LeishMANIAdb
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RING-CH-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
RING-CH-type domain-containing protein
Gene product:
RING-variant domain containing protein, putative
Species:
Leishmania mexicana
UniProt:
E9B1F1_LEIMU
TriTrypDb:
LmxM.30.0030
Length:
1055

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6
GO:0005737 cytoplasm 2 1

Expansion

Sequence features

E9B1F1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1F1

Function

Biological processes
Term Name Level Count
GO:0000209 protein polyubiquitination 8 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0016567 protein ubiquitination 7 1
GO:0019538 protein metabolic process 3 1
GO:0032446 protein modification by small protein conjugation 6 1
GO:0036211 protein modification process 4 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043412 macromolecule modification 4 1
GO:0044238 primary metabolic process 2 1
GO:0070647 protein modification by small protein conjugation or removal 5 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 7
GO:0008270 zinc ion binding 6 7
GO:0043167 ion binding 2 7
GO:0043169 cation binding 3 7
GO:0046872 metal ion binding 4 7
GO:0046914 transition metal ion binding 5 7
GO:0003824 catalytic activity 1 1
GO:0004842 ubiquitin-protein transferase activity 4 1
GO:0016740 transferase activity 2 1
GO:0019787 ubiquitin-like protein transferase activity 3 1
GO:0061630 ubiquitin protein ligase activity 5 1
GO:0061659 ubiquitin-like protein ligase activity 4 1
GO:0140096 catalytic activity, acting on a protein 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 401 405 PF00656 0.400
CLV_NRD_NRD_1 344 346 PF00675 0.430
CLV_NRD_NRD_1 402 404 PF00675 0.645
CLV_NRD_NRD_1 620 622 PF00675 0.421
CLV_NRD_NRD_1 701 703 PF00675 0.424
CLV_NRD_NRD_1 732 734 PF00675 0.420
CLV_NRD_NRD_1 87 89 PF00675 0.419
CLV_PCSK_FUR_1 342 346 PF00082 0.447
CLV_PCSK_KEX2_1 344 346 PF00082 0.430
CLV_PCSK_KEX2_1 402 404 PF00082 0.645
CLV_PCSK_KEX2_1 613 615 PF00082 0.476
CLV_PCSK_KEX2_1 620 622 PF00082 0.425
CLV_PCSK_KEX2_1 701 703 PF00082 0.421
CLV_PCSK_KEX2_1 732 734 PF00082 0.420
CLV_PCSK_KEX2_1 87 89 PF00082 0.419
CLV_PCSK_PC1ET2_1 613 615 PF00082 0.441
CLV_PCSK_SKI1_1 224 228 PF00082 0.426
CLV_PCSK_SKI1_1 258 262 PF00082 0.395
