Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B1G3_LEIMU

TriTrypDb:

LmxM.30.0150

Length:

321

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B1G3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1G3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	18	20	PF00675	0.466
CLV_NRD_NRD_1	185	187	PF00675	0.547
CLV_NRD_NRD_1	258	260	PF00675	0.531
CLV_NRD_NRD_1	282	284	PF00675	0.379
CLV_NRD_NRD_1	292	294	PF00675	0.387
CLV_NRD_NRD_1	61	63	PF00675	0.453
CLV_PCSK_KEX2_1	18	20	PF00082	0.474
CLV_PCSK_KEX2_1	185	187	PF00082	0.517
CLV_PCSK_KEX2_1	257	259	PF00082	0.536
CLV_PCSK_KEX2_1	292	294	PF00082	0.439
CLV_PCSK_KEX2_1	61	63	PF00082	0.529
CLV_PCSK_PC7_1	14	20	PF00082	0.554
CLV_PCSK_PC7_1	57	63	PF00082	0.560
CLV_PCSK_SKI1_1	172	176	PF00082	0.504
CLV_PCSK_SKI1_1	18	22	PF00082	0.456
CLV_PCSK_SKI1_1	186	190	PF00082	0.423
CLV_PCSK_SKI1_1	314	318	PF00082	0.500
CLV_Separin_Fungi	161	167	PF03568	0.344
DEG_APCC_DBOX_1	17	25	PF00400	0.469
DEG_APCC_DBOX_1	291	299	PF00400	0.516
DEG_Nend_UBRbox_1	1	4	PF02207	0.717
DOC_AGCK_PIF_1	248	253	PF00069	0.493
DOC_CKS1_1	67	72	PF01111	0.570
DOC_CYCLIN_RxL_1	14	25	PF00134	0.588
DOC_MAPK_gen_1	18	26	PF00069	0.487
DOC_MAPK_gen_1	313	319	PF00069	0.468
DOC_PP1_RVXF_1	170	177	PF00149	0.232
DOC_PP1_RVXF_1	312	319	PF00149	0.525
DOC_PP4_FxxP_1	64	67	PF00568	0.585
DOC_USP7_MATH_1	112	116	PF00917	0.391
DOC_USP7_MATH_1	83	87	PF00917	0.454
DOC_WW_Pin1_4	242	247	PF00397	0.538
DOC_WW_Pin1_4	66	71	PF00397	0.541
LIG_14-3-3_CanoR_1	202	211	PF00244	0.299
LIG_14-3-3_CanoR_1	263	273	PF00244	0.511
LIG_14-3-3_CanoR_1	283	287	PF00244	0.457
LIG_14-3-3_CanoR_1	34	44	PF00244	0.592
LIG_14-3-3_CanoR_1	61	65	PF00244	0.565
LIG_Actin_WH2_2	41	59	PF00022	0.597
LIG_Actin_WH2_2	9	24	PF00022	0.523
LIG_BRCT_BRCA1_1	244	248	PF00533	0.495
LIG_deltaCOP1_diTrp_1	269	278	PF00928	0.572
LIG_eIF4E_1	108	114	PF01652	0.509
LIG_FHA_1	212	218	PF00498	0.449
LIG_FHA_1	30	36	PF00498	0.597
LIG_LIR_Apic_2	46	52	PF02991	0.541
LIG_LIR_Apic_2	63	67	PF02991	0.453
LIG_LIR_Gen_1	171	180	PF02991	0.442
LIG_LIR_Gen_1	191	199	PF02991	0.383
LIG_LIR_Gen_1	232	240	PF02991	0.493
LIG_LIR_Gen_1	38	48	PF02991	0.501
LIG_LIR_Gen_1	74	83	PF02991	0.410
LIG_LIR_Gen_1	95	103	PF02991	0.538
LIG_LIR_Nem_3	103	108	PF02991	0.454
LIG_LIR_Nem_3	15	20	PF02991	0.455
LIG_LIR_Nem_3	171	176	PF02991	0.438
LIG_LIR_Nem_3	191	196	PF02991	0.386
LIG_LIR_Nem_3	230	236	PF02991	0.467
LIG_LIR_Nem_3	270	276	PF02991	0.547
LIG_LIR_Nem_3	38	43	PF02991	0.446
LIG_LIR_Nem_3	74	80	PF02991	0.415
LIG_LIR_Nem_3	95	99	PF02991	0.508
