PHD-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B1L3_LEIMU

TriTrypDb:

LmxM.30.0620

Length:

816

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B1L3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1L3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	140	144	PF00656	0.593
CLV_C14_Caspase3-7	463	467	PF00656	0.692
CLV_C14_Caspase3-7	577	581	PF00656	0.503
CLV_C14_Caspase3-7	787	791	PF00656	0.695
CLV_NRD_NRD_1	148	150	PF00675	0.677
CLV_NRD_NRD_1	154	156	PF00675	0.693
CLV_NRD_NRD_1	184	186	PF00675	0.538
CLV_NRD_NRD_1	34	36	PF00675	0.645
CLV_NRD_NRD_1	622	624	PF00675	0.576
CLV_NRD_NRD_1	735	737	PF00675	0.688
CLV_PCSK_FUR_1	645	649	PF00082	0.798
CLV_PCSK_KEX2_1	116	118	PF00082	0.796
CLV_PCSK_KEX2_1	147	149	PF00082	0.646
CLV_PCSK_KEX2_1	154	156	PF00082	0.632
CLV_PCSK_KEX2_1	622	624	PF00082	0.574
CLV_PCSK_KEX2_1	647	649	PF00082	0.784
CLV_PCSK_PC1ET2_1	116	118	PF00082	0.608
CLV_PCSK_PC1ET2_1	147	149	PF00082	0.670
CLV_PCSK_PC1ET2_1	154	156	PF00082	0.634
CLV_PCSK_PC1ET2_1	647	649	PF00082	0.764
CLV_PCSK_SKI1_1	148	152	PF00082	0.676
CLV_PCSK_SKI1_1	155	159	PF00082	0.674
CLV_PCSK_SKI1_1	221	225	PF00082	0.629
CLV_PCSK_SKI1_1	412	416	PF00082	0.588
CLV_PCSK_SKI1_1	561	565	PF00082	0.500
CLV_PCSK_SKI1_1	609	613	PF00082	0.536
DEG_Nend_UBRbox_2	1	3	PF02207	0.799
DEG_SCF_FBW7_1	403	409	PF00400	0.480
DEG_SCF_FBW7_2	172	177	PF00400	0.680
DEG_SCF_FBW7_2	725	732	PF00400	0.664
DEG_SPOP_SBC_1	406	410	PF00917	0.533
DOC_CKS1_1	403	408	PF01111	0.478
DOC_CKS1_1	44	49	PF01111	0.546
DOC_CYCLIN_RxL_1	233	245	PF00134	0.686
DOC_MAPK_FxFP_2	81	84	PF00069	0.660
DOC_MAPK_gen_1	357	365	PF00069	0.674
DOC_MAPK_MEF2A_6	485	494	PF00069	0.565
DOC_MAPK_RevD_3	723	737	PF00069	0.699
DOC_PP1_RVXF_1	236	243	PF00149	0.562
DOC_PP4_FxxP_1	443	446	PF00568	0.579
DOC_PP4_FxxP_1	81	84	PF00568	0.660
DOC_SPAK_OSR1_1	238	242	PF12202	0.643
DOC_USP7_MATH_1	157	161	PF00917	0.738
DOC_USP7_MATH_1	206	210	PF00917	0.735
DOC_USP7_MATH_1	257	261	PF00917	0.696
DOC_USP7_MATH_1	379	383	PF00917	0.691
DOC_USP7_MATH_1	460	464	PF00917	0.604
DOC_USP7_MATH_1	468	472	PF00917	0.622
DOC_USP7_MATH_1	504	508	PF00917	0.681
DOC_USP7_MATH_1	512	516	PF00917	0.638
DOC_USP7_MATH_1	532	536	PF00917	0.609
DOC_USP7_MATH_1	579	583	PF00917	0.723
DOC_USP7_MATH_1	678	682	PF00917	0.800
DOC_USP7_MATH_1	710	714	PF00917	0.523
