Microtubule-associated tumor suppressor candidate 2

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B1G1_LEIMU

TriTrypDb:

LmxM.30.0130

Length:

823

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B1G1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1G1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	12	16	PF00656	0.640
CLV_NRD_NRD_1	281	283	PF00675	0.626
CLV_NRD_NRD_1	332	334	PF00675	0.472
CLV_NRD_NRD_1	377	379	PF00675	0.464
CLV_NRD_NRD_1	523	525	PF00675	0.574
CLV_NRD_NRD_1	543	545	PF00675	0.350
CLV_NRD_NRD_1	587	589	PF00675	0.450
CLV_NRD_NRD_1	607	609	PF00675	0.383
CLV_NRD_NRD_1	616	618	PF00675	0.524
CLV_NRD_NRD_1	641	643	PF00675	0.483
CLV_PCSK_FUR_1	330	334	PF00082	0.555
CLV_PCSK_FUR_1	585	589	PF00082	0.451
CLV_PCSK_FUR_1	605	609	PF00082	0.386
CLV_PCSK_FUR_1	614	618	PF00082	0.443
CLV_PCSK_FUR_1	7	11	PF00082	0.633
CLV_PCSK_KEX2_1	100	102	PF00082	0.636
CLV_PCSK_KEX2_1	140	142	PF00082	0.634
CLV_PCSK_KEX2_1	280	282	PF00082	0.609
CLV_PCSK_KEX2_1	332	334	PF00082	0.472
CLV_PCSK_KEX2_1	484	486	PF00082	0.499
CLV_PCSK_KEX2_1	508	510	PF00082	0.523
CLV_PCSK_KEX2_1	523	525	PF00082	0.551
CLV_PCSK_KEX2_1	587	589	PF00082	0.462
CLV_PCSK_KEX2_1	598	600	PF00082	0.487
CLV_PCSK_KEX2_1	607	609	PF00082	0.355
CLV_PCSK_KEX2_1	616	618	PF00082	0.388
CLV_PCSK_KEX2_1	9	11	PF00082	0.611
CLV_PCSK_PC1ET2_1	100	102	PF00082	0.636
CLV_PCSK_PC1ET2_1	140	142	PF00082	0.634
CLV_PCSK_PC1ET2_1	484	486	PF00082	0.499
CLV_PCSK_PC1ET2_1	508	510	PF00082	0.559
CLV_PCSK_PC1ET2_1	598	600	PF00082	0.483
CLV_PCSK_PC1ET2_1	9	11	PF00082	0.630
CLV_PCSK_PC7_1	276	282	PF00082	0.585
CLV_PCSK_SKI1_1	38	42	PF00082	0.717
CLV_PCSK_SKI1_1	544	548	PF00082	0.514
CLV_PCSK_SKI1_1	598	602	PF00082	0.607
CLV_PCSK_SKI1_1	664	668	PF00082	0.454
DEG_APCC_DBOX_1	486	494	PF00400	0.445
DEG_APCC_DBOX_1	813	821	PF00400	0.605
DEG_COP1_1	178	185	PF00400	0.493
DEG_SPOP_SBC_1	235	239	PF00917	0.631
DOC_CKS1_1	170	175	PF01111	0.643
DOC_MAPK_gen_1	470	479	PF00069	0.496
DOC_MAPK_gen_1	484	492	PF00069	0.388
DOC_MAPK_gen_1	550	558	PF00069	0.493
DOC_MAPK_MEF2A_6	30	37	PF00069	0.621
DOC_MAPK_MEF2A_6	369	376	PF00069	0.478
DOC_PIKK_1	784	792	PF02985	0.509
DOC_PP1_RVXF_1	382	389	PF00149	0.475
DOC_PP2B_LxvP_1	150	153	PF13499	0.628
DOC_PP2B_LxvP_1	222	225	PF13499	0.645
DOC_PP2B_LxvP_1	75	78	PF13499	0.481
