Transmembrane protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B1G5_LEIMU

TriTrypDb:

LmxM.30.0170

Length:

508

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0005789	endoplasmic reticulum membrane	4	1
GO:0031090	organelle membrane	3	1

Expansion

Sequence features

E9B1G5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1G5

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	1
GO:0006996	organelle organization	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0034389	lipid droplet organization	5	1
GO:0044238	primary metabolic process	2	1
GO:0070925	organelle assembly	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0140042	lipid droplet formation	6	1
GO:0140694	non-membrane-bounded organelle assembly	6	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	476	478	PF00675	0.562
CLV_NRD_NRD_1	494	496	PF00675	0.425
CLV_NRD_NRD_1	6	8	PF00675	0.582
CLV_PCSK_FUR_1	4	8	PF00082	0.391
CLV_PCSK_FUR_1	474	478	PF00082	0.456
CLV_PCSK_KEX2_1	3	5	PF00082	0.526
CLV_PCSK_KEX2_1	476	478	PF00082	0.554
CLV_PCSK_KEX2_1	494	496	PF00082	0.425
CLV_PCSK_KEX2_1	6	8	PF00082	0.536
CLV_PCSK_PC1ET2_1	3	5	PF00082	0.397
CLV_PCSK_SKI1_1	250	254	PF00082	0.427
CLV_PCSK_SKI1_1	383	387	PF00082	0.576
CLV_PCSK_SKI1_1	397	401	PF00082	0.653
CLV_PCSK_SKI1_1	71	75	PF00082	0.247
DEG_APCC_DBOX_1	249	257	PF00400	0.227
DEG_APCC_DBOX_1	293	301	PF00400	0.335
DEG_APCC_DBOX_1	66	74	PF00400	0.603
DEG_Nend_UBRbox_3	1	3	PF02207	0.736
DOC_MAPK_gen_1	303	313	PF00069	0.406
DOC_MAPK_gen_1	378	387	PF00069	0.364
DOC_MAPK_MEF2A_6	294	301	PF00069	0.372
DOC_MAPK_MEF2A_6	338	346	PF00069	0.435
DOC_MAPK_MEF2A_6	349	356	PF00069	0.399
DOC_MAPK_NFAT4_5	294	302	PF00069	0.422
DOC_PP1_RVXF_1	301	308	PF00149	0.406
DOC_PP1_RVXF_1	381	388	PF00149	0.433
DOC_PP2B_LxvP_1	9	12	PF13499	0.725
DOC_PP4_FxxP_1	146	149	PF00568	0.508
DOC_PP4_FxxP_1	309	312	PF00568	0.394
DOC_PP4_FxxP_1	350	353	PF00568	0.355
DOC_PP4_FxxP_1	455	458	PF00568	0.730
DOC_USP7_MATH_1	268	272	PF00917	0.484
DOC_USP7_MATH_1	333	337	PF00917	0.465
DOC_USP7_MATH_1	419	423	PF00917	0.491
DOC_USP7_MATH_1	442	446	PF00917	0.708
DOC_USP7_MATH_1	53	57	PF00917	0.708
DOC_WW_Pin1_4	208	213	PF00397	0.490
DOC_WW_Pin1_4	348	353	PF00397	0.420
DOC_WW_Pin1_4	469	474	PF00397	0.635
DOC_WW_Pin1_4	499	504	PF00397	0.790
DOC_WW_Pin1_4	7	12	PF00397	0.758
LIG_14-3-3_CanoR_1	202	212	PF00244	0.469
LIG_14-3-3_CanoR_1	397	404	PF00244	0.461
LIG_14-3-3_CanoR_1	476	484	PF00244	0.800
LIG_14-3-3_CanoR_1	494	500	PF00244	0.636
LIG_14-3-3_CanoR_1	58	63	PF00244	0.639
LIG_Actin_WH2_2	481	496	PF00022	0.756
LIG_Actin_WH2_2	56	73	PF00022	0.689
LIG_BRCT_BRCA1_1	327	331	PF00533	0.513
LIG_BRCT_BRCA1_1	480	484	PF00533	0.704
LIG_BRCT_BRCA1_1	495	499	PF00533	0.778
