Lipase_3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B1E4_LEIMU

TriTrypDb:

LmxM.29.3700

Length:

857

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9B1E4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1E4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	622	626	PF00656	0.228
CLV_C14_Caspase3-7	748	752	PF00656	0.403
CLV_C14_Caspase3-7	807	811	PF00656	0.331
CLV_MEL_PAP_1	567	573	PF00089	0.519
CLV_NRD_NRD_1	268	270	PF00675	0.605
CLV_NRD_NRD_1	324	326	PF00675	0.495
CLV_NRD_NRD_1	411	413	PF00675	0.422
CLV_NRD_NRD_1	460	462	PF00675	0.372
CLV_NRD_NRD_1	492	494	PF00675	0.455
CLV_NRD_NRD_1	530	532	PF00675	0.409
CLV_PCSK_KEX2_1	223	225	PF00082	0.363
CLV_PCSK_KEX2_1	239	241	PF00082	0.349
CLV_PCSK_KEX2_1	313	315	PF00082	0.386
CLV_PCSK_KEX2_1	323	325	PF00082	0.428
CLV_PCSK_KEX2_1	411	413	PF00082	0.443
CLV_PCSK_KEX2_1	462	464	PF00082	0.417
CLV_PCSK_KEX2_1	492	494	PF00082	0.450
CLV_PCSK_KEX2_1	530	532	PF00082	0.435
CLV_PCSK_KEX2_1	768	770	PF00082	0.577
CLV_PCSK_PC1ET2_1	223	225	PF00082	0.363
CLV_PCSK_PC1ET2_1	239	241	PF00082	0.349
CLV_PCSK_PC1ET2_1	313	315	PF00082	0.386
CLV_PCSK_PC1ET2_1	462	464	PF00082	0.417
CLV_PCSK_PC1ET2_1	768	770	PF00082	0.577
CLV_PCSK_PC7_1	235	241	PF00082	0.495
CLV_PCSK_SKI1_1	473	477	PF00082	0.311
CLV_PCSK_SKI1_1	536	540	PF00082	0.366
CLV_PCSK_SKI1_1	544	548	PF00082	0.276
CLV_PCSK_SKI1_1	716	720	PF00082	0.576
CLV_PCSK_SKI1_1	724	728	PF00082	0.593
DEG_APCC_DBOX_1	147	155	PF00400	0.521
DEG_Nend_UBRbox_3	1	3	PF02207	0.722
DEG_SPOP_SBC_1	745	749	PF00917	0.248
DOC_CDC14_PxL_1	254	262	PF14671	0.305
DOC_CKS1_1	571	576	PF01111	0.389
DOC_CYCLIN_RxL_1	499	507	PF00134	0.725
DOC_CYCLIN_yCln2_LP_2	476	482	PF00134	0.696
DOC_CYCLIN_yCln2_LP_2	774	780	PF00134	0.429
DOC_MAPK_FxFP_2	14	17	PF00069	0.750
DOC_MAPK_gen_1	223	229	PF00069	0.564
DOC_MAPK_gen_1	269	276	PF00069	0.447
DOC_MAPK_gen_1	469	478	PF00069	0.653
DOC_MAPK_gen_1	768	776	PF00069	0.395
DOC_MAPK_JIP1_4	635	641	PF00069	0.430
DOC_MAPK_MEF2A_6	148	155	PF00069	0.566
DOC_MAPK_MEF2A_6	769	778	PF00069	0.373
DOC_MAPK_RevD_3	399	413	PF00069	0.434
DOC_MAPK_RevD_3	448	463	PF00069	0.349
DOC_PP1_RVXF_1	334	340	PF00149	0.644
DOC_PP2B_LxvP_1	476	479	PF13499	0.691
DOC_PP2B_LxvP_1	774	777	PF13499	0.436
DOC_PP2B_PxIxI_1	705	711	PF00149	0.382
DOC_PP4_FxxP_1	14	17	PF00568	0.750
DOC_PP4_FxxP_1	178	181	PF00568	0.370
DOC_PP4_FxxP_1	571	574	PF00568	0.402
DOC_PP4_FxxP_1	781	784	PF00568	0.322
DOC_SPAK_OSR1_1	531	535	PF12202	0.640
DOC_USP7_MATH_1	10	14	PF00917	0.797
DOC_USP7_MATH_1	17	21	PF00917	0.704
DOC_USP7_MATH_1	326	330	PF00917	0.497
