Mevalonate kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Mevalonate kinase

Gene product:

mevalonate kinase, putative

Species:

Leishmania mexicana

UniProt:

E9B1K6_LEIMU

TriTrypDb:

LmxM.30.0560

Length:

352

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0110165	cellular anatomical entity	1	11
GO:0005777	peroxisome	6	1
GO:0005829	cytosol	2	1
GO:0020015	glycosome	7	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9B1K6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1K6

PDB structure(s): 2hfs_A , 2hfs_B , 2hfu_A , 2hfu_B

Function

Biological processes
Term	Name	Level	Count
GO:0006084	acetyl-CoA metabolic process	5	11
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006163	purine nucleotide metabolic process	5	11
GO:0006629	lipid metabolic process	3	11
GO:0006637	acyl-CoA metabolic process	4	11
GO:0006644	phospholipid metabolic process	4	11
GO:0006694	steroid biosynthetic process	5	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006753	nucleoside phosphate metabolic process	4	11
GO:0006790	sulfur compound metabolic process	3	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0008202	steroid metabolic process	4	11
GO:0008610	lipid biosynthetic process	4	11
GO:0008654	phospholipid biosynthetic process	5	11
GO:0009058	biosynthetic process	2	11
GO:0009117	nucleotide metabolic process	5	11
GO:0009150	purine ribonucleotide metabolic process	6	11
GO:0009240	isopentenyl diphosphate biosynthetic process	6	11
GO:0009259	ribonucleotide metabolic process	5	11
GO:0009987	cellular process	1	11
GO:0016125	sterol metabolic process	4	11
GO:0016126	sterol biosynthetic process	5	11
GO:0016310	phosphorylation	5	11
GO:0019287	isopentenyl diphosphate biosynthetic process, mevalonate pathway	6	11
GO:0019637	organophosphate metabolic process	3	11
GO:0019693	ribose phosphate metabolic process	4	11
GO:0033865	nucleoside bisphosphate metabolic process	5	11
GO:0033875	ribonucleoside bisphosphate metabolic process	6	11
GO:0034032	purine nucleoside bisphosphate metabolic process	5	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0035383	thioester metabolic process	3	11
GO:0043603	amide metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044255	cellular lipid metabolic process	3	11
GO:0044281	small molecule metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0046490	isopentenyl diphosphate metabolic process	5	11
GO:0055086	nucleobase-containing small molecule metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0072521	purine-containing compound metabolic process	4	11
GO:0090407	organophosphate biosynthetic process	4	11
GO:1901135	carbohydrate derivative metabolic process	3	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:1901362	organic cyclic compound biosynthetic process	4	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901576	organic substance biosynthetic process	3	11
GO:1901615	organic hydroxy compound metabolic process	3	11
GO:1901617	organic hydroxy compound biosynthetic process	4	11

