Putative nucleolar protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleolar protein, putative

Species:

Leishmania mexicana

UniProt:

E9B1G7_LEIMU

TriTrypDb:

LmxM.30.0190

Length:

625

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

E9B1G7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1G7

Function

Biological processes
Term	Name	Level	Count
GO:0001510	RNA methylation	4	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009451	RNA modification	5	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0022613	ribonucleoprotein complex biogenesis	4	11
GO:0032259	methylation	2	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0042254	ribosome biogenesis	5	11
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0043414	macromolecule methylation	3	12
GO:0044085	cellular component biogenesis	3	11
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0071840	cellular component organization or biogenesis	2	11
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0000154	rRNA modification	6	1
GO:0000470	maturation of LSU-rRNA	9	1
GO:0006364	rRNA processing	8	1
GO:0016072	rRNA metabolic process	7	1
GO:0031167	rRNA methylation	5	1
GO:0034470	ncRNA processing	7	1
GO:0034660	ncRNA metabolic process	6	1
GO:0070475	rRNA base methylation	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0008168	methyltransferase activity	4	12
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0008169	C-methyltransferase activity	5	1
GO:0008173	RNA methyltransferase activity	4	1
GO:0008649	rRNA methyltransferase activity	5	1
GO:0009383	rRNA (cytosine-C5-)-methyltransferase activity	6	1
GO:0016434	rRNA (cytosine) methyltransferase activity	6	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140102	catalytic activity, acting on a rRNA	4	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	98	102	PF00656	0.696
CLV_NRD_NRD_1	129	131	PF00675	0.503
CLV_NRD_NRD_1	270	272	PF00675	0.251
CLV_NRD_NRD_1	479	481	PF00675	0.260
CLV_NRD_NRD_1	51	53	PF00675	0.687
CLV_NRD_NRD_1	512	514	PF00675	0.220
CLV_NRD_NRD_1	611	613	PF00675	0.719
CLV_NRD_NRD_1	617	619	PF00675	0.704
CLV_PCSK_KEX2_1	128	130	PF00082	0.503
CLV_PCSK_KEX2_1	269	271	PF00082	0.251
CLV_PCSK_KEX2_1	279	281	PF00082	0.251
CLV_PCSK_KEX2_1	478	480	PF00082	0.263
CLV_PCSK_KEX2_1	512	514	PF00082	0.220
CLV_PCSK_KEX2_1	560	562	PF00082	0.680
CLV_PCSK_KEX2_1	576	578	PF00082	0.539
CLV_PCSK_KEX2_1	617	619	PF00082	0.716
CLV_PCSK_PC1ET2_1	269	271	PF00082	0.251
CLV_PCSK_PC1ET2_1	279	281	PF00082	0.251
CLV_PCSK_PC1ET2_1	560	562	PF00082	0.723
CLV_PCSK_PC1ET2_1	576	578	PF00082	0.505
CLV_PCSK_PC1ET2_1	617	619	PF00082	0.743
CLV_PCSK_SKI1_1	129	133	PF00082	0.486
CLV_PCSK_SKI1_1	149	153	PF00082	0.411
CLV_PCSK_SKI1_1	23	27	PF00082	0.666
CLV_PCSK_SKI1_1	4	8	PF00082	0.640
CLV_PCSK_SKI1_1	405	409	PF00082	0.263
CLV_PCSK_SKI1_1	422	426	PF00082	0.263
CLV_PCSK_SKI1_1	441	445	PF00082	0.263
CLV_PCSK_SKI1_1	612	616	PF00082	0.811
CLV_Separin_Metazoa	217	221	PF03568	0.471
DEG_APCC_DBOX_1	219	227	PF00400	0.441
DEG_APCC_DBOX_1	478	486	PF00400	0.348
DEG_ODPH_VHL_1	329	340	PF01847	0.451
DEG_SPOP_SBC_1	554	558	PF00917	0.687