DOC_USP7_MATH_1	392	396	PF00917	0.398
DOC_USP7_MATH_1	745	749	PF00917	0.416
DOC_USP7_MATH_1	94	98	PF00917	0.714
DOC_WW_Pin1_4	108	113	PF00397	0.678
DOC_WW_Pin1_4	176	181	PF00397	0.289
DOC_WW_Pin1_4	382	387	PF00397	0.449
DOC_WW_Pin1_4	570	575	PF00397	0.437
DOC_WW_Pin1_4	578	583	PF00397	0.441
DOC_WW_Pin1_4	584	589	PF00397	0.433
DOC_WW_Pin1_4	702	707	PF00397	0.336
LIG_14-3-3_CanoR_1	217	223	PF00244	0.582
LIG_14-3-3_CanoR_1	269	274	PF00244	0.455
LIG_14-3-3_CanoR_1	325	331	PF00244	0.567
LIG_14-3-3_CanoR_1	463	468	PF00244	0.668
LIG_14-3-3_CanoR_1	570	574	PF00244	0.448
LIG_14-3-3_CanoR_1	681	686	PF00244	0.348
LIG_14-3-3_CanoR_1	769	777	PF00244	0.404
LIG_14-3-3_CanoR_1	803	809	PF00244	0.355
LIG_14-3-3_CanoR_1	834	839	PF00244	0.341
LIG_APCC_ABBA_1	683	688	PF00400	0.390
LIG_BRCT_BRCA1_1	143	147	PF00533	0.543
LIG_BRCT_BRCA1_1	195	199	PF00533	0.289
LIG_BRCT_BRCA1_1	359	363	PF00533	0.408
LIG_BRCT_BRCA1_1	722	726	PF00533	0.317
LIG_EH1_1	246	254	PF00400	0.468
LIG_eIF4E_1	156	162	PF01652	0.331
LIG_eIF4E_1	247	253	PF01652	0.450
LIG_eIF4E_1	419	425	PF01652	0.337
LIG_FHA_1	150	156	PF00498	0.386
LIG_FHA_1	168	174	PF00498	0.223
LIG_FHA_1	287	293	PF00498	0.405
LIG_FHA_1	35	41	PF00498	0.796
LIG_FHA_1	383	389	PF00498	0.458
LIG_FHA_1	442	448	PF00498	0.359
LIG_FHA_1	585	591	PF00498	0.401
LIG_FHA_1	784	790	PF00498	0.380
LIG_FHA_2	342	348	PF00498	0.549
LIG_FHA_2	466	472	PF00498	0.604
LIG_FHA_2	49	55	PF00498	0.752
LIG_FHA_2	620	626	PF00498	0.241
LIG_FHA_2	732	738	PF00498	0.445
LIG_FHA_2	835	841	PF00498	0.323
LIG_FHA_2	843	849	PF00498	0.363
LIG_GBD_Chelix_1	205	213	PF00786	0.480
LIG_GBD_Chelix_1	425	433	PF00786	0.480
LIG_LIR_Apic_2	125	129	PF02991	0.722
LIG_LIR_Apic_2	13	17	PF02991	0.749
LIG_LIR_Gen_1	130	139	PF02991	0.555
LIG_LIR_Gen_1	170	178	PF02991	0.324
LIG_LIR_Gen_1	191	200	PF02991	0.299
LIG_LIR_Gen_1	202	211	PF02991	0.282
LIG_LIR_Gen_1	355	365	PF02991	0.506
LIG_LIR_Gen_1	405	410	PF02991	0.463
LIG_LIR_Gen_1	662	671	PF02991	0.323
LIG_LIR_Gen_1	786	793	PF02991	0.425
LIG_LIR_Gen_1	804	812	PF02991	0.391
LIG_LIR_Nem_3	120	126	PF02991	0.727
LIG_LIR_Nem_3	130	134	PF02991	0.568
LIG_LIR_Nem_3	144	150	PF02991	0.539
LIG_LIR_Nem_3	170	174	PF02991	0.304
LIG_LIR_Nem_3	191	197	PF02991	0.285
LIG_LIR_Nem_3	202	206	PF02991	0.309
LIG_LIR_Nem_3	355	361	PF02991	0.564
LIG_LIR_Nem_3	387	393	PF02991	0.355
LIG_LIR_Nem_3	405	409	PF02991	0.245
LIG_LIR_Nem_3	594	600	PF02991	0.371
LIG_LIR_Nem_3	66	70	PF02991	0.741
LIG_LIR_Nem_3	660	664	PF02991	0.317
LIG_LIR_Nem_3	668	674	PF02991	0.325
LIG_LIR_Nem_3	684	689	PF02991	0.316
LIG_LIR_Nem_3	74	79	PF02991	0.655