CLV_PCSK_SKI1_1 292 296 PF00082 0.597
CLV_PCSK_SKI1_1 353 357 PF00082 0.425
CLV_PCSK_SKI1_1 441 445 PF00082 0.618
CLV_PCSK_SKI1_1 551 555 PF00082 0.671
CLV_PCSK_SKI1_1 585 589 PF00082 0.489
CLV_PCSK_SKI1_1 840 844 PF00082 0.388
DEG_APCC_DBOX_1 777 785 PF00400 0.554
DEG_COP1_1 739 746 PF00400 0.554
DEG_MDM2_SWIB_1 604 612 PF02201 0.614
DEG_Nend_UBRbox_2 1 3 PF02207 0.622
DOC_ANK_TNKS_1 343 350 PF00023 0.651
DOC_CDC14_PxL_1 553 561 PF14671 0.329
DOC_CDC14_PxL_1 62 70 PF14671 0.608
DOC_CDC14_PxL_1 792 800 PF14671 0.619
DOC_CDC14_PxL_1 868 876 PF14671 0.670
DOC_CKS1_1 175 180 PF01111 0.729
DOC_CKS1_1 93 98 PF01111 0.486
DOC_CYCLIN_RxL_1 1022 1035 PF00134 0.542
DOC_CYCLIN_RxL_1 350 359 PF00134 0.661
DOC_CYCLIN_RxL_1 438 445 PF00134 0.426
DOC_CYCLIN_RxL_1 545 555 PF00134 0.469
DOC_CYCLIN_yCln2_LP_2 294 297 PF00134 0.466
DOC_CYCLIN_yCln2_LP_2 433 439 PF00134 0.388
DOC_CYCLIN_yCln2_LP_2 554 560 PF00134 0.329
DOC_CYCLIN_yCln2_LP_2 93 99 PF00134 0.495
DOC_MAPK_DCC_7 431 439 PF00069 0.450
DOC_MAPK_DCC_7 470 480 PF00069 0.357
DOC_MAPK_gen_1 1022 1031 PF00069 0.540
DOC_MAPK_gen_1 124 131 PF00069 0.369
DOC_MAPK_gen_1 84 94 PF00069 0.515
DOC_MAPK_MEF2A_6 708 716 PF00069 0.626
DOC_MAPK_MEF2A_6 753 762 PF00069 0.596
DOC_PP1_SILK_1 609 614 PF00149 0.668
DOC_PP2B_LxvP_1 293 296 PF13499 0.512
DOC_PP2B_LxvP_1 554 557 PF13499 0.329
DOC_SPAK_OSR1_1 899 903 PF12202 0.291
DOC_SPAK_OSR1_1 949 953 PF12202 0.661
DOC_USP7_MATH_1 220 224 PF00917 0.580
DOC_USP7_MATH_1 310 314 PF00917 0.396
DOC_USP7_MATH_1 466 470 PF00917 0.465
DOC_USP7_MATH_1 571 575 PF00917 0.315
DOC_USP7_MATH_1 67 71 PF00917 0.643
DOC_WW_Pin1_4 1042 1047 PF00397 0.707
DOC_WW_Pin1_4 174 179 PF00397 0.767
DOC_WW_Pin1_4 452 457 PF00397 0.509
DOC_WW_Pin1_4 473 478 PF00397 0.464
DOC_WW_Pin1_4 520 525 PF00397 0.388
DOC_WW_Pin1_4 591 596 PF00397 0.714
DOC_WW_Pin1_4 631 636 PF00397 0.647
DOC_WW_Pin1_4 92 97 PF00397 0.486
LIG_14-3-3_CanoR_1 115 123 PF00244 0.316
LIG_14-3-3_CanoR_1 244 249 PF00244 0.633
LIG_14-3-3_CanoR_1 350 356 PF00244 0.608
LIG_14-3-3_CanoR_1 363 369 PF00244 0.597
LIG_14-3-3_CanoR_1 424 432 PF00244 0.438
LIG_14-3-3_CanoR_1 441 447 PF00244 0.348
LIG_14-3-3_CanoR_1 493 498 PF00244 0.322
LIG_14-3-3_CanoR_1 614 620 PF00244 0.666
LIG_14-3-3_CanoR_1 621 629 PF00244 0.624
LIG_14-3-3_CanoR_1 736 744 PF00244 0.617
LIG_14-3-3_CanoR_1 783 792 PF00244 0.561
LIG_14-3-3_CanoR_1 797 801 PF00244 0.304
LIG_14-3-3_CanoR_1 860 864 PF00244 0.619
LIG_Actin_RPEL_3 396 415 PF02755 0.443
LIG_Actin_WH2_2 323 340 PF00022 0.388
LIG_Actin_WH2_2 477 495 PF00022 0.261
LIG_Actin_WH2_2 845 862 PF00022 0.456
LIG_APCC_ABBA_1 163 168 PF00400 0.665
LIG_APCC_ABBA_1 415 420 PF00400 0.333
LIG_BRCT_BRCA1_1 246 250 PF00533 0.590
LIG_BRCT_BRCA1_1 623 627 PF00533 0.637
LIG_BRCT_BRCA1_1 670 674 PF00533 0.278
LIG_BRCT_BRCA1_1 719 723 PF00533 0.596
LIG_CSL_BTD_1 672 675 PF09270 0.388
LIG_CtBP_PxDLS_1 477 481 PF00389 0.338
LIG_CtBP_PxDLS_1 878 882 PF00389 0.584
LIG_deltaCOP1_diTrp_1 666 674 PF00928 0.463
LIG_deltaCOP1_diTrp_1 942 950 PF00928 0.662
LIG_EH1_1 949 957 PF00400 0.660
LIG_eIF4E_1 255 261 PF01652 0.478
LIG_eIF4E_1 486 492 PF01652 0.436
LIG_FHA_1 1016 1022 PF00498 0.687
LIG_FHA_1 190 196 PF00498 0.691
LIG_FHA_1 225 231 PF00498 0.638
LIG_FHA_1 310 316 PF00498 0.462
LIG_FHA_1 363 369 PF00498 0.612
LIG_FHA_1 409 415 PF00498 0.475
LIG_FHA_1 507 513 PF00498 0.529
LIG_FHA_1 55 61 PF00498 0.577
LIG_FHA_1 562 568 PF00498 0.312
LIG_FHA_1 754 760 PF00498 0.507
LIG_FHA_1 81 87 PF00498 0.568
LIG_FHA_1 841 847 PF00498 0.461
LIG_FHA_1 933 939 PF00498 0.671
LIG_FHA_2 1031 1037 PF00498 0.672
LIG_FHA_2 550 556 PF00498 0.469
LIG_FHA_2 631 637 PF00498 0.641
LIG_FHA_2 722 728 PF00498 0.561
LIG_GBD_Chelix_1 439 447 PF00786 0.627
LIG_IRF3_LxIS_1 490 495 PF10401 0.207
LIG_LIR_Apic_2 28 34 PF02991 0.516
LIG_LIR_Gen_1 103 112 PF02991 0.207
LIG_LIR_Gen_1 404 414 PF02991 0.401
LIG_LIR_Gen_1 498 507 PF02991 0.654
LIG_LIR_Gen_1 516 527 PF02991 0.281
LIG_LIR_Gen_1 536 544 PF02991 0.406
LIG_LIR_Gen_1 599 609 PF02991 0.657
LIG_LIR_Gen_1 720 730 PF02991 0.543
LIG_LIR_Gen_1 827 835 PF02991 0.420
LIG_LIR_Nem_3 103 107 PF02991 0.207
LIG_LIR_Nem_3 130 134 PF02991 0.397
LIG_LIR_Nem_3 404 409 PF02991 0.365
LIG_LIR_Nem_3 449 454 PF02991 0.425
LIG_LIR_Nem_3 482 486 PF02991 0.297
LIG_LIR_Nem_3 498 503 PF02991 0.449
LIG_LIR_Nem_3 516 522 PF02991 0.281
LIG_LIR_Nem_3 523 528 PF02991 0.368
LIG_LIR_Nem_3 536 542 PF02991 0.355
LIG_LIR_Nem_3 566 572 PF02991 0.312
LIG_LIR_Nem_3 586 592 PF02991 0.547
LIG_LIR_Nem_3 599 605 PF02991 0.630
LIG_LIR_Nem_3 671 676 PF02991 0.283
LIG_LIR_Nem_3 720 726 PF02991 0.548