DOC_CYCLIN_RxL_1	435	449	PF00134	0.476
DOC_CYCLIN_yCln2_LP_2	240	246	PF00134	0.476
DOC_MAPK_gen_1	189	198	PF00069	0.417
DOC_MAPK_gen_1	210	218	PF00069	0.440
DOC_MAPK_gen_1	255	263	PF00069	0.463
DOC_MAPK_gen_1	289	297	PF00069	0.451
DOC_MAPK_gen_1	398	408	PF00069	0.451
DOC_MAPK_gen_1	478	484	PF00069	0.476
DOC_MAPK_gen_1	500	510	PF00069	0.537
DOC_MAPK_gen_1	579	588	PF00069	0.760
DOC_MAPK_MEF2A_6	289	297	PF00069	0.451
DOC_PP2B_LxvP_1	240	243	PF13499	0.476
DOC_PP2B_LxvP_1	408	411	PF13499	0.451
DOC_PP2B_LxvP_1	599	602	PF13499	0.758
DOC_PP4_FxxP_1	491	494	PF00568	0.451
DOC_USP7_MATH_1	21	25	PF00917	0.676
DOC_USP7_MATH_1	319	323	PF00917	0.537
DOC_USP7_MATH_1	554	558	PF00917	0.698
DOC_USP7_MATH_1	607	611	PF00917	0.547
DOC_USP7_MATH_2	286	292	PF00917	0.451
DOC_USP7_UBL2_3	23	27	PF12436	0.691
DOC_USP7_UBL2_3	38	42	PF12436	0.539
DOC_USP7_UBL2_3	49	53	PF12436	0.660
DOC_USP7_UBL2_3	591	595	PF12436	0.727
DOC_USP7_UBL2_3	613	617	PF12436	0.733
DOC_WW_Pin1_4	151	156	PF00397	0.621
DOC_WW_Pin1_4	550	555	PF00397	0.660
LIG_14-3-3_CanoR_1	262	267	PF00244	0.476
LIG_14-3-3_CanoR_1	370	375	PF00244	0.463
LIG_14-3-3_CanoR_1	435	443	PF00244	0.463
LIG_14-3-3_CanoR_1	503	509	PF00244	0.436
LIG_14-3-3_CanoR_1	561	571	PF00244	0.639
LIG_AP_GAE_1	107	113	PF02883	0.561
LIG_BIR_II_1	1	5	PF00653	0.627
LIG_CaM_IQ_9	568	584	PF13499	0.677
LIG_FHA_1	193	199	PF00498	0.451
LIG_FHA_1	258	264	PF00498	0.464
LIG_FHA_1	29	35	PF00498	0.680
LIG_FHA_1	3	9	PF00498	0.534
LIG_FHA_1	346	352	PF00498	0.451
LIG_FHA_1	356	362	PF00498	0.444
LIG_FHA_1	382	388	PF00498	0.480
LIG_FHA_1	413	419	PF00498	0.513
LIG_FHA_2	182	188	PF00498	0.464
LIG_FHA_2	387	393	PF00498	0.463
LIG_FHA_2	606	612	PF00498	0.747
LIG_LIR_Gen_1	214	223	PF02991	0.383
LIG_LIR_Gen_1	228	237	PF02991	0.375
LIG_LIR_Gen_1	288	298	PF02991	0.451
LIG_LIR_Gen_1	394	403	PF02991	0.537
LIG_LIR_Gen_1	427	436	PF02991	0.372
LIG_LIR_Gen_1	95	100	PF02991	0.625
LIG_LIR_Nem_3	214	218	PF02991	0.411
LIG_LIR_Nem_3	228	232	PF02991	0.380
LIG_LIR_Nem_3	288	293	PF02991	0.451
LIG_LIR_Nem_3	322	326	PF02991	0.332
LIG_LIR_Nem_3	394	399	PF02991	0.488
LIG_LIR_Nem_3	427	433	PF02991	0.421
LIG_LIR_Nem_3	95	99	PF02991	0.620
LIG_MAD2	12	20	PF02301	0.650
LIG_MAD2	336	344	PF02301	0.451
LIG_PCNA_PIPBox_1	234	243	PF02747	0.503
LIG_REV1ctd_RIR_1	522	532	PF16727	0.463
LIG_SH2_GRB2like	504	507	PF00017	0.348
LIG_SH2_NCK_1	430	434	PF00017	0.412
LIG_SH2_SRC	227	230	PF00017	0.427
LIG_SH2_SRC	430	433	PF00017	0.412
LIG_SH2_STAP1	229	233	PF00017	0.466
LIG_SH2_STAP1	396	400	PF00017	0.463
LIG_SH2_STAP1	68	72	PF00017	0.588
LIG_SH2_STAT3	315	318	PF00017	0.451
LIG_SH2_STAT3	350	353	PF00017	0.451
LIG_SH2_STAT5	215	218	PF00017	0.459
LIG_SH2_STAT5	310	313	PF00017	0.444
LIG_SH2_STAT5	350	353	PF00017	0.451
LIG_SH2_STAT5	456	459	PF00017	0.463
LIG_SH2_STAT5	514	517	PF00017	0.512
LIG_SH2_STAT5	78	81	PF00017	0.486
LIG_SH3_3	363	369	PF00018	0.476
LIG_SH3_3	42	48	PF00018	0.518
LIG_SUMO_SIM_anti_2	214	222	PF11976	0.446
LIG_SUMO_SIM_par_1	221	228	PF11976	0.442
LIG_TRAF2_1	166	169	PF00917	0.692
LIG_TRAF2_1	184	187	PF00917	0.357
LIG_TRAF2_1	330	333	PF00917	0.463
