Putative FG-GAP repeat protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

intergrin alpha chain protein, putative

Species:

Leishmania mexicana

UniProt:

E9B1F9_LEIMU

TriTrypDb:

LmxM.30.0110

Length:

793

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 9, no: 1
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9B1F9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1F9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	742	746	PF00656	0.414
CLV_C14_Caspase3-7	77	81	PF00656	0.320
CLV_NRD_NRD_1	181	183	PF00675	0.665
CLV_NRD_NRD_1	197	199	PF00675	0.708
CLV_PCSK_KEX2_1	146	148	PF00082	0.615
CLV_PCSK_KEX2_1	181	183	PF00082	0.642
CLV_PCSK_KEX2_1	197	199	PF00082	0.684
CLV_PCSK_KEX2_1	297	299	PF00082	0.714
CLV_PCSK_KEX2_1	779	781	PF00082	0.475
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.615
CLV_PCSK_PC1ET2_1	297	299	PF00082	0.703
CLV_PCSK_PC1ET2_1	779	781	PF00082	0.476
CLV_PCSK_SKI1_1	65	69	PF00082	0.508
DEG_APCC_DBOX_1	280	288	PF00400	0.521
DEG_APCC_DBOX_1	720	728	PF00400	0.387
DEG_Nend_Nbox_1	1	3	PF02207	0.679
DEG_ODPH_VHL_1	2	15	PF01847	0.566
DEG_SCF_FBW7_1	164	170	PF00400	0.486
DEG_SCF_FBW7_1	331	338	PF00400	0.413
DEG_SPOP_SBC_1	209	213	PF00917	0.410
DEG_SPOP_SBC_1	28	32	PF00917	0.550
DOC_CDC14_PxL_1	137	145	PF14671	0.415
DOC_CKS1_1	164	169	PF01111	0.515
DOC_CKS1_1	332	337	PF01111	0.322
DOC_CKS1_1	412	417	PF01111	0.406
DOC_CKS1_1	51	56	PF01111	0.319
DOC_CYCLIN_yCln2_LP_2	412	418	PF00134	0.355
DOC_CYCLIN_yCln2_LP_2	453	459	PF00134	0.444
DOC_CYCLIN_yCln2_LP_2	763	769	PF00134	0.408
DOC_MAPK_DCC_7	760	770	PF00069	0.408
DOC_MAPK_DCC_7	98	108	PF00069	0.356
DOC_MAPK_gen_1	179	188	PF00069	0.463
DOC_MAPK_gen_1	310	320	PF00069	0.455
DOC_MAPK_MEF2A_6	281	288	PF00069	0.471
DOC_MAPK_MEF2A_6	691	699	PF00069	0.385
DOC_MAPK_MEF2A_6	726	735	PF00069	0.326
DOC_MAPK_MEF2A_6	760	767	PF00069	0.438
DOC_MAPK_NFAT4_5	281	289	PF00069	0.473
DOC_MAPK_RevD_3	766	780	PF00069	0.447
DOC_PP1_RVXF_1	503	509	PF00149	0.395
DOC_PP2B_LxvP_1	138	141	PF13499	0.418
DOC_PP2B_LxvP_1	735	738	PF13499	0.375
DOC_PP2B_LxvP_1	763	766	PF13499	0.447
DOC_PP4_FxxP_1	710	713	PF00568	0.406
DOC_PP4_FxxP_1	92	95	PF00568	0.381
DOC_USP7_MATH_1	280	284	PF00917	0.408
