LeishMANIAdb
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PINc domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
PINc domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B1H6_LEIMU
TriTrypDb:
LmxM.30.0255
Length:
114

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 4
NetGPI no yes: 0, no: 4
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B1H6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1H6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 101 103 PF00675 0.711
CLV_NRD_NRD_1 7 9 PF00675 0.469
CLV_PCSK_KEX2_1 101 103 PF00082 0.579
CLV_PCSK_KEX2_1 7 9 PF00082 0.469
DEG_APCC_DBOX_1 100 108 PF00400 0.708
DOC_PP2B_LxvP_1 107 110 PF13499 0.700
DOC_USP7_UBL2_3 51 55 PF12436 0.497
LIG_14-3-3_CanoR_1 101 105 PF00244 0.705
LIG_14-3-3_CanoR_1 15 19 PF00244 0.454
LIG_BRCT_BRCA1_1 8 12 PF00533 0.623
LIG_LIR_Gen_1 60 71 PF02991 0.547
LIG_LIR_Gen_1 79 87 PF02991 0.588
LIG_LIR_Nem_3 60 66 PF02991 0.549
LIG_LIR_Nem_3 79 84 PF02991 0.592
LIG_LIR_Nem_3 85 90 PF02991 0.698
LIG_PDZ_Wminus1_1 112 114 PF00595 0.497
LIG_Pex14_1 77 81 PF04695 0.427
LIG_SH2_CRK 81 85 PF00017 0.450
LIG_WRC_WIRS_1 40 45 PF05994 0.737
MOD_CK1_1 100 106 PF00069 0.646
MOD_CK2_1 70 76 PF00069 0.573
MOD_GlcNHglycan 72 75 PF01048 0.616
MOD_GlcNHglycan 8 11 PF01048 0.605
MOD_NEK2_1 6 11 PF00069 0.611
MOD_NEK2_2 14 19 PF00069 0.452
MOD_PKA_2 100 106 PF00069 0.707
MOD_PKA_2 14 20 PF00069 0.454
MOD_PKA_2 23 29 PF00069 0.422
MOD_PKA_2 6 12 PF00069 0.687
TRG_DiLeu_BaLyEn_6 102 107 PF01217 0.594
TRG_ENDOCYTIC_2 81 84 PF00928 0.447
TRG_ER_diArg_1 6 8 PF00400 0.446

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8ISD3 Leishmania donovani 73% 70%
A4I6B8 Leishmania infantum 72% 70%
Q4Q6N8 Leishmania major 82% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS