Flagellar associated protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B1E2_LEIMU

TriTrypDb:

LmxM.29.3680

Length:

442

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B1E2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1E2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	198	202	PF00656	0.527
CLV_C14_Caspase3-7	227	231	PF00656	0.555
CLV_NRD_NRD_1	122	124	PF00675	0.602
CLV_NRD_NRD_1	137	139	PF00675	0.577
CLV_NRD_NRD_1	193	195	PF00675	0.519
CLV_NRD_NRD_1	246	248	PF00675	0.605
CLV_NRD_NRD_1	421	423	PF00675	0.582
CLV_NRD_NRD_1	44	46	PF00675	0.466
CLV_NRD_NRD_1	60	62	PF00675	0.607
CLV_PCSK_KEX2_1	122	124	PF00082	0.594
CLV_PCSK_KEX2_1	137	139	PF00082	0.548
CLV_PCSK_KEX2_1	192	194	PF00082	0.514
CLV_PCSK_KEX2_1	288	290	PF00082	0.543
CLV_PCSK_KEX2_1	421	423	PF00082	0.582
CLV_PCSK_KEX2_1	43	45	PF00082	0.423
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.541
CLV_PCSK_PC1ET2_1	288	290	PF00082	0.477
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.423
CLV_PCSK_SKI1_1	133	137	PF00082	0.558
CLV_PCSK_SKI1_1	142	146	PF00082	0.594
CLV_PCSK_SKI1_1	170	174	PF00082	0.503
CLV_PCSK_SKI1_1	179	183	PF00082	0.498
CLV_PCSK_SKI1_1	274	278	PF00082	0.437
CLV_PCSK_SKI1_1	288	292	PF00082	0.443
CLV_PCSK_SKI1_1	431	435	PF00082	0.517
DEG_Nend_UBRbox_1	1	4	PF02207	0.655
DOC_CYCLIN_RxL_1	426	436	PF00134	0.510
DOC_MAPK_gen_1	178	186	PF00069	0.515
DOC_MAPK_gen_1	353	362	PF00069	0.477
DOC_PP2B_LxvP_1	319	322	PF13499	0.458
DOC_USP7_MATH_1	241	245	PF00917	0.553
DOC_USP7_UBL2_3	188	192	PF12436	0.538
LIG_14-3-3_CanoR_1	193	200	PF00244	0.596
LIG_EH1_1	328	336	PF00400	0.522
LIG_FHA_1	119	125	PF00498	0.461
LIG_FHA_1	185	191	PF00498	0.595
LIG_FHA_1	357	363	PF00498	0.569
LIG_FHA_1	376	382	PF00498	0.562
LIG_FHA_2	194	200	PF00498	0.538
LIG_FHA_2	254	260	PF00498	0.574
LIG_FHA_2	262	268	PF00498	0.566
LIG_FHA_2	349	355	PF00498	0.482
LIG_FHA_2	364	370	PF00498	0.426
LIG_FHA_2	4	10	PF00498	0.494
LIG_LIR_Gen_1	201	210	PF02991	0.564
LIG_LIR_Nem_3	201	207	PF02991	0.563
LIG_LIR_Nem_3	52	56	PF02991	0.521
LIG_LIR_Nem_3	73	78	PF02991	0.599
LIG_Pex14_2	130	134	PF04695	0.408
LIG_SH2_CRK	346	350	PF00017	0.470
LIG_SH2_CRK	75	79	PF00017	0.634
LIG_SH2_STAP1	429	433	PF00017	0.328
LIG_SH2_STAT5	58	61	PF00017	0.513
LIG_SH3_3	36	42	PF00018	0.429
LIG_SH3_5	54	58	PF00018	0.435
LIG_SUMO_SIM_anti_2	359	364	PF11976	0.383
LIG_SUMO_SIM_par_1	182	187	PF11976	0.573
LIG_SUMO_SIM_par_1	358	364	PF11976	0.577
LIG_TRAF2_1	217	220	PF00917	0.582
LIG_TRAF2_1	336	339	PF00917	0.449
LIG_TRAF2_1	391	394	PF00917	0.453
LIG_UBA3_1	143	150	PF00899	0.655
LIG_UBA3_1	183	188	PF00899	0.522
LIG_UBA3_1	362	370	PF00899	0.475
