Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B1K0_LEIMU

TriTrypDb:

LmxM.30.0500

Length:

640

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B1K0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1K0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	204	206	PF00675	0.641
CLV_NRD_NRD_1	225	227	PF00675	0.623
CLV_NRD_NRD_1	405	407	PF00675	0.649
CLV_NRD_NRD_1	422	424	PF00675	0.494
CLV_NRD_NRD_1	440	442	PF00675	0.510
CLV_NRD_NRD_1	47	49	PF00675	0.594
CLV_PCSK_KEX2_1	204	206	PF00082	0.641
CLV_PCSK_KEX2_1	225	227	PF00082	0.732
CLV_PCSK_KEX2_1	405	407	PF00082	0.715
CLV_PCSK_KEX2_1	422	424	PF00082	0.555
CLV_PCSK_KEX2_1	440	442	PF00082	0.536
CLV_PCSK_KEX2_1	47	49	PF00082	0.594
CLV_PCSK_KEX2_1	532	534	PF00082	0.459
CLV_PCSK_PC1ET2_1	422	424	PF00082	0.550
CLV_PCSK_PC1ET2_1	532	534	PF00082	0.432
CLV_PCSK_PC7_1	221	227	PF00082	0.589
CLV_PCSK_SKI1_1	158	162	PF00082	0.528
CLV_PCSK_SKI1_1	197	201	PF00082	0.618
CLV_PCSK_SKI1_1	307	311	PF00082	0.529
CLV_PCSK_SKI1_1	317	321	PF00082	0.573
CLV_PCSK_SKI1_1	504	508	PF00082	0.490
CLV_PCSK_SKI1_1	631	635	PF00082	0.629
DEG_APCC_DBOX_1	306	314	PF00400	0.523
DOC_CYCLIN_yCln2_LP_2	164	170	PF00134	0.478
DOC_CYCLIN_yCln2_LP_2	343	349	PF00134	0.599
DOC_MAPK_gen_1	264	273	PF00069	0.495
DOC_MAPK_gen_1	511	518	PF00069	0.534
DOC_MAPK_gen_1	532	539	PF00069	0.428
DOC_MAPK_MEF2A_6	532	539	PF00069	0.497
DOC_PP2B_LxvP_1	164	167	PF13499	0.469
DOC_USP7_MATH_1	172	176	PF00917	0.631
DOC_USP7_MATH_1	179	183	PF00917	0.570
DOC_USP7_MATH_1	404	408	PF00917	0.783
DOC_USP7_MATH_1	498	502	PF00917	0.582
DOC_USP7_MATH_1	563	567	PF00917	0.564
DOC_USP7_MATH_1	597	601	PF00917	0.481
DOC_USP7_MATH_1	627	631	PF00917	0.610
DOC_USP7_MATH_1	67	71	PF00917	0.616
DOC_USP7_UBL2_3	464	468	PF12436	0.604
DOC_WW_Pin1_4	101	106	PF00397	0.572
DOC_WW_Pin1_4	15	20	PF00397	0.692
DOC_WW_Pin1_4	185	190	PF00397	0.609
DOC_WW_Pin1_4	259	264	PF00397	0.676
DOC_WW_Pin1_4	291	296	PF00397	0.594
DOC_WW_Pin1_4	30	35	PF00397	0.621
DOC_WW_Pin1_4	493	498	PF00397	0.710
LIG_14-3-3_CanoR_1	180	185	PF00244	0.599
LIG_14-3-3_CanoR_1	204	212	PF00244	0.605
LIG_14-3-3_CanoR_1	225	234	PF00244	0.575
LIG_14-3-3_CanoR_1	307	315	PF00244	0.518
LIG_14-3-3_CanoR_1	361	369	PF00244	0.642
LIG_14-3-3_CanoR_1	405	413	PF00244	0.646
LIG_14-3-3_CanoR_1	423	428	PF00244	0.679
LIG_14-3-3_CanoR_1	89	93	PF00244	0.648
LIG_BRCT_BRCA1_1	90	94	PF00533	0.580
LIG_BRCT_BRCA1_2	90	96	PF00533	0.655
LIG_FHA_1	159	165	PF00498	0.481
LIG_FHA_1	34	40	PF00498	0.579
LIG_FHA_1	409	415	PF00498	0.739
LIG_FHA_2	212	218	PF00498	0.573
LIG_FHA_2	236	242	PF00498	0.641
