cGMP-dependent protein kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B1J9_LEIMU

TriTrypDb:

LmxM.30.0490

Length:

817

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B1J9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1J9

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016310	phosphorylation	5	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	375	379	PF00656	0.653
CLV_C14_Caspase3-7	457	461	PF00656	0.614
CLV_C14_Caspase3-7	638	642	PF00656	0.490
CLV_C14_Caspase3-7	81	85	PF00656	0.701
CLV_NRD_NRD_1	104	106	PF00675	0.643
CLV_NRD_NRD_1	139	141	PF00675	0.490
CLV_NRD_NRD_1	210	212	PF00675	0.349
CLV_NRD_NRD_1	433	435	PF00675	0.431
CLV_NRD_NRD_1	481	483	PF00675	0.718
CLV_NRD_NRD_1	650	652	PF00675	0.366
CLV_PCSK_FUR_1	805	809	PF00082	0.418
CLV_PCSK_KEX2_1	104	106	PF00082	0.653
CLV_PCSK_KEX2_1	139	141	PF00082	0.490
CLV_PCSK_KEX2_1	210	212	PF00082	0.497
CLV_PCSK_KEX2_1	380	382	PF00082	0.624
CLV_PCSK_KEX2_1	433	435	PF00082	0.438
CLV_PCSK_KEX2_1	481	483	PF00082	0.718
CLV_PCSK_KEX2_1	650	652	PF00082	0.486
CLV_PCSK_KEX2_1	807	809	PF00082	0.418
CLV_PCSK_PC1ET2_1	380	382	PF00082	0.624
CLV_PCSK_PC1ET2_1	807	809	PF00082	0.430
CLV_PCSK_PC7_1	100	106	PF00082	0.647
CLV_PCSK_SKI1_1	115	119	PF00082	0.595
CLV_PCSK_SKI1_1	139	143	PF00082	0.491
CLV_PCSK_SKI1_1	380	384	PF00082	0.589
CLV_PCSK_SKI1_1	46	50	PF00082	0.618
CLV_PCSK_SKI1_1	650	654	PF00082	0.395
DEG_Kelch_Keap1_1	597	602	PF01344	0.504
DOC_CYCLIN_yCln2_LP_2	618	621	PF00134	0.426
DOC_CYCLIN_yCln2_LP_2	657	663	PF00134	0.274
DOC_CYCLIN_yCln2_LP_2	789	795	PF00134	0.370
DOC_MAPK_gen_1	422	431	PF00069	0.515
DOC_MAPK_gen_1	805	812	PF00069	0.547
DOC_MAPK_MEF2A_6	791	799	PF00069	0.408
DOC_PP1_RVXF_1	796	802	PF00149	0.419
DOC_PP2B_LxvP_1	466	469	PF13499	0.502
DOC_PP2B_LxvP_1	618	621	PF13499	0.515
DOC_PP2B_LxvP_1	779	782	PF13499	0.424
DOC_PP4_FxxP_1	40	43	PF00568	0.626
DOC_PP4_FxxP_1	48	51	PF00568	0.588
DOC_USP7_MATH_1	129	133	PF00917	0.391
DOC_USP7_MATH_1	179	183	PF00917	0.540
DOC_USP7_MATH_1	244	248	PF00917	0.617
DOC_USP7_MATH_1	384	388	PF00917	0.582
DOC_USP7_MATH_1	51	55	PF00917	0.640
DOC_USP7_MATH_1	570	574	PF00917	0.702
DOC_USP7_MATH_1	635	639	PF00917	0.440
DOC_USP7_MATH_1	730	734	PF00917	0.586
DOC_USP7_MATH_1	782	786	PF00917	0.450
DOC_USP7_MATH_1	9	13	PF00917	0.703
DOC_WW_Pin1_4	175	180	PF00397	0.505
DOC_WW_Pin1_4	227	232	PF00397	0.367
DOC_WW_Pin1_4	279	284	PF00397	0.515
DOC_WW_Pin1_4	474	479	PF00397	0.675
DOC_WW_Pin1_4	578	583	PF00397	0.496
DOC_WW_Pin1_4	626	631	PF00397	0.444
DOC_WW_Pin1_4	636	641	PF00397	0.362
LIG_14-3-3_CanoR_1	115	124	PF00244	0.540
LIG_14-3-3_CanoR_1	273	279	PF00244	0.297
LIG_14-3-3_CanoR_1	422	427	PF00244	0.598
LIG_14-3-3_CanoR_1	46	51	PF00244	0.506
LIG_14-3-3_CanoR_1	508	512	PF00244	0.522
LIG_14-3-3_CanoR_1	519	524	PF00244	0.424
LIG_14-3-3_CanoR_1	609	614	PF00244	0.452
LIG_14-3-3_CanoR_1	623	631	PF00244	0.413
LIG_14-3-3_CanoR_1	798	806	PF00244	0.424
LIG_BRCT_BRCA1_1	181	185	PF00533	0.481
LIG_BRCT_BRCA1_1	281	285	PF00533	0.459
LIG_Clathr_ClatBox_1	538	542	PF01394	0.476
LIG_deltaCOP1_diTrp_1	213	220	PF00928	0.482
LIG_EH1_1	748	756	PF00400	0.255
LIG_EVH1_2	620	624	PF00568	0.359
LIG_FHA_1	388	394	PF00498	0.471
LIG_FHA_1	626	632	PF00498	0.499
LIG_FHA_1	69	75	PF00498	0.688
LIG_FHA_1	8	14	PF00498	0.706
LIG_FHA_2	264	270	PF00498	0.556
LIG_FHA_2	368	374	PF00498	0.446
LIG_FHA_2	455	461	PF00498	0.589
LIG_FHA_2	610	616	PF00498	0.444
LIG_FHA_2	692	698	PF00498	0.463
LIG_FHA_2	748	754	PF00498	0.301
LIG_IRF3_LxIS_1	321	326	PF10401	0.369
LIG_IRF3_LxIS_1	450	455	PF10401	0.510
LIG_LIR_Apic_2	38	43	PF02991	0.596
LIG_LIR_Gen_1	132	142	PF02991	0.478
LIG_LIR_Gen_1	182	193	PF02991	0.565
LIG_LIR_Gen_1	282	293	PF02991	0.428
LIG_LIR_Gen_1	320	330	PF02991	0.443
LIG_LIR_Gen_1	36	45	PF02991	0.483
LIG_LIR_Gen_1	499	506	PF02991	0.251
LIG_LIR_Gen_1	667	676	PF02991	0.449
LIG_LIR_Gen_1	683	690	PF02991	0.374
LIG_LIR_Gen_1	91	101	PF02991	0.457
LIG_LIR_Nem_3	132	138	PF02991	0.489
LIG_LIR_Nem_3	182	188	PF02991	0.553
LIG_LIR_Nem_3	282	288	PF02991	0.435
LIG_LIR_Nem_3	320	325	PF02991	0.505
LIG_LIR_Nem_3	36	40	PF02991	0.541
LIG_LIR_Nem_3	667	671	PF02991	0.448
LIG_LIR_Nem_3	683	689	PF02991	0.414
LIG_LIR_Nem_3	785	789	PF02991	0.433
LIG_LIR_Nem_3	803	809	PF02991	0.481
LIG_LIR_Nem_3	91	97	PF02991	0.607
LIG_PCNA_PIPBox_1	281	290	PF02747	0.337
LIG_PCNA_yPIPBox_3	254	263	PF02747	0.402
LIG_Pex14_2	502	506	PF04695	0.288
LIG_Pex14_2	668	672	PF04695	0.436
LIG_Pex14_2	677	681	PF04695	0.467
LIG_Pex14_2	786	790	PF04695	0.436
LIG_SH2_CRK	260	264	PF00017	0.445
LIG_SH2_CRK	806	810	PF00017	0.473
LIG_SH2_PTP2	770	773	PF00017	0.382
LIG_SH2_STAT3	278	281	PF00017	0.541
LIG_SH2_STAT3	391	394	PF00017	0.467
LIG_SH2_STAT5	219	222	PF00017	0.437
LIG_SH2_STAT5	227	230	PF00017	0.471
LIG_SH2_STAT5	278	281	PF00017	0.504
LIG_SH2_STAT5	532	535	PF00017	0.438
LIG_SH2_STAT5	661	664	PF00017	0.360
LIG_SH2_STAT5	725	728	PF00017	0.532
LIG_SH2_STAT5	770	773	PF00017	0.345
LIG_SH2_STAT5	796	799	PF00017	0.393
LIG_SH3_3	173	179	PF00018	0.358
LIG_SH3_3	225	231	PF00018	0.468
LIG_SH3_3	390	396	PF00018	0.477
LIG_SH3_3	41	47	PF00018	0.681
LIG_SH3_3	466	472	PF00018	0.496
LIG_SH3_3	576	582	PF00018	0.553
LIG_SH3_3	634	640	PF00018	0.267
LIG_SH3_3	789	795	PF00018	0.436
LIG_SUMO_SIM_anti_2	328	333	PF11976	0.404
LIG_SUMO_SIM_anti_2	362	367	PF11976	0.444
LIG_SUMO_SIM_anti_2	405	412	PF11976	0.469
LIG_SUMO_SIM_anti_2	592	600	PF11976	0.462
LIG_SUMO_SIM_par_1	160	166	PF11976	0.380
LIG_SUMO_SIM_par_1	405	412	PF11976	0.490
LIG_SUMO_SIM_par_1	450	457	PF11976	0.398
LIG_SUMO_SIM_par_1	63	69	PF11976	0.665
LIG_TRAF2_1	16	19	PF00917	0.551
LIG_TRAF2_1	370	373	PF00917	0.595
LIG_TRAF2_1	740	743	PF00917	0.414
LIG_TRFH_1	227	231	PF08558	0.547
LIG_TYR_ITIM	768	773	PF00017	0.379
LIG_UBA3_1	64	73	PF00899	0.465
LIG_WRC_WIRS_1	264	269	PF05994	0.531
LIG_WRC_WIRS_1	746	751	PF05994	0.481
MOD_CDK_SPxK_1	626	632	PF00069	0.502
MOD_CDK_SPxxK_3	474	481	PF00069	0.622
MOD_CK1_1	247	253	PF00069	0.528
MOD_CK1_1	38	44	PF00069	0.712
MOD_CK1_1	387	393	PF00069	0.430
MOD_CK1_1	477	483	PF00069	0.673
MOD_CK1_1	507	513	PF00069	0.422
MOD_CK1_1	608	614	PF00069	0.271
MOD_CK1_1	626	632	PF00069	0.593
MOD_CK1_1	745	751	PF00069	0.450
MOD_CK2_1	367	373	PF00069	0.542
MOD_CK2_1	422	428	PF00069	0.521
MOD_CK2_1	441	447	PF00069	0.321
MOD_CK2_1	51	57	PF00069	0.748
MOD_CK2_1	609	615	PF00069	0.452
MOD_CK2_1	691	697	PF00069	0.568
MOD_CK2_1	737	743	PF00069	0.441
MOD_CK2_1	810	816	PF00069	0.487
MOD_Cter_Amidation	648	651	PF01082	0.280
MOD_GlcNHglycan	108	111	PF01048	0.632
MOD_GlcNHglycan	29	33	PF01048	0.739
MOD_GlcNHglycan	306	310	PF01048	0.647
MOD_GlcNHglycan	325	328	PF01048	0.264
MOD_GlcNHglycan	40	43	PF01048	0.697
MOD_GlcNHglycan	411	414	PF01048	0.477
MOD_GlcNHglycan	572	575	PF01048	0.649
MOD_GlcNHglycan	589	592	PF01048	0.425
MOD_GlcNHglycan	625	628	PF01048	0.695
MOD_GlcNHglycan	732	735	PF01048	0.634
MOD_GlcNHglycan	812	815	PF01048	0.434
MOD_GSK3_1	111	118	PF00069	0.513
MOD_GSK3_1	175	182	PF00069	0.636
MOD_GSK3_1	301	308	PF00069	0.516
MOD_GSK3_1	342	349	PF00069	0.452
MOD_GSK3_1	376	383	PF00069	0.657
MOD_GSK3_1	452	459	PF00069	0.573
MOD_GSK3_1	46	53	PF00069	0.637
MOD_GSK3_1	470	477	PF00069	0.596
MOD_GSK3_1	481	488	PF00069	0.565
MOD_GSK3_1	566	573	PF00069	0.735
MOD_GSK3_1	587	594	PF00069	0.439
MOD_GSK3_1	605	612	PF00069	0.353
MOD_GSK3_1	626	633	PF00069	0.430
MOD_GSK3_1	737	744	PF00069	0.542
MOD_GSK3_1	88	95	PF00069	0.667
MOD_LATS_1	418	424	PF00433	0.506
MOD_N-GLC_1	690	695	PF02516	0.450
MOD_NEK2_1	1	6	PF00069	0.523
MOD_NEK2_1	263	268	PF00069	0.524
