Putative CYC2-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CYC2-like protein, putative

Species:

Leishmania mexicana

UniProt:

E9B1D7_LEIMU

TriTrypDb:

LmxM.29.3630

Length:

247

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B1D7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1D7

Function

Biological processes
Term	Name	Level	Count
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	6	11
GO:0001932	regulation of protein phosphorylation	7	11
GO:0019220	regulation of phosphate metabolic process	6	11
GO:0019222	regulation of metabolic process	3	11
GO:0031323	regulation of cellular metabolic process	4	11
GO:0031399	regulation of protein modification process	6	11
GO:0042325	regulation of phosphorylation	7	11
GO:0043549	regulation of kinase activity	5	11
GO:0045859	regulation of protein kinase activity	6	11
GO:0050789	regulation of biological process	2	11
GO:0050790	regulation of catalytic activity	3	11
GO:0050794	regulation of cellular process	3	11
GO:0051171	regulation of nitrogen compound metabolic process	4	11
GO:0051174	regulation of phosphorus metabolic process	5	11
GO:0051246	regulation of protein metabolic process	5	11
GO:0051338	regulation of transferase activity	4	11
GO:0051726	regulation of cell cycle	4	11
GO:0060255	regulation of macromolecule metabolic process	4	11
GO:0065007	biological regulation	1	11
GO:0065009	regulation of molecular function	2	11
GO:0071900	regulation of protein serine/threonine kinase activity	7	11
GO:0080090	regulation of primary metabolic process	4	11
GO:1904029	regulation of cyclin-dependent protein kinase activity	5	11

