35	41	PF00454	0.457
MOD_PIKK_1	60	66	PF00454	0.380
MOD_Plk_1	4	10	PF00069	0.468
MOD_Plk_1	49	55	PF00069	0.323
MOD_Plk_4	236	242	PF00069	0.625
MOD_ProDKin_1	184	190	PF00069	0.687
MOD_SUMO_for_1	124	127	PF00179	0.486
TRG_DiLeu_BaLyEn_6	111	116	PF01217	0.404
TRG_ENDOCYTIC_2	82	85	PF00928	0.362
TRG_Pf-PMV_PEXEL_1	114	119	PF00026	0.524
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.414
TRG_Pf-PMV_PEXEL_1	143	147	PF00026	0.477

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IFD2	Leishmania donovani	88%	100%
A0A3S7X485	Leishmania donovani	36%	100%
A0A3S7X4C0	Leishmania donovani	38%	100%
A4HJ46	Leishmania braziliensis	69%	93%
A4HJ57	Leishmania braziliensis	40%	100%
A4HJ58	Leishmania braziliensis	37%	96%
A4I6G2	Leishmania infantum	88%	100%
A4I6H2	Leishmania infantum	38%	100%
E9B1N0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9B1N1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
Q9BHE7	Leishmania major	34%	100%
Q9BHF8	Leishmania major	82%	95%