DOC_USP7_MATH_1	488	492	PF00917	0.399
DOC_USP7_MATH_1	638	642	PF00917	0.364
DOC_USP7_MATH_1	689	693	PF00917	0.475
DOC_WW_Pin1_4	163	168	PF00397	0.454
DOC_WW_Pin1_4	205	210	PF00397	0.545
DOC_WW_Pin1_4	274	279	PF00397	0.461
DOC_WW_Pin1_4	331	336	PF00397	0.319
DOC_WW_Pin1_4	411	416	PF00397	0.337
DOC_WW_Pin1_4	457	462	PF00397	0.364
DOC_WW_Pin1_4	50	55	PF00397	0.311
DOC_WW_Pin1_4	628	633	PF00397	0.379
DOC_WW_Pin1_4	658	663	PF00397	0.434
DOC_WW_Pin1_4	685	690	PF00397	0.444
DOC_WW_Pin1_4	99	104	PF00397	0.336
LIG_14-3-3_CanoR_1	281	285	PF00244	0.516
LIG_14-3-3_CanoR_1	313	320	PF00244	0.411
LIG_14-3-3_CanoR_1	403	410	PF00244	0.431
LIG_14-3-3_CanoR_1	505	509	PF00244	0.389
LIG_14-3-3_CanoR_1	691	696	PF00244	0.427
LIG_14-3-3_CanoR_1	726	732	PF00244	0.350
LIG_14-3-3_CanoR_1	96	101	PF00244	0.455
LIG_APCC_ABBA_1	703	708	PF00400	0.323
LIG_APCC_ABBAyCdc20_2	702	708	PF00400	0.325
LIG_BRCT_BRCA1_1	352	356	PF00533	0.301
LIG_BRCT_BRCA1_1	432	436	PF00533	0.416
LIG_BRCT_BRCA1_1	747	751	PF00533	0.413
LIG_FHA_1	120	126	PF00498	0.316
LIG_FHA_1	168	174	PF00498	0.508
LIG_FHA_1	189	195	PF00498	0.508
LIG_FHA_1	237	243	PF00498	0.403
LIG_FHA_1	313	319	PF00498	0.350
LIG_FHA_1	332	338	PF00498	0.337
LIG_FHA_1	378	384	PF00498	0.346
LIG_FHA_1	412	418	PF00498	0.392
LIG_FHA_1	469	475	PF00498	0.440
LIG_FHA_1	51	57	PF00498	0.343
LIG_FHA_1	522	528	PF00498	0.324
LIG_FHA_1	589	595	PF00498	0.373
LIG_FHA_1	641	647	PF00498	0.399
LIG_FHA_1	672	678	PF00498	0.398
LIG_FHA_1	692	698	PF00498	0.350
LIG_FHA_1	713	719	PF00498	0.402
LIG_FHA_1	742	748	PF00498	0.393
LIG_FHA_1	760	766	PF00498	0.378
LIG_FHA_2	170	176	PF00498	0.525
LIG_FHA_2	187	193	PF00498	0.341
LIG_FHA_2	211	217	PF00498	0.407
LIG_FHA_2	236	242	PF00498	0.468
LIG_FHA_2	264	270	PF00498	0.381
LIG_FHA_2	317	323	PF00498	0.333
LIG_FHA_2	336	342	PF00498	0.404
LIG_FHA_2	460	466	PF00498	0.402
LIG_FHA_2	505	511	PF00498	0.323
LIG_FHA_2	664	670	PF00498	0.426
LIG_FHA_2	678	684	PF00498	0.266
LIG_FHA_2	81	87	PF00498	0.396
LIG_Integrin_isoDGR_2	576	578	PF01839	0.564
LIG_LIR_Apic_2	48	54	PF02991	0.347
LIG_LIR_Apic_2	708	713	PF02991	0.336
LIG_LIR_Apic_2	99	103	PF02991	0.348
LIG_LIR_Gen_1	225	234	PF02991	0.433
LIG_LIR_Gen_1	391	400	PF02991	0.342
LIG_LIR_Gen_1	630	640	PF02991	0.432