DOC_USP7_MATH_1	153	157	PF00917	0.620
DOC_USP7_MATH_1	183	187	PF00917	0.603
DOC_USP7_MATH_1	201	205	PF00917	0.619
DOC_USP7_MATH_1	236	240	PF00917	0.626
DOC_USP7_MATH_1	252	256	PF00917	0.690
DOC_USP7_MATH_1	296	300	PF00917	0.599
DOC_USP7_MATH_1	314	318	PF00917	0.612
DOC_USP7_MATH_1	323	327	PF00917	0.489
DOC_USP7_MATH_1	33	37	PF00917	0.612
DOC_USP7_MATH_1	362	366	PF00917	0.503
DOC_USP7_MATH_1	816	820	PF00917	0.670
DOC_USP7_MATH_1	82	86	PF00917	0.671
DOC_USP7_MATH_2	158	164	PF00917	0.628
DOC_USP7_UBL2_3	432	436	PF12436	0.463
DOC_USP7_UBL2_3	594	598	PF12436	0.530
DOC_WW_Pin1_4	105	110	PF00397	0.661
DOC_WW_Pin1_4	154	159	PF00397	0.666
DOC_WW_Pin1_4	169	174	PF00397	0.568
DOC_WW_Pin1_4	181	186	PF00397	0.661
DOC_WW_Pin1_4	194	199	PF00397	0.595
DOC_WW_Pin1_4	292	297	PF00397	0.548
DOC_WW_Pin1_4	319	324	PF00397	0.739
DOC_WW_Pin1_4	99	104	PF00397	0.773
LIG_14-3-3_CanoR_1	369	375	PF00244	0.478
LIG_14-3-3_CanoR_1	585	591	PF00244	0.488
LIG_14-3-3_CanoR_1	623	629	PF00244	0.544
LIG_14-3-3_CanoR_1	664	672	PF00244	0.488
LIG_14-3-3_CanoR_1	778	782	PF00244	0.553
LIG_14-3-3_CanoR_1	808	817	PF00244	0.661
LIG_Actin_WH2_2	341	358	PF00022	0.467
LIG_Actin_WH2_2	385	402	PF00022	0.444
LIG_Actin_WH2_2	529	546	PF00022	0.520
LIG_BIR_II_1	1	5	PF00653	0.590
LIG_BRCT_BRCA1_1	213	217	PF00533	0.670
LIG_BRCT_BRCA1_1	47	51	PF00533	0.606
LIG_EVH1_1	222	226	PF00568	0.665
LIG_FHA_1	238	244	PF00498	0.675
LIG_FHA_1	246	252	PF00498	0.584
LIG_FHA_1	264	270	PF00498	0.571
LIG_FHA_1	322	328	PF00498	0.611
LIG_FHA_1	628	634	PF00498	0.525
LIG_FHA_1	706	712	PF00498	0.541
LIG_FHA_1	748	754	PF00498	0.439
LIG_FHA_1	81	87	PF00498	0.638
LIG_FHA_2	155	161	PF00498	0.624
LIG_FHA_2	591	597	PF00498	0.509
LIG_FHA_2	665	671	PF00498	0.491
LIG_FHA_2	708	714	PF00498	0.489
LIG_FHA_2	778	784	PF00498	0.512
LIG_Integrin_isoDGR_2	785	787	PF01839	0.506
LIG_LIR_Gen_1	163	171	PF02991	0.569
LIG_LIR_Gen_1	393	402	PF02991	0.557
LIG_LIR_Nem_3	163	167	PF02991	0.576
LIG_LIR_Nem_3	393	399	PF02991	0.564
LIG_LIR_Nem_3	421	426	PF02991	0.440
LIG_NRBOX	440	446	PF00104	0.499
LIG_PTB_Apo_2	303	310	PF02174	0.472
LIG_SH2_CRK	164	168	PF00017	0.570
LIG_SH2_CRK	423	427	PF00017	0.505
LIG_SH2_STAP1	446	450	PF00017	0.508
LIG_SH2_STAP1	629	633	PF00017	0.516
LIG_SH2_STAT3	678	681	PF00017	0.532
LIG_SH2_STAT5	629	632	PF00017	0.528