LIG_LIR_Nem_3 827 831 PF02991 0.426
LIG_NRBOX 289 295 PF00104 0.350
LIG_NRBOX 510 516 PF00104 0.388
LIG_NRBOX 757 763 PF00104 0.509
LIG_NRBOX 88 94 PF00104 0.523
LIG_NRBOX 922 928 PF00104 0.388
LIG_PALB2_WD40_1 830 838 PF16756 0.275
LIG_PCNA_PIPBox_1 710 719 PF02747 0.538
LIG_PCNA_yPIPBox_3 701 713 PF02747 0.600
LIG_Pex14_1 670 674 PF04695 0.275
LIG_Pex14_1 816 820 PF04695 0.427
LIG_Pex14_2 104 108 PF04695 0.207
LIG_Pex14_2 134 138 PF04695 0.207
LIG_Pex14_2 537 541 PF04695 0.416
LIG_Pex14_2 604 608 PF04695 0.655
LIG_SH2_GRB2like 629 632 PF00017 0.660
LIG_SH2_NCK_1 31 35 PF00017 0.529
LIG_SH2_PTP2 384 387 PF00017 0.315
LIG_SH2_PTP2 828 831 PF00017 0.401
LIG_SH2_SRC 31 34 PF00017 0.529
LIG_SH2_STAP1 255 259 PF00017 0.620
LIG_SH2_STAP1 525 529 PF00017 0.312
LIG_SH2_STAP1 56 60 PF00017 0.573
LIG_SH2_STAP1 563 567 PF00017 0.312
LIG_SH2_STAP1 650 654 PF00017 0.388
LIG_SH2_STAT3 56 59 PF00017 0.584
LIG_SH2_STAT3 870 873 PF00017 0.662
LIG_SH2_STAT5 139 142 PF00017 0.340
LIG_SH2_STAT5 169 172 PF00017 0.691
LIG_SH2_STAT5 214 217 PF00017 0.654
LIG_SH2_STAT5 319 322 PF00017 0.388
LIG_SH2_STAT5 35 38 PF00017 0.475
LIG_SH2_STAT5 384 387 PF00017 0.376
LIG_SH2_STAT5 525 528 PF00017 0.338
LIG_SH2_STAT5 56 59 PF00017 0.564
LIG_SH2_STAT5 563 566 PF00017 0.312
LIG_SH2_STAT5 589 592 PF00017 0.648
LIG_SH2_STAT5 606 609 PF00017 0.616
LIG_SH2_STAT5 791 794 PF00017 0.560
LIG_SH2_STAT5 820 823 PF00017 0.464
LIG_SH2_STAT5 828 831 PF00017 0.393
LIG_SH3_3 1037 1043 PF00018 0.648
LIG_SH3_3 126 132 PF00018 0.330
LIG_SH3_3 168 174 PF00018 0.646
LIG_SH3_3 175 181 PF00018 0.668
LIG_SH3_3 312 318 PF00018 0.405
LIG_SH3_3 374 380 PF00018 0.251
LIG_SH3_3 451 457 PF00018 0.413
LIG_SH3_3 465 471 PF00018 0.413
LIG_SH3_3 518 524 PF00018 0.291
LIG_SH3_3 669 675 PF00018 0.252
LIG_SH3_3 79 85 PF00018 0.636
LIG_SH3_3 803 809 PF00018 0.402
LIG_SH3_3 826 832 PF00018 0.440
LIG_SH3_3 884 890 PF00018 0.475
LIG_SH3_3 955 961 PF00018 0.717
LIG_SH3_3 963 969 PF00018 0.689
LIG_SH3_3 998 1004 PF00018 0.697
LIG_SH3_4 431 438 PF00018 0.455
LIG_Sin3_3 835 842 PF02671 0.340
LIG_SUMO_SIM_anti_2 1035 1041 PF11976 0.603
LIG_SUMO_SIM_anti_2 395 401 PF11976 0.469
LIG_SUMO_SIM_anti_2 498 506 PF11976 0.316
LIG_SUMO_SIM_anti_2 755 764 PF11976 0.504
LIG_SUMO_SIM_par_1 476 482 PF11976 0.338
LIG_SUMO_SIM_par_1 558 564 PF11976 0.388