LIG_LIR_Gen_1	71	79	PF02991	0.390
LIG_LIR_Gen_1	725	735	PF02991	0.344
LIG_LIR_LC3C_4	122	127	PF02991	0.363
LIG_LIR_LC3C_4	614	617	PF02991	0.312
LIG_LIR_Nem_3	225	230	PF02991	0.429
LIG_LIR_Nem_3	32	38	PF02991	0.446
LIG_LIR_Nem_3	391	397	PF02991	0.343
LIG_LIR_Nem_3	448	453	PF02991	0.396
LIG_LIR_Nem_3	507	511	PF02991	0.328
LIG_LIR_Nem_3	541	545	PF02991	0.413
LIG_LIR_Nem_3	652	658	PF02991	0.372
LIG_LIR_Nem_3	666	670	PF02991	0.372
LIG_LIR_Nem_3	678	682	PF02991	0.270
LIG_LIR_Nem_3	71	75	PF02991	0.350
LIG_LIR_Nem_3	725	731	PF02991	0.352
LIG_LYPXL_yS_3	35	38	PF13949	0.400
LIG_MLH1_MIPbox_1	352	356	PF16413	0.301
LIG_NRBOX	8	14	PF00104	0.557
LIG_PDZ_Class_2	788	793	PF00595	0.739
LIG_Pex14_2	436	440	PF04695	0.384
LIG_Pex14_2	675	679	PF04695	0.428
LIG_Pex14_2	751	755	PF04695	0.336
LIG_SH2_CRK	100	104	PF00017	0.352
LIG_SH2_CRK	227	231	PF00017	0.434
LIG_SH2_CRK	51	55	PF00017	0.393
LIG_SH2_CRK	728	732	PF00017	0.339
LIG_SH2_CRK	761	765	PF00017	0.408
LIG_SH2_GRB2like	564	567	PF00017	0.402
LIG_SH2_PTP2	655	658	PF00017	0.327
LIG_SH2_STAP1	227	231	PF00017	0.504
LIG_SH2_STAP1	564	568	PF00017	0.393
LIG_SH2_STAP1	693	697	PF00017	0.428
LIG_SH2_STAP1	761	765	PF00017	0.434
LIG_SH2_STAT3	625	628	PF00017	0.361
LIG_SH2_STAT5	121	124	PF00017	0.319
LIG_SH2_STAT5	137	140	PF00017	0.396
LIG_SH2_STAT5	354	357	PF00017	0.309
LIG_SH2_STAT5	580	583	PF00017	0.312
LIG_SH2_STAT5	625	628	PF00017	0.393
LIG_SH2_STAT5	633	636	PF00017	0.410
LIG_SH2_STAT5	655	658	PF00017	0.327
LIG_SH2_STAT5	693	696	PF00017	0.360
LIG_SH2_STAT5	761	764	PF00017	0.402
LIG_SH3_2	164	169	PF14604	0.485
LIG_SH3_2	686	691	PF14604	0.449
LIG_SH3_3	161	167	PF00018	0.443
LIG_SH3_3	537	543	PF00018	0.340
LIG_SH3_3	64	70	PF00018	0.419
LIG_SH3_3	683	689	PF00018	0.429
LIG_SH3_3	717	723	PF00018	0.446
LIG_SH3_3	780	786	PF00018	0.593
LIG_SH3_3	85	91	PF00018	0.433
LIG_SUMO_SIM_anti_2	283	288	PF11976	0.504
LIG_SUMO_SIM_anti_2	345	350	PF11976	0.343
LIG_SUMO_SIM_anti_2	567	572	PF11976	0.338
LIG_SUMO_SIM_par_1	115	122	PF11976	0.396
LIG_SUMO_SIM_par_1	13	18	PF11976	0.663
LIG_SUMO_SIM_par_1	590	596	PF11976	0.423
LIG_SUMO_SIM_par_1	692	698	PF11976	0.438
LIG_TRAF2_1	238	241	PF00917	0.407
LIG_TYR_ITIM	759	764	PF00017	0.408
