Putative amastin

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative amastin

Gene product:

amastin, putative

Species:

Leishmania mexicana

UniProt:

E9B1J3_LEIMU

TriTrypDb:

LmxM.30.0450

Length:

195

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Part of the greater amastin family, a cell adhesion protein critical for intracellular parasitism. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 11, no: 191
NetGPI	no	yes: 0, no: 202

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	180
GO:0110165	cellular anatomical entity	1	180

Expansion

Sequence features

E9B1J3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1J3

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016485	protein processing	5	1
GO:0016540	protein autoprocessing	6	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008234	cysteine-type peptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	53	55	PF00675	0.535
DEG_MDM2_SWIB_1	156	164	PF02201	0.323
DOC_CYCLIN_yCln2_LP_2	170	176	PF00134	0.579
DOC_MAPK_gen_1	54	62	PF00069	0.215
DOC_MAPK_MEF2A_6	108	116	PF00069	0.575
DOC_MAPK_MEF2A_6	4	13	PF00069	0.620
DOC_MAPK_MEF2A_6	54	62	PF00069	0.378
DOC_PP2B_LxvP_1	170	173	PF13499	0.576
LIG_BIR_II_1	1	5	PF00653	0.719
LIG_CORNRBOX	5	13	PF00104	0.218
LIG_CtBP_PxDLS_1	142	146	PF00389	0.197
LIG_EH1_1	9	17	PF00400	0.395
LIG_eIF4E_1	10	16	PF01652	0.383
LIG_eIF4E_1	90	96	PF01652	0.277
LIG_FHA_1	130	136	PF00498	0.419
LIG_FHA_1	57	63	PF00498	0.356
LIG_FHA_2	23	29	PF00498	0.408
LIG_LIR_Apic_2	28	34	PF02991	0.370
LIG_LIR_Gen_1	151	161	PF02991	0.357
LIG_LIR_Gen_1	163	173	PF02991	0.409
LIG_LIR_Gen_1	35	44	PF02991	0.203
LIG_LIR_Gen_1	80	90	PF02991	0.253
LIG_LIR_Nem_3	151	156	PF02991	0.432
LIG_LIR_Nem_3	163	168	PF02991	0.418
LIG_LIR_Nem_3	35	39	PF02991	0.207
LIG_LIR_Nem_3	80	85	PF02991	0.250
LIG_Pex14_2	149	153	PF04695	0.364
LIG_Pex14_2	156	160	PF04695	0.409
LIG_Pex14_2	165	169	PF04695	0.397
LIG_PTB_Apo_2	163	170	PF02174	0.433
LIG_SH2_PTP2	10	13	PF00017	0.360
LIG_SH2_PTP2	31	34	PF00017	0.220
LIG_SH2_STAT5	10	13	PF00017	0.487
LIG_SH2_STAT5	102	105	PF00017	0.432
LIG_SH2_STAT5	31	34	PF00017	0.226
LIG_TYR_ITIM	8	13	PF00017	0.466
LIG_UBA3_1	29	33	PF00899	0.224
MOD_CK2_1	176	182	PF00069	0.672
MOD_GlcNHglycan	178	181	PF01048	0.357
MOD_NEK2_1	129	134	PF00069	0.484
MOD_NEK2_1	176	181	PF00069	0.611
MOD_NEK2_1	22	27	PF00069	0.403
MOD_NEK2_1	42	47	PF00069	0.328
MOD_NEK2_2	83	88	PF00069	0.476
MOD_Plk_4	42	48	PF00069	0.309
MOD_SUMO_for_1	32	35	PF00179	0.215
TRG_ENDOCYTIC_2	10	13	PF00928	0.466
TRG_ER_diArg_1	70	73	PF00400	0.356
TRG_NES_CRM1_1	163	175	PF08389	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2C4	Leptomonas seymouri	31%	100%
A0A0N0P547	Leptomonas seymouri	40%	100%
A0A0N0P993	Leptomonas seymouri	26%	87%
A0A0N1HWY5	Leptomonas seymouri	24%	100%
A0A0N1PDH0	Leptomonas seymouri	36%	97%
A0A0S4J784	Bodo saltans	29%	87%
A0A1X0NQ58	Trypanosomatidae	29%	100%
A0A1X0NUH1	Trypanosomatidae	28%	86%
A0A1X0P2R3	Trypanosomatidae	27%	92%
A0A1X0P988	Trypanosomatidae	38%	100%
A0A381MTA7	Leishmania infantum	45%	100%
A0A381MTB8	Leishmania infantum	44%	100%
A0A381MTC7	Leishmania infantum	46%	95%
A0A381MTN2	Leishmania infantum	38%	100%
A0A381MVY0	Leishmania infantum	45%	100%
A0A3Q8ID16	Leishmania donovani	32%	100%
A0A3Q8IE85	Leishmania donovani	51%	100%
A0A3Q8IEC2	Leishmania donovani	41%	100%
A0A3Q8IEI1	Leishmania donovani	43%	100%
A0A3Q8IF65	Leishmania donovani	64%	99%
A0A3Q8IFB9	Leishmania donovani	34%	96%
A0A3Q8IFH7	Leishmania donovani	46%	95%
A0A3Q8IH65	Leishmania donovani	43%	100%
A0A3Q8IHN2	Leishmania donovani	42%	100%
A0A3Q8IHW7	Leishmania donovani	45%	100%
A0A3Q8IHZ6	Leishmania donovani	51%	92%
A0A3Q8IIH1	Leishmania donovani	43%	100%
A0A3Q8IL03	Leishmania donovani	42%	100%
A0A3Q8IUK8	Leishmania donovani	41%	100%