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004496	mevalonate kinase activity	5	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	175	179	PF00656	0.419
CLV_C14_Caspase3-7	320	324	PF00656	0.504
CLV_NRD_NRD_1	191	193	PF00675	0.380
CLV_NRD_NRD_1	83	85	PF00675	0.379
CLV_PCSK_FUR_1	238	242	PF00082	0.233
CLV_PCSK_KEX2_1	10	12	PF00082	0.663
CLV_PCSK_KEX2_1	191	193	PF00082	0.380
CLV_PCSK_KEX2_1	240	242	PF00082	0.373
CLV_PCSK_KEX2_1	83	85	PF00082	0.374
CLV_PCSK_KEX2_1	94	96	PF00082	0.394
CLV_PCSK_PC1ET2_1	10	12	PF00082	0.417
CLV_PCSK_PC1ET2_1	240	242	PF00082	0.373
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.423
CLV_PCSK_SKI1_1	196	200	PF00082	0.366
CLV_PCSK_SKI1_1	254	258	PF00082	0.284
CLV_PCSK_SKI1_1	26	30	PF00082	0.466
CLV_PCSK_SKI1_1	327	331	PF00082	0.320
CLV_PCSK_SKI1_1	41	45	PF00082	0.278
DEG_APCC_DBOX_1	206	214	PF00400	0.311
DOC_CYCLIN_RxL_1	4	18	PF00134	0.410
DOC_MAPK_gen_1	99	106	PF00069	0.383
DOC_MAPK_MEF2A_6	308	315	PF00069	0.419
DOC_MAPK_RevD_3	69	84	PF00069	0.246
DOC_PP1_RVXF_1	198	205	PF00149	0.471
DOC_PP1_RVXF_1	39	46	PF00149	0.286
DOC_PP1_RVXF_1	8	15	PF00149	0.436
DOC_PP4_FxxP_1	22	25	PF00568	0.342
DOC_USP7_MATH_1	134	138	PF00917	0.419
DOC_USP7_MATH_1	27	31	PF00917	0.500
DOC_USP7_UBL2_3	196	200	PF12436	0.441
DOC_USP7_UBL2_3	31	35	PF12436	0.489
DOC_WW_Pin1_4	170	175	PF00397	0.419
LIG_14-3-3_CanoR_1	144	152	PF00244	0.450
LIG_APCC_ABBA_1	118	123	PF00400	0.202
LIG_APCC_ABBA_1	42	47	PF00400	0.274
LIG_APCC_ABBAyCdc20_2	41	47	PF00400	0.275
LIG_BRCT_BRCA1_1	18	22	PF00533	0.382
LIG_eIF4E_1	39	45	PF01652	0.361
LIG_FHA_1	219	225	PF00498	0.408
LIG_FHA_1	245	251	PF00498	0.479
LIG_FHA_2	153	159	PF00498	0.438
LIG_LIR_Apic_2	19	25	PF02991	0.342
LIG_LIR_Gen_1	244	253	PF02991	0.381
LIG_LIR_Nem_3	183	187	PF02991	0.437
LIG_LIR_Nem_3	197	202	PF02991	0.341
LIG_LIR_Nem_3	244	249	PF02991	0.400
LIG_LIR_Nem_3	295	299	PF02991	0.499
LIG_MLH1_MIPbox_1	18	22	PF16413	0.382
LIG_PDZ_Class_1	347	352	PF00595	0.455
LIG_Pex14_2	45	49	PF04695	0.291
LIG_SH2_CRK	184	188	PF00017	0.458
LIG_SH2_CRK	296	300	PF00017	0.513
LIG_SH2_CRK	39	43	PF00017	0.367
LIG_SH2_STAP1	246	250	PF00017	0.442
LIG_SH2_STAT3	190	193	PF00017	0.316
LIG_SH2_STAT3	342	345	PF00017	0.433
LIG_SH2_STAT3	90	93	PF00017	0.512
LIG_SH2_STAT5	209	212	PF00017	0.320
LIG_SH2_STAT5	246	249	PF00017	0.455
LIG_SH2_STAT5	342	345	PF00017	0.389
LIG_SH2_STAT5	64	67	PF00017	0.299
LIG_SH2_STAT5	90	93	PF00017	0.399
LIG_SH3_3	122	128	PF00018	0.432
LIG_SH3_3	70	76	PF00018	0.443
LIG_SH3_3	82	88	PF00018	0.302
LIG_SUMO_SIM_anti_2	285	290	PF11976	0.343
LIG_SUMO_SIM_par_1	209	215	PF11976	0.353
LIG_TRAF2_1	155	158	PF00917	0.499
LIG_TYR_ITIM	37	42	PF00017	0.369
LIG_Vh1_VBS_1	210	228	PF01044	0.226
MOD_CK1_1	30	36	PF00069	0.453
MOD_CK1_1	62	68	PF00069	0.362
MOD_CK2_1	152	158	PF00069	0.499
MOD_CK2_1	279	285	PF00069	0.419
MOD_GlcNHglycan	112	116	PF01048	0.483
MOD_GlcNHglycan	129	132	PF01048	0.195
MOD_GlcNHglycan	134	137	PF01048	0.219
MOD_GlcNHglycan	161	164	PF01048	0.227
MOD_GlcNHglycan	174	177	PF01048	0.217
MOD_GlcNHglycan	196	199	PF01048	0.457
MOD_GlcNHglycan	303	306	PF01048	0.219
MOD_GSK3_1	140	147	PF00069	0.461
MOD_GSK3_1	16	23	PF00069	0.433
MOD_GSK3_1	211	218	PF00069	0.214
MOD_GSK3_1	244	251	PF00069	0.512
MOD_GSK3_1	340	347	PF00069	0.456
MOD_N-GLC_1	152	157	PF02516	0.251
MOD_N-GLC_1	159	164	PF02516	0.212
MOD_N-GLC_1	4	9	PF02516	0.420
MOD_NEK2_1	16	21	PF00069	0.422
MOD_NEK2_1	242	247	PF00069	0.216
MOD_NEK2_1	303	308	PF00069	0.419
MOD_OFUCOSY	276	283	PF10250	0.247
MOD_PIKK_1	248	254	PF00454	0.399
MOD_Plk_1	159	165	PF00069	0.432
MOD_Plk_1	4	10	PF00069	0.420
MOD_ProDKin_1	170	176	PF00069	0.419
MOD_SUMO_for_1	329	332	PF00179	0.378
MOD_SUMO_rev_2	189	198	PF00179	0.291
MOD_SUMO_rev_2	332	339	PF00179	0.456
MOD_SUMO_rev_2	96	101	PF00179	0.304
TRG_ENDOCYTIC_2	184	187	PF00928	0.458
TRG_ENDOCYTIC_2	209	212	PF00928	0.320
TRG_ENDOCYTIC_2	246	249	PF00928	0.395
TRG_ENDOCYTIC_2	296	299	PF00928	0.513
TRG_ENDOCYTIC_2	39	42	PF00928	0.366
TRG_ER_diArg_1	190	192	PF00400	0.347
TRG_ER_diArg_1	83	85	PF00400	0.333
TRG_Pf-PMV_PEXEL_1	144	148	PF00026	0.247