DOC_USP7_MATH_1	778	782	PF00917	0.711
DOC_USP7_MATH_1	87	91	PF00917	0.516
DOC_USP7_UBL2_3	147	151	PF12436	0.666
DOC_USP7_UBL2_3	152	156	PF12436	0.689
DOC_USP7_UBL2_3	411	415	PF12436	0.787
DOC_WW_Pin1_4	102	107	PF00397	0.730
DOC_WW_Pin1_4	170	175	PF00397	0.685
DOC_WW_Pin1_4	202	207	PF00397	0.732
DOC_WW_Pin1_4	265	270	PF00397	0.731
DOC_WW_Pin1_4	402	407	PF00397	0.644
DOC_WW_Pin1_4	43	48	PF00397	0.597
DOC_WW_Pin1_4	556	561	PF00397	0.517
DOC_WW_Pin1_4	679	684	PF00397	0.749
DOC_WW_Pin1_4	725	730	PF00397	0.658
DOC_WW_Pin1_4	795	800	PF00397	0.623
LIG_14-3-3_CanoR_1	277	283	PF00244	0.650
LIG_14-3-3_CanoR_1	298	304	PF00244	0.691
LIG_14-3-3_CanoR_1	362	366	PF00244	0.693
LIG_14-3-3_CanoR_1	380	385	PF00244	0.634
LIG_14-3-3_CanoR_1	389	393	PF00244	0.615
LIG_14-3-3_CanoR_1	401	406	PF00244	0.721
LIG_14-3-3_CanoR_1	483	492	PF00244	0.602
LIG_14-3-3_CanoR_1	536	542	PF00244	0.463
LIG_14-3-3_CanoR_1	588	593	PF00244	0.643
LIG_14-3-3_CanoR_1	622	628	PF00244	0.463
LIG_14-3-3_CanoR_1	645	655	PF00244	0.518
LIG_14-3-3_CanoR_1	690	695	PF00244	0.618
LIG_14-3-3_CanoR_1	711	715	PF00244	0.509
LIG_14-3-3_CanoR_1	79	84	PF00244	0.612
LIG_APCC_ABBA_1	727	732	PF00400	0.672
LIG_BIR_III_4	2	6	PF00653	0.680
LIG_BIR_III_4	580	584	PF00653	0.476
LIG_BRCT_BRCA1_1	712	716	PF00533	0.531
LIG_BRCT_BRCA1_1	763	767	PF00533	0.665
LIG_deltaCOP1_diTrp_1	213	220	PF00928	0.576
LIG_deltaCOP1_diTrp_1	74	83	PF00928	0.656
LIG_FHA_1	10	16	PF00498	0.543
LIG_FHA_1	133	139	PF00498	0.592
LIG_FHA_1	171	177	PF00498	0.681
LIG_FHA_1	335	341	PF00498	0.690
LIG_FHA_1	536	542	PF00498	0.599
LIG_FHA_2	106	112	PF00498	0.610
LIG_FHA_2	138	144	PF00498	0.617
LIG_FHA_2	298	304	PF00498	0.774
LIG_FHA_2	325	331	PF00498	0.773
LIG_FHA_2	362	368	PF00498	0.638
LIG_FHA_2	419	425	PF00498	0.585
LIG_FHA_2	565	571	PF00498	0.790
LIG_FHA_2	785	791	PF00498	0.643
LIG_LIR_Gen_1	18	28	PF02991	0.593
LIG_LIR_Gen_1	317	328	PF02991	0.733
LIG_LIR_Gen_1	526	533	PF02991	0.461
LIG_LIR_Gen_1	713	723	PF02991	0.585
LIG_LIR_Gen_1	728	738	PF02991	0.498
LIG_LIR_Gen_1	801	810	PF02991	0.642
LIG_LIR_Nem_3	18	24	PF02991	0.593
LIG_LIR_Nem_3	219	223	PF02991	0.717
LIG_LIR_Nem_3	27	33	PF02991	0.546
LIG_LIR_Nem_3	317	323	PF02991	0.705
LIG_LIR_Nem_3	518	523	PF02991	0.477
LIG_LIR_Nem_3	526	531	PF02991	0.372
LIG_LIR_Nem_3	614	618	PF02991	0.625
