Ribosomal_L7Ae domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B1L2_LEIMU

TriTrypDb:

LmxM.30.0610

Length:

559

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	1
GO:1990904	ribonucleoprotein complex	2	1
GO:0005840	ribosome	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B1L2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1L2

Function

Biological processes
Term	Name	Level	Count
GO:0001514	selenocysteine incorporation	7	1
GO:0006414	translational elongation	5	1
GO:0006417	regulation of translation	6	1
GO:0006451	translational readthrough	6	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0034248	regulation of amide metabolic process	5	1
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1901576	organic substance biosynthetic process	3	1
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0003729	mRNA binding	5	11
GO:0005488	binding	1	11
GO:0035368	selenocysteine insertion sequence binding	6	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003730	mRNA 3'-UTR binding	6	1
GO:0043021	ribonucleoprotein complex binding	3	1
GO:0044877	protein-containing complex binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	248	252	PF00656	0.738
CLV_NRD_NRD_1	158	160	PF00675	0.661
CLV_NRD_NRD_1	189	191	PF00675	0.519
CLV_NRD_NRD_1	199	201	PF00675	0.526
CLV_NRD_NRD_1	209	211	PF00675	0.463
CLV_NRD_NRD_1	455	457	PF00675	0.568
CLV_PCSK_FUR_1	207	211	PF00082	0.526
CLV_PCSK_KEX2_1	158	160	PF00082	0.650
CLV_PCSK_KEX2_1	169	171	PF00082	0.400
CLV_PCSK_KEX2_1	189	191	PF00082	0.503
CLV_PCSK_KEX2_1	198	200	PF00082	0.473
CLV_PCSK_KEX2_1	209	211	PF00082	0.379
CLV_PCSK_KEX2_1	93	95	PF00082	0.482
CLV_PCSK_PC1ET2_1	169	171	PF00082	0.348
CLV_PCSK_PC1ET2_1	198	200	PF00082	0.482
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.507
CLV_PCSK_SKI1_1	210	214	PF00082	0.482
CLV_PCSK_SKI1_1	338	342	PF00082	0.551
CLV_PCSK_SKI1_1	374	378	PF00082	0.365
CLV_PCSK_SKI1_1	399	403	PF00082	0.505
CLV_PCSK_SKI1_1	407	411	PF00082	0.467
CLV_PCSK_SKI1_1	457	461	PF00082	0.584
CLV_PCSK_SKI1_1	531	535	PF00082	0.477
CLV_PCSK_SKI1_1	542	546	PF00082	0.417
DEG_APCC_DBOX_1	404	412	PF00400	0.398
DEG_APCC_DBOX_1	530	538	PF00400	0.418
DEG_SCF_FBW7_1	130	137	PF00400	0.457
DEG_SPOP_SBC_1	323	327	PF00917	0.547
DOC_CKS1_1	418	423	PF01111	0.563
DOC_MAPK_gen_1	374	384	PF00069	0.393
DOC_MAPK_gen_1	385	394	PF00069	0.352
DOC_MAPK_gen_1	399	408	PF00069	0.475
DOC_MAPK_gen_1	515	524	PF00069	0.484
DOC_MAPK_MEF2A_6	402	410	PF00069	0.468
DOC_PP2B_LxvP_1	254	257	PF13499	0.449
DOC_PP4_FxxP_1	261	264	PF00568	0.597
DOC_USP7_MATH_1	132	136	PF00917	0.720
DOC_USP7_MATH_1	174	178	PF00917	0.477
DOC_USP7_MATH_1	257	261	PF00917	0.513
DOC_USP7_MATH_1	28	32	PF00917	0.743
DOC_USP7_MATH_1	322	326	PF00917	0.646
DOC_USP7_MATH_1	339	343	PF00917	0.546
DOC_USP7_MATH_1	444	448	PF00917	0.638
DOC_USP7_MATH_1	451	455	PF00917	0.473
DOC_USP7_MATH_1	49	53	PF00917	0.665
DOC_USP7_MATH_1	514	518	PF00917	0.523
DOC_USP7_MATH_1	536	540	PF00917	0.349
DOC_USP7_UBL2_3	453	457	PF12436	0.668
DOC_WW_Pin1_4	125	130	PF00397	0.641
DOC_WW_Pin1_4	324	329	PF00397	0.699
DOC_WW_Pin1_4	417	422	PF00397	0.471
DOC_WW_Pin1_4	442	447	PF00397	0.775
DOC_WW_Pin1_4	78	83	PF00397	0.637
LIG_14-3-3_CanoR_1	189	197	PF00244	0.428
LIG_14-3-3_CanoR_1	244	254	PF00244	0.594
LIG_14-3-3_CanoR_1	39	46	PF00244	0.694
LIG_14-3-3_CanoR_1	505	511	PF00244	0.538
LIG_14-3-3_CanoR_1	542	551	PF00244	0.389
LIG_BRCT_BRCA1_1	341	345	PF00533	0.507
LIG_CaM_IQ_9	201	217	PF13499	0.409
LIG_CaM_IQ_9	391	407	PF13499	0.470
LIG_FHA_1	107	113	PF00498	0.476
LIG_FHA_1	316	322	PF00498	0.410
LIG_FHA_1	349	355	PF00498	0.320
LIG_FHA_2	411	417	PF00498	0.435
LIG_FHA_2	460	466	PF00498	0.418
LIG_IRF3_LxIS_1	108	115	PF10401	0.415
LIG_LIR_Apic_2	260	264	PF02991	0.601
LIG_LIR_Gen_1	177	186	PF02991	0.410
LIG_LIR_Gen_1	360	370	PF02991	0.326
LIG_LIR_Nem_3	177	182	PF02991	0.384
LIG_LIR_Nem_3	265	270	PF02991	0.520
LIG_LIR_Nem_3	283	289	PF02991	0.352
LIG_LIR_Nem_3	360	366	PF02991	0.342
LIG_LIR_Nem_3	509	513	PF02991	0.446
LIG_LIR_Nem_3	539	543	PF02991	0.359
LIG_LYPXL_yS_3	286	289	PF13949	0.465
LIG_MYND_3	119	123	PF01753	0.521
LIG_SH2_NCK_1	191	195	PF00017	0.358
LIG_SH2_PTP2	179	182	PF00017	0.324
LIG_SH2_STAP1	510	514	PF00017	0.343
LIG_SH2_STAP1	547	551	PF00017	0.363
LIG_SH2_STAT3	370	373	PF00017	0.345
LIG_SH2_STAT5	179	182	PF00017	0.324
LIG_SH2_STAT5	349	352	PF00017	0.337
LIG_SH2_STAT5	390	393	PF00017	0.417
LIG_SH2_STAT5	543	546	PF00017	0.499
LIG_SH2_STAT5	547	550	PF00017	0.476
LIG_SH3_3	126	132	PF00018	0.686
LIG_SH3_3	415	421	PF00018	0.597
LIG_SH3_3	422	428	PF00018	0.669
LIG_SH3_3	473	479	PF00018	0.586
LIG_SUMO_SIM_anti_2	309	316	PF11976	0.344
LIG_SUMO_SIM_par_1	407	414	PF11976	0.428
LIG_TRAF2_1	137	140	PF00917	0.475
LIG_UBA3_1	365	371	PF00899	0.454
LIG_WRC_WIRS_1	258	263	PF05994	0.664
LIG_WW_1	255	258	PF00397	0.441
MOD_CDC14_SPxK_1	128	131	PF00782	0.456
MOD_CDK_SPxK_1	125	131	PF00069	0.461
MOD_CDK_SPxxK_3	442	449	PF00069	0.598
MOD_CK1_1	220	226	PF00069	0.448
MOD_CK1_1	327	333	PF00069	0.626
MOD_CK1_1	433	439	PF00069	0.680
MOD_CK1_1	452	458	PF00069	0.602
MOD_CK1_1	501	507	PF00069	0.424
MOD_CK2_1	134	140	PF00069	0.751
MOD_CK2_1	154	160	PF00069	0.597
MOD_CK2_1	410	416	PF00069	0.375
MOD_CK2_1	459	465	PF00069	0.435
MOD_Cter_Amidation	187	190	PF01082	0.369
MOD_GlcNHglycan	114	117	PF01048	0.558
MOD_GlcNHglycan	136	139	PF01048	0.685
MOD_GlcNHglycan	236	239	PF01048	0.517
MOD_GlcNHglycan	275	278	PF01048	0.518