LIG_FHA_2	333	339	PF00498	0.583
LIG_FHA_2	340	346	PF00498	0.549
LIG_FHA_2	510	516	PF00498	0.491
LIG_FHA_2	587	593	PF00498	0.577
LIG_Integrin_RGD_1	398	400	PF01839	0.664
LIG_LIR_Gen_1	128	134	PF02991	0.465
LIG_LIR_Nem_3	128	132	PF02991	0.458
LIG_PCNA_PIPBox_1	613	622	PF02747	0.521
LIG_SH2_CRK	248	252	PF00017	0.541
LIG_SH2_SRC	546	549	PF00017	0.448
LIG_SH2_STAT5	256	259	PF00017	0.632
LIG_SH2_STAT5	348	351	PF00017	0.558
LIG_SH2_STAT5	509	512	PF00017	0.500
LIG_SH2_STAT5	546	549	PF00017	0.446
LIG_SH3_3	102	108	PF00018	0.546
LIG_SH3_3	147	153	PF00018	0.641
LIG_SUMO_SIM_anti_2	128	134	PF11976	0.465
LIG_SUMO_SIM_anti_2	429	434	PF11976	0.621
LIG_SUMO_SIM_par_1	534	540	PF11976	0.492
LIG_TRAF2_1	335	338	PF00917	0.601
LIG_TRAF2_1	472	475	PF00917	0.614
LIG_TRAF2_1	572	575	PF00917	0.483
LIG_TRFH_1	320	324	PF08558	0.643
MOD_CDK_SPK_2	259	264	PF00069	0.676
MOD_CDK_SPxxK_3	185	192	PF00069	0.605
MOD_CK1_1	103	109	PF00069	0.579
MOD_CK1_1	224	230	PF00069	0.542
MOD_CK1_1	30	36	PF00069	0.523
MOD_CK1_1	305	311	PF00069	0.586
MOD_CK1_1	357	363	PF00069	0.738
MOD_CK1_1	365	371	PF00069	0.573
MOD_CK1_1	408	414	PF00069	0.770
MOD_CK1_1	426	432	PF00069	0.651
MOD_CK1_1	460	466	PF00069	0.572
MOD_CK1_1	502	508	PF00069	0.517
MOD_CK1_1	576	582	PF00069	0.699
MOD_CK1_1	632	638	PF00069	0.650
MOD_CK1_1	95	101	PF00069	0.665
MOD_CK2_1	211	217	PF00069	0.580
MOD_CK2_1	26	32	PF00069	0.585
MOD_CK2_1	326	332	PF00069	0.681
MOD_CK2_1	339	345	PF00069	0.489
MOD_CK2_1	569	575	PF00069	0.506
MOD_CK2_1	586	592	PF00069	0.577
MOD_CK2_1	8	14	PF00069	0.767
MOD_GlcNHglycan	139	142	PF01048	0.580
MOD_GlcNHglycan	174	177	PF01048	0.641
MOD_GlcNHglycan	228	231	PF01048	0.632
MOD_GlcNHglycan	274	277	PF01048	0.593
MOD_GlcNHglycan	378	381	PF01048	0.697
MOD_GlcNHglycan	400	403	PF01048	0.759
MOD_GlcNHglycan	407	410	PF01048	0.555
MOD_GlcNHglycan	443	446	PF01048	0.700
MOD_GlcNHglycan	501	504	PF01048	0.569
MOD_GlcNHglycan	561	564	PF01048	0.631
MOD_GlcNHglycan	571	574	PF01048	0.678
MOD_GlcNHglycan	575	578	PF01048	0.657
MOD_GlcNHglycan	589	592	PF01048	0.692
MOD_GlcNHglycan	634	637	PF01048	0.651
MOD_GlcNHglycan	69	72	PF01048	0.700
MOD_GlcNHglycan	79	82	PF01048	0.609
MOD_GlcNHglycan	83	86	PF01048	0.588
MOD_GSK3_1	20	27	PF00069	0.669
MOD_GSK3_1	200	207	PF00069	0.576
MOD_GSK3_1	211	218	PF00069	0.560
MOD_GSK3_1	221	228	PF00069	0.517
MOD_GSK3_1	259	266	PF00069	0.732
MOD_GSK3_1	279	286	PF00069	0.385
MOD_GSK3_1	28	35	PF00069	0.767
MOD_GSK3_1	305	312	PF00069	0.586
MOD_GSK3_1	365	372	PF00069	0.611
MOD_GSK3_1	39	46	PF00069	0.692
MOD_GSK3_1	4	11	PF00069	0.789
MOD_GSK3_1	404	411	PF00069	0.748