MOD_NEK2_1	323	328	PF00069	0.358
MOD_NEK2_1	35	40	PF00069	0.602
MOD_NEK2_1	66	71	PF00069	0.604
MOD_NEK2_1	810	815	PF00069	0.516
MOD_NMyristoyl	1	7	PF02799	0.666
MOD_PIKK_1	167	173	PF00454	0.452
MOD_PIKK_1	277	283	PF00454	0.461
MOD_PIKK_1	485	491	PF00454	0.637
MOD_PK_1	422	428	PF00069	0.458
MOD_PKA_1	380	386	PF00069	0.496
MOD_PKA_1	481	487	PF00069	0.604
MOD_PKA_2	367	373	PF00069	0.515
MOD_PKA_2	380	386	PF00069	0.656
MOD_PKA_2	481	487	PF00069	0.604
MOD_PKA_2	507	513	PF00069	0.480
MOD_PKA_2	608	614	PF00069	0.316
MOD_PKA_2	763	769	PF00069	0.354
MOD_PKB_1	420	428	PF00069	0.461
MOD_PKB_1	517	525	PF00069	0.494
MOD_Plk_1	244	250	PF00069	0.533
MOD_Plk_1	462	468	PF00069	0.713
MOD_Plk_1	496	502	PF00069	0.460
MOD_Plk_1	591	597	PF00069	0.402
MOD_Plk_1	741	747	PF00069	0.548
MOD_Plk_2-3	301	307	PF00069	0.449
MOD_Plk_2-3	456	462	PF00069	0.529
MOD_Plk_2-3	737	743	PF00069	0.441
MOD_Plk_4	247	253	PF00069	0.582
MOD_Plk_4	274	280	PF00069	0.293
MOD_Plk_4	462	468	PF00069	0.650
MOD_Plk_4	507	513	PF00069	0.278
MOD_Plk_4	533	539	PF00069	0.470
MOD_Plk_4	60	66	PF00069	0.645
MOD_Plk_4	667	673	PF00069	0.386
MOD_Plk_4	685	691	PF00069	0.222
MOD_Plk_4	712	718	PF00069	0.447
MOD_ProDKin_1	175	181	PF00069	0.507
MOD_ProDKin_1	227	233	PF00069	0.369
MOD_ProDKin_1	279	285	PF00069	0.508
MOD_ProDKin_1	474	480	PF00069	0.674
MOD_ProDKin_1	578	584	PF00069	0.475
MOD_ProDKin_1	626	632	PF00069	0.437
MOD_ProDKin_1	636	642	PF00069	0.357
MOD_SUMO_rev_2	372	382	PF00179	0.461
TRG_DiLeu_BaEn_4	447	453	PF01217	0.403
TRG_DiLeu_BaLyEn_6	307	312	PF01217	0.489
TRG_ENDOCYTIC_2	260	263	PF00928	0.485
TRG_ENDOCYTIC_2	586	589	PF00928	0.426
TRG_ENDOCYTIC_2	770	773	PF00928	0.382
TRG_ENDOCYTIC_2	796	799	PF00928	0.533
TRG_ENDOCYTIC_2	806	809	PF00928	0.415
TRG_ER_diArg_1	138	140	PF00400	0.494
TRG_ER_diArg_1	432	434	PF00400	0.441
TRG_ER_diArg_1	481	483	PF00400	0.617
TRG_ER_diArg_1	528	531	PF00400	0.322
TRG_ER_diArg_1	726	729	PF00400	0.354
TRG_ER_diArg_1	775	778	PF00400	0.396
TRG_NES_CRM1_1	320	335	PF08389	0.342
TRG_Pf-PMV_PEXEL_1	257	261	PF00026	0.452
TRG_Pf-PMV_PEXEL_1	294	298	PF00026	0.466
TRG_Pf-PMV_PEXEL_1	443	447	PF00026	0.519
TRG_Pf-PMV_PEXEL_1	481	485	PF00026	0.609

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8T1	Leptomonas seymouri	41%	99%
A0A1X0NPV7	Trypanosomatidae	22%	97%
A0A3R7KL00	Trypanosoma rangeli	25%	76%
A0A3S7X491	Leishmania donovani	84%	99%
A4HJ27	Leishmania braziliensis	64%	100%
A4I6E9	Leishmania infantum	84%	99%
Q4Q6L4	Leishmania major	83%	100%