LIG_WRC_WIRS_1	664	669	PF05994	0.457
LIG_WRC_WIRS_1	69	74	PF05994	0.416
MOD_CDC14_SPxK_1	688	691	PF00782	0.448
MOD_CDK_SPK_2	50	55	PF00069	0.311
MOD_CDK_SPxK_1	163	169	PF00069	0.467
MOD_CDK_SPxK_1	685	691	PF00069	0.439
MOD_CDK_SPxxK_3	274	281	PF00069	0.454
MOD_CDK_SPxxK_3	658	665	PF00069	0.435
MOD_CK1_1	274	280	PF00069	0.499
MOD_CK2_1	169	175	PF00069	0.518
MOD_CK2_1	186	192	PF00069	0.340
MOD_CK2_1	210	216	PF00069	0.530
MOD_CK2_1	235	241	PF00069	0.539
MOD_CK2_1	263	269	PF00069	0.381
MOD_DYRK1A_RPxSP_1	163	167	PF00069	0.507
MOD_DYRK1A_RPxSP_1	685	689	PF00069	0.440
MOD_GlcNHglycan	42	45	PF01048	0.598
MOD_GlcNHglycan	440	443	PF01048	0.488
MOD_GlcNHglycan	457	460	PF01048	0.580
MOD_GlcNHglycan	488	491	PF01048	0.603
MOD_GlcNHglycan	524	527	PF01048	0.551
MOD_GlcNHglycan	585	588	PF01048	0.585
MOD_GlcNHglycan	649	652	PF01048	0.600
MOD_GlcNHglycan	770	773	PF01048	0.480
MOD_GSK3_1	163	170	PF00069	0.511
MOD_GSK3_1	184	191	PF00069	0.527
MOD_GSK3_1	205	212	PF00069	0.445
MOD_GSK3_1	222	229	PF00069	0.350
MOD_GSK3_1	312	319	PF00069	0.352
MOD_GSK3_1	331	338	PF00069	0.381
MOD_GSK3_1	350	357	PF00069	0.234
MOD_GSK3_1	398	405	PF00069	0.393
MOD_GSK3_1	455	462	PF00069	0.351
MOD_GSK3_1	46	53	PF00069	0.326
MOD_GSK3_1	464	471	PF00069	0.377
MOD_GSK3_1	486	493	PF00069	0.369
MOD_GSK3_1	627	634	PF00069	0.368
MOD_GSK3_1	677	684	PF00069	0.347
MOD_GSK3_1	685	692	PF00069	0.409
MOD_GSK3_1	739	746	PF00069	0.360
MOD_LATS_1	94	100	PF00433	0.467
MOD_N-GLC_1	28	33	PF02516	0.644
MOD_N-GLC_1	316	321	PF02516	0.567
MOD_N-GLC_1	403	408	PF02516	0.599
MOD_N-GLC_1	486	491	PF02516	0.624
MOD_N-GLC_1	689	694	PF02516	0.522
MOD_NEK2_1	186	191	PF00069	0.532
MOD_NEK2_1	292	297	PF00069	0.470
MOD_NEK2_1	312	317	PF00069	0.277
MOD_NEK2_1	350	355	PF00069	0.301
MOD_NEK2_1	377	382	PF00069	0.406
MOD_NEK2_1	398	403	PF00069	0.341
MOD_NEK2_1	40	45	PF00069	0.338
MOD_NEK2_1	429	434	PF00069	0.379
MOD_NEK2_1	521	526	PF00069	0.325
MOD_NEK2_1	531	536	PF00069	0.340
MOD_NEK2_1	615	620	PF00069	0.302
MOD_NEK2_1	627	632	PF00069	0.323
MOD_NEK2_1	649	654	PF00069	0.378
MOD_NEK2_1	727	732	PF00069	0.353
MOD_NEK2_1	743	748	PF00069	0.281
MOD_NEK2_1	768	773	PF00069	0.395
MOD_NEK2_2	219	224	PF00069	0.485
MOD_PIKK_1	126	132	PF00454	0.320
