Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B1I8_LEIMU

TriTrypDb:

LmxM.30.0370

Length:

678

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 8
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B1I8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1I8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004497	monooxygenase activity	3	2
GO:0005488	binding	1	2
GO:0005506	iron ion binding	6	2
GO:0016491	oxidoreductase activity	2	2
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	2
GO:0020037	heme binding	4	2
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2
GO:0046906	tetrapyrrole binding	3	2
GO:0046914	transition metal ion binding	5	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	11	15	PF00656	0.601
CLV_C14_Caspase3-7	338	342	PF00656	0.478
CLV_NRD_NRD_1	21	23	PF00675	0.638
CLV_NRD_NRD_1	33	35	PF00675	0.501
CLV_PCSK_KEX2_1	21	23	PF00082	0.644
CLV_PCSK_KEX2_1	33	35	PF00082	0.515
CLV_PCSK_KEX2_1	528	530	PF00082	0.424
CLV_PCSK_PC1ET2_1	528	530	PF00082	0.539
CLV_PCSK_PC7_1	524	530	PF00082	0.452
CLV_PCSK_SKI1_1	101	105	PF00082	0.615
CLV_PCSK_SKI1_1	137	141	PF00082	0.496
CLV_PCSK_SKI1_1	39	43	PF00082	0.637
CLV_PCSK_SKI1_1	633	637	PF00082	0.551
DEG_Nend_UBRbox_1	1	4	PF02207	0.665
DEG_SCF_FBW7_1	497	504	PF00400	0.444
DEG_SPOP_SBC_1	67	71	PF00917	0.529
DOC_CYCLIN_yCln2_LP_2	573	579	PF00134	0.420
DOC_CYCLIN_yCln2_LP_2	618	621	PF00134	0.460
DOC_MAPK_gen_1	528	535	PF00069	0.495
DOC_MAPK_MEF2A_6	289	297	PF00069	0.395
DOC_PP1_RVXF_1	135	141	PF00149	0.544
DOC_PP2B_LxvP_1	13	16	PF13499	0.631
DOC_PP2B_LxvP_1	190	193	PF13499	0.454
DOC_PP2B_LxvP_1	412	415	PF13499	0.433
DOC_PP2B_LxvP_1	618	621	PF13499	0.463
DOC_PP4_FxxP_1	309	312	PF00568	0.472
DOC_PP4_FxxP_1	617	620	PF00568	0.418
DOC_PP4_MxPP_1	185	188	PF00568	0.602
DOC_USP7_MATH_1	112	116	PF00917	0.604
DOC_USP7_MATH_1	335	339	PF00917	0.572
DOC_USP7_MATH_1	342	346	PF00917	0.739
DOC_USP7_MATH_1	350	354	PF00917	0.663
DOC_USP7_MATH_1	366	370	PF00917	0.479
DOC_USP7_MATH_1	408	412	PF00917	0.681
DOC_USP7_MATH_1	637	641	PF00917	0.479
DOC_WW_Pin1_4	104	109	PF00397	0.692
DOC_WW_Pin1_4	123	128	PF00397	0.583
DOC_WW_Pin1_4	170	175	PF00397	0.369
DOC_WW_Pin1_4	206	211	PF00397	0.644
DOC_WW_Pin1_4	358	363	PF00397	0.588
DOC_WW_Pin1_4	406	411	PF00397	0.576
DOC_WW_Pin1_4	476	481	PF00397	0.456
DOC_WW_Pin1_4	497	502	PF00397	0.497
DOC_WW_Pin1_4	660	665	PF00397	0.685
DOC_WW_Pin1_4	77	82	PF00397	0.672
LIG_14-3-3_CanoR_1	113	119	PF00244	0.708
LIG_14-3-3_CanoR_1	156	163	PF00244	0.473
LIG_14-3-3_CanoR_1	2	8	PF00244	0.603
LIG_14-3-3_CanoR_1	266	273	PF00244	0.387
LIG_14-3-3_CanoR_1	306	312	PF00244	0.554
LIG_14-3-3_CanoR_1	336	346	PF00244	0.439
LIG_14-3-3_CanoR_1	438	444	PF00244	0.399
LIG_Actin_WH2_2	269	285	PF00022	0.298
LIG_Actin_WH2_2	5	23	PF00022	0.617
LIG_BRCT_BRCA1_1	202	206	PF00533	0.489
LIG_CtBP_PxDLS_1	174	178	PF00389	0.495
LIG_EH1_1	290	298	PF00400	0.216