LIG_UBA3_1	78	87	PF00899	0.570
MOD_CK1_1	35	41	PF00069	0.668
MOD_CK1_1	361	367	PF00069	0.563
MOD_CK2_1	151	157	PF00069	0.555
MOD_CK2_1	253	259	PF00069	0.575
MOD_CK2_1	261	267	PF00069	0.541
MOD_CK2_1	3	9	PF00069	0.440
MOD_CK2_1	312	318	PF00069	0.560
MOD_CK2_1	348	354	PF00069	0.510
MOD_CK2_1	363	369	PF00069	0.522
MOD_CK2_1	429	435	PF00069	0.571
MOD_Cter_Amidation	59	62	PF01082	0.651
MOD_GlcNHglycan	251	256	PF01048	0.578
MOD_GlcNHglycan	399	402	PF01048	0.487
MOD_GSK3_1	129	136	PF00069	0.588
MOD_GSK3_1	211	218	PF00069	0.519
MOD_GSK3_1	28	35	PF00069	0.619
MOD_GSK3_1	429	436	PF00069	0.507
MOD_N-GLC_1	68	73	PF02516	0.582
MOD_NEK2_1	184	189	PF00069	0.491
MOD_NEK2_1	356	361	PF00069	0.517
MOD_NEK2_1	363	368	PF00069	0.532
MOD_NEK2_1	433	438	PF00069	0.514
MOD_NEK2_1	49	54	PF00069	0.606
MOD_PIKK_1	312	318	PF00454	0.543
MOD_PK_1	358	364	PF00069	0.570
MOD_PKA_1	192	198	PF00069	0.567
MOD_PKA_2	192	198	PF00069	0.548
MOD_PKA_2	211	217	PF00069	0.316
MOD_PKA_2	4	10	PF00069	0.522
MOD_PKA_2	63	69	PF00069	0.580
MOD_Plk_1	101	107	PF00069	0.517
MOD_Plk_1	151	157	PF00069	0.593
MOD_Plk_1	212	218	PF00069	0.513
MOD_Plk_1	261	267	PF00069	0.580
MOD_Plk_1	429	435	PF00069	0.413
MOD_Plk_1	68	74	PF00069	0.580
MOD_Plk_2-3	22	28	PF00069	0.335
MOD_Plk_2-3	253	259	PF00069	0.546
MOD_Plk_4	179	185	PF00069	0.344
MOD_Plk_4	199	205	PF00069	0.549
MOD_Plk_4	35	41	PF00069	0.672
MOD_Plk_4	358	364	PF00069	0.532
MOD_Plk_4	429	435	PF00069	0.483
MOD_SUMO_for_1	257	260	PF00179	0.516
MOD_SUMO_rev_2	126	135	PF00179	0.649
MOD_SUMO_rev_2	166	172	PF00179	0.589
TRG_DiLeu_BaEn_1	102	107	PF01217	0.601
TRG_DiLeu_BaEn_1	369	374	PF01217	0.413
TRG_DiLeu_LyEn_5	102	107	PF01217	0.594
TRG_ENDOCYTIC_2	204	207	PF00928	0.530
TRG_ENDOCYTIC_2	346	349	PF00928	0.438
TRG_ENDOCYTIC_2	75	78	PF00928	0.618
TRG_ER_diArg_1	122	124	PF00400	0.632
TRG_ER_diArg_1	137	140	PF00400	0.585
TRG_ER_diArg_1	161	164	PF00400	0.617
TRG_NES_CRM1_1	354	369	PF08389	0.376
TRG_NLS_Bipartite_1	43	65	PF00514	0.366
TRG_NLS_MonoCore_2	60	65	PF00514	0.604
TRG_Pf-PMV_PEXEL_1	105	109	PF00026	0.577
TRG_Pf-PMV_PEXEL_1	122	126	PF00026	0.476
TRG_Pf-PMV_PEXEL_1	173	177	PF00026	0.614
TRG_Pf-PMV_PEXEL_1	431	435	PF00026	0.543

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II28	Leptomonas seymouri	67%	100%
A0A0S4JHV1	Bodo saltans	28%	72%
A0A1X0P1A4	Trypanosomatidae	39%	99%
A0A3Q8ISB1	Leishmania donovani	88%	100%
A0A422NMD4	Trypanosoma rangeli	37%	98%
A4HIV4	Leishmania braziliensis	70%	100%
A4I659	Leishmania infantum	88%	100%
C9ZRH9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	97%
Q4Q6S0	Leishmania major	85%	100%
V5B747	Trypanosoma cruzi	38%	98%