Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B1H2_LEIMU

TriTrypDb:

LmxM.30.0221

Length:

234

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B1H2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1H2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	85	89	PF00656	0.727
CLV_NRD_NRD_1	155	157	PF00675	0.671
CLV_NRD_NRD_1	192	194	PF00675	0.695
CLV_PCSK_KEX2_1	155	157	PF00082	0.671
CLV_PCSK_KEX2_1	192	194	PF00082	0.695
CLV_PCSK_SKI1_1	168	172	PF00082	0.681
CLV_PCSK_SKI1_1	192	196	PF00082	0.502
DOC_USP7_MATH_1	213	217	PF00917	0.692
DOC_USP7_MATH_1	51	55	PF00917	0.674
DOC_USP7_MATH_1	67	71	PF00917	0.685
LIG_14-3-3_CanoR_1	192	197	PF00244	0.494
LIG_14-3-3_CanoR_1	24	29	PF00244	0.547
LIG_Actin_WH2_2	177	194	PF00022	0.649
LIG_EVH1_1	125	129	PF00568	0.759
LIG_FHA_1	142	148	PF00498	0.637
LIG_FHA_1	173	179	PF00498	0.658
LIG_FHA_2	18	24	PF00498	0.547
LIG_FHA_2	193	199	PF00498	0.611
LIG_LIR_Gen_1	146	154	PF02991	0.573
LIG_LIR_Nem_3	146	151	PF02991	0.638
LIG_MYND_1	128	132	PF01753	0.759
LIG_NRP_CendR_1	233	234	PF00754	0.782
LIG_SH2_CRK	148	152	PF00017	0.653
LIG_SH3_1	125	131	PF00018	0.765
LIG_SH3_3	123	129	PF00018	0.765
LIG_SH3_3	130	136	PF00018	0.647
LIG_SH3_3	204	210	PF00018	0.697
LIG_SH3_3	212	218	PF00018	0.692
LIG_SH3_3	223	229	PF00018	0.538
LIG_SUMO_SIM_par_1	15	20	PF11976	0.534
LIG_TRAF2_1	116	119	PF00917	0.759
LIG_TRAF2_1	54	57	PF00917	0.576
LIG_TRFH_1	125	129	PF08558	0.766
LIG_WW_2	128	131	PF00397	0.762
MOD_CK1_1	216	222	PF00069	0.612
MOD_CK2_1	113	119	PF00069	0.756
MOD_CK2_1	17	23	PF00069	0.527
MOD_CK2_1	51	57	PF00069	0.785
MOD_CK2_1	7	13	PF00069	0.503
MOD_GSK3_1	216	223	PF00069	0.610
MOD_GSK3_1	24	31	PF00069	0.546
MOD_GSK3_1	69	76	PF00069	0.657
MOD_NEK2_1	17	22	PF00069	0.519
MOD_NEK2_1	4	9	PF00069	0.505
MOD_PKA_1	192	198	PF00069	0.611
MOD_PKA_2	192	198	PF00069	0.677
MOD_PKA_2	213	219	PF00069	0.543
MOD_PKA_2	23	29	PF00069	0.549
MOD_Plk_4	146	152	PF00069	0.575
MOD_Plk_4	220	226	PF00069	0.554
TRG_ENDOCYTIC_2	148	151	PF00928	0.644
TRG_ER_diArg_1	154	156	PF00400	0.574
TRG_ER_diArg_1	191	193	PF00400	0.683

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IIB3	Leishmania donovani	92%	100%
A4HIZ7	Leishmania braziliensis	70%	100%
A4I6B4	Leishmania infantum	93%	100%
E9B1H0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	100%	100%
Q4Q6P2	Leishmania major	91%	100%