MOD_GlcNHglycan	30	33	PF01048	0.697
MOD_GlcNHglycan	422	425	PF01048	0.712
MOD_GlcNHglycan	446	449	PF01048	0.675
MOD_GSK3_1	130	137	PF00069	0.684
MOD_GSK3_1	140	147	PF00069	0.704
MOD_GSK3_1	174	181	PF00069	0.441
MOD_GSK3_1	213	220	PF00069	0.526
MOD_GSK3_1	242	249	PF00069	0.770
MOD_GSK3_1	28	35	PF00069	0.769
MOD_GSK3_1	323	330	PF00069	0.651
MOD_GSK3_1	348	355	PF00069	0.368
MOD_GSK3_1	440	447	PF00069	0.682
MOD_NEK2_1	112	117	PF00069	0.510
MOD_NEK2_1	18	23	PF00069	0.706
MOD_NEK2_1	217	222	PF00069	0.573
MOD_NEK2_1	232	237	PF00069	0.568
MOD_NEK2_1	333	338	PF00069	0.664
MOD_NEK2_1	340	345	PF00069	0.497
MOD_NEK2_1	361	366	PF00069	0.371
MOD_NEK2_1	432	437	PF00069	0.757
MOD_NEK2_1	498	503	PF00069	0.494
MOD_NEK2_1	551	556	PF00069	0.500
MOD_NEK2_2	174	179	PF00069	0.324
MOD_NEK2_2	257	262	PF00069	0.484
MOD_NEK2_2	459	464	PF00069	0.535
MOD_PIKK_1	161	167	PF00454	0.544
MOD_PIKK_1	189	195	PF00454	0.298
MOD_PIKK_1	226	232	PF00454	0.604
MOD_PIKK_1	333	339	PF00454	0.580
MOD_PIKK_1	49	55	PF00454	0.763
MOD_PKA_1	189	195	PF00069	0.307
MOD_PKA_2	144	150	PF00069	0.492
MOD_PKA_2	189	195	PF00069	0.500
MOD_PKA_2	226	232	PF00069	0.653
MOD_PKA_2	243	249	PF00069	0.612
MOD_PKA_2	38	44	PF00069	0.742
MOD_PKA_2	481	487	PF00069	0.674
MOD_PKA_2	506	512	PF00069	0.537
MOD_PKA_2	54	60	PF00069	0.648
MOD_PKA_2	87	93	PF00069	0.552
MOD_Plk_1	551	557	PF00069	0.457
MOD_Plk_2-3	140	146	PF00069	0.700
MOD_Plk_2-3	5	11	PF00069	0.542
MOD_Plk_4	174	180	PF00069	0.429
MOD_Plk_4	263	269	PF00069	0.581
MOD_Plk_4	340	346	PF00069	0.558
MOD_Plk_4	41	47	PF00069	0.773
MOD_ProDKin_1	125	131	PF00069	0.643
MOD_ProDKin_1	324	330	PF00069	0.703
MOD_ProDKin_1	417	423	PF00069	0.476
MOD_ProDKin_1	442	448	PF00069	0.776
MOD_ProDKin_1	78	84	PF00069	0.631
TRG_DiLeu_BaEn_1	465	470	PF01217	0.418
TRG_ENDOCYTIC_2	179	182	PF00928	0.382
TRG_ENDOCYTIC_2	258	261	PF00928	0.543
TRG_ENDOCYTIC_2	286	289	PF00928	0.586
TRG_ER_diArg_1	189	191	PF00400	0.508
TRG_ER_diArg_1	199	201	PF00400	0.476
TRG_ER_diArg_1	206	209	PF00400	0.473
TRG_ER_diArg_1	387	390	PF00400	0.417
TRG_ER_diArg_1	405	408	PF00400	0.409
TRG_ER_diArg_1	505	508	PF00400	0.407
TRG_ER_diArg_1	86	89	PF00400	0.622
TRG_NLS_MonoExtN_4	196	202	PF00514	0.475
TRG_NLS_MonoExtN_4	453	460	PF00514	0.546
TRG_Pf-PMV_PEXEL_1	374	378	PF00026	0.442

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMN8	Leptomonas seymouri	50%	100%
A0A1X0NJ63	Trypanosomatidae	27%	87%
A0A3R7LBH7	Trypanosoma rangeli	30%	99%
A0A3S7X464	Leishmania donovani	87%	100%
A4HJ40	Leishmania braziliensis	70%	100%
A4I6F5	Leishmania infantum	87%	100%
C9ZN70	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
Q9BHF1	Leishmania major	86%	100%
V5BDV6	Trypanosoma cruzi	27%	93%