LIG_SH2_STAT5	802	805	PF00017	0.494
LIG_SH3_1	101	107	PF00018	0.614
LIG_SH3_2	198	203	PF14604	0.511
LIG_SH3_3	101	107	PF00018	0.695
LIG_SH3_3	165	171	PF00018	0.671
LIG_SH3_3	179	185	PF00018	0.610
LIG_SH3_3	195	201	PF00018	0.503
LIG_SH3_3	220	226	PF00018	0.677
LIG_SH3_3	61	67	PF00018	0.648
LIG_SUMO_SIM_anti_2	108	114	PF11976	0.518
LIG_TRAF2_1	265	268	PF00917	0.544
LIG_TRAF2_1	716	719	PF00917	0.540
LIG_WW_3	224	228	PF00397	0.682
MOD_CDC14_SPxK_1	295	298	PF00782	0.615
MOD_CDC14_SPxK_1	322	325	PF00782	0.583
MOD_CDK_SPxK_1	292	298	PF00069	0.580
MOD_CDK_SPxK_1	319	325	PF00069	0.724
MOD_CDK_SPxxK_3	154	161	PF00069	0.624
MOD_CDK_SPxxK_3	169	176	PF00069	0.529
MOD_CK1_1	163	169	PF00069	0.688
MOD_CK1_1	181	187	PF00069	0.623
MOD_CK1_1	238	244	PF00069	0.616
MOD_CK1_1	36	42	PF00069	0.587
MOD_CK1_1	457	463	PF00069	0.478
MOD_CK1_1	50	56	PF00069	0.675
MOD_CK1_1	624	630	PF00069	0.544
MOD_CK1_1	85	91	PF00069	0.592
MOD_CK2_1	132	138	PF00069	0.614
MOD_CK2_1	15	21	PF00069	0.640
MOD_CK2_1	154	160	PF00069	0.621
MOD_CK2_1	465	471	PF00069	0.497
MOD_CK2_1	664	670	PF00069	0.490
MOD_GlcNHglycan	129	132	PF01048	0.651
MOD_GlcNHglycan	141	144	PF01048	0.595
MOD_GlcNHglycan	298	301	PF01048	0.721
MOD_GlcNHglycan	360	363	PF01048	0.468
MOD_GlcNHglycan	417	420	PF01048	0.461
MOD_GlcNHglycan	500	504	PF01048	0.498
MOD_GlcNHglycan	633	636	PF01048	0.519
MOD_GlcNHglycan	739	742	PF01048	0.660
MOD_GlcNHglycan	87	90	PF01048	0.592
MOD_GSK3_1	190	197	PF00069	0.697
MOD_GSK3_1	234	241	PF00069	0.693
MOD_GSK3_1	284	291	PF00069	0.565
MOD_GSK3_1	292	299	PF00069	0.557
MOD_GSK3_1	300	307	PF00069	0.609
MOD_GSK3_1	319	326	PF00069	0.689
MOD_GSK3_1	358	365	PF00069	0.510
MOD_GSK3_1	36	43	PF00069	0.686
MOD_GSK3_1	436	443	PF00069	0.513
MOD_GSK3_1	586	593	PF00069	0.454
MOD_GSK3_1	627	634	PF00069	0.526
MOD_GSK3_1	680	687	PF00069	0.481
MOD_GSK3_1	703	710	PF00069	0.486
MOD_GSK3_1	76	83	PF00069	0.610
MOD_GSK3_1	765	772	PF00069	0.515
MOD_GSK3_1	802	809	PF00069	0.516
MOD_GSK3_1	816	823	PF00069	0.532
MOD_GSK3_1	99	106	PF00069	0.713
MOD_LATS_1	806	812	PF00433	0.608
MOD_N-GLC_1	245	250	PF02516	0.669
MOD_N-GLC_1	263	268	PF02516	0.602
MOD_N-GLC_1	43	48	PF02516	0.581
MOD_NEK2_1	190	195	PF00069	0.620
MOD_NEK2_1	304	309	PF00069	0.613
MOD_NEK2_1	492	497	PF00069	0.582
MOD_NEK2_1	672	677	PF00069	0.529
MOD_NEK2_1	807	812	PF00069	0.459
