Disabled homolog 1-like

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B1D6_LEIMU

TriTrypDb:

LmxM.29.3620

Length:

370

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B1D6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1D6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	13	17	PF00082	0.660
CLV_PCSK_SKI1_1	55	59	PF00082	0.767
CLV_PCSK_SKI1_1	72	76	PF00082	0.763
DEG_APCC_DBOX_1	225	233	PF00400	0.745
DEG_Nend_UBRbox_2	1	3	PF02207	0.615
DEG_SPOP_SBC_1	248	252	PF00917	0.632
DOC_CKS1_1	288	293	PF01111	0.756
DOC_CKS1_1	294	299	PF01111	0.656
DOC_CYCLIN_yCln2_LP_2	294	300	PF00134	0.755
DOC_MAPK_gen_1	22	30	PF00069	0.658
DOC_PP2B_LxvP_1	66	69	PF13499	0.728
DOC_PP4_FxxP_1	156	159	PF00568	0.710
DOC_PP4_FxxP_1	199	202	PF00568	0.612
DOC_PP4_FxxP_1	244	247	PF00568	0.805
DOC_USP7_MATH_1	109	113	PF00917	0.727
DOC_USP7_MATH_1	119	123	PF00917	0.742
DOC_USP7_MATH_1	149	153	PF00917	0.762
DOC_USP7_MATH_1	159	163	PF00917	0.753
DOC_USP7_MATH_1	280	284	PF00917	0.596
DOC_USP7_MATH_2	159	165	PF00917	0.792
DOC_USP7_UBL2_3	218	222	PF12436	0.769
DOC_WW_Pin1_4	134	139	PF00397	0.738
DOC_WW_Pin1_4	140	145	PF00397	0.695
DOC_WW_Pin1_4	217	222	PF00397	0.722
DOC_WW_Pin1_4	243	248	PF00397	0.817
DOC_WW_Pin1_4	256	261	PF00397	0.675
DOC_WW_Pin1_4	265	270	PF00397	0.628
DOC_WW_Pin1_4	287	292	PF00397	0.715
DOC_WW_Pin1_4	293	298	PF00397	0.718
DOC_WW_Pin1_4	58	63	PF00397	0.758
LIG_14-3-3_CanoR_1	226	230	PF00244	0.746
LIG_14-3-3_CanoR_1	24	31	PF00244	0.688
LIG_APCC_ABBA_1	196	201	PF