FtsJ domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

FtsJ-like methyltransferase, putative

Species:

Leishmania mexicana

UniProt:

E9B1L6_LEIMU

TriTrypDb:

LmxM.30.0650

Length:

335

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0030684	preribosome	3	1
GO:0030687	preribosome, large subunit precursor	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:1990904	ribonucleoprotein complex	2	1
GO:0016020	membrane	2	1

Expansion

Sequence features

E9B1L6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1L6

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	13
GO:0032259	methylation	2	13
GO:0000154	rRNA modification	6	1
GO:0000460	maturation of 5.8S rRNA	9	1
GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0000466	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0000470	maturation of LSU-rRNA	9	1
GO:0001510	RNA methylation	4	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0009451	RNA modification	5	1
GO:0009987	cellular process	1	3
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0031167	rRNA methylation	5	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:0051301	cell division	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0008168	methyltransferase activity	4	13
GO:0016740	transferase activity	2	13
GO:0016741	transferase activity, transferring one-carbon groups	3	13
GO:0008171	O-methyltransferase activity	5	1
GO:0008173	RNA methyltransferase activity	4	1
GO:0008649	rRNA methyltransferase activity	5	1
GO:0008650	rRNA (uridine-2'-O-)-methyltransferase activity	6	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016435	rRNA (guanine) methyltransferase activity	6	1
GO:0016436	rRNA (uridine) methyltransferase activity	6	1
GO:0062105	RNA 2'-O-methyltransferase activity	5	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140102	catalytic activity, acting on a rRNA	4	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	293	297	PF00656	0.466
CLV_NRD_NRD_1	271	273	PF00675	0.754
CLV_PCSK_KEX2_1	271	273	PF00082	0.754
CLV_PCSK_SKI1_1	54	58	PF00082	0.254
DEG_Nend_Nbox_1	1	3	PF02207	0.370
DEG_SPOP_SBC_1	192	196	PF00917	0.496
DOC_MAPK_DCC_7	193	203	PF00069	0.555
DOC_MAPK_gen_1	22	31	PF00069	0.532
DOC_MAPK_gen_1	274	284	PF00069	0.604
DOC_PP1_RVXF_1	297	303	PF00149	0.344
DOC_PP4_FxxP_1	285	288	PF00568	0.490
DOC_USP7_MATH_1	149	153	PF00917	0.392
DOC_USP7_MATH_1	175	179	PF00917	0.525
DOC_USP7_MATH_1	192	196	PF00917	0.392
DOC_USP7_MATH_1	232	236	PF00917	0.521
DOC_USP7_MATH_1	280	284	PF00917	0.601
DOC_WW_Pin1_4	102	107	PF00397	0.545
DOC_WW_Pin1_4	256	261	PF00397	0.537
DOC_WW_Pin1_4	55	60	PF00397	0.401
LIG_14-3-3_CanoR_1	108	117	PF00244	0.568
LIG_14-3-3_CanoR_1	137	142	PF00244	0.535
LIG_14-3-3_CanoR_1	187	192	PF00244	0.541
LIG_14-3-3_CanoR_1	193	201	PF00244	0.542
LIG_14-3-3_CanoR_1	24	29	PF00244	0.496
LIG_14-3-3_CanoR_1	256	260	PF00244	0.581
LIG_14-3-3_CanoR_1	277	283	PF00244	0.592
LIG_14-3-3_CanoR_1	3	11	PF00244	0.469
LIG_14-3-3_CanoR_1	87	93	PF00244	0.489
LIG_Actin_WH2_2	75	92	PF00022	0.349
LIG_BIR_III_2	172	176	PF00653	0.496
LIG_BRCT_BRCA1_1	156	160	PF00533	0.488
LIG_BRCT_BRCA1_1	209	213	PF00533	0.352
LIG_FHA_1	117	123	PF00498	0.531
LIG_FHA_1	169	175	PF00498	0.349
LIG_FHA_1	218	224	PF00498	0.540
