Autophagy-related protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MFS/sugar transport protein, putative

Species:

Leishmania mexicana

UniProt:

E9B1F2_LEIMU

TriTrypDb:

LmxM.30.0040

Length:

546

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	13
GO:0110165	cellular anatomical entity	1	13

Expansion

Sequence features

E9B1F2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1F2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0008643	carbohydrate transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0071702	organic substance transport	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	27	31	PF00656	0.655
CLV_NRD_NRD_1	125	127	PF00675	0.377
CLV_NRD_NRD_1	267	269	PF00675	0.389
CLV_PCSK_FUR_1	123	127	PF00082	0.327
CLV_PCSK_KEX2_1	125	127	PF00082	0.392
CLV_PCSK_KEX2_1	259	261	PF00082	0.337
CLV_PCSK_KEX2_1	267	269	PF00082	0.383
CLV_PCSK_KEX2_1	288	290	PF00082	0.407
CLV_PCSK_PC1ET2_1	259	261	PF00082	0.355
CLV_PCSK_PC1ET2_1	288	290	PF00082	0.346
CLV_PCSK_SKI1_1	295	299	PF00082	0.403
CLV_PCSK_SKI1_1	301	305	PF00082	0.302
CLV_PCSK_SKI1_1	427	431	PF00082	0.361
CLV_PCSK_SKI1_1	485	489	PF00082	0.255
DEG_APCC_DBOX_1	63	71	PF00400	0.275
DOC_CDC14_PxL_1	498	506	PF14671	0.333
DOC_MAPK_gen_1	125	134	PF00069	0.531
DOC_MAPK_gen_1	506	515	PF00069	0.588
DOC_MAPK_MEF2A_6	126	135	PF00069	0.538
DOC_MAPK_MEF2A_6	408	417	PF00069	0.325
DOC_MAPK_MEF2A_6	427	436	PF00069	0.328
DOC_PP4_FxxP_1	313	316	PF00568	0.312
DOC_USP7_MATH_1	26	30	PF00917	0.751
DOC_USP7_MATH_1	364	368	PF00917	0.542
DOC_USP7_MATH_1	385	389	PF00917	0.330
DOC_USP7_MATH_1	416	420	PF00917	0.313
DOC_USP7_MATH_1	9	13	PF00917	0.633
DOC_USP7_UBL2_3	408	412	PF12436	0.305
DOC_WW_Pin1_4	189	194	PF00397	0.540
LIG_14-3-3_CanoR_1	272	276	PF00244	0.682
LIG_14-3-3_CanoR_1	281	285	PF00244	0.606
LIG_14-3-3_CanoR_1	289	298	PF00244	0.553
LIG_14-3-3_CterR_2	544	546	PF00244	0.596
LIG_Actin_WH2_2	413	429	PF00022	0.289
LIG_BIR_II_1	1	5	PF00653	0.669
LIG_EH_1	377	381	PF12763	0.473
LIG_eIF4E_1	483	489	PF01652	0.234
LIG_FHA_1	148	154	PF00498	0.431
LIG_FHA_1	169	175	PF00498	0.382
LIG_FHA_1	331	337	PF00498	0.310
LIG_FHA_1	431	437	PF00498	0.445
LIG_FHA_1	510	516	PF00498	0.618
LIG_FHA_2	25	31	PF00498	0.654
LIG_FHA_2	291	297	PF00498	0.633
LIG_FHA_2	40	46	PF00498	0.534
LIG_LIR_Gen_1	103	114	PF02991	0.388
LIG_LIR_Gen_1	154	164	PF02991	0.409
LIG_LIR_Gen_1	171	181	PF02991	0.280
LIG_LIR_Gen_1	309	318	PF02991	0.510
LIG_LIR_Gen_1	394	402	PF02991	0.395
LIG_LIR_Gen_1	42	52	PF02991	0.641
LIG_LIR_Nem_3	103	109	PF02991	0.343
LIG_LIR_Nem_3	127	132	PF02991	0.550
LIG_LIR_Nem_3	309	315	PF02991	0.510
LIG_LIR_Nem_3	394	398	PF02991	0.474
LIG_LIR_Nem_3	410	414	PF02991	0.294
LIG_LIR_Nem_3	447	453	PF02991	0.511
LIG_NRBOX	347	353	PF00104	0.312
LIG_Pex14_1	39	43	PF04695	0.635
LIG_Pex14_2	298	302	PF04695	0.410
LIG_Pex14_2	304	308	PF04695	0.350
LIG_Pex14_2	326	330	PF04695	0.288
LIG_Pex14_2	395	399	PF04695	0.342
LIG_PTB_Apo_2	318	325	PF02174	0.421
LIG_SH2_CRK	106	110	PF00017	0.312
LIG_SH2_GRB2like	233	236	PF00017	0.292
LIG_SH2_NCK_1	445	449	PF00017	0.509
LIG_SH2_STAP1	102	106	PF00017	0.369
LIG_SH2_STAP1	157	161	PF00017	0.329
LIG_SH2_STAP1	357	361	PF00017	0.281
LIG_SH2_STAP1	445	449	PF00017	0.509
LIG_SH2_STAP1	453	457	PF00017	0.260
LIG_SH2_STAT3	362	365	PF00017	0.544