MOD_NEK2_2	33	38	PF00069	0.621
MOD_PIKK_1	166	172	PF00454	0.650
MOD_PIKK_1	238	244	PF00454	0.658
MOD_PIKK_1	284	290	PF00454	0.631
MOD_PIKK_1	436	442	PF00454	0.490
MOD_PIKK_1	492	498	PF00454	0.548
MOD_PIKK_1	55	61	PF00454	0.660
MOD_PIKK_1	622	628	PF00454	0.467
MOD_PIKK_1	680	686	PF00454	0.480
MOD_PIKK_1	809	815	PF00454	0.568
MOD_PKA_2	160	166	PF00069	0.674
MOD_PKA_2	288	294	PF00069	0.534
MOD_PKA_2	586	592	PF00069	0.451
MOD_PKA_2	622	628	PF00069	0.512
MOD_PKA_2	672	678	PF00069	0.567
MOD_PKA_2	684	690	PF00069	0.419
MOD_PKA_2	765	771	PF00069	0.458
MOD_PKA_2	777	783	PF00069	0.436
MOD_PKA_2	807	813	PF00069	0.510
MOD_Plk_1	178	184	PF00069	0.498
MOD_Plk_1	23	29	PF00069	0.595
MOD_Plk_1	252	258	PF00069	0.489
MOD_Plk_1	769	775	PF00069	0.507
MOD_Plk_2-3	13	19	PF00069	0.628
MOD_Plk_2-3	211	217	PF00069	0.612
MOD_Plk_2-3	263	269	PF00069	0.581
MOD_Plk_2-3	777	783	PF00069	0.568
MOD_Plk_4	108	114	PF00069	0.529
MOD_Plk_4	183	189	PF00069	0.605
MOD_Plk_4	300	306	PF00069	0.478
MOD_Plk_4	440	446	PF00069	0.515
MOD_Plk_4	674	680	PF00069	0.472
MOD_Plk_4	777	783	PF00069	0.512
MOD_ProDKin_1	154	160	PF00069	0.670
MOD_ProDKin_1	169	175	PF00069	0.570
MOD_ProDKin_1	181	187	PF00069	0.662
MOD_ProDKin_1	194	200	PF00069	0.599
MOD_ProDKin_1	292	298	PF00069	0.551
MOD_ProDKin_1	319	325	PF00069	0.738
MOD_ProDKin_1	99	105	PF00069	0.775
MOD_SUMO_rev_2	135	142	PF00179	0.516
MOD_SUMO_rev_2	380	386	PF00179	0.475
MOD_SUMO_rev_2	393	402	PF00179	0.480
MOD_SUMO_rev_2	591	600	PF00179	0.525
TRG_DiLeu_BaEn_1	777	782	PF01217	0.435
TRG_ENDOCYTIC_2	164	167	PF00928	0.579
TRG_ENDOCYTIC_2	423	426	PF00928	0.444
TRG_ER_diArg_1	256	259	PF00400	0.493
TRG_ER_diArg_1	280	282	PF00400	0.601
TRG_ER_diArg_1	329	332	PF00400	0.496
TRG_ER_diArg_1	585	588	PF00400	0.453
TRG_ER_diArg_1	605	608	PF00400	0.391
TRG_ER_diArg_1	614	617	PF00400	0.524
TRG_Pf-PMV_PEXEL_1	332	336	PF00026	0.467
TRG_Pf-PMV_PEXEL_1	404	408	PF00026	0.489
TRG_Pf-PMV_PEXEL_1	599	603	PF00026	0.534
TRG_Pf-PMV_PEXEL_1	642	646	PF00026	0.481
TRG_Pf-PMV_PEXEL_1	723	727	PF00026	0.539

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE76	Leptomonas seymouri	55%	100%
A0A1X0NJ20	Trypanosomatidae	32%	92%
A0A3Q8IFY0	Leishmania donovani	87%	100%
A4HIX7	Leishmania braziliensis	72%	99%
A4I6A6	Leishmania infantum	87%	100%
Q4Q6Q1	Leishmania major	87%	99%