NARG2_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B1F7_LEIMU

TriTrypDb:

LmxM.30.0090

Length:

492

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B1F7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1F7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	132	134	PF00675	0.453
CLV_NRD_NRD_1	168	170	PF00675	0.416
CLV_NRD_NRD_1	177	179	PF00675	0.490
CLV_NRD_NRD_1	393	395	PF00675	0.651
CLV_NRD_NRD_1	70	72	PF00675	0.502
CLV_PCSK_KEX2_1	168	170	PF00082	0.399
CLV_PCSK_KEX2_1	179	181	PF00082	0.430
CLV_PCSK_KEX2_1	31	33	PF00082	0.459
CLV_PCSK_KEX2_1	311	313	PF00082	0.653
CLV_PCSK_KEX2_1	393	395	PF00082	0.626
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.466
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.459
CLV_PCSK_PC1ET2_1	311	313	PF00082	0.653
CLV_PCSK_SKI1_1	133	137	PF00082	0.496
CLV_PCSK_SKI1_1	143	147	PF00082	0.353
CLV_PCSK_SKI1_1	229	233	PF00082	0.406
CLV_PCSK_SKI1_1	316	320	PF00082	0.537
CLV_PCSK_SKI1_1	35	39	PF00082	0.486
CLV_PCSK_SKI1_1	367	371	PF00082	0.578
CLV_Separin_Metazoa	287	291	PF03568	0.588
CLV_Separin_Metazoa	68	72	PF03568	0.486
DEG_APCC_DBOX_1	242	250	PF00400	0.501
DEG_APCC_DBOX_1	445	453	PF00400	0.552
DOC_CYCLIN_yCln2_LP_2	422	428	PF00134	0.517
DOC_MAPK_gen_1	35	45	PF00069	0.467
DOC_MAPK_gen_1	393	402	PF00069	0.421
DOC_MAPK_MEF2A_6	156	165	PF00069	0.463
DOC_MAPK_MEF2A_6	229	238	PF00069	0.371
DOC_MAPK_RevD_3	358	373	PF00069	0.581
DOC_PP1_RVXF_1	154	160	PF00149	0.451
DOC_PP2B_LxvP_1	422	425	PF13499	0.549
DOC_PP4_FxxP_1	144	147	PF00568	0.359
DOC_PP4_FxxP_1	273	276	PF00568	0.541
DOC_USP7_MATH_1	484	488	PF00917	0.619
DOC_USP7_UBL2_3	31	35	PF12436	0.477
DOC_WW_Pin1_4	157	162	PF00397	0.410
DOC_WW_Pin1_4	258	263	PF00397	0.626
DOC_WW_Pin1_4	91	96	PF00397	0.571
LIG_14-3-3_CanoR_1	255	262	PF00244	0.515
LIG_14-3-3_CanoR_1	316	325	PF00244	0.724
LIG_14-3-3_CanoR_1	32	38	PF00244	0.540
LIG_Actin_WH2_2	242	257	PF00022	0.411
LIG_AP2alpha_1	379	383	PF02296	0.448
LIG_AP2alpha_2	184	186	PF02296	0.459
LIG_BIR_II_1	1	5	PF00653	0.744
LIG_CSL_BTD_1	158	161	PF09270	0.420
LIG_deltaCOP1_diTrp_1	244	250	PF00928	0.401
LIG_FHA_1	230	236	PF00498	0.376
LIG_FHA_1	419	425	PF00498	0.515
LIG_FHA_1	85	91	PF00498	0.532
LIG_FHA_2	115	121	PF00498	0.500
LIG_FHA_2	259	265	PF00498	0.633
LIG_FHA_2	298	304	PF00498	0.586
LIG_FHA_2	317	323	PF00498	0.560
LIG_FHA_2	407	413	PF00498	0.516
LIG_FHA_2	460	466	PF00498	0.479
LIG_FHA_2	477	483	PF00498	0.603
LIG_GBD_Chelix_1	21	29	PF00786	0.507
LIG_HCF-1_HBM_1	227	230	PF13415	0.407
LIG_LIR_Apic_2	189	195	PF02991	0.423
LIG_LIR_Apic_2	271	276	PF02991	0.620
LIG_LIR_Gen_1	293	304	PF02991	0.593
LIG_LIR_Gen_1	377	386	PF02991	0.497
LIG_LIR_Nem_3	170	176	PF02991	0.514
LIG_LIR_Nem_3	293	299	PF02991	0.531
LIG_LIR_Nem_3	303	309	PF02991	0.526
LIG_LIR_Nem_3	353	357	PF02991	0.555
LIG_LIR_Nem_3	377	382	PF02991	0.380
LIG_PCNA_yPIPBox_3	148	158	PF02747	0.437
LIG_Pex14_1	459	463	PF04695	0.520
LIG_Pex14_2	379	383	PF04695	0.448
LIG_Pex14_2	51	55	PF04695	0.444
LIG_SH2_CRK	192	196	PF00017	0.534
LIG_SH2_CRK	26	30	PF00017	0.428
LIG_SH2_GRB2like	150	153	PF00017	0.448
LIG_SH2_SRC	150	153	PF00017	0.500
LIG_SH2_STAP1	306	310	PF00017	0.517
LIG_SH2_STAP1	60	64	PF00017	0.439