LIG_SH2_STAT5	110	113	PF00017	0.348
LIG_SH2_STAT5	233	236	PF00017	0.292
LIG_SH2_STAT5	263	266	PF00017	0.582
LIG_SH2_STAT5	312	315	PF00017	0.315
LIG_SH2_STAT5	362	365	PF00017	0.576
LIG_SH2_STAT5	80	83	PF00017	0.357
LIG_SH3_3	187	193	PF00018	0.524
LIG_SH3_3	410	416	PF00018	0.364
LIG_SH3_3	496	502	PF00018	0.342
LIG_SUMO_SIM_par_1	253	258	PF11976	0.304
LIG_TYR_ITIM	104	109	PF00017	0.373
LIG_UBA3_1	251	259	PF00899	0.274
LIG_WRC_WIRS_1	392	397	PF05994	0.369
LIG_WRC_WIRS_1	82	87	PF05994	0.355
MOD_CK1_1	367	373	PF00069	0.601
MOD_CK1_1	465	471	PF00069	0.328
MOD_CK1_1	534	540	PF00069	0.670
MOD_CK1_1	72	78	PF00069	0.410
MOD_CK1_1	84	90	PF00069	0.401
MOD_CK1_1	91	97	PF00069	0.375
MOD_CK2_1	189	195	PF00069	0.587
MOD_CK2_1	290	296	PF00069	0.589
MOD_Cter_Amidation	286	289	PF01082	0.328
MOD_GlcNHglycan	195	199	PF01048	0.364
MOD_GlcNHglycan	387	390	PF01048	0.340
MOD_GlcNHglycan	422	425	PF01048	0.416
MOD_GlcNHglycan	457	460	PF01048	0.371
MOD_GlcNHglycan	464	467	PF01048	0.385
MOD_GSK3_1	189	196	PF00069	0.588
MOD_GSK3_1	212	219	PF00069	0.446
MOD_GSK3_1	266	273	PF00069	0.596
MOD_GSK3_1	328	335	PF00069	0.352
MOD_GSK3_1	336	343	PF00069	0.309
MOD_GSK3_1	35	42	PF00069	0.633
MOD_GSK3_1	416	423	PF00069	0.326
MOD_GSK3_1	451	458	PF00069	0.493
MOD_GSK3_1	461	468	PF00069	0.303
MOD_GSK3_1	471	478	PF00069	0.309
MOD_GSK3_1	531	538	PF00069	0.631
MOD_GSK3_1	68	75	PF00069	0.356
MOD_GSK3_1	81	88	PF00069	0.371
MOD_LATS_1	23	29	PF00433	0.663
MOD_N-GLC_1	88	93	PF02516	0.501
MOD_NEK2_1	216	221	PF00069	0.449
MOD_NEK2_1	255	260	PF00069	0.423
MOD_NEK2_1	306	311	PF00069	0.377
MOD_NEK2_1	319	324	PF00069	0.340
MOD_NEK2_1	330	335	PF00069	0.349
MOD_NEK2_1	336	341	PF00069	0.290
MOD_NEK2_1	402	407	PF00069	0.487
MOD_NEK2_1	444	449	PF00069	0.561
MOD_NEK2_1	471	476	PF00069	0.356
MOD_NEK2_1	68	73	PF00069	0.305
MOD_NEK2_1	85	90	PF00069	0.423
MOD_NEK2_2	416	421	PF00069	0.301
MOD_PIKK_1	202	208	PF00454	0.480
MOD_PIKK_1	3	9	PF00454	0.683
MOD_PIKK_1	32	38	PF00454	0.648
MOD_PIKK_1	336	342	PF00454	0.264
MOD_PIKK_1	72	78	PF00454	0.304
MOD_PKA_2	24	30	PF00069	0.689
MOD_PKA_2	266	272	PF00069	0.638
MOD_PKA_2	280	286	PF00069	0.557
MOD_Plk_1	509	515	PF00069	0.668
MOD_Plk_1	519	525	PF00069	0.731
MOD_Plk_1	88	94	PF00069	0.373
MOD_Plk_4	156	162	PF00069	0.382
MOD_Plk_4	168	174	PF00069	0.306
MOD_Plk_4	212	218	PF00069	0.404
MOD_Plk_4	340	346	PF00069	0.275
MOD_Plk_4	35	41	PF00069	0.652
MOD_Plk_4	391	397	PF00069	0.497
MOD_Plk_4	416	422	PF00069	0.298
MOD_Plk_4	43	49	PF00069	0.617
MOD_ProDKin_1	189	195	PF00069	0.540
TRG_ENDOCYTIC_2	106	109	PF00928	0.377
TRG_ENDOCYTIC_2	157	160	PF00928	0.360
TRG_ENDOCYTIC_2	175	178	PF00928	0.311
TRG_ENDOCYTIC_2	312	315	PF00928	0.321
TRG_ENDOCYTIC_2	411	414	PF00928	0.335
TRG_ER_diArg_1	122	125	PF00400	0.580
TRG_ER_diArg_1	266	268	PF00400	0.652

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYC7	Leptomonas seymouri	56%	99%
A0A0N1I3H1	Leptomonas seymouri	29%	80%
A0A3Q8IF44	Leishmania donovani	91%	100%
A0A3Q8ILR5	Leishmania donovani	27%	100%
A4HIW8	Leishmania braziliensis	81%	100%
A4HL09	Leishmania braziliensis	27%	97%
A4I8J0	Leishmania infantum	27%	100%
E9AHK6	Leishmania infantum	91%	100%
E9B3F0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
Q4Q4Q0	Leishmania major	29%	100%
Q4Q6R0	Leishmania major	88%	100%