A0A3Q8IUR5	Leishmania donovani	38%	100%
A0A3S5H662	Leishmania donovani	66%	97%
A0A3S5H663	Leishmania donovani	67%	97%
A0A3S5H665	Leishmania donovani	68%	97%
A0A3S5H666	Leishmania donovani	46%	100%
A0A3S5H667	Leishmania donovani	68%	96%
A0A3S5H7D2	Leishmania donovani	33%	100%
A0A3S5H7L2	Leishmania donovani	42%	95%
A0A3S5H7V9	Leishmania donovani	41%	98%
A0A3S5H7W2	Leishmania donovani	24%	100%
A0A3S5H7W6	Leishmania donovani	42%	98%
A0A3S7WQA0	Leishmania donovani	68%	96%
A0A3S7WQA8	Leishmania donovani	44%	100%
A0A3S7WQC1	Leishmania donovani	44%	100%
A0A3S7X2E6	Leishmania donovani	42%	100%
A0A3S7X357	Leishmania donovani	25%	88%
A0A3S7X453	Leishmania donovani	64%	99%
A0A3S7X472	Leishmania donovani	63%	98%
A0A3S7X7E5	Leishmania donovani	45%	78%
A0A3S7X7M4	Leishmania donovani	51%	92%
A0A3S7X7U1	Leishmania donovani	44%	93%
A0A3S7X7U4	Leishmania donovani	44%	75%
A0A3S7X7W2	Leishmania donovani	40%	93%
A0A3S7X7Y0	Leishmania donovani	39%	100%
A4H595	Leishmania braziliensis	39%	100%
A4H596	Leishmania braziliensis	40%	100%
A4H597	Leishmania braziliensis	40%	100%
A4H5D1	Leishmania braziliensis	45%	100%
A4H5D2	Leishmania braziliensis	40%	100%
A4H5G0	Leishmania braziliensis	48%	100%
A4H5G4	Leishmania braziliensis	37%	100%
A4H5G6	Leishmania braziliensis	40%	100%
A4H5G7	Leishmania braziliensis	41%	100%
A4H5G9	Leishmania braziliensis	43%	98%
A4H5H0	Leishmania braziliensis	43%	98%
A4H5H1	Leishmania braziliensis	46%	100%
A4H5H2	Leishmania braziliensis	43%	100%
A4H5H3	Leishmania braziliensis	40%	100%
A4H6C8	Leishmania braziliensis	42%	100%
A4H7D7	Leishmania braziliensis	46%	100%
A4H9E8	Leishmania braziliensis	46%	100%
A4H9E9	Leishmania braziliensis	39%	100%
A4HAJ4	Leishmania braziliensis	45%	100%
A4HAJ5	Leishmania braziliensis	37%	100%
A4HAJ6	Leishmania braziliensis	40%	100%
A4HAL1	Leishmania braziliensis	43%	100%
A4HAL2	Leishmania braziliensis	28%	100%
A4HAM2	Leishmania braziliensis	46%	100%
A4HAM4	Leishmania braziliensis	44%	100%
A4HAR1	Leishmania braziliensis	46%	100%
A4HAZ8	Leishmania braziliensis	49%	100%
A4HB00	Leishmania braziliensis	42%	100%
A4HB02	Leishmania braziliensis	42%	100%
A4HB47	Leishmania braziliensis	34%	100%
A4HBJ0	Leishmania braziliensis	42%	98%
A4HBJ1	Leishmania braziliensis	46%	100%
A4HBJ2	Leishmania braziliensis	39%	100%
A4HDI3	Leishmania braziliensis	30%	100%
A4HDI4	Leishmania braziliensis	31%	100%
A4HDL3	Leishmania braziliensis	33%	100%
A4HDL4	Leishmania braziliensis	31%	100%
A4HI43	Leishmania braziliensis	26%	100%
A4HTM3	Leishmania infantum	43%	100%
A4HTM4	Leishmania infantum	45%	100%
A4HTM5	Leishmania infantum	46%	100%
A4I0W4	Leishmania infantum	32%	100%
A4I0W5	Leishmania infantum	32%	100%
A4I4J2	Leishmania infantum	41%	95%
A4I4J3	Leishmania infantum	47%	76%
A4I5B9	Leishmania infantum	25%	88%
A4I6E5	Leishmania infantum	62%	98%
A4I9Q4	Leishmania infantum	41%	100%
A4I9R4	Leishmania infantum	24%	100%
A4I9R5	Leishmania infantum	34%	96%
A4I9R7	Leishmania infantum	47%	99%
A4I9W8	Leishmania infantum	44%	75%
A4I9X0	Leishmania infantum	40%	93%
A4IA59	Leishmania infantum	38%	75%
A4IAL7	Leishmania infantum	43%	100%
A4IAM1	Leishmania infantum	43%	100%
A4IAM2	Leishmania infantum	42%	100%
C6K3X9	Leptomonas seymouri	25%	100%
E8NHC3	Leishmania infantum	65%	97%
E8NHD3	Leishmania infantum	43%	95%
E8NHD6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	99%
E8NHD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E8NHE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E8NHF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
E8NHF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	97%
E8NHF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	99%
E8NHG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
E8NHH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
E8NHH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E8NHI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
E8NHI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E8NHK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%
E8NHK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	99%
E8NHL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E8NHL9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E8NHM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E8NHM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
E8NHM3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
E8NHM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%
E8NHM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	98%
E8NHM7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E8NHP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E8NHQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
E8NHQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
E8NHR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	99%
E8NHR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	98%
E8NHS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
E9AG81	Leishmania infantum	68%	96%
E9AG82	Leishmania infantum	67%	96%
E9AG83	Leishmania infantum	46%	98%
E9AG85	Leishmania infantum	67%	96%
E9AHI9	Leishmania infantum	42%	100%
E9AHT2	Leishmania infantum	52%	92%
E9AME9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AMF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	100%
E9AMF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	100%
E9AMF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
E9AMF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
E9AMF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
E9AMF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
E9AMF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E9AMF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9AMF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9ASP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E9AWW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9AWW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9B0L6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B1J4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	94%
E9B1J5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	92%
E9B4L9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	98%
E9B4R7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	98%
E9B4R8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	99%
E9B4R9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	96%
E9B4S0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B4Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	95%
Q4Q1U9	Leishmania major	43%	98%
Q4Q305	Leishmania major	42%	98%
Q4Q309	Leishmania major	43%	100%
Q4Q313	Leishmania major	42%	98%
Q4Q317	Leishmania major	41%	100%
Q4Q325	Leishmania major	44%	100%
Q4Q327	Leishmania major	44%	98%
Q4Q329	Leishmania major	43%	98%
Q4Q333	Leishmania major	41%	98%
Q4Q335	Leishmania major	43%	98%
Q4Q337	Leishmania major	42%	100%
Q4Q339	Leishmania major	42%	98%
Q4Q341	Leishmania major	48%	100%
Q4Q397	Leishmania major	49%	74%
Q4Q3A7	Leishmania major	27%	100%
Q4Q3A8	Leishmania major	33%	100%
Q4Q3A9	Leishmania major	50%	100%
Q4Q3F7	Leishmania major	48%	100%
Q4Q6L8	Leishmania major	58%	100%
Q4Q7L6	Leishmania major	25%	100%
Q4QAK5	Leishmania major	33%	100%
Q4QAK6	Leishmania major	32%	100%
Q4QI84	Leishmania major	44%	100%
Q4QI85	Leishmania major	42%	100%
Q4QI86	Leishmania major	44%	100%
Q4QI87	Leishmania major	44%	100%
Q4QI88	Leishmania major	47%	100%
Q4QI92	Leishmania major	63%	100%
Q4QI93	Leishmania major	64%	100%
Q4QI95	Leishmania major	63%	100%
Q4QI97	Leishmania major	64%	100%
Q4QIA0	Leishmania major	65%	100%
Q4QIA1	Leishmania major	65%	100%