LIG_LIR_Nem_3	786	791	PF02991	0.386
LIG_LIR_Nem_3	804	809	PF02991	0.413
LIG_LIR_Nem_3	85	91	PF02991	0.564
LIG_MLH1_MIPbox_1	195	199	PF16413	0.289
LIG_MLH1_MIPbox_1	722	726	PF16413	0.239
LIG_NRBOX	150	156	PF00104	0.378
LIG_NRBOX	423	429	PF00104	0.188
LIG_PCNA_PIPBox_1	213	222	PF02747	0.632
LIG_Pex14_2	195	199	PF04695	0.355
LIG_Pex14_2	628	632	PF04695	0.321
LIG_Pex14_2	725	729	PF04695	0.379
LIG_PTB_Apo_2	75	82	PF02174	0.659
LIG_PTB_Phospho_1	75	81	PF10480	0.662
LIG_REV1ctd_RIR_1	723	730	PF16727	0.308
LIG_SH2_CRK	126	130	PF00017	0.710
LIG_SH2_CRK	280	284	PF00017	0.296
LIG_SH2_CRK	358	362	PF00017	0.562
LIG_SH2_CRK	419	423	PF00017	0.404
LIG_SH2_CRK	671	675	PF00017	0.303
LIG_SH2_GRB2like	280	283	PF00017	0.345
LIG_SH2_GRB2like	76	79	PF00017	0.683
LIG_SH2_NCK_1	126	130	PF00017	0.710
LIG_SH2_NCK_1	280	284	PF00017	0.353
LIG_SH2_NCK_1	91	95	PF00017	0.722
LIG_SH2_PTP2	664	667	PF00017	0.394
LIG_SH2_PTP2	788	791	PF00017	0.242
LIG_SH2_SRC	121	124	PF00017	0.756
LIG_SH2_SRC	126	129	PF00017	0.477
LIG_SH2_SRC	280	283	PF00017	0.353
LIG_SH2_SRC	65	68	PF00017	0.750
LIG_SH2_SRC	664	667	PF00017	0.387
LIG_SH2_SRC	71	74	PF00017	0.671
LIG_SH2_SRC	808	811	PF00017	0.330
LIG_SH2_STAP1	169	173	PF00017	0.509
LIG_SH2_STAP1	27	31	PF00017	0.783
LIG_SH2_STAP1	280	284	PF00017	0.325
LIG_SH2_STAP1	296	300	PF00017	0.262
LIG_SH2_STAP1	35	39	PF00017	0.705
LIG_SH2_STAP1	419	423	PF00017	0.361
LIG_SH2_STAP1	480	484	PF00017	0.726
LIG_SH2_STAP1	648	652	PF00017	0.437
LIG_SH2_STAP1	766	770	PF00017	0.335
LIG_SH2_STAT3	275	278	PF00017	0.385
LIG_SH2_STAT3	374	377	PF00017	0.398
LIG_SH2_STAT3	480	483	PF00017	0.677
LIG_SH2_STAT3	79	82	PF00017	0.686
LIG_SH2_STAT5	150	153	PF00017	0.341
LIG_SH2_STAT5	156	159	PF00017	0.317
LIG_SH2_STAT5	169	172	PF00017	0.271
LIG_SH2_STAT5	194	197	PF00017	0.447
LIG_SH2_STAT5	200	203	PF00017	0.447
LIG_SH2_STAT5	236	239	PF00017	0.602
LIG_SH2_STAT5	244	247	PF00017	0.349
LIG_SH2_STAT5	275	278	PF00017	0.370
LIG_SH2_STAT5	35	38	PF00017	0.771
LIG_SH2_STAT5	382	385	PF00017	0.419
LIG_SH2_STAT5	402	405	PF00017	0.308
LIG_SH2_STAT5	480	483	PF00017	0.724
LIG_SH2_STAT5	497	500	PF00017	0.613
LIG_SH2_STAT5	508	511	PF00017	0.652
LIG_SH2_STAT5	618	621	PF00017	0.295
LIG_SH2_STAT5	648	651	PF00017	0.461
LIG_SH2_STAT5	664	667	PF00017	0.270
LIG_SH2_STAT5	742	745	PF00017	0.357
LIG_SH2_STAT5	788	791	PF00017	0.381
LIG_SH2_STAT5	808	811	PF00017	0.291
LIG_SH2_STAT5	841	844	PF00017	0.407
LIG_SH2_STAT5	91	94	PF00017	0.742
LIG_SH3_3	177	183	PF00018	0.421
LIG_SH3_3	252	258	PF00018	0.447
LIG_SH3_3	37	43	PF00018	0.761
LIG_SH3_3	385	391	PF00018	0.337
LIG_SH3_3	585	591	PF00018	0.429