LIG_FHA_1	123	129	PF00498	0.684
LIG_FHA_1	2	8	PF00498	0.744
LIG_FHA_1	30	36	PF00498	0.598
LIG_FHA_1	448	454	PF00498	0.467
LIG_FHA_1	502	508	PF00498	0.472
LIG_FHA_1	546	552	PF00498	0.405
LIG_FHA_2	112	118	PF00498	0.544
LIG_FHA_2	247	253	PF00498	0.440
LIG_FHA_2	282	288	PF00498	0.303
LIG_FHA_2	566	572	PF00498	0.472
LIG_FHA_2	644	650	PF00498	0.460
LIG_FHA_2	85	91	PF00498	0.487
LIG_IBAR_NPY_1	43	45	PF08397	0.537
LIG_LIR_Apic_2	308	312	PF02991	0.481
LIG_LIR_Gen_1	548	556	PF02991	0.417
LIG_LIR_Nem_3	361	367	PF02991	0.510
LIG_LIR_Nem_3	469	475	PF02991	0.376
LIG_LIR_Nem_3	525	530	PF02991	0.407
LIG_LIR_Nem_3	548	553	PF02991	0.363
LIG_LIR_Nem_3	568	573	PF02991	0.420
LIG_MYND_1	175	179	PF01753	0.495
LIG_MYND_1	616	620	PF01753	0.465
LIG_NRBOX	217	223	PF00104	0.391
LIG_NRBOX	562	568	PF00104	0.425
LIG_Pex14_2	360	364	PF04695	0.443
LIG_SH2_CRK	242	246	PF00017	0.382
LIG_SH2_CRK	625	629	PF00017	0.379
LIG_SH2_GRB2like	50	53	PF00017	0.387
LIG_SH2_NCK_1	625	629	PF00017	0.415
LIG_SH2_PTP2	550	553	PF00017	0.457
LIG_SH2_SRC	50	53	PF00017	0.380
LIG_SH2_STAP1	231	235	PF00017	0.502
LIG_SH2_STAP1	242	246	PF00017	0.422
LIG_SH2_STAP1	488	492	PF00017	0.436
LIG_SH2_STAT3	233	236	PF00017	0.236
LIG_SH2_STAT5	200	203	PF00017	0.477
LIG_SH2_STAT5	246	249	PF00017	0.218
LIG_SH2_STAT5	432	435	PF00017	0.383
LIG_SH2_STAT5	475	478	PF00017	0.331
LIG_SH2_STAT5	50	53	PF00017	0.527
LIG_SH2_STAT5	550	553	PF00017	0.460
LIG_SH3_3	121	127	PF00018	0.517
LIG_SH3_3	185	191	PF00018	0.491
LIG_SH3_3	365	371	PF00018	0.378
LIG_SH3_3	38	44	PF00018	0.573
LIG_SUMO_SIM_par_1	237	243	PF11976	0.200
LIG_SUMO_SIM_par_1	268	274	PF11976	0.337
LIG_TRAF2_1	327	330	PF00917	0.408
LIG_TRAF2_1	87	90	PF00917	0.626
LIG_TYR_ITIM	623	628	PF00017	0.421
LIG_WRC_WIRS_1	567	572	PF05994	0.432
LIG_WW_3	186	190	PF00397	0.492
MOD_CDK_SPK_2	358	363	PF00069	0.540
MOD_CK1_1	107	113	PF00069	0.572
MOD_CK1_1	220	226	PF00069	0.434
MOD_CK1_1	274	280	PF00069	0.511
MOD_CK1_1	305	311	PF00069	0.378
MOD_CK1_1	353	359	PF00069	0.516
MOD_CK1_1	406	412	PF00069	0.535
MOD_CK1_1	464	470	PF00069	0.441
MOD_CK1_1	479	485	PF00069	0.277
MOD_CK1_1	545	551	PF00069	0.325
MOD_CK2_1	111	117	PF00069	0.715
MOD_CK2_1	281	287	PF00069	0.401
MOD_CK2_1	310	316	PF00069	0.443
MOD_CK2_1	384	390	PF00069	0.631
MOD_CK2_1	393	399	PF00069	0.415
MOD_CK2_1	439	445	PF00069	0.445
MOD_CK2_1	516	522	PF00069	0.466
MOD_CK2_1	565	571	PF00069	0.482
MOD_CK2_1	84	90	PF00069	0.492
MOD_GlcNHglycan	114	117	PF01048	0.731
MOD_GlcNHglycan	119	122	PF01048	0.719
MOD_GlcNHglycan	146	149	PF01048	0.601
MOD_GlcNHglycan	158	161	PF01048	0.589
MOD_GlcNHglycan	222	225	PF01048	0.415
MOD_GlcNHglycan	256	259	PF01048	0.432
MOD_GlcNHglycan	267	270	PF01048	0.517
MOD_GlcNHglycan	273	276	PF01048	0.552
MOD_GlcNHglycan	330	336	PF01048	0.539
MOD_GlcNHglycan	368	371	PF01048	0.483
MOD_GlcNHglycan	386	389	PF01048	0.594
MOD_GlcNHglycan	418	421	PF01048	0.475