LIG_TYR_ITSM	392	399	PF00017	0.502
LIG_UBA3_1	444	452	PF00899	0.499
MOD_CK1_1	423	429	PF00069	0.435
MOD_CK1_1	460	466	PF00069	0.451
MOD_CK1_1	533	539	PF00069	0.574
MOD_CK1_1	605	611	PF00069	0.671
MOD_CK1_1	76	82	PF00069	0.567
MOD_CK2_1	181	187	PF00069	0.467
MOD_CK2_1	391	397	PF00069	0.537
MOD_CK2_1	605	611	PF00069	0.710
MOD_CK2_1	85	91	PF00069	0.726
MOD_Cter_Amidation	40	43	PF01082	0.575
MOD_GlcNHglycan	339	343	PF01048	0.312
MOD_GlcNHglycan	412	415	PF01048	0.282
MOD_GlcNHglycan	84	90	PF01048	0.670
MOD_GSK3_1	147	154	PF00069	0.626
MOD_GSK3_1	253	260	PF00069	0.537
MOD_GSK3_1	412	419	PF00069	0.453
MOD_GSK3_1	420	427	PF00069	0.448
MOD_GSK3_1	504	511	PF00069	0.496
MOD_GSK3_1	530	537	PF00069	0.510
MOD_GSK3_1	545	552	PF00069	0.614
MOD_GSK3_1	562	569	PF00069	0.573
MOD_GSK3_1	597	604	PF00069	0.686
MOD_GSK3_1	68	75	PF00069	0.542
MOD_N-GLC_1	28	33	PF02516	0.695
MOD_N-GLC_1	545	550	PF02516	0.609
MOD_N-GLC_1	566	571	PF02516	0.484
MOD_N-GLC_1	73	78	PF02516	0.724
MOD_NEK2_1	179	184	PF00069	0.635
MOD_NEK2_1	253	258	PF00069	0.522
MOD_NEK2_1	338	343	PF00069	0.500
MOD_NEK2_1	355	360	PF00069	0.367
MOD_NEK2_1	381	386	PF00069	0.463
MOD_NEK2_1	508	513	PF00069	0.481
MOD_NEK2_1	532	537	PF00069	0.589
MOD_NEK2_2	21	26	PF00069	0.661
MOD_PIKK_1	434	440	PF00454	0.463
MOD_PK_1	420	426	PF00069	0.451
MOD_PKA_1	530	536	PF00069	0.432
MOD_PKA_2	256	262	PF00069	0.451
MOD_PKA_2	434	440	PF00069	0.463
MOD_Plk_1	420	426	PF00069	0.446
MOD_Plk_1	68	74	PF00069	0.700
MOD_Plk_4	319	325	PF00069	0.451
MOD_Plk_4	346	352	PF00069	0.447
MOD_Plk_4	4	10	PF00069	0.425
MOD_Plk_4	460	466	PF00069	0.451
MOD_ProDKin_1	151	157	PF00069	0.623
MOD_ProDKin_1	550	556	PF00069	0.662
MOD_SUMO_for_1	122	125	PF00179	0.488
MOD_SUMO_for_1	202	205	PF00179	0.479
MOD_SUMO_rev_2	116	124	PF00179	0.498
MOD_SUMO_rev_2	605	614	PF00179	0.499
TRG_DiLeu_BaEn_1	214	219	PF01217	0.432
TRG_DiLeu_BaEn_2	227	233	PF01217	0.351
TRG_DiLeu_BaEn_2	244	250	PF01217	0.376
TRG_DiLeu_BaEn_3	467	473	PF01217	0.556
TRG_ENDOCYTIC_2	215	218	PF00928	0.402
TRG_ENDOCYTIC_2	229	232	PF00928	0.359
TRG_ENDOCYTIC_2	396	399	PF00928	0.449
TRG_ENDOCYTIC_2	430	433	PF00928	0.449
TRG_ER_diArg_1	127	130	PF00400	0.502
TRG_ER_diArg_1	477	480	PF00400	0.460
TRG_ER_diArg_1	512	514	PF00400	0.421
TRG_ER_diArg_1	577	580	PF00400	0.710
TRG_NLS_Bipartite_1	559	580	PF00514	0.715
TRG_NLS_MonoExtC_3	575	581	PF00514	0.750
TRG_Pf-PMV_PEXEL_1	130	134	PF00026	0.565
TRG_Pf-PMV_PEXEL_1	135	139	PF00026	0.571
TRG_Pf-PMV_PEXEL_1	271	275	PF00026	0.251
TRG_Pf-PMV_PEXEL_1	405	409	PF00026	0.251

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P967	Leptomonas seymouri	72%	100%
A0A0S4KG56	Bodo saltans	64%	100%
A0A1X0NJV9	Trypanosomatidae	68%	100%
A0A3Q8IJS8	Leishmania donovani	90%	100%
A0A422N5J0	Trypanosoma rangeli	70%	100%
A4HIZ4	Leishmania braziliensis	81%	100%
A4I6B1	Leishmania infantum	90%	100%
C9ZN38	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	100%
Q08J23	Homo sapiens	25%	81%
Q1HFZ0	Mus musculus	25%	83%
Q28E61	Xenopus tropicalis	25%	78%
Q4Q6P5	Leishmania major	90%	100%
Q4V7N2	Xenopus laevis	25%	90%
Q922K7	Mus musculus	48%	79%
V5BIK5	Trypanosoma cruzi	66%	100%