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE67	Leptomonas seymouri	78%	100%
A0A0S4KH54	Bodo saltans	60%	100%
A0A1D8PEL1	Candida albicans (strain SC5314 / ATCC MYA-2876)	23%	82%
A0A1X0NJ39	Trypanosomatidae	63%	100%
A0A3R7M8L1	Trypanosoma rangeli	61%	100%
A0A3S7X459	Leishmania donovani	95%	100%
A4HJ34	Leishmania braziliensis	86%	100%
A4I6L2	Leishmania infantum	94%	100%
B5R741	Salmonella gallinarum (strain 287/91 / NCTC 13346)	24%	92%
B6YST1	Thermococcus onnurineus (strain NA1)	33%	100%
C5A7L8	Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)	35%	100%
C6A3T5	Thermococcus sibiricus (strain DSM 12597 / MM 739)	33%	100%
C9ZN67	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
O27995	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	28%	100%
O58107	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	26%	100%
O59291	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	33%	100%
P07277	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	79%
P17256	Rattus norvegicus	24%	89%
P46086	Arabidopsis thaliana	26%	93%
Q03426	Homo sapiens	25%	89%
Q03PA8	Levilactobacillus brevis (strain ATCC 367 / BCRC 12310 / CIP 105137 / JCM 1170 / LMG 11437 / NCIMB 947 / NCTC 947)	25%	91%
Q09780	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	87%
Q4Q6K7	Leishmania major	94%	100%
Q50559	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	29%	100%
Q58487	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	28%	100%
Q5E9T8	Bos taurus	25%	89%
Q5JJC6	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	36%	100%
Q86AG7	Dictyostelium discoideum	24%	90%
Q8U0F3	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	33%	100%
Q980D2	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	28%	100%
Q9HHB6	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	27%	100%
Q9R008	Mus musculus	26%	89%
Q9V187	Pyrococcus abyssi (strain GE5 / Orsay)	31%	100%
Q9Y946	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	31%	100%