MOD_GlcNHglycan	535	538	PF01048	0.580
MOD_GlcNHglycan	58	61	PF01048	0.433
MOD_GlcNHglycan	598	601	PF01048	0.595
MOD_GlcNHglycan	639	642	PF01048	0.680
MOD_GlcNHglycan	668	672	PF01048	0.656
MOD_GlcNHglycan	70	73	PF01048	0.602
MOD_GSK3_1	107	114	PF00069	0.689
MOD_GSK3_1	144	151	PF00069	0.517
MOD_GSK3_1	271	278	PF00069	0.497
MOD_GSK3_1	301	308	PF00069	0.530
MOD_GSK3_1	331	338	PF00069	0.588
MOD_GSK3_1	342	349	PF00069	0.479
MOD_GSK3_1	384	391	PF00069	0.552
MOD_GSK3_1	447	454	PF00069	0.468
MOD_GSK3_1	461	468	PF00069	0.308
MOD_GSK3_1	497	504	PF00069	0.369
MOD_GSK3_1	541	548	PF00069	0.311
MOD_GSK3_1	633	640	PF00069	0.468
MOD_GSK3_1	66	73	PF00069	0.579
MOD_GSK3_1	80	87	PF00069	0.735
MOD_N-GLC_1	353	358	PF02516	0.553
MOD_NEK2_1	1	6	PF00069	0.645
MOD_NEK2_1	111	116	PF00069	0.660
MOD_NEK2_1	245	250	PF00069	0.352
MOD_NEK2_1	296	301	PF00069	0.348
MOD_NEK2_1	346	351	PF00069	0.633
MOD_NEK2_1	403	408	PF00069	0.588
MOD_NEK2_1	465	470	PF00069	0.370
MOD_NEK2_1	541	546	PF00069	0.435
MOD_NEK2_1	8	13	PF00069	0.609
MOD_NEK2_2	246	251	PF00069	0.356
MOD_PIKK_1	130	136	PF00454	0.436
MOD_PKA_2	1	7	PF00069	0.662
MOD_PKA_2	112	118	PF00069	0.729
MOD_PKA_2	143	149	PF00069	0.663
MOD_PKA_2	265	271	PF00069	0.500
MOD_PKA_2	305	311	PF00069	0.484
MOD_PKA_2	335	341	PF00069	0.431
MOD_PKA_2	384	390	PF00069	0.587
MOD_PKA_2	416	422	PF00069	0.501
MOD_PKA_2	451	457	PF00069	0.500
MOD_PKB_1	154	162	PF00069	0.459
MOD_Plk_1	287	293	PF00069	0.444
MOD_Plk_2-3	14	20	PF00069	0.525
MOD_Plk_4	217	223	PF00069	0.391
MOD_Plk_4	240	246	PF00069	0.275
MOD_Plk_4	259	265	PF00069	0.427
MOD_Plk_4	371	377	PF00069	0.427
MOD_Plk_4	461	467	PF00069	0.458
MOD_Plk_4	8	14	PF00069	0.634
MOD_ProDKin_1	104	110	PF00069	0.690
MOD_ProDKin_1	123	129	PF00069	0.582
MOD_ProDKin_1	170	176	PF00069	0.376
MOD_ProDKin_1	206	212	PF00069	0.656
MOD_ProDKin_1	358	364	PF00069	0.571
MOD_ProDKin_1	406	412	PF00069	0.583
MOD_ProDKin_1	476	482	PF00069	0.465
MOD_ProDKin_1	497	503	PF00069	0.490
MOD_ProDKin_1	660	666	PF00069	0.683
MOD_ProDKin_1	77	83	PF00069	0.673
MOD_SUMO_for_1	201	204	PF00179	0.426
MOD_SUMO_rev_2	31	41	PF00179	0.610
TRG_DiLeu_BaLyEn_6	368	373	PF01217	0.375
TRG_ENDOCYTIC_2	242	245	PF00928	0.496
TRG_ENDOCYTIC_2	550	553	PF00928	0.457
TRG_ENDOCYTIC_2	574	577	PF00928	0.422
TRG_ENDOCYTIC_2	625	628	PF00928	0.425
TRG_ER_diArg_1	153	156	PF00400	0.543
TRG_ER_diArg_1	20	22	PF00400	0.567
TRG_ER_diArg_1	33	36	PF00400	0.491
TRG_ER_diArg_1	405	408	PF00400	0.637
TRG_Pf-PMV_PEXEL_1	33	37	PF00026	0.586
TRG_Pf-PMV_PEXEL_1	395	399	PF00026	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8T2	Leptomonas seymouri	45%	100%
A0A3R7MH20	Trypanosoma rangeli	32%	100%
A0A3S7X435	Leishmania donovani	85%	100%
A4HJ12	Leishmania braziliensis	72%	100%
A4I6K2	Leishmania infantum	85%	100%
C9ZJE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
Q4Q6M6	Leishmania major	85%	100%
V5AYQ1	Trypanosoma cruzi	30%	100%