LIG_LIR_Nem_3	713	719	PF02991	0.582
LIG_LIR_Nem_3	728	733	PF02991	0.510
LIG_LIR_Nem_3	743	748	PF02991	0.468
LIG_LIR_Nem_3	75	81	PF02991	0.581
LIG_LIR_Nem_3	801	806	PF02991	0.580
LIG_Pex14_1	744	748	PF04695	0.517
LIG_SH2_CRK	320	324	PF00017	0.723
LIG_SH2_CRK	37	41	PF00017	0.582
LIG_SH2_CRK	615	619	PF00017	0.602
LIG_SH2_CRK	625	629	PF00017	0.396
LIG_SH2_GRB2like	37	40	PF00017	0.614
LIG_SH2_NCK_1	320	324	PF00017	0.723
LIG_SH2_NCK_1	625	629	PF00017	0.511
LIG_SH2_PTP2	21	24	PF00017	0.629
LIG_SH2_SRC	21	24	PF00017	0.588
LIG_SH2_SRC	37	40	PF00017	0.573
LIG_SH2_STAP1	436	440	PF00017	0.596
LIG_SH2_STAT5	21	24	PF00017	0.545
LIG_SH2_STAT5	227	230	PF00017	0.582
LIG_SH2_STAT5	275	278	PF00017	0.538
LIG_SH2_STAT5	413	416	PF00017	0.499
LIG_SH2_STAT5	594	597	PF00017	0.623
LIG_SH3_3	19	25	PF00018	0.625
LIG_SH3_3	225	231	PF00018	0.648
LIG_SH3_3	259	265	PF00018	0.539
LIG_SH3_3	400	406	PF00018	0.734
LIG_SH3_3	41	47	PF00018	0.515
LIG_SH3_3	526	532	PF00018	0.476
LIG_SH3_3	779	785	PF00018	0.646
LIG_SH3_3	81	87	PF00018	0.621
LIG_SUMO_SIM_par_1	134	140	PF11976	0.579
LIG_SUMO_SIM_par_1	336	341	PF11976	0.655
LIG_SxIP_EBH_1	715	724	PF03271	0.609
LIG_TRAF2_1	656	659	PF00917	0.782
LIG_TRAF2_2	656	661	PF00917	0.645
LIG_TYR_ITIM	19	24	PF00017	0.594
LIG_TYR_ITIM	318	323	PF00017	0.719
LIG_UBA3_1	516	522	PF00899	0.465
LIG_WRC_WIRS_1	800	805	PF05994	0.647
MOD_CDK_SPK_2	170	175	PF00069	0.694
MOD_CDK_SPK_2	556	561	PF00069	0.483
MOD_CK1_1	120	126	PF00069	0.649
MOD_CK1_1	161	167	PF00069	0.556
MOD_CK1_1	229	235	PF00069	0.678
MOD_CK1_1	268	274	PF00069	0.689
MOD_CK1_1	291	297	PF00069	0.706
MOD_CK1_1	305	311	PF00069	0.731
MOD_CK1_1	417	423	PF00069	0.591
MOD_CK1_1	48	54	PF00069	0.739
MOD_CK1_1	506	512	PF00069	0.724
MOD_CK1_1	515	521	PF00069	0.566
MOD_CK1_1	535	541	PF00069	0.609
MOD_CK1_1	626	632	PF00069	0.554
MOD_CK1_1	681	687	PF00069	0.725
MOD_CK1_1	717	723	PF00069	0.547
MOD_CK1_1	773	779	PF00069	0.709
MOD_CK1_1	82	88	PF00069	0.618
MOD_CK2_1	105	111	PF00069	0.616
MOD_CK2_1	297	303	PF00069	0.746
MOD_CK2_1	324	330	PF00069	0.757
MOD_CK2_1	361	367	PF00069	0.635
MOD_CK2_1	564	570	PF00069	0.807
MOD_CK2_1	581	587	PF00069	0.610
MOD_CK2_1	778	784	PF00069	0.724
MOD_CK2_1	795	801	PF00069	0.560
MOD_CMANNOS	449	452	PF00535	0.680
MOD_Cter_Amidation	152	155	PF01082	0.533
MOD_GlcNHglycan	159	163	PF01048	0.742
