Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B1L1_LEIMU

TriTrypDb:

LmxM.30.0600

Length:

458

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9B1L1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1L1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	174	176	PF00675	0.736
CLV_NRD_NRD_1	231	233	PF00675	0.775
CLV_NRD_NRD_1	68	70	PF00675	0.617
CLV_NRD_NRD_1	78	80	PF00675	0.622
CLV_PCSK_KEX2_1	231	233	PF00082	0.715
CLV_PCSK_KEX2_1	68	70	PF00082	0.617
CLV_PCSK_KEX2_1	78	80	PF00082	0.622
CLV_PCSK_KEX2_1	82	84	PF00082	0.641
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.658
CLV_PCSK_PC7_1	78	84	PF00082	0.647
CLV_PCSK_SKI1_1	337	341	PF00082	0.641
CLV_PCSK_SKI1_1	348	352	PF00082	0.546
CLV_PCSK_SKI1_1	36	40	PF00082	0.659
CLV_Separin_Metazoa	72	76	PF03568	0.405
DEG_APCC_DBOX_1	336	344	PF00400	0.438
DEG_SPOP_SBC_1	395	399	PF00917	0.636
DOC_MAPK_gen_1	33	43	PF00069	0.359
DOC_MIT_MIM_1	117	125	PF04212	0.347
DOC_PP4_MxPP_1	442	445	PF00568	0.612
DOC_USP7_MATH_1	169	173	PF00917	0.527
DOC_USP7_MATH_1	235	239	PF00917	0.573
DOC_USP7_MATH_1	49	53	PF00917	0.501
DOC_USP7_MATH_1	62	66	PF00917	0.454
DOC_USP7_MATH_1	85	89	PF00917	0.383
DOC_USP7_UBL2_3	286	290	PF12436	0.486
DOC_WW_Pin1_4	105	110	PF00397	0.506
DOC_WW_Pin1_4	140	145	PF00397	0.425
DOC_WW_Pin1_4	200	205	PF00397	0.603
DOC_WW_Pin1_4	386	391	PF00397	0.740
DOC_WW_Pin1_4	403	408	PF00397	0.695
DOC_WW_Pin1_4	412	417	PF00397	0.829
DOC_WW_Pin1_4	427	432	PF00397	0.777
DOC_WW_Pin1_4	50	55	PF00397	0.537
LIG_14-3-3_CanoR_1	216	226	PF00244	0.555
LIG_14-3-3_CanoR_1	231	239	PF00244	0.497
LIG_14-3-3_CanoR_1	312	316	PF00244	0.459
LIG_14-3-3_CanoR_1	61	70	PF00244	0.520
LIG_Actin_WH2_2	332	350	PF00022	0.436
LIG_APCC_ABBAyCdc20_2	176	182	PF00400	0.535
LIG_EH1_1	350	358	PF00400	0.222
LIG_FHA_1	141	147	PF00498	0.415
LIG_FHA_1	179	185	PF00498	0.403
LIG_FHA_1	358	364	PF00498	0.411
LIG_FHA_1	397	403	PF00498	0.753
LIG_FHA_1	404	410	PF00498	0.743
LIG_FHA_1	62	68	PF00498	0.449
LIG_FHA_2	2	8	PF00498	0.591
LIG_FHA_2	220	226	PF00498	0.515
LIG_FHA_2	253	259	PF00498	0.467
LIG_FHA_2	434	440	PF00498	0.847
LIG_IRF3_LxIS_1	363	368	PF10401	0.513
LIG_LIR_Gen_1	162	173	PF02991	0.372
LIG_LIR_Nem_3	162	168	PF02991	0.370
LIG_LIR_Nem_3	453	458	PF02991	0.615
LIG_NRBOX	69	75	PF00104	0.403
LIG_PCNA_PIPBox_1	133	142	PF02747	0.501
LIG_Pex14_1	324	328	PF04695	0.483
LIG_SH2_STAP1	180	184	PF00017	0.461
LIG_SH2_STAT3	113	116	PF00017	0.444
LIG_SH2_STAT3	139	142	PF00017	0.503
LIG_SH2_STAT3	376	379	PF00017	0.729
LIG_SH2_STAT5	139	142	PF00017	0.503
LIG_SH2_STAT5	180	183	PF00017	0.523
LIG_SH2_STAT5	315	318	PF00017	0.505
LIG_SH3_1	327	333	PF00018	0.477
LIG_SH3_3	103	109	PF00018	0.521
LIG_SH3_3	180	186	PF00018	0.594
LIG_SH3_3	327	333	PF00018	0.433
LIG_SH3_3	336	342	PF00018	0.392
LIG_SH3_3	367	373	PF00018	0.674
LIG_SH3_3	404	410	PF00018	0.797