LIG_Clathr_ClatBox_1	253	257	PF01394	0.224
LIG_DLG_GKlike_1	163	170	PF00625	0.473
LIG_eIF4E_1	69	75	PF01652	0.520
LIG_FHA_1	114	120	PF00498	0.424
LIG_FHA_1	151	157	PF00498	0.501
LIG_FHA_1	159	165	PF00498	0.483
LIG_FHA_1	195	201	PF00498	0.390
LIG_FHA_1	287	293	PF00498	0.401
LIG_FHA_1	349	355	PF00498	0.466
LIG_FHA_1	387	393	PF00498	0.399
LIG_FHA_1	404	410	PF00498	0.196
LIG_FHA_1	43	49	PF00498	0.702
LIG_FHA_1	488	494	PF00498	0.752
LIG_FHA_2	59	65	PF00498	0.662
LIG_GBD_Chelix_1	297	305	PF00786	0.593
LIG_GBD_Chelix_1	87	95	PF00786	0.408
LIG_LIR_Apic_2	145	149	PF02991	0.510
LIG_LIR_Apic_2	366	371	PF02991	0.411
LIG_LIR_Apic_2	452	458	PF02991	0.745
LIG_LIR_Gen_1	179	189	PF02991	0.471
LIG_LIR_Gen_1	295	304	PF02991	0.379
LIG_LIR_Gen_1	315	323	PF02991	0.363
LIG_LIR_Gen_1	345	354	PF02991	0.371
LIG_LIR_Gen_1	405	415	PF02991	0.383
LIG_LIR_Nem_3	179	185	PF02991	0.477
LIG_LIR_Nem_3	295	299	PF02991	0.384
LIG_LIR_Nem_3	315	319	PF02991	0.359
LIG_LIR_Nem_3	328	334	PF02991	0.365
LIG_LIR_Nem_3	345	350	PF02991	0.284
LIG_LIR_Nem_3	405	410	PF02991	0.346
LIG_LIR_Nem_3	66	72	PF02991	0.551
LIG_NRBOX	425	431	PF00104	0.484
LIG_Pex14_1	314	318	PF04695	0.485
LIG_Pex14_1	398	402	PF04695	0.452
LIG_Pex14_2	275	279	PF04695	0.378
LIG_SH2_CRK	77	81	PF00017	0.194
LIG_SH2_PTP2	72	75	PF00017	0.408
LIG_SH2_STAP1	235	239	PF00017	0.355
LIG_SH2_STAP1	316	320	PF00017	0.410
LIG_SH2_STAP1	77	81	PF00017	0.358
LIG_SH2_STAT5	235	238	PF00017	0.411
LIG_SH2_STAT5	318	321	PF00017	0.439
LIG_SH2_STAT5	60	63	PF00017	0.678
LIG_SH2_STAT5	69	72	PF00017	0.620
LIG_SH2_STAT5	77	80	PF00017	0.344
LIG_SH3_3	206	212	PF00018	0.422
LIG_SH3_3	327	333	PF00018	0.453
LIG_SH3_3	8	14	PF00018	0.764
LIG_Sin3_3	82	89	PF02671	0.408
LIG_SUMO_SIM_anti_2	165	171	PF11976	0.470
LIG_SUMO_SIM_anti_2	251	258	PF11976	0.273
LIG_SUMO_SIM_anti_2	295	302	PF11976	0.327
LIG_SUMO_SIM_anti_2	339	345	PF11976	0.346
LIG_SUMO_SIM_anti_2	405	412	PF11976	0.370
LIG_SUMO_SIM_par_1	251	258	PF11976	0.389
LIG_SUMO_SIM_par_1	295	302	PF11976	0.402
LIG_SUMO_SIM_par_1	84	90	PF11976	0.431
LIG_TRAF2_1	244	247	PF00917	0.463
LIG_TRAF2_1	451	454	PF00917	0.581
LIG_TRFH_1	222	226	PF08558	0.482
LIG_TYR_ITIM	70	75	PF00017	0.536
LIG_WRC_WIRS_1	404	409	PF05994	0.380
LIG_WRC_WIRS_1	443	448	PF05994	0.650
LIG_WRC_WIRS_1	59	64	PF05994	0.694
LIG_WW_2	11	14	PF00397	0.716
LIG_WW_3	457	461	PF00397	0.642
MOD_CDC14_SPxK_1	502	505	PF00782	0.733
MOD_CDK_SPK_2	208	213	PF00069	0.495
MOD_CDK_SPK_2	469	474	PF00069	0.580
MOD_CDK_SPxK_1	499	505	PF00069	0.791
MOD_CDK_SPxxK_3	469	476	PF00069	0.637
MOD_CK1_1	469	475	PF00069	0.618
MOD_CK1_1	98	104	PF00069	0.420
MOD_CK2_1	2	8	PF00069	0.762
MOD_CK2_1	333	339	PF00069	0.445
MOD_CK2_1	442	448	PF00069	0.714