LIG_NRBOX	194	200	PF00104	0.436
LIG_PCNA_yPIPBox_3	136	146	PF02747	0.489
LIG_SH2_CRK	17	21	PF00017	0.514
LIG_SH2_CRK	273	277	PF00017	0.588
LIG_SH2_NCK_1	68	72	PF00017	0.567
LIG_SH2_STAT5	145	148	PF00017	0.490
LIG_SH2_STAT5	207	210	PF00017	0.453
LIG_SH2_STAT5	68	71	PF00017	0.572
LIG_SH3_3	64	70	PF00018	0.581
LIG_SUMO_SIM_anti_2	194	200	PF11976	0.411
LIG_TRAF2_1	152	155	PF00917	0.558
LIG_TYR_ITSM	13	20	PF00017	0.403
LIG_WRC_WIRS_1	212	217	PF05994	0.405
MOD_CK1_1	127	133	PF00069	0.528
MOD_CK1_1	301	307	PF00069	0.493
MOD_CK1_1	86	92	PF00069	0.494
MOD_CK2_1	149	155	PF00069	0.559
MOD_CK2_1	178	184	PF00069	0.477
MOD_GlcNHglycan	114	117	PF01048	0.334
MOD_GlcNHglycan	179	183	PF01048	0.467
MOD_GlcNHglycan	303	307	PF01048	0.516
MOD_GSK3_1	278	285	PF00069	0.381
MOD_GSK3_1	298	305	PF00069	0.488
MOD_N-GLC_1	242	247	PF02516	0.532
MOD_N-GLC_2	201	203	PF02516	0.453
MOD_NEK2_1	12	17	PF00069	0.498
MOD_NEK2_1	302	307	PF00069	0.346
MOD_NEK2_2	229	234	PF00069	0.519
MOD_NEK2_2	83	88	PF00069	0.485
MOD_PIKK_1	124	130	PF00454	0.437
MOD_PIKK_1	278	284	PF00454	0.377
MOD_PIKK_1	29	35	PF00454	0.618
MOD_PK_1	22	28	PF00069	0.492
MOD_PKA_2	282	288	PF00069	0.479
MOD_PKA_2	60	66	PF00069	0.566
MOD_Plk_1	178	184	PF00069	0.484
MOD_Plk_1	191	197	PF00069	0.410
MOD_Plk_1	229	235	PF00069	0.542
MOD_Plk_1	83	89	PF00069	0.263
MOD_Plk_2-3	158	164	PF00069	0.553
MOD_Plk_4	141	147	PF00069	0.333
MOD_Plk_4	211	217	PF00069	0.361
MOD_Plk_4	222	228	PF00069	0.373
MOD_Plk_4	282	288	PF00069	0.479
MOD_Plk_4	83	89	PF00069	0.461
MOD_ProDKin_1	242	248	PF00069	0.529
MOD_ProDKin_1	66	72	PF00069	0.538
MOD_SUMO_for_1	188	191	PF00179	0.475
MOD_SUMO_rev_2	181	190	PF00179	0.560
TRG_DiLeu_BaEn_1	191	196	PF01217	0.465
TRG_DiLeu_BaEn_1	260	265	PF01217	0.543
TRG_DiLeu_LyEn_5	260	265	PF01217	0.476
TRG_ENDOCYTIC_2	108	111	PF00928	0.519
TRG_ENDOCYTIC_2	17	20	PF00928	0.462
TRG_ENDOCYTIC_2	253	256	PF00928	0.479
TRG_ENDOCYTIC_2	273	276	PF00928	0.584
TRG_ER_diArg_1	17	19	PF00400	0.494
TRG_ER_diArg_1	256	259	PF00400	0.525
TRG_ER_diArg_1	291	293	PF00400	0.507
TRG_ER_diArg_1	60	62	PF00400	0.521
TRG_Pf-PMV_PEXEL_1	91	95	PF00026	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1X3	Leptomonas seymouri	56%	100%
A0A1X0NJP2	Trypanosomatidae	28%	100%
A0A3S5H7P2	Leishmania donovani	88%	100%
A0A422N5I6	Trypanosoma rangeli	29%	98%
A4HIX9	Leishmania braziliensis	77%	100%
A4I6A7	Leishmania infantum	88%	100%
C9ZN34	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
Q4Q6P9	Leishmania major	89%	100%
V5DEV4	Trypanosoma cruzi	29%	99%