MOD_GlcNHglycan	168	171	PF01048	0.734
MOD_GlcNHglycan	208	211	PF01048	0.672
MOD_GlcNHglycan	228	231	PF01048	0.698
MOD_GlcNHglycan	244	247	PF01048	0.543
MOD_GlcNHglycan	259	262	PF01048	0.724
MOD_GlcNHglycan	290	293	PF01048	0.794
MOD_GlcNHglycan	306	310	PF01048	0.732
MOD_GlcNHglycan	385	388	PF01048	0.660
MOD_GlcNHglycan	394	397	PF01048	0.579
MOD_GlcNHglycan	47	50	PF01048	0.730
MOD_GlcNHglycan	508	511	PF01048	0.711
MOD_GlcNHglycan	544	547	PF01048	0.465
MOD_GlcNHglycan	577	580	PF01048	0.703
MOD_GlcNHglycan	581	584	PF01048	0.580
MOD_GlcNHglycan	59	62	PF01048	0.637
MOD_GlcNHglycan	628	631	PF01048	0.498
MOD_GlcNHglycan	634	637	PF01048	0.567
MOD_GlcNHglycan	642	645	PF01048	0.663
MOD_GlcNHglycan	650	653	PF01048	0.584
MOD_GlcNHglycan	756	759	PF01048	0.682
MOD_GlcNHglycan	772	775	PF01048	0.449
MOD_GlcNHglycan	8	12	PF01048	0.657
MOD_GSK3_1	112	119	PF00069	0.720
MOD_GSK3_1	120	127	PF00069	0.650
MOD_GSK3_1	137	144	PF00069	0.524
MOD_GSK3_1	157	164	PF00069	0.561
MOD_GSK3_1	166	173	PF00069	0.699
MOD_GSK3_1	202	209	PF00069	0.709
MOD_GSK3_1	284	291	PF00069	0.651
MOD_GSK3_1	334	341	PF00069	0.701
MOD_GSK3_1	379	386	PF00069	0.641
MOD_GSK3_1	388	395	PF00069	0.603
MOD_GSK3_1	401	408	PF00069	0.683
MOD_GSK3_1	414	421	PF00069	0.728
MOD_GSK3_1	462	469	PF00069	0.739
MOD_GSK3_1	504	511	PF00069	0.689
MOD_GSK3_1	531	538	PF00069	0.616
MOD_GSK3_1	571	578	PF00069	0.760
MOD_GSK3_1	626	633	PF00069	0.462
MOD_GSK3_1	710	717	PF00069	0.537
MOD_GSK3_1	795	802	PF00069	0.641
MOD_GSK3_1	87	94	PF00069	0.596
MOD_LATS_1	399	405	PF00433	0.616
MOD_N-GLC_1	120	125	PF02516	0.663
MOD_N-GLC_1	542	547	PF02516	0.484
MOD_N-GLC_1	659	664	PF02516	0.820
MOD_N-GLC_1	761	766	PF02516	0.674
MOD_N-GLC_1	91	96	PF02516	0.762
MOD_N-GLC_2	699	701	PF02516	0.469
MOD_NEK2_1	112	117	PF00069	0.691
MOD_NEK2_1	314	319	PF00069	0.579
MOD_NEK2_1	366	371	PF00069	0.533
MOD_NEK2_1	414	419	PF00069	0.755
MOD_NEK2_1	484	489	PF00069	0.634
MOD_NEK2_1	595	600	PF00069	0.515
MOD_NEK2_1	632	637	PF00069	0.368
MOD_NEK2_1	702	707	PF00069	0.509
MOD_NEK2_1	738	743	PF00069	0.498
MOD_NEK2_1	91	96	PF00069	0.738
MOD_NEK2_2	537	542	PF00069	0.552
MOD_PIKK_1	372	378	PF00454	0.715
MOD_PIKK_1	595	601	PF00454	0.534
MOD_PIKK_1	717	723	PF00454	0.583
MOD_PKA_1	116	122	PF00069	0.788
MOD_PKA_1	415	421	PF00069	0.720
MOD_PKA_2	116	122	PF00069	0.783