MOD_PIKK_1	29	35	PF00454	0.487
MOD_PIKK_1	70	76	PF00454	0.340
MOD_PK_1	198	204	PF00069	0.458
MOD_PKA_1	197	203	PF00069	0.452
MOD_PKA_2	197	203	PF00069	0.571
MOD_PKA_2	280	286	PF00069	0.493
MOD_PKA_2	312	318	PF00069	0.341
MOD_PKA_2	402	408	PF00069	0.260
MOD_PKA_2	504	510	PF00069	0.376
MOD_PKA_2	531	537	PF00069	0.428
MOD_PKA_2	582	588	PF00069	0.437
MOD_Plk_1	184	190	PF00069	0.536
MOD_Plk_1	316	322	PF00069	0.368
MOD_Plk_1	422	428	PF00069	0.458
MOD_Plk_1	677	683	PF00069	0.429
MOD_Plk_1	689	695	PF00069	0.290
MOD_Plk_2-3	422	428	PF00069	0.446
MOD_Plk_2-3	504	510	PF00069	0.366
MOD_Plk_4	169	175	PF00069	0.547
MOD_Plk_4	222	228	PF00069	0.378
MOD_Plk_4	350	356	PF00069	0.299
MOD_Plk_4	46	52	PF00069	0.320
MOD_Plk_4	546	552	PF00069	0.357
MOD_Plk_4	597	603	PF00069	0.320
MOD_Plk_4	759	765	PF00069	0.397
MOD_ProDKin_1	163	169	PF00069	0.458
MOD_ProDKin_1	205	211	PF00069	0.545
MOD_ProDKin_1	274	280	PF00069	0.457
MOD_ProDKin_1	331	337	PF00069	0.320
MOD_ProDKin_1	411	417	PF00069	0.335
MOD_ProDKin_1	457	463	PF00069	0.363
MOD_ProDKin_1	50	56	PF00069	0.311
MOD_ProDKin_1	628	634	PF00069	0.378
MOD_ProDKin_1	658	664	PF00069	0.433
MOD_ProDKin_1	685	691	PF00069	0.439
MOD_ProDKin_1	99	105	PF00069	0.339
MOD_SUMO_rev_2	129	134	PF00179	0.351
MOD_SUMO_rev_2	322	327	PF00179	0.453
MOD_SUMO_rev_2	478	483	PF00179	0.406
MOD_SUMO_rev_2	593	599	PF00179	0.397
TRG_DiLeu_BaLyEn_6	393	398	PF01217	0.410
TRG_ENDOCYTIC_2	137	140	PF00928	0.426
TRG_ENDOCYTIC_2	227	230	PF00928	0.434
TRG_ENDOCYTIC_2	35	38	PF00928	0.455
TRG_ENDOCYTIC_2	633	636	PF00928	0.410
TRG_ENDOCYTIC_2	655	658	PF00928	0.327
TRG_ENDOCYTIC_2	728	731	PF00928	0.326
TRG_ENDOCYTIC_2	761	764	PF00928	0.408
TRG_ER_diArg_1	181	183	PF00400	0.461
TRG_ER_diArg_1	702	705	PF00400	0.399
TRG_NES_CRM1_1	725	741	PF08389	0.381
TRG_Pf-PMV_PEXEL_1	310	314	PF00026	0.644

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8U3	Leptomonas seymouri	67%	100%
A0A0S4JVN8	Bodo saltans	41%	91%
A0A3S7X408	Leishmania donovani	92%	100%
A0A422NXM6	Trypanosoma rangeli	46%	93%
A4HIX5	Leishmania braziliensis	81%	99%
A4I6A4	Leishmania infantum	92%	100%
C9ZTY0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	94%
Q4Q6Q3	Leishmania major	91%	99%
V5AJ13	Trypanosoma cruzi	44%	96%