Putative amino acid transporter

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amino acid transporter, putative

Species:

Leishmania mexicana

UniProt:

E9B1I3_LEIMU

TriTrypDb:

LmxM.30.0320

Length:

274

Annotations

LeishMANIAdb annotations

An enormously expanded group of various amino acid transporters.. Localization: Cell surface (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 24
NetGPI	no	yes: 0, no: 24

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	23
GO:0110165	cellular anatomical entity	1	23

Expansion

Sequence features

E9B1I3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1I3

Function

Biological processes
Term	Name	Level	Count
GO:0003333	amino acid transmembrane transport	5	2
GO:0006810	transport	3	2
GO:0006865	amino acid transport	5	2
GO:0009987	cellular process	1	2
GO:0015849	organic acid transport	5	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0055085	transmembrane transport	2	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:1903825	organic acid transmembrane transport	3	2
GO:1905039	carboxylic acid transmembrane transport	4	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016787	hydrolase activity	2	10
GO:0005215	transporter activity	1	2
GO:0005342	organic acid transmembrane transporter activity	3	2
GO:0015171	amino acid transmembrane transporter activity	5	2
GO:0015179	L-amino acid transmembrane transporter activity	6	2
GO:0022857	transmembrane transporter activity	2	2
GO:0046943	carboxylic acid transmembrane transporter activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	124	128	PF00656	0.228
CLV_PCSK_SKI1_1	94	98	PF00082	0.281
DEG_APCC_DBOX_1	93	101	PF00400	0.367
DEG_Nend_Nbox_1	1	3	PF02207	0.438
DOC_MAPK_FxFP_2	221	224	PF00069	0.390
DOC_MAPK_gen_1	48	57	PF00069	0.286
DOC_MAPK_MEF2A_6	20	29	PF00069	0.415
DOC_PP1_RVXF_1	236	242	PF00149	0.492
DOC_PP2B_LxvP_1	199	202	PF13499	0.342
DOC_PP2B_PxIxI_1	201	207	PF00149	0.257
DOC_PP4_FxxP_1	221	224	PF00568	0.342
DOC_USP7_MATH_1	123	127	PF00917	0.205
DOC_USP7_MATH_1	269	273	PF00917	0.259
DOC_USP7_MATH_2	13	19	PF00917	0.537
LIG_14-3-3_CanoR_1	20	26	PF00244	0.452
LIG_14-3-3_CanoR_1	203	207	PF00244	0.339
LIG_14-3-3_CanoR_1	94	103	PF00244	0.483
LIG_Actin_WH2_2	5	22	PF00022	0.375
LIG_BRCT_BRCA1_1	230	234	PF00533	0.421
LIG_eIF4E_1	110	116	PF01652	0.343
LIG_FHA_1	22	28	PF00498	0.345
LIG_FHA_1	234	240	PF00498	0.423
LIG_FHA_1	245	251	PF00498	0.317
LIG_FHA_1	34	40	PF00498	0.336
LIG_LIR_Gen_1	247	256	PF02991	0.315
LIG_LIR_Nem_3	113	119	PF02991	0.313
LIG_LIR_Nem_3	165	171	PF02991	0.489
LIG_LIR_Nem_3	205	211	PF02991	0.227
LIG_LIR_Nem_3	225	230	PF02991	0.397
LIG_LIR_Nem_3	247	251	PF02991	0.353
LIG_NRBOX	96	102	PF00104	0.424
LIG_Pex14_2	214	218	PF04695	0.423
LIG_Pex14_2	223	227	PF04695	0.423
LIG_Pex14_2	29	33	PF04695	0.205
LIG_SH2_CRK	133	137	PF00017	0.218
LIG_SH2_CRK	248	252	PF00017	0.215
LIG_SH2_STAP1	248	252	PF00017	0.341
LIG_SH2_STAT5	110	113	PF00017	0.372
LIG_SH2_STAT5	118	121	PF00017	0.266
LIG_SH2_STAT5	145	148	PF00017	0.374
LIG_SH3_3	3	9	PF00018	0.547
LIG_SH3_3	75	81	PF00018	0.343
LIG_SUMO_SIM_anti_2	23	29	PF11976	0.331
LIG_UBA3_1	129	137	PF00899	0.339
LIG_UBA3_1	7	14	PF00899	0.548
LIG_WRC_WIRS_1	54	59	PF05994	0.236
MOD_CK1_1	41	47	PF00069	0.311
MOD_GlcNHglycan	230	233	PF01048	0.194
MOD_GlcNHglycan	262	265	PF01048	0.330
MOD_GlcNHglycan	67	70	PF01048	0.266
MOD_GlcNHglycan	97	100	PF01048	0.191
MOD_GSK3_1	228	235	PF00069	0.455
MOD_NEK2_1	101	106	PF00069	0.404
MOD_NEK2_1	141	146	PF00069	0.202
MOD_NEK2_1	228	233	PF00069	0.522
MOD_NEK2_1	244	249	PF00069	0.330
MOD_NEK2_1	250	255	PF00069	0.371
MOD_NEK2_1	33	38	PF00069	0.340
MOD_NEK2_2	88	93	PF00069	0.367
MOD_PIKK_1	173	179	PF00454	0.428
MOD_PKA_2	202	208	PF00069	0.377
MOD_Plk_1	173	179	PF00069	0.367
MOD_Plk_4	125	131	PF00069	0.279
MOD_Plk_4	141	147	PF00069	0.427
MOD_Plk_4	222	228	PF00069	0.364
TRG_ENDOCYTIC_2	118	121	PF00928	0.304
TRG_ENDOCYTIC_2	133	136	PF00928	0.299
TRG_ENDOCYTIC_2	145	148	PF00928	0.357
TRG_ENDOCYTIC_2	168	171	PF00928	0.484
TRG_ENDOCYTIC_2	248	251	PF00928	0.387

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P613	Leptomonas seymouri	29%	67%
A0A0N0P6F5	Leptomonas seymouri	28%	67%
A0A0S4JCF0	Bodo saltans	25%	66%
A0A0S4JEJ9	Bodo saltans	27%	100%
A0A1X0NDW9	Trypanosomatidae	44%	100%
A0A1X0P4S1	Trypanosomatidae	26%	67%
A0A3Q8IN54	Leishmania donovani	28%	86%
A0A3R7KDS3	Trypanosoma rangeli	40%	67%
A0A3S7XA86	Leishmania donovani	26%	67%
A0A422N5W8	Trypanosoma rangeli	29%	67%
A0A451EJH9	Leishmania donovani	36%	92%
A4HNJ6	Leishmania braziliensis	28%	67%
A4HNJ7	Leishmania braziliensis	28%	68%
A4IC53	Leishmania infantum	26%	67%
A4IC66	Leishmania infantum	28%	68%
D0A362	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	67%
E8NHF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	66%
E9AG08	Leishmania major	26%	67%
E9AG09	Leishmania major	28%	68%
E9AHD8	Leishmania infantum	50%	100%
E9B761	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	67%
E9B762	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	68%
V5DET2	Trypanosoma cruzi	53%	78%