MOD_PKA_2	276	282	PF00069	0.545
MOD_PKA_2	297	303	PF00069	0.691
MOD_PKA_2	361	367	PF00069	0.686
MOD_PKA_2	379	385	PF00069	0.660
MOD_PKA_2	388	394	PF00069	0.639
MOD_PKA_2	484	490	PF00069	0.587
MOD_PKA_2	535	541	PF00069	0.581
MOD_PKA_2	689	695	PF00069	0.640
MOD_PKA_2	710	716	PF00069	0.518
MOD_PKB_1	139	147	PF00069	0.386
MOD_PKB_1	688	696	PF00069	0.670
MOD_PKB_1	77	85	PF00069	0.678
MOD_Plk_1	338	344	PF00069	0.637
MOD_Plk_1	366	372	PF00069	0.569
MOD_Plk_1	436	442	PF00069	0.673
MOD_Plk_1	630	636	PF00069	0.510
MOD_Plk_1	738	744	PF00069	0.504
MOD_Plk_1	91	97	PF00069	0.746
MOD_Plk_4	132	138	PF00069	0.641
MOD_Plk_4	161	167	PF00069	0.582
MOD_Plk_4	361	367	PF00069	0.633
MOD_Plk_4	380	386	PF00069	0.715
MOD_Plk_4	388	394	PF00069	0.733
MOD_Plk_4	512	518	PF00069	0.616
MOD_Plk_4	524	530	PF00069	0.482
MOD_Plk_4	581	587	PF00069	0.680
MOD_Plk_4	623	629	PF00069	0.470
MOD_Plk_4	740	746	PF00069	0.650
MOD_ProDKin_1	102	108	PF00069	0.717
MOD_ProDKin_1	170	176	PF00069	0.686
MOD_ProDKin_1	202	208	PF00069	0.732
MOD_ProDKin_1	265	271	PF00069	0.730
MOD_ProDKin_1	402	408	PF00069	0.642
MOD_ProDKin_1	43	49	PF00069	0.600
MOD_ProDKin_1	556	562	PF00069	0.518
MOD_ProDKin_1	679	685	PF00069	0.747
MOD_ProDKin_1	725	731	PF00069	0.662
MOD_ProDKin_1	795	801	PF00069	0.620
MOD_SUMO_for_1	174	177	PF00179	0.740
MOD_SUMO_rev_2	251	258	PF00179	0.715
TRG_DiLeu_BaEn_1	132	137	PF01217	0.361
TRG_DiLeu_BaLyEn_6	219	224	PF01217	0.717
TRG_DiLeu_BaLyEn_6	790	795	PF01217	0.643
TRG_ENDOCYTIC_2	21	24	PF00928	0.588
TRG_ENDOCYTIC_2	320	323	PF00928	0.723
TRG_ENDOCYTIC_2	37	40	PF00928	0.351
TRG_ENDOCYTIC_2	615	618	PF00928	0.574
TRG_ENDOCYTIC_2	625	628	PF00928	0.441
TRG_ER_diArg_1	138	141	PF00400	0.558
TRG_ER_diArg_1	482	485	PF00400	0.621
TRG_ER_diArg_1	622	624	PF00400	0.574
TRG_NLS_MonoExtC_3	146	151	PF00514	0.537
TRG_NLS_MonoExtC_3	153	158	PF00514	0.501
TRG_NLS_MonoExtN_4	148	155	PF00514	0.471
TRG_Pf-PMV_PEXEL_1	194	198	PF00026	0.653

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8T0	Leptomonas seymouri	46%	99%
A0A1X0NK18	Trypanosomatidae	27%	100%
A0A3R7NKJ0	Trypanosoma rangeli	27%	100%
A0A3S7X461	Leishmania donovani	88%	100%
A4HJ41	Leishmania braziliensis	74%	100%
A4I6F6	Leishmania infantum	88%	100%
C9ZN74	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
Q4Q6K1	Leishmania major	86%	100%