LIG_FHA_2	25	31	PF00498	0.483
LIG_LIR_Apic_2	283	288	PF02991	0.523
LIG_LIR_Gen_1	210	219	PF02991	0.402
LIG_LIR_Nem_3	15	20	PF02991	0.454
LIG_LIR_Nem_3	210	216	PF02991	0.402
LIG_NRBOX	149	155	PF00104	0.540
LIG_PCNA_yPIPBox_3	147	158	PF02747	0.529
LIG_SH2_STAT3	2	5	PF00017	0.540
LIG_SH2_STAT5	243	246	PF00017	0.531
LIG_SH3_1	100	106	PF00018	0.349
LIG_SH3_2	103	108	PF14604	0.349
LIG_SH3_3	100	106	PF00018	0.349
LIG_SH3_3	257	263	PF00018	0.635
LIG_SH3_3	319	325	PF00018	0.573
LIG_SH3_3	65	71	PF00018	0.459
LIG_SUMO_SIM_anti_2	128	134	PF11976	0.458
LIG_SUMO_SIM_anti_2	94	100	PF11976	0.349
LIG_SUMO_SIM_par_1	60	65	PF11976	0.535
LIG_SUMO_SIM_par_1	9	15	PF11976	0.469
LIG_WW_3	105	109	PF00397	0.496
MOD_CDC14_SPxK_1	105	108	PF00782	0.555
MOD_CDK_SPxK_1	102	108	PF00069	0.555
MOD_CK1_1	112	118	PF00069	0.499
MOD_CK1_1	186	192	PF00069	0.519
MOD_CK1_1	278	284	PF00069	0.612
MOD_CK1_1	55	61	PF00069	0.424
MOD_CK1_1	94	100	PF00069	0.504
MOD_CK2_1	176	182	PF00069	0.516
MOD_CK2_1	232	238	PF00069	0.540
MOD_GlcNHglycan	111	114	PF01048	0.296
MOD_GlcNHglycan	189	192	PF01048	0.317
MOD_GlcNHglycan	195	198	PF01048	0.319
MOD_GlcNHglycan	277	280	PF01048	0.593
MOD_GlcNHglycan	331	335	PF01048	0.756
MOD_GlcNHglycan	5	8	PF01048	0.269
MOD_GlcNHglycan	54	57	PF01048	0.329
MOD_GlcNHglycan	93	96	PF01048	0.149
MOD_GSK3_1	108	115	PF00069	0.552
MOD_GSK3_1	164	171	PF00069	0.399
MOD_GSK3_1	183	190	PF00069	0.522
MOD_GSK3_1	232	239	PF00069	0.540
MOD_NEK2_1	139	144	PF00069	0.449
MOD_NEK2_1	148	153	PF00069	0.449
MOD_NEK2_1	154	159	PF00069	0.449
MOD_NEK2_1	217	222	PF00069	0.524
MOD_NEK2_2	280	285	PF00069	0.588
MOD_OFUCOSY	304	311	PF10250	0.463
MOD_PIKK_1	217	223	PF00454	0.506
MOD_PK_1	137	143	PF00069	0.555
MOD_PKA_2	176	182	PF00069	0.561
MOD_PKA_2	186	192	PF00069	0.540
MOD_PKA_2	23	29	PF00069	0.496
MOD_PKA_2	255	261	PF00069	0.614
MOD_PKA_2	270	276	PF00069	0.707
MOD_PKB_1	22	30	PF00069	0.496
MOD_Plk_4	128	134	PF00069	0.458
MOD_Plk_4	149	155	PF00069	0.496
MOD_Plk_4	24	30	PF00069	0.517
MOD_Plk_4	280	286	PF00069	0.576
MOD_Plk_4	94	100	PF00069	0.489
MOD_ProDKin_1	102	108	PF00069	0.545
MOD_ProDKin_1	256	262	PF00069	0.544
MOD_ProDKin_1	55	61	PF00069	0.401
TRG_ENDOCYTIC_2	17	20	PF00928	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8S5	Leptomonas seymouri	55%	94%
A0A0S4IVN5	Bodo saltans	35%	100%
A0A0S4IYL1	Bodo saltans	33%	99%
A0A1X0NJE7	Trypanosomatidae	34%	100%
A0A3R7L564	Trypanosoma rangeli	37%	100%
A0A3S7X469	Leishmania donovani	88%	100%
A0A422NPF8	Trypanosoma rangeli	24%	89%
A0A451EJH4	Leishmania donovani	23%	73%
A4HRN5	Leishmania infantum	23%	73%
A4I6F9	Leishmania infantum	88%	100%
C9ZN77	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9ACB3	Leishmania major	23%	73%
E9AIU3	Leishmania braziliensis	72%	100%
E9AJK1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	74%
O36015	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
P38238	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
Q22031	Caenorhabditis elegans	22%	99%
Q466Q1	Methanosarcina barkeri (strain Fusaro / DSM 804)	27%	100%
Q54VA8	Dictyostelium discoideum	23%	100%
Q8UHR0	Agrobacterium fabrum (strain C58 / ATCC 33970)	24%	100%
Q9BHC8	Leishmania major	89%	100%
V5ANC5	Trypanosoma cruzi	37%	94%