C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B1F6_LEIMU

TriTrypDb:

LmxM.30.0080

Length:

240

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B1F6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1F6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	9
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	169	173	PF00656	0.812
CLV_C14_Caspase3-7	20	24	PF00656	0.751
CLV_NRD_NRD_1	110	112	PF00675	0.667
CLV_PCSK_KEX2_1	110	112	PF00082	0.686
CLV_PCSK_SKI1_1	217	221	PF00082	0.777
DEG_SCF_SKP2-CKS1_1	190	197	PF00560	0.752
DOC_USP7_MATH_1	190	194	PF00917	0.812
DOC_USP7_UBL2_3	185	189	PF12436	0.789
DOC_USP7_UBL2_3	205	209	PF12436	0.587
DOC_USP7_UBL2_3	213	217	PF12436	0.667
DOC_USP7_UBL2_3	222	226	PF12436	0.764
DOC_WW_Pin1_4	191	196	PF00397	0.815
LIG_14-3-3_CanoR_1	128	136	PF00244	0.656
LIG_14-3-3_CanoR_1	18	22	PF00244	0.751
LIG_BIR_III_4	8	12	PF00653	0.822
LIG_BRCT_BRCA1_1	138	142	PF00533	0.581
LIG_CaM_IQ_9	133	149	PF13499	0.590
LIG_FHA_2	120	126	PF00498	0.730
LIG_FHA_2	167	173	PF00498	0.783
LIG_LIR_Gen_1	90	100	PF02991	0.796
LIG_PTB_Apo_2	55	62	PF02174	0.753
LIG_PTB_Phospho_1	55	61	PF10480	0.753
LIG_SH2_CRK	40	44	PF00017	0.728
LIG_SH2_CRK	48	52	PF00017	0.639
LIG_SH2_CRK	61	65	PF00017	0.732
LIG_SH2_NCK_1	16	20	PF00017	0.747
LIG_SH2_NCK_1	40	44	PF00017	0.714
LIG_SH2_NCK_1	61	65	PF00017	0.753
LIG_SH2_SRC	48	51	PF00017	0.721
LIG_SH2_STAT3	7	10	PF00017	0.760
LIG_SH3_3	221	227	PF00018	0.759
LIG_SH3_3	66	72	PF00018	0.758
LIG_TRAF2_1	204	207	PF00917	0.544
LIG_TRAF2_1	229	232	PF00917	0.637
MOD_CDK_SPxK_1	191	197	PF00069	0.751
MOD_CK2_1	119	125	PF00069	0.735
MOD_CK2_1	190	196	PF00069	0.853
MOD_CK2_1	215	221	PF00069	0.556
MOD_GlcNHglycan	206	212	PF01048	0.797
MOD_GlcNHglycan	216	220	PF01048	0.599
MOD_GlcNHglycan	89	92	PF01048	0.735
MOD_GSK3_1	191	198	PF00069	0.772
MOD_N-GLC_1	26	31	PF02516	0.800
MOD_NEK2_1	136	141	PF00069	0.633
MOD_OFUCOSY	133	140	PF10250	0.584
MOD_PIKK_1	119	125	PF00454	0.654
MOD_PKA_2	127	133	PF00069	0.625
MOD_PKA_2	17	23	PF00069	0.832
MOD_Plk_1	199	205	PF00069	0.758
MOD_ProDKin_1	191	197	PF00069	0.812
MOD_SUMO_for_1	204	207	PF00179	0.758
MOD_SUMO_rev_2	206	211	PF00179	0.592
TRG_ENDOCYTIC_2	93	96	PF00928	0.707
TRG_ER_diArg_1	109	111	PF00400	0.702
TRG_NLS_MonoExtN_4	108	115	PF00514	0.667
TRG_Pf-PMV_PEXEL_1	147	151	PF00026	0.539

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IA54	Leptomonas seymouri	66%	100%
A0A1X0P7C1	Trypanosomatidae	43%	100%
A0A3Q8ISC2	Leishmania donovani	91%	100%
A4HIX2	Leishmania braziliensis	77%	96%
A4I6A1	Leishmania infantum	92%	100%
D0A543	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
Q4Q6Q6	Leishmania major	92%	96%