MOD_CK2_1	58	64	PF00069	0.642
MOD_GlcNHglycan	205	208	PF01048	0.708
MOD_GlcNHglycan	257	260	PF01048	0.583
MOD_GlcNHglycan	327	330	PF01048	0.707
MOD_GlcNHglycan	417	420	PF01048	0.382
MOD_GlcNHglycan	90	94	PF01048	0.487
MOD_GSK3_1	188	195	PF00069	0.370
MOD_GSK3_1	277	284	PF00069	0.366
MOD_GSK3_1	386	393	PF00069	0.348
MOD_GSK3_1	415	422	PF00069	0.342
MOD_GSK3_1	462	469	PF00069	0.603
MOD_GSK3_1	484	491	PF00069	0.755
MOD_GSK3_1	495	502	PF00069	0.738
MOD_GSK3_1	58	65	PF00069	0.636
MOD_GSK3_1	94	101	PF00069	0.481
MOD_N-GLC_1	363	368	PF02516	0.533
MOD_N-GLC_1	499	504	PF02516	0.590
MOD_NEK2_1	156	161	PF00069	0.480
MOD_NEK2_1	188	193	PF00069	0.413
MOD_NEK2_1	279	284	PF00069	0.362
MOD_NEK2_1	292	297	PF00069	0.365
MOD_NEK2_1	363	368	PF00069	0.404
MOD_NEK2_1	386	391	PF00069	0.361
MOD_NEK2_1	415	420	PF00069	0.371
MOD_NEK2_1	488	493	PF00069	0.751
MOD_NEK2_1	62	67	PF00069	0.612
MOD_NEK2_1	95	100	PF00069	0.439
MOD_NEK2_2	194	199	PF00069	0.439
MOD_NEK2_2	42	47	PF00069	0.672
MOD_NEK2_2	53	58	PF00069	0.495
MOD_PIKK_1	158	164	PF00454	0.489
MOD_PIKK_1	488	494	PF00454	0.752
MOD_PK_1	281	287	PF00069	0.416
MOD_PKA_2	150	156	PF00069	0.516
MOD_PKA_2	478	484	PF00069	0.719
MOD_PKA_2	493	499	PF00069	0.766
MOD_Plk_1	138	144	PF00069	0.505
MOD_Plk_1	363	369	PF00069	0.332
MOD_Plk_1	488	494	PF00069	0.737
MOD_Plk_1	63	69	PF00069	0.570
MOD_Plk_2-3	448	454	PF00069	0.740
MOD_Plk_4	165	171	PF00069	0.470
MOD_Plk_4	403	409	PF00069	0.373
MOD_Plk_4	462	468	PF00069	0.725
MOD_Plk_4	58	64	PF00069	0.675
MOD_Plk_4	75	81	PF00069	0.267
MOD_ProDKin_1	208	214	PF00069	0.490
MOD_ProDKin_1	348	354	PF00069	0.421
MOD_ProDKin_1	469	475	PF00069	0.636
MOD_ProDKin_1	499	505	PF00069	0.791
MOD_ProDKin_1	7	13	PF00069	0.756
MOD_SUMO_for_1	231	234	PF00179	0.472
MOD_SUMO_for_1	244	247	PF00179	0.298
TRG_DiLeu_BaEn_1	152	157	PF01217	0.477
TRG_DiLeu_BaLyEn_6	380	385	PF01217	0.391
TRG_ENDOCYTIC_2	316	319	PF00928	0.388
TRG_ENDOCYTIC_2	347	350	PF00928	0.346
TRG_ENDOCYTIC_2	60	63	PF00928	0.672
TRG_ENDOCYTIC_2	72	75	PF00928	0.410
TRG_ENDOCYTIC_2	77	80	PF00928	0.369
TRG_ER_diArg_1	358	361	PF00400	0.367
TRG_ER_diArg_1	4	7	PF00400	0.727
TRG_ER_diArg_1	473	476	PF00400	0.778
TRG_ER_diArg_1	493	495	PF00400	0.603
TRG_NES_CRM1_1	24	39	PF08389	0.700
TRG_NLS_MonoExtC_3	2	7	PF00514	0.595
TRG_Pf-PMV_PEXEL_1	135	139	PF00026	0.741
TRG_Pf-PMV_PEXEL_1	154	158	PF00026	0.667

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8U6	Leptomonas seymouri	57%	100%
A0A1X0NJH4	Trypanosomatidae	36%	100%
A0A3Q8IEM5	Leishmania donovani	90%	100%
A4HIZ2	Leishmania braziliensis	74%	100%
A4I6A9	Leishmania infantum	90%	100%
C9ZN36	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
Q4Q6P7	Leishmania major	90%	100%
V5BN41	Trypanosoma cruzi	40%	100%