LIG_SH2_STAT5	100	103	PF00017	0.450
LIG_SH2_STAT5	225	228	PF00017	0.404
LIG_SH2_STAT5	230	233	PF00017	0.383
LIG_SH2_STAT5	237	240	PF00017	0.332
LIG_SH2_STAT5	296	299	PF00017	0.515
LIG_SH2_STAT5	439	442	PF00017	0.489
LIG_SH2_STAT5	463	466	PF00017	0.531
LIG_SH2_STAT5	60	63	PF00017	0.397
LIG_SH3_3	155	161	PF00018	0.417
LIG_SH3_3	327	333	PF00018	0.788
LIG_SUMO_SIM_par_1	117	123	PF11976	0.457
LIG_SUMO_SIM_par_1	358	364	PF11976	0.511
LIG_UBA3_1	418	427	PF00899	0.451
MOD_CDK_SPK_2	157	162	PF00069	0.445
MOD_CK1_1	257	263	PF00069	0.460
MOD_CK1_1	331	337	PF00069	0.719
MOD_CK1_1	374	380	PF00069	0.323
MOD_CK1_1	431	437	PF00069	0.486
MOD_CK2_1	114	120	PF00069	0.465
MOD_CK2_1	258	264	PF00069	0.629
MOD_CK2_1	288	294	PF00069	0.587
MOD_CK2_1	297	303	PF00069	0.554
MOD_CK2_1	316	322	PF00069	0.710
MOD_CK2_1	374	380	PF00069	0.390
MOD_CK2_1	406	412	PF00069	0.461
MOD_CK2_1	476	482	PF00069	0.521
MOD_CMANNOS	247	250	PF00535	0.353
MOD_GlcNHglycan	204	207	PF01048	0.495
MOD_GlcNHglycan	290	293	PF01048	0.629
MOD_GlcNHglycan	333	336	PF01048	0.679
MOD_GlcNHglycan	353	357	PF01048	0.601
MOD_GlcNHglycan	433	436	PF01048	0.521
MOD_GSK3_1	110	117	PF00069	0.441
MOD_GSK3_1	184	191	PF00069	0.496
MOD_GSK3_1	196	203	PF00069	0.480
MOD_GSK3_1	250	257	PF00069	0.404
MOD_GSK3_1	459	466	PF00069	0.466
MOD_GSK3_1	96	103	PF00069	0.446
MOD_NEK2_1	186	191	PF00069	0.430
MOD_NEK2_1	305	310	PF00069	0.540
MOD_NEK2_1	352	357	PF00069	0.581
MOD_NEK2_1	418	423	PF00069	0.518
MOD_NEK2_1	428	433	PF00069	0.663
MOD_NEK2_2	250	255	PF00069	0.363
MOD_OFUCOSY	315	320	PF10250	0.432
MOD_PIKK_1	447	453	PF00454	0.548
MOD_PIKK_1	84	90	PF00454	0.560
MOD_PKA_2	123	129	PF00069	0.517
MOD_PKA_2	167	173	PF00069	0.451
MOD_PKA_2	254	260	PF00069	0.453
MOD_PKA_2	297	303	PF00069	0.589
MOD_Plk_1	6	12	PF00069	0.641
MOD_Plk_2-3	105	111	PF00069	0.642
MOD_Plk_2-3	114	120	PF00069	0.515
MOD_Plk_2-3	78	84	PF00069	0.477
MOD_Plk_4	114	120	PF00069	0.510
MOD_Plk_4	150	156	PF00069	0.426
MOD_Plk_4	193	199	PF00069	0.489
MOD_Plk_4	305	311	PF00069	0.543
MOD_Plk_4	374	380	PF00069	0.453
MOD_Plk_4	45	51	PF00069	0.370
MOD_Plk_4	459	465	PF00069	0.539
MOD_Plk_4	6	12	PF00069	0.662
MOD_Plk_4	96	102	PF00069	0.383
MOD_ProDKin_1	157	163	PF00069	0.415
MOD_ProDKin_1	258	264	PF00069	0.629
MOD_ProDKin_1	91	97	PF00069	0.560
MOD_SUMO_rev_2	205	215	PF00179	0.444
MOD_SUMO_rev_2	366	375	PF00179	0.524
TRG_DiLeu_BaEn_1	114	119	PF01217	0.574
TRG_DiLeu_BaLyEn_6	364	369	PF01217	0.458
TRG_ENDOCYTIC_2	173	176	PF00928	0.542
TRG_ENDOCYTIC_2	26	29	PF00928	0.393
TRG_ENDOCYTIC_2	296	299	PF00928	0.499
TRG_NLS_MonoExtC_3	132	137	PF00514	0.549
TRG_Pf-PMV_PEXEL_1	367	371	PF00026	0.554
TRG_Pf-PMV_PEXEL_1	469	473	PF00026	0.503

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8U9	Leptomonas seymouri	71%	100%
A0A0S4JY56	Bodo saltans	44%	96%
A0A3Q8ICB7	Leishmania donovani	93%	100%
A4HIX3	Leishmania braziliensis	82%	100%
A4I6A2	Leishmania infantum	93%	100%
C9ZM74	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	83%
C9ZQH7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	86%
C9ZWU9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	91%
Q4Q6Q5	Leishmania major	93%	100%
V5BLG2	Trypanosoma cruzi	38%	88%