LIG_SH3_3	641	647	PF00018	0.422
LIG_SUMO_SIM_anti_2	395	400	PF11976	0.387
LIG_SUMO_SIM_anti_2	405	411	PF11976	0.542
LIG_SUMO_SIM_anti_2	421	426	PF11976	0.150
LIG_SUMO_SIM_anti_2	751	760	PF11976	0.367
LIG_SUMO_SIM_par_1	572	578	PF11976	0.261
LIG_SUMO_SIM_par_1	672	678	PF11976	0.389
LIG_SUMO_SIM_par_1	751	760	PF11976	0.338
LIG_TYR_ITIM	245	250	PF00017	0.389
LIG_TYR_ITIM	356	361	PF00017	0.629
LIG_TYR_ITSM	784	791	PF00017	0.223
LIG_UBA3_1	215	223	PF00899	0.441
LIG_UBA3_1	505	510	PF00899	0.652
LIG_Vh1_VBS_1	198	216	PF01044	0.402
LIG_WRC_WIRS_1	139	144	PF05994	0.577
LIG_WRC_WIRS_1	189	194	PF05994	0.362
LIG_WRC_WIRS_1	200	205	PF05994	0.288
LIG_WW_1	128	131	PF00397	0.682
MOD_CK1_1	309	315	PF00069	0.546
MOD_CK1_1	380	386	PF00069	0.436
MOD_CK1_1	405	411	PF00069	0.488
MOD_CK1_1	578	584	PF00069	0.375
MOD_CK1_1	634	640	PF00069	0.414
MOD_CK1_1	749	755	PF00069	0.432
MOD_CK1_1	804	810	PF00069	0.394
MOD_CK1_1	815	821	PF00069	0.363
MOD_CK2_1	326	332	PF00069	0.642
MOD_CK2_1	341	347	PF00069	0.543
MOD_CK2_1	465	471	PF00069	0.608
MOD_CK2_1	48	54	PF00069	0.741
MOD_CK2_1	834	840	PF00069	0.272
MOD_GlcNHglycan	143	146	PF01048	0.300
MOD_GlcNHglycan	308	311	PF01048	0.413
MOD_GlcNHglycan	577	580	PF01048	0.516
MOD_GlcNHglycan	601	604	PF01048	0.521
MOD_GlcNHglycan	748	751	PF01048	0.676
MOD_GlcNHglycan	752	755	PF01048	0.645
MOD_GlcNHglycan	770	773	PF01048	0.554
MOD_GlcNHglycan	799	802	PF01048	0.618
MOD_GlcNHglycan	96	99	PF01048	0.520
MOD_GSK3_1	23	30	PF00069	0.777
MOD_GSK3_1	34	41	PF00069	0.735
MOD_GSK3_1	357	364	PF00069	0.507
MOD_GSK3_1	378	385	PF00069	0.405
MOD_GSK3_1	627	634	PF00069	0.404
MOD_GSK3_1	745	752	PF00069	0.452
MOD_GSK3_1	783	790	PF00069	0.360
MOD_GSK3_1	797	804	PF00069	0.331
MOD_GSK3_1	808	815	PF00069	0.314
MOD_N-GLC_1	10	15	PF02516	0.591
MOD_N-GLC_1	108	113	PF02516	0.490
MOD_N-GLC_1	167	172	PF02516	0.368
MOD_N-GLC_1	17	22	PF02516	0.447
MOD_N-GLC_1	54	59	PF02516	0.574
MOD_N-GLC_1	657	662	PF02516	0.591
MOD_N-GLC_1	794	799	PF02516	0.605
MOD_N-GLC_1	825	830	PF02516	0.639
MOD_N-GLC_2	830	832	PF02516	0.588
MOD_NEK2_1	167	172	PF00069	0.381
MOD_NEK2_1	199	204	PF00069	0.342
MOD_NEK2_1	286	291	PF00069	0.408
MOD_NEK2_1	357	362	PF00069	0.518
MOD_NEK2_1	431	436	PF00069	0.426
MOD_NEK2_1	532	537	PF00069	0.643
MOD_NEK2_1	561	566	PF00069	0.508
MOD_NEK2_1	616	621	PF00069	0.309
MOD_NEK2_1	812	817	PF00069	0.272
MOD_NEK2_1	842	847	PF00069	0.406
MOD_NEK2_2	193	198	PF00069	0.213
MOD_NEK2_2	369	374	PF00069	0.434
MOD_PIKK_1	48	54	PF00454	0.798
MOD_PIKK_1	486	492	PF00454	0.544
MOD_PIKK_1	794	800	PF00454	0.374
MOD_PK_1	787	793	PF00069	0.319