LIG_SH3_3	411	417	PF00018	0.781
LIG_SH3_3	425	431	PF00018	0.693
LIG_SH3_3	437	443	PF00018	0.792
LIG_SUMO_SIM_par_1	355	360	PF11976	0.411
LIG_SUMO_SIM_par_1	362	368	PF11976	0.411
LIG_SUMO_SIM_par_1	423	430	PF11976	0.626
LIG_TRAF2_1	222	225	PF00917	0.593
LIG_UBA3_1	364	372	PF00899	0.398
LIG_WW_2	407	410	PF00397	0.481
MOD_CDC14_SPxK_1	108	111	PF00782	0.503
MOD_CDK_SPxK_1	105	111	PF00069	0.530
MOD_CK1_1	386	392	PF00069	0.718
MOD_CK1_1	52	58	PF00069	0.682
MOD_CK1_1	6	12	PF00069	0.779
MOD_CK2_1	1	7	PF00069	0.759
MOD_CK2_1	219	225	PF00069	0.652
MOD_CK2_1	303	309	PF00069	0.605
MOD_GlcNHglycan	233	236	PF01048	0.783
MOD_GlcNHglycan	246	249	PF01048	0.520
MOD_GlcNHglycan	278	281	PF01048	0.559
MOD_GlcNHglycan	290	293	PF01048	0.558
MOD_GlcNHglycan	47	50	PF01048	0.633
MOD_GlcNHglycan	7	11	PF01048	0.756
MOD_GSK3_1	138	145	PF00069	0.550
MOD_GSK3_1	149	156	PF00069	0.565
MOD_GSK3_1	2	9	PF00069	0.573
MOD_GSK3_1	215	222	PF00069	0.700
MOD_GSK3_1	231	238	PF00069	0.626
MOD_GSK3_1	284	291	PF00069	0.467
MOD_GSK3_1	299	306	PF00069	0.390
MOD_GSK3_1	386	393	PF00069	0.744
MOD_GSK3_1	396	403	PF00069	0.752
MOD_GSK3_1	412	419	PF00069	0.471
MOD_GSK3_1	45	52	PF00069	0.649
MOD_GSK3_1	85	92	PF00069	0.606
MOD_N-GLC_1	210	215	PF02516	0.661
MOD_NEK2_1	1	6	PF00069	0.737
MOD_NEK2_1	244	249	PF00069	0.676
MOD_NEK2_1	276	281	PF00069	0.557
MOD_NEK2_1	335	340	PF00069	0.489
MOD_NEK2_1	352	357	PF00069	0.381
MOD_NEK2_1	365	370	PF00069	0.425
MOD_NEK2_1	43	48	PF00069	0.683
MOD_NEK2_1	89	94	PF00069	0.761
MOD_NEK2_2	303	308	PF00069	0.399
MOD_PIKK_1	138	144	PF00454	0.624
MOD_PIKK_1	217	223	PF00454	0.635
MOD_PKA_1	231	237	PF00069	0.728
MOD_PKA_2	120	126	PF00069	0.616
MOD_PKA_2	215	221	PF00069	0.734
MOD_PKA_2	231	237	PF00069	0.526
MOD_PKA_2	311	317	PF00069	0.568
MOD_PKA_2	60	66	PF00069	0.603
MOD_Plk_1	209	215	PF00069	0.788
MOD_Plk_1	438	444	PF00069	0.607
MOD_Plk_1	85	91	PF00069	0.586
MOD_Plk_4	210	216	PF00069	0.732
MOD_Plk_4	311	317	PF00069	0.627
MOD_Plk_4	352	358	PF00069	0.494
MOD_Plk_4	371	377	PF00069	0.505
MOD_ProDKin_1	105	111	PF00069	0.627
MOD_ProDKin_1	140	146	PF00069	0.522
MOD_ProDKin_1	200	206	PF00069	0.772
MOD_ProDKin_1	386	392	PF00069	0.685
MOD_ProDKin_1	403	409	PF00069	0.620
MOD_ProDKin_1	412	418	PF00069	0.809
MOD_ProDKin_1	427	433	PF00069	0.733
MOD_ProDKin_1	50	56	PF00069	0.675
TRG_DiLeu_BaEn_1	210	215	PF01217	0.515
TRG_DiLeu_BaLyEn_6	131	136	PF01217	0.527
TRG_ENDOCYTIC_2	180	183	PF00928	0.762
TRG_ER_diArg_1	231	233	PF00400	0.522
TRG_ER_diArg_1	67	69	PF00400	0.518
TRG_ER_diArg_1	78	80	PF00400	0.518
TRG_Pf-PMV_PEXEL_1	134	138	PF00026	0.548
TRG_Pf-PMV_PEXEL_1	68	72	PF00026	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IBU0	Leptomonas seymouri	47%	99%
A0A3S7X462	Leishmania donovani	85%	100%
A4HJ39	Leishmania braziliensis	70%	98%
A4I6F4	Leishmania infantum	85%	100%
Q9BHF0	Leishmania major	84%	100%