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0019899	enzyme binding	3	11
GO:0019900	kinase binding	4	11
GO:0019901	protein kinase binding	5	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	38	42	PF00656	0.503
CLV_NRD_NRD_1	94	96	PF00675	0.264
CLV_PCSK_KEX2_1	94	96	PF00082	0.264
CLV_PCSK_SKI1_1	110	114	PF00082	0.216
CLV_PCSK_SKI1_1	74	78	PF00082	0.325
CLV_PCSK_SKI1_1	95	99	PF00082	0.262
DEG_APCC_DBOX_1	109	117	PF00400	0.264
DEG_SCF_FBW7_1	7	14	PF00400	0.258
DOC_CYCLIN_RxL_1	104	114	PF00134	0.223
DOC_MAPK_HePTP_8	139	151	PF00069	0.357
DOC_MAPK_MEF2A_6	142	151	PF00069	0.300
DOC_PP2B_PxIxI_1	63	69	PF00149	0.300
DOC_PP4_FxxP_1	232	235	PF00568	0.639
DOC_PP4_FxxP_1	240	243	PF00568	0.524
DOC_USP7_MATH_1	235	239	PF00917	0.607
DOC_USP7_MATH_1	36	40	PF00917	0.527
DOC_USP7_MATH_1	5	9	PF00917	0.581
DOC_WW_Pin1_4	204	209	PF00397	0.491
DOC_WW_Pin1_4	7	12	PF00397	0.439
DOC_WW_Pin1_4	79	84	PF00397	0.288
LIG_14-3-3_CanoR_1	110	120	PF00244	0.246
LIG_14-3-3_CanoR_1	150	158	PF00244	0.409
LIG_14-3-3_CanoR_1	176	183	PF00244	0.447
LIG_14-3-3_CanoR_1	195	203	PF00244	0.497
LIG_14-3-3_CanoR_1	74	79	PF00244	0.315
LIG_BIR_II_1	1	5	PF00653	0.436
LIG_BRCT_BRCA1_1	53	57	PF00533	0.284
LIG_Clathr_ClatBox_1	155	159	PF01394	0.444
LIG_deltaCOP1_diTrp_1	230	240	PF00928	0.615
LIG_FHA_1	112	118	PF00498	0.253
LIG_FHA_1	12	18	PF00498	0.339
LIG_FHA_1	167	173	PF00498	0.248
LIG_FHA_1	70	76	PF00498	0.407
LIG_FHA_2	138	144	PF00498	0.313
LIG_FHA_2	205	211	PF00498	0.486
LIG_FHA_2	36	42	PF00498	0.545
LIG_LIR_Apic_2	230	235	PF02991	0.554
LIG_LIR_Apic_2	238	243	PF02991	0.550
LIG_LIR_Gen_1	131	139	PF02991	0.288
LIG_LIR_Gen_1	165	175	PF02991	0.442
LIG_LIR_Nem_3	131	136	PF02991	0.279
LIG_LIR_Nem_3	165	170	PF02991	0.312
LIG_LIR_Nem_3	230	236	PF02991	0.654
LIG_PCNA_yPIPBox_3	9	20	PF02747	0.449
LIG_Pex14_2	221	225	PF04695	0.555
LIG_SH2_CRK	167	171	PF00017	0.301
LIG_SH2_NCK_1	133	137	PF00017	0.250
LIG_SH2_SRC	133	136	PF00017	0.319
LIG_SH2_STAP1	71	75	PF00017	0.289
LIG_SH2_STAT5	23	26	PF00017	0.291
LIG_SH2_STAT5	71	74	PF00017	0.289
LIG_SH2_STAT5	92	95	PF00017	0.278
LIG_SH3_3	41	47	PF00018	0.563
LIG_SUMO_SIM_par_1	14	21	PF11976	0.420
LIG_SUMO_SIM_par_1	168	173	PF11976	0.487
MOD_CK1_1	238	244	PF00069	0.437
MOD_CK2_1	224	230	PF00069	0.455
MOD_GlcNHglycan	198	201	PF01048	0.566
MOD_GlcNHglycan	20	23	PF01048	0.480
MOD_GlcNHglycan	237	240	PF01048	0.656
MOD_GSK3_1	187	194	PF00069	0.403
MOD_GSK3_1	7	14	PF00069	0.413
MOD_N-GLC_1	187	192	PF02516	0.370
MOD_NEK2_1	111	116	PF00069	0.212
MOD_NEK2_1	203	208	PF00069	0.635
MOD_NEK2_1	221	226	PF00069	0.615
MOD_NEK2_1	58	63	PF00069	0.357
MOD_NEK2_2	128	133	PF00069	0.378
MOD_NEK2_2	64	69	PF00069	0.357
MOD_PKA_1	69	75	PF00069	0.319
MOD_PKA_2	175	181	PF00069	0.418
MOD_Plk_1	160	166	PF00069	0.404
MOD_Plk_1	36	42	PF00069	0.470
MOD_Plk_4	128	134	PF00069	0.286
MOD_Plk_4	166	172	PF00069	0.349
MOD_Plk_4	74	80	PF00069	0.325
MOD_ProDKin_1	204	210	PF00069	0.494
MOD_ProDKin_1	7	13	PF00069	0.432
MOD_ProDKin_1	79	85	PF00069	0.288
TRG_DiLeu_BaLyEn_6	107	112	PF01217	0.325
TRG_ENDOCYTIC_2	127	130	PF00928	0.256
TRG_ENDOCYTIC_2	133	136	PF00928	0.248
TRG_ENDOCYTIC_2	167	170	PF00928	0.302
TRG_ER_diArg_1	93	95	PF00400	0.289
TRG_NES_CRM1_1	148	161	PF08389	0.347
TRG_Pf-PMV_PEXEL_1	150	154	PF00026	0.262

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRS5	Leptomonas seymouri	63%	100%
A0A0S4JHS7	Bodo saltans	39%	78%
A0A1X0P2T0	Trypanosomatidae	47%	100%
A0A3Q8IJQ6	Leishmania donovani	88%	98%
A0A3R7RLR0	Trypanosoma rangeli	49%	100%
A4HIU9	Leishmania braziliensis	72%	100%
A4I654	Leishmania infantum	89%	98%
C9ZRH4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
O42979	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
Q4Q6S5	Leishmania major	88%	100%
Q75HV0	Oryza sativa subsp. japonica	31%	100%