MOD_PKA_1	269	275	PF00069	0.451
MOD_PKA_1	463	469	PF00069	0.669
MOD_PKA_1	768	774	PF00069	0.404
MOD_PKA_2	569	575	PF00069	0.423
MOD_PKA_2	768	774	PF00069	0.395
MOD_PKA_2	833	839	PF00069	0.329
MOD_PKB_1	461	469	PF00069	0.635
MOD_Plk_1	167	173	PF00069	0.367
MOD_Plk_1	23	29	PF00069	0.799
MOD_Plk_1	657	663	PF00069	0.388
MOD_Plk_1	812	818	PF00069	0.298
MOD_Plk_2-3	122	128	PF00069	0.739
MOD_Plk_2-3	23	29	PF00069	0.804
MOD_Plk_4	138	144	PF00069	0.555
MOD_Plk_4	149	155	PF00069	0.323
MOD_Plk_4	199	205	PF00069	0.363
MOD_Plk_4	269	275	PF00069	0.393
MOD_Plk_4	286	292	PF00069	0.230
MOD_Plk_4	341	347	PF00069	0.554
MOD_Plk_4	352	358	PF00069	0.547
MOD_Plk_4	384	390	PF00069	0.308
MOD_Plk_4	402	408	PF00069	0.293
MOD_Plk_4	493	499	PF00069	0.699
MOD_Plk_4	627	633	PF00069	0.371
MOD_Plk_4	634	640	PF00069	0.328
MOD_Plk_4	681	687	PF00069	0.346
MOD_Plk_4	71	77	PF00069	0.735
MOD_Plk_4	738	744	PF00069	0.323
MOD_Plk_4	834	840	PF00069	0.386
MOD_ProDKin_1	108	114	PF00069	0.675
MOD_ProDKin_1	176	182	PF00069	0.292
MOD_ProDKin_1	382	388	PF00069	0.450
MOD_ProDKin_1	570	576	PF00069	0.433
MOD_ProDKin_1	578	584	PF00069	0.442
MOD_ProDKin_1	702	708	PF00069	0.332
MOD_SUMO_rev_2	485	489	PF00179	0.672
MOD_SUMO_rev_2	733	741	PF00179	0.300
TRG_DiLeu_BaLyEn_6	255	260	PF01217	0.480
TRG_DiLeu_BaLyEn_6	703	708	PF01217	0.416
TRG_ENDOCYTIC_2	131	134	PF00928	0.585
TRG_ENDOCYTIC_2	150	153	PF00928	0.190
TRG_ENDOCYTIC_2	175	178	PF00928	0.353
TRG_ENDOCYTIC_2	194	197	PF00928	0.415
TRG_ENDOCYTIC_2	200	203	PF00928	0.399
TRG_ENDOCYTIC_2	247	250	PF00928	0.340
TRG_ENDOCYTIC_2	280	283	PF00928	0.290
TRG_ENDOCYTIC_2	296	299	PF00928	0.250
TRG_ENDOCYTIC_2	358	361	PF00928	0.520
TRG_ENDOCYTIC_2	419	422	PF00928	0.307
TRG_ENDOCYTIC_2	664	667	PF00928	0.319
TRG_ENDOCYTIC_2	671	674	PF00928	0.300
TRG_ENDOCYTIC_2	788	791	PF00928	0.325
TRG_ER_diArg_1	322	325	PF00400	0.686
TRG_ER_diArg_1	410	412	PF00400	0.633
TRG_ER_diArg_1	492	494	PF00400	0.696
TRG_ER_diArg_1	530	532	PF00400	0.636
TRG_ER_diArg_1	722	725	PF00400	0.451
TRG_NLS_MonoCore_2	460	465	PF00514	0.645
TRG_NLS_MonoExtN_4	461	466	PF00514	0.684
TRG_Pf-PMV_PEXEL_1	502	507	PF00026	0.493
TRG_Pf-PMV_PEXEL_1	687	691	PF00026	0.567

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHB4	Leptomonas seymouri	70%	100%
A0A1X0P1U6	Trypanosomatidae	50%	100%
A0A3S7X3Y7	Leishmania donovani	91%	100%
A0A422NAB6	Trypanosoma rangeli	46%	100%
A4HIV7	Leishmania braziliensis	78%	100%
A4I5Z7	Leishmania infantum	91%	100%
C9ZRI1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
Q4Q6R8	Leishmania major	89%	100%
V5BX06	Trypanosoma cruzi	47%	100%