LIG_SUMO_SIM_par_1 755 764 PF11976 0.461
LIG_SUMO_SIM_par_1 808 814 PF11976 0.360
LIG_TYR_ITIM 382 387 PF00017 0.312
LIG_TYR_ITIM 587 592 PF00017 0.621
LIG_WRC_WIRS_1 101 106 PF05994 0.207
LIG_WRC_WIRS_1 280 285 PF05994 0.402
LIG_WRC_WIRS_1 494 499 PF05994 0.388
LIG_WRC_WIRS_1 914 919 PF05994 0.340
LIG_WW_1 296 299 PF00397 0.545
MOD_CDC14_SPxK_1 594 597 PF00782 0.574
MOD_CDK_SPxK_1 591 597 PF00069 0.580
MOD_CK1_1 116 122 PF00069 0.478
MOD_CK1_1 246 252 PF00069 0.384
MOD_CK1_1 359 365 PF00069 0.507
MOD_CK1_1 469 475 PF00069 0.606
MOD_CK1_1 476 482 PF00069 0.531
MOD_CK1_1 495 501 PF00069 0.193
MOD_CK1_1 506 512 PF00069 0.275
MOD_CK1_1 523 529 PF00069 0.213
MOD_CK1_1 630 636 PF00069 0.492
MOD_CK1_1 777 783 PF00069 0.470
MOD_CK1_1 909 915 PF00069 0.255
MOD_CK2_1 40 46 PF00069 0.388
MOD_CK2_1 476 482 PF00069 0.582
MOD_CK2_1 549 555 PF00069 0.584
MOD_CK2_1 630 636 PF00069 0.541
MOD_CMANNOS 667 670 PF00535 0.510
MOD_GlcNHglycan 207 210 PF01048 0.604
MOD_GlcNHglycan 267 270 PF01048 0.439
MOD_GlcNHglycan 312 315 PF01048 0.568
MOD_GlcNHglycan 425 428 PF01048 0.579
MOD_GlcNHglycan 471 474 PF01048 0.600
MOD_GlcNHglycan 486 489 PF01048 0.355
MOD_GSK3_1 1048 1055 PF00069 0.531
MOD_GSK3_1 203 210 PF00069 0.537
MOD_GSK3_1 220 227 PF00069 0.400
MOD_GSK3_1 275 282 PF00069 0.450
MOD_GSK3_1 306 313 PF00069 0.549
MOD_GSK3_1 469 476 PF00069 0.560
MOD_GSK3_1 492 499 PF00069 0.375
MOD_GSK3_1 503 510 PF00069 0.443
MOD_GSK3_1 513 520 PF00069 0.356
MOD_GSK3_1 579 586 PF00069 0.601
MOD_GSK3_1 627 634 PF00069 0.604
MOD_GSK3_1 717 724 PF00069 0.495
MOD_GSK3_1 909 916 PF00069 0.245
MOD_N-GLC_1 630 635 PF02516 0.494
MOD_N-GLC_1 753 758 PF02516 0.429
MOD_NEK2_1 100 105 PF00069 0.458
MOD_NEK2_1 107 112 PF00069 0.255
MOD_NEK2_1 113 118 PF00069 0.453
MOD_NEK2_1 356 361 PF00069 0.499
MOD_NEK2_1 484 489 PF00069 0.328
MOD_NEK2_1 492 497 PF00069 0.399
MOD_NEK2_1 503 508 PF00069 0.381
MOD_NEK2_1 549 554 PF00069 0.599
MOD_NEK2_1 615 620 PF00069 0.485
MOD_NEK2_1 679 684 PF00069 0.349
MOD_NEK2_1 760 765 PF00069 0.468
MOD_NEK2_1 80 85 PF00069 0.507
MOD_NEK2_1 858 863 PF00069 0.471
MOD_NEK2_1 932 937 PF00069 0.539
MOD_NEK2_2 571 576 PF00069 0.315
MOD_NEK2_2 622 627 PF00069 0.454
MOD_NEK2_2 67 72 PF00069 0.554
MOD_PIKK_1 203 209 PF00454 0.612
MOD_PIKK_1 639 645 PF00454 0.565