MOD_GSK3_1	498	505	PF00069	0.540
MOD_GSK3_1	559	566	PF00069	0.623
MOD_GSK3_1	569	576	PF00069	0.733
MOD_GSK3_1	597	604	PF00069	0.572
MOD_GSK3_1	73	80	PF00069	0.786
MOD_GSK3_1	88	95	PF00069	0.614
MOD_N-GLC_1	305	310	PF02516	0.632
MOD_N-GLC_1	332	337	PF02516	0.635
MOD_N-GLC_1	362	367	PF02516	0.587
MOD_N-GLC_1	390	395	PF02516	0.693
MOD_N-GLC_1	627	632	PF02516	0.647
MOD_N-GLC_1	67	72	PF02516	0.589
MOD_N-GLC_2	255	257	PF02516	0.625
MOD_NEK2_1	215	220	PF00069	0.483
MOD_NEK2_1	234	239	PF00069	0.620
MOD_NEK2_1	354	359	PF00069	0.564
MOD_NEK2_1	390	395	PF00069	0.621
MOD_NEK2_1	433	438	PF00069	0.554
MOD_NEK2_1	620	625	PF00069	0.655
MOD_NEK2_1	77	82	PF00069	0.657
MOD_NEK2_1	88	93	PF00069	0.537
MOD_NEK2_2	629	634	PF00069	0.481
MOD_PIKK_1	204	210	PF00454	0.624
MOD_PIKK_1	283	289	PF00454	0.480
MOD_PIKK_1	324	330	PF00454	0.656
MOD_PIKK_1	390	396	PF00454	0.688
MOD_PIKK_1	412	418	PF00454	0.500
MOD_PIKK_1	98	104	PF00454	0.669
MOD_PK_1	634	640	PF00069	0.472
MOD_PKA_1	204	210	PF00069	0.614
MOD_PKA_1	225	231	PF00069	0.637
MOD_PKA_1	405	411	PF00069	0.713
MOD_PKA_1	423	429	PF00069	0.537
MOD_PKA_2	179	185	PF00069	0.582
MOD_PKA_2	204	210	PF00069	0.614
MOD_PKA_2	224	230	PF00069	0.455
MOD_PKA_2	263	269	PF00069	0.598
MOD_PKA_2	404	410	PF00069	0.746
MOD_PKA_2	43	49	PF00069	0.636
MOD_PKA_2	601	607	PF00069	0.620
MOD_PKA_2	88	94	PF00069	0.609
MOD_Plk_1	279	285	PF00069	0.515
MOD_Plk_1	305	311	PF00069	0.637
MOD_Plk_1	365	371	PF00069	0.573
MOD_Plk_1	475	481	PF00069	0.612
MOD_Plk_1	514	520	PF00069	0.609
MOD_Plk_1	67	73	PF00069	0.589
MOD_Plk_2-3	332	338	PF00069	0.588
MOD_Plk_2-3	339	345	PF00069	0.550
MOD_Plk_2-3	475	481	PF00069	0.718
MOD_Plk_4	128	134	PF00069	0.461
MOD_Plk_4	211	217	PF00069	0.504
MOD_Plk_4	279	285	PF00069	0.494
MOD_Plk_4	339	345	PF00069	0.653
MOD_Plk_4	95	101	PF00069	0.593
MOD_ProDKin_1	101	107	PF00069	0.573
MOD_ProDKin_1	15	21	PF00069	0.691
MOD_ProDKin_1	185	191	PF00069	0.609
MOD_ProDKin_1	259	265	PF00069	0.676
MOD_ProDKin_1	291	297	PF00069	0.595
MOD_ProDKin_1	30	36	PF00069	0.620
MOD_ProDKin_1	493	499	PF00069	0.709
MOD_SUMO_rev_2	140	150	PF00179	0.623
MOD_SUMO_rev_2	458	466	PF00179	0.581
MOD_SUMO_rev_2	6	11	PF00179	0.530
MOD_SUMO_rev_2	70	77	PF00179	0.615
TRG_ER_diArg_1	404	406	PF00400	0.647
TRG_NLS_Bipartite_1	405	426	PF00514	0.504
TRG_Pf-PMV_PEXEL_1	504	508	PF00026	0.649

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IA33	Leptomonas seymouri	45%	100%
A0A3S7X488	Leishmania donovani	88%	100%
A4HJ28	Leishmania braziliensis	62%	100%
A4I6K7	Leishmania infantum	88%	100%
Q4Q6L3	Leishmania major	88%	100%