J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B1K1_LEIMU

TriTrypDb:

LmxM.30.0510

Length:

603

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

E9B1K1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1K1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	418	422	PF00656	0.617
CLV_NRD_NRD_1	225	227	PF00675	0.427
CLV_NRD_NRD_1	26	28	PF00675	0.488
CLV_NRD_NRD_1	304	306	PF00675	0.285
CLV_NRD_NRD_1	309	311	PF00675	0.263
CLV_NRD_NRD_1	408	410	PF00675	0.318
CLV_NRD_NRD_1	497	499	PF00675	0.436
CLV_PCSK_KEX2_1	26	28	PF00082	0.488
CLV_PCSK_KEX2_1	407	409	PF00082	0.302
CLV_PCSK_KEX2_1	468	470	PF00082	0.459
CLV_PCSK_KEX2_1	497	499	PF00082	0.468
CLV_PCSK_PC1ET2_1	468	470	PF00082	0.472
CLV_PCSK_SKI1_1	108	112	PF00082	0.399
CLV_PCSK_SKI1_1	26	30	PF00082	0.528
CLV_PCSK_SKI1_1	310	314	PF00082	0.306
CLV_PCSK_SKI1_1	369	373	PF00082	0.463
CLV_PCSK_SKI1_1	411	415	PF00082	0.377
CLV_PCSK_SKI1_1	497	501	PF00082	0.485
CLV_PCSK_SKI1_1	531	535	PF00082	0.324
DEG_APCC_DBOX_1	530	538	PF00400	0.612
DEG_COP1_1	354	363	PF00400	0.740
DEG_Nend_Nbox_1	1	3	PF02207	0.509
DEG_SCF_FBW7_1	243	250	PF00400	0.687
DOC_CKS1_1	438	443	PF01111	0.468
DOC_CYCLIN_yClb5_NLxxxL_5	414	420	PF00134	0.590
DOC_CYCLIN_yCln2_LP_2	380	386	PF00134	0.612
DOC_MAPK_gen_1	547	556	PF00069	0.550
DOC_PP1_RVXF_1	529	536	PF00149	0.589
DOC_USP7_MATH_1	247	251	PF00917	0.759
DOC_USP7_MATH_1	256	260	PF00917	0.767
DOC_USP7_MATH_1	299	303	PF00917	0.554
DOC_USP7_MATH_1	50	54	PF00917	0.728
DOC_USP7_MATH_1	583	587	PF00917	0.634
DOC_USP7_MATH_1	592	596	PF00917	0.730
DOC_USP7_UBL2_3	227	231	PF12436	0.646
DOC_WW_Pin1_4	243	248	PF00397	0.747
DOC_WW_Pin1_4	437	442	PF00397	0.469
DOC_WW_Pin1_4	537	542	PF00397	0.636
DOC_WW_Pin1_4	587	592	PF00397	0.773
DOC_WW_Pin1_4	71	76	PF00397	0.754
LIG_14-3-3_CanoR_1	213	222	PF00244	0.646
LIG_14-3-3_CanoR_1	26	32	PF00244	0.654
LIG_14-3-3_CanoR_1	346	350	PF00244	0.518
LIG_Actin_WH2_2	397	413	PF00022	0.553
LIG_APCC_ABBA_1	313	318	PF00400	0.467
LIG_Clathr_ClatBox_1	532	536	PF01394	0.603
LIG_deltaCOP1_diTrp_1	192	202	PF00928	0.581
LIG_deltaCOP1_diTrp_1	472	478	PF00928	0.662
LIG_deltaCOP1_diTrp_1	5	11	PF00928	0.166
LIG_FHA_2	187	193	PF00498	0.466
LIG_FHA_2	215	221	PF00498	0.594
LIG_FHA_2	244	250	PF00498	0.793
LIG_FHA_2	261	267	PF00498	0.593
LIG_FHA_2	298	304	PF00498	0.484
LIG_FHA_2	588	594	PF00498	0.751
LIG_GBD_Chelix_1	412	420	PF00786	0.352
LIG_LIR_Gen_1	209	215	PF02991	0.618
LIG_LIR_Gen_1	327	337	PF02991	0.467
LIG_LIR_Gen_1	92	103	PF02991	0.712
LIG_LIR_Nem_3	136	140	PF02991	0.270
LIG_LIR_Nem_3	163	168	PF02991	0.382
LIG_LIR_Nem_3	209	214	PF02991	0.599
LIG_LIR_Nem_3	327	333	PF02991	0.467
LIG_LIR_Nem_3	348	352	PF02991	0.514
LIG_LIR_Nem_3	92	98	PF02991	0.702
LIG_Pex14_2	386	390	PF04695	0.609
LIG_SH2_CRK	137	141	PF00017	0.500
LIG_SH2_CRK	168	172	PF00017	0.400
LIG_SH2_CRK	290	294	PF00017	0.484
LIG_SH2_CRK	337	341	PF00017	0.508
LIG_SH2_STAP1	308	312	PF00017	0.540
LIG_SH2_STAP1	475	479	PF00017	0.682
LIG_SH2_STAT5	308	311	PF00017	0.538
LIG_SH2_STAT5	449	452	PF00017	0.553
LIG_SH3_3	318	324	PF00018	0.546
LIG_SH3_3	435	441	PF00018	0.477
LIG_SH3_3	54	60	PF00018	0.759
LIG_SH3_3	62	68	PF00018	0.739
LIG_SUMO_SIM_anti_2	552	558	PF11976	0.624
LIG_TRAF2_1	32	35	PF00917	0.669
LIG_TRAF2_1	558	561	PF00917	0.632
MOD_CDK_SPxxK_3	537	544	PF00069	0.634
MOD_CK1_1	183	189	PF00069	0.667
MOD_CK1_1	257	263	PF00069	0.774
MOD_CK1_1	297	303	PF00069	0.573
MOD_CK1_1	473	479	PF00069	0.601
MOD_CK1_1	481	487	PF00069	0.638
MOD_CK1_1	568	574	PF00069	0.648
MOD_CK1_1	595	601	PF00069	0.659
MOD_CK2_1	186	192	PF00069	0.669
MOD_CK2_1	206	212	PF00069	0.540
MOD_CK2_1	260	266	PF00069	0.742
MOD_CK2_1	297	303	PF00069	0.475
MOD_CK2_1	35	41	PF00069	0.815
MOD_CK2_1	422	428	PF00069	0.614
MOD_GlcNHglycan	182	185	PF01048	0.468
MOD_GlcNHglycan	249	252	PF01048	0.575
MOD_GlcNHglycan	255	259	PF01048	0.592
MOD_GlcNHglycan	424	427	PF01048	0.414
MOD_GlcNHglycan	428	431	PF01048	0.428
MOD_GlcNHglycan	46	49	PF01048	0.579
MOD_GlcNHglycan	480	483	PF01048	0.440
MOD_GlcNHglycan	51	55	PF01048	0.517
MOD_GlcNHglycan	62	65	PF01048	0.559
MOD_GlcNHglycan	80	83	PF01048	0.583
MOD_GSK3_1	22	29	PF00069	0.679
MOD_GSK3_1	233	240	PF00069	0.652
MOD_GSK3_1	243	250	PF00069	0.731
MOD_GSK3_1	256	263	PF00069	0.785
MOD_GSK3_1	294	301	PF00069	0.465
MOD_GSK3_1	338	345	PF00069	0.544
MOD_GSK3_1	422	429	PF00069	0.619
MOD_GSK3_1	470	477	PF00069	0.581
MOD_GSK3_1	568	575	PF00069	0.580
MOD_GSK3_1	583	590	PF00069	0.693
MOD_GSK3_1	591	598	PF00069	0.756
MOD_GSK3_1	97	104	PF00069	0.619
MOD_N-GLC_1	324	329	PF02516	0.345
MOD_NEK2_1	101	106	PF00069	0.652
MOD_NEK2_1	535	540	PF00069	0.571
MOD_NEK2_2	324	329	PF00069	0.509
MOD_PKA_1	233	239	PF00069	0.608
MOD_PKA_1	26	32	PF00069	0.699
MOD_PKA_2	26	32	PF00069	0.713
MOD_PKA_2	345	351	PF00069	0.563
MOD_PKA_2	568	574	PF00069	0.614
MOD_Plk_1	234	240	PF00069	0.704
MOD_Plk_1	324	330	PF00069	0.523
MOD_Plk_1	535	541	PF00069	0.548
MOD_Plk_1	552	558	PF00069	0.543
MOD_Plk_1	96	102	PF00069	0.698
MOD_Plk_2-3	35	41	PF00069	0.671
MOD_Plk_4	35	41	PF00069	0.780
MOD_Plk_4	445	451	PF00069	0.552
MOD_Plk_4	470	476	PF00069	0.632
MOD_Plk_4	481	487	PF00069	0.673
MOD_Plk_4	552	558	PF00069	0.585
MOD_Plk_4	97	103	PF00069	0.642
MOD_ProDKin_1	243	249	PF00069	0.748
MOD_ProDKin_1	437	443	PF00069	0.466
MOD_ProDKin_1	537	543	PF00069	0.637
MOD_ProDKin_1	587	593	PF00069	0.774
MOD_ProDKin_1	71	77	PF00069	0.744
TRG_ENDOCYTIC_2	137	140	PF00928	0.494
TRG_ENDOCYTIC_2	168	171	PF00928	0.400
TRG_ENDOCYTIC_2	289	292	PF00928	0.467
TRG_ENDOCYTIC_2	337	340	PF00928	0.501
TRG_ENDOCYTIC_2	352	355	PF00928	0.580
TRG_ER_diArg_1	26	28	PF00400	0.707
TRG_ER_diArg_1	407	409	PF00400	0.515
TRG_NES_CRM1_1	378	391	PF08389	0.621
TRG_Pf-PMV_PEXEL_1	503	507	PF00026	0.478

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IBU7	Leptomonas seymouri	60%	99%
A0A0S4JJ62	Bodo saltans	30%	100%
A0A1X0NJF9	Trypanosomatidae	41%	100%
A0A1X0NZV2	Trypanosomatidae	42%	100%
A0A3S7X455	Leishmania donovani	93%	100%
A0A422NZZ9	Trypanosoma rangeli	40%	100%
A4HJ29	Leishmania braziliensis	80%	98%
A4I6K8	Leishmania infantum	93%	100%
C9ZN58	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
C9ZWY2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
Q4Q6L2	Leishmania major	90%	99%
V5BN17	Trypanosoma cruzi	39%	100%