MOD_PIKK_1 811 817 PF00454 0.572
MOD_PIKK_1 872 878 PF00454 0.406
MOD_PKA_2 235 241 PF00069 0.525
MOD_PKA_2 243 249 PF00069 0.468
MOD_PKA_2 362 368 PF00069 0.438
MOD_PKA_2 423 429 PF00069 0.567
MOD_PKA_2 469 475 PF00069 0.446
MOD_PKA_2 492 498 PF00069 0.428
MOD_PKA_2 639 645 PF00069 0.565
MOD_PKA_2 777 783 PF00069 0.452
MOD_PKA_2 796 802 PF00069 0.214
MOD_PKA_2 859 865 PF00069 0.515
MOD_Plk_1 224 230 PF00069 0.496
MOD_Plk_1 721 727 PF00069 0.461
MOD_Plk_1 753 759 PF00069 0.438
MOD_Plk_4 100 106 PF00069 0.286
MOD_Plk_4 108 114 PF00069 0.330
MOD_Plk_4 323 329 PF00069 0.319
MOD_Plk_4 356 362 PF00069 0.499
MOD_Plk_4 364 370 PF00069 0.511
MOD_Plk_4 496 502 PF00069 0.343
MOD_Plk_4 507 513 PF00069 0.338
MOD_Plk_4 523 529 PF00069 0.312
MOD_Plk_4 585 591 PF00069 0.541
MOD_Plk_4 607 613 PF00069 0.516
MOD_Plk_4 754 760 PF00069 0.399
MOD_Plk_4 859 865 PF00069 0.468
MOD_Plk_4 888 894 PF00069 0.340
MOD_Plk_4 909 915 PF00069 0.328
MOD_Plk_4 918 924 PF00069 0.366
MOD_ProDKin_1 1042 1048 PF00069 0.640
MOD_ProDKin_1 174 180 PF00069 0.724
MOD_ProDKin_1 452 458 PF00069 0.639
MOD_ProDKin_1 473 479 PF00069 0.572
MOD_ProDKin_1 520 526 PF00069 0.388
MOD_ProDKin_1 591 597 PF00069 0.648
MOD_ProDKin_1 631 637 PF00069 0.556
MOD_ProDKin_1 92 98 PF00069 0.327
TRG_DiLeu_BaEn_1 555 560 PF01217 0.388
TRG_DiLeu_BaLyEn_6 289 294 PF01217 0.500
TRG_DiLeu_BaLyEn_6 554 559 PF01217 0.388
TRG_DiLeu_BaLyEn_6 955 960 PF01217 0.578
TRG_ENDOCYTIC_2 384 387 PF00928 0.352
TRG_ENDOCYTIC_2 525 528 PF00928 0.338
TRG_ENDOCYTIC_2 589 592 PF00928 0.553
TRG_ENDOCYTIC_2 606 609 PF00928 0.509
TRG_ENDOCYTIC_2 828 831 PF00928 0.516
TRG_ER_diArg_1 1021 1024 PF00400 0.596
TRG_ER_diArg_1 123 126 PF00400 0.525
TRG_ER_diArg_1 342 345 PF00400 0.530
TRG_ER_diArg_1 619 621 PF00400 0.510
TRG_ER_diArg_1 700 702 PF00400 0.546
TRG_ER_diArg_1 732 734 PF00400 0.515
TRG_ER_diArg_1 746 749 PF00400 0.378
TRG_ER_diArg_1 86 88 PF00400 0.514
TRG_NES_CRM1_1 581 596 PF08389 0.565
TRG_Pf-PMV_PEXEL_1 1027 1032 PF00026 0.401
TRG_Pf-PMV_PEXEL_1 551 555 PF00026 0.586

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PFJ7 Leptomonas seymouri 38% 98%
A0A3Q8IJR8 Leishmania donovani 89% 100%
A4HIW7 Leishmania braziliensis 73% 100%
A4I697 Leishmania infantum 90% 100%
Q4Q6R1 Leishmania major 88% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS