NLE domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B1G8_LEIMU

TriTrypDb:

LmxM.30.0200

Length:

544

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9B1G8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1G8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	273	277	PF00656	0.475
CLV_C14_Caspase3-7	313	317	PF00656	0.437
CLV_MEL_PAP_1	369	375	PF00089	0.313
CLV_NRD_NRD_1	180	182	PF00675	0.349
CLV_NRD_NRD_1	269	271	PF00675	0.525
CLV_NRD_NRD_1	64	66	PF00675	0.425
CLV_PCSK_KEX2_1	180	182	PF00082	0.368
CLV_PCSK_KEX2_1	271	273	PF00082	0.475
CLV_PCSK_KEX2_1	64	66	PF00082	0.425
CLV_PCSK_PC1ET2_1	271	273	PF00082	0.475
CLV_PCSK_PC7_1	176	182	PF00082	0.464
CLV_PCSK_SKI1_1	366	370	PF00082	0.315
CLV_PCSK_SKI1_1	40	44	PF00082	0.445
DEG_APCC_DBOX_1	454	462	PF00400	0.411
DEG_SPOP_SBC_1	50	54	PF00917	0.410
DOC_CYCLIN_RxL_1	37	46	PF00134	0.438
DOC_CYCLIN_yCln2_LP_2	42	45	PF00134	0.444
DOC_CYCLIN_yCln2_LP_2	56	62	PF00134	0.418
DOC_MAPK_gen_1	354	361	PF00069	0.507
DOC_MAPK_MEF2A_6	354	361	PF00069	0.507
DOC_PP2B_LxvP_1	42	45	PF13499	0.444
DOC_PP4_FxxP_1	135	138	PF00568	0.390
DOC_PP4_FxxP_1	451	454	PF00568	0.411
DOC_PP4_FxxP_1	8	11	PF00568	0.413
DOC_USP7_MATH_1	131	135	PF00917	0.277
DOC_USP7_MATH_1	244	248	PF00917	0.428
DOC_USP7_MATH_1	263	267	PF00917	0.349
DOC_USP7_MATH_1	282	286	PF00917	0.406
DOC_USP7_MATH_1	329	333	PF00917	0.431
DOC_USP7_MATH_1	38	42	PF00917	0.657
DOC_USP7_MATH_1	410	414	PF00917	0.420
DOC_USP7_MATH_1	472	476	PF00917	0.492
DOC_USP7_MATH_1	481	485	PF00917	0.268
DOC_USP7_MATH_1	83	87	PF00917	0.416
DOC_USP7_UBL2_3	267	271	PF12436	0.587
DOC_USP7_UBL2_3	445	449	PF12436	0.369
DOC_WW_Pin1_4	191	196	PF00397	0.307
DOC_WW_Pin1_4	64	69	PF00397	0.416
DOC_WW_Pin1_4	81	86	PF00397	0.464
DOC_WW_Pin1_4	9	14	PF00397	0.415
LIG_14-3-3_CanoR_1	180	189	PF00244	0.344
LIG_14-3-3_CanoR_1	495	504	PF00244	0.382
LIG_APCC_ABBA_1	204	209	PF00400	0.375
LIG_BIR_II_1	1	5	PF00653	0.372
LIG_BRCT_BRCA1_1	66	70	PF00533	0.412
LIG_Clathr_ClatBox_1	188	192	PF01394	0.322
LIG_Clathr_ClatBox_1	501	505	PF01394	0.331
LIG_eIF4E_1	169	175	PF01652	0.338
LIG_FHA_1	192	198	PF00498	0.369
LIG_FHA_1	28	34	PF00498	0.445
LIG_FHA_1	310	316	PF00498	0.467
LIG_FHA_1	334	340	PF00498	0.435
LIG_FHA_1	486	492	PF00498	0.321
LIG_FHA_1	497	503	PF00498	0.382
LIG_FHA_1	507	513	PF00498	0.290
LIG_FHA_1	52	58	PF00498	0.430
LIG_FHA_1	72	78	PF00498	0.728
LIG_FHA_2	271	277	PF00498	0.492
LIG_FHA_2	358	364	PF00498	0.436
LIG_LIR_Apic_2	132	138	PF02991	0.220
LIG_LIR_Apic_2	450	454	PF02991	0.418
LIG_LIR_Gen_1	158	169	PF02991	0.178
LIG_LIR_Gen_1	341	346	PF02991	0.363
LIG_LIR_Nem_3	158	164	PF02991	0.207
LIG_LIR_Nem_3	172	178	PF02991	0.336
LIG_LIR_Nem_3	36	42	PF02991	0.434
LIG_MYND_1	58	62	PF01753	0.431
LIG_PTB_Apo_2	187	194	PF02174	0.339
LIG_PTB_Phospho_1	187	193	PF10480	0.341
LIG_SH2_STAP1	126	130	PF00017	0.163
LIG_SH2_STAP1	230	234	PF00017	0.421
LIG_SH2_STAP1	29	33	PF00017	0.444
LIG_SH2_STAP1	459	463	PF00017	0.295
LIG_SH2_STAT3	517	520	PF00017	0.463
LIG_SH2_STAT5	169	172	PF00017	0.258
LIG_SH2_STAT5	193	196	PF00017	0.310
LIG_SH2_STAT5	29	32	PF00017	0.446
LIG_SH2_STAT5	517	520	PF00017	0.411
LIG_SH3_3	17	23	PF00018	0.452
LIG_SH3_3	211	217	PF00018	0.421
LIG_SH3_3	257	263	PF00018	0.363
LIG_SH3_3	28	34	PF00018	0.432
LIG_SH3_3	63	69	PF00018	0.513
LIG_SUMO_SIM_par_1	28	36	PF11976	0.440
LIG_SUMO_SIM_par_1	499	505	PF11976	0.334
LIG_SUMO_SIM_par_1	509	516	PF11976	0.304
LIG_TRAF2_1	184	187	PF00917	0.354
LIG_WRC_WIRS_1	118	123	PF05994	0.258
LIG_WRC_WIRS_1	245	250	PF05994	0.461
LIG_WRC_WIRS_1	358	363	PF05994	0.325
LIG_WRC_WIRS_1	448	453	PF05994	0.376
LIG_WW_3	19	23	PF00397	0.452
MOD_CDC14_SPxK_1	84	87	PF00782	0.462
MOD_CDK_SPxK_1	81	87	PF00069	0.464
MOD_CK1_1	265	271	PF00069	0.558
MOD_CK1_1	297	303	PF00069	0.437
MOD_CK1_1	332	338	PF00069	0.473
MOD_CK1_1	430	436	PF00069	0.430
MOD_CK1_1	475	481	PF00069	0.404
MOD_CK1_1	52	58	PF00069	0.468
MOD_CK1_1	86	92	PF00069	0.475
MOD_CK1_1	95	101	PF00069	0.736
MOD_CK2_1	126	132	PF00069	0.182
MOD_CK2_1	181	187	PF00069	0.344
MOD_Cter_Amidation	268	271	PF01082	0.577
MOD_GlcNHglycan	115	118	PF01048	0.414
MOD_GlcNHglycan	282	285	PF01048	0.390
MOD_GlcNHglycan	373	376	PF01048	0.340
MOD_GlcNHglycan	383	386	PF01048	0.275
MOD_GlcNHglycan	421	424	PF01048	0.570
MOD_GlcNHglycan	429	432	PF01048	0.436
MOD_GlcNHglycan	45	48	PF01048	0.441
MOD_GlcNHglycan	451	454	PF01048	0.309
MOD_GlcNHglycan	473	477	PF01048	0.577
MOD_GlcNHglycan	524	527	PF01048	0.328
MOD_GSK3_1	113	120	PF00069	0.398
MOD_GSK3_1	122	129	PF00069	0.251
MOD_GSK3_1	282	289	PF00069	0.339
MOD_GSK3_1	329	336	PF00069	0.504
MOD_GSK3_1	481	488	PF00069	0.296
MOD_GSK3_1	496	503	PF00069	0.325
MOD_GSK3_1	518	525	PF00069	0.351
MOD_GSK3_1	531	538	PF00069	0.330
MOD_GSK3_1	79	86	PF00069	0.578
MOD_GSK3_1	88	95	PF00069	0.671
MOD_N-GLC_1	529	534	PF02516	0.322
MOD_N-GLC_2	71	73	PF02516	0.418
MOD_NEK2_1	121	126	PF00069	0.282
MOD_NEK2_1	224	229	PF00069	0.431
MOD_NEK2_1	280	285	PF00069	0.328
MOD_NEK2_1	295	300	PF00069	0.293
MOD_NEK2_1	304	309	PF00069	0.458
MOD_NEK2_1	327	332	PF00069	0.451
MOD_NEK2_1	427	432	PF00069	0.344
MOD_NEK2_1	439	444	PF00069	0.315
MOD_NEK2_1	494	499	PF00069	0.436
MOD_NEK2_1	513	518	PF00069	0.224
MOD_NEK2_1	79	84	PF00069	0.513
MOD_NEK2_2	117	122	PF00069	0.390
MOD_NEK2_2	210	215	PF00069	0.421
MOD_NEK2_2	244	249	PF00069	0.447
MOD_NEK2_2	333	338	PF00069	0.421
MOD_PIKK_1	400	406	PF00454	0.482
MOD_PK_1	286	292	PF00069	0.328
MOD_PKA_1	270	276	PF00069	0.536
MOD_PKA_2	371	377	PF00069	0.326
MOD_PKA_2	494	500	PF00069	0.365
MOD_Plk_1	131	137	PF00069	0.258
MOD_Plk_1	27	33	PF00069	0.450
MOD_Plk_1	333	339	PF00069	0.435
MOD_Plk_1	485	491	PF00069	0.305
MOD_Plk_1	513	519	PF00069	0.299
MOD_Plk_4	117	123	PF00069	0.277
MOD_Plk_4	170	176	PF00069	0.338
MOD_Plk_4	459	465	PF00069	0.335
MOD_Plk_4	475	481	PF00069	0.286
MOD_Plk_4	513	519	PF00069	0.351
MOD_Plk_4	52	58	PF00069	0.506
MOD_Plk_4	92	98	PF00069	0.742
MOD_ProDKin_1	191	197	PF00069	0.310
MOD_ProDKin_1	64	70	PF00069	0.417
MOD_ProDKin_1	81	87	PF00069	0.464
MOD_ProDKin_1	9	15	PF00069	0.418
MOD_SUMO_rev_2	525	532	PF00179	0.356
TRG_ER_diArg_1	272	275	PF00400	0.564
TRG_ER_diArg_1	436	439	PF00400	0.309
TRG_ER_diArg_1	63	65	PF00400	0.432
TRG_NES_CRM1_1	144	158	PF08389	0.277
TRG_NLS_MonoExtC_3	269	274	PF00514	0.484
TRG_NLS_MonoExtN_4	267	274	PF00514	0.486

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8U0	Leptomonas seymouri	83%	100%
A0A0S4ITM8	Bodo saltans	23%	100%
A0A1X0NJ30	Trypanosomatidae	62%	100%
A0A3S5IQK0	Trypanosoma rangeli	63%	100%
A0A3S7X417	Leishmania donovani	93%	100%
A1CH75	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	23%	100%
A1CXL0	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	24%	100%
A2QI22	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	24%	100%
A3LQ86	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	22%	100%
A4HIZ5	Leishmania braziliensis	87%	100%
A4I6B2	Leishmania infantum	92%	100%
A4R2Q6	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	22%	100%
A5DL92	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	24%	100%
A6R3K5	Ajellomyces capsulatus (strain NAm1 / WU24)	26%	100%
A6S0T8	Botryotinia fuckeliana (strain B05.10)	25%	100%
A7ECP3	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	25%	100%
A7RHG8	Nematostella vectensis	30%	100%
A7TMF9	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	23%	100%
A8IR43	Chlamydomonas reinhardtii	28%	100%
A8PD13	Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)	25%	100%
A8QB65	Brugia malayi	25%	100%
A8XL02	Caenorhabditis briggsae	22%	100%
A9UP22	Monosiga brevicollis	27%	100%
B0DWM8	Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686)	27%	100%
B0W517	Culex quinquefasciatus	28%	100%
B0Y5V6	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	25%	100%
B2B5V0	Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383)	24%	100%
B2VZH2	Pyrenophora tritici-repentis (strain Pt-1C-BFP)	27%	100%
B3MJV8	Drosophila ananassae	27%	100%
B3N534	Drosophila erecta	28%	100%
B4GT01	Drosophila persimilis	28%	100%
B4HWV6	Drosophila sechellia	29%	100%
B4JPT9	Drosophila grimshawi	27%	100%
B4KKN1	Drosophila mojavensis	27%	100%
B4LS78	Drosophila virilis	27%	100%
B4MU54	Drosophila willistoni	27%	100%
B4P116	Drosophila yakuba	28%	100%
B4Q9T6	Drosophila simulans	29%	100%
B5DG67	Salmo salar	25%	100%
B6GZD3	Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255)	24%	100%
B7PY76	Ixodes scapularis	25%	100%
C9ZN39	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
G0SC29	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	25%	100%
G0SFB5	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	23%	100%
P25382	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	100%
P61480	Rattus norvegicus	26%	100%
P91343	Caenorhabditis elegans	23%	100%
Q0CLJ4	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	24%	100%
Q0UXP3	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	25%	100%
Q0VC24	Bos taurus	27%	100%
Q17BB0	Aedes aegypti	28%	100%
Q1DJF7	Coccidioides immitis (strain RS)	24%	100%
Q29KQ0	Drosophila pseudoobscura pseudoobscura	28%	100%
Q2GXT0	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	24%	100%
Q2UGK1	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	24%	100%
Q4Q6P4	Leishmania major	93%	100%
Q4WP10	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	25%	100%
Q54W52	Dictyostelium discoideum	24%	100%
Q5APF0	Candida albicans (strain SC5314 / ATCC MYA-2876)	23%	100%
Q5B4R1	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	24%	100%
Q5BJ90	Xenopus tropicalis	26%	100%
Q5REE6	Pongo abelii	27%	100%
Q6BLS5	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	23%	100%
Q6CU59	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	25%	100%
Q6FKK3	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	26%	100%
Q6NX08	Danio rerio	26%	100%
Q756D0	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	25%	100%
Q7QJ33	Anopheles gambiae	28%	100%
Q8H594	Oryza sativa subsp. japonica	28%	100%
Q9C2I5	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	23%	100%
Q9GZL7	Homo sapiens	27%	100%
Q9JJA4	Mus musculus	27%	100%
Q9LF27	Arabidopsis thaliana	27%	100%
Q9URY0	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
Q9VKQ3	Drosophila melanogaster	28%	100%
V5AYL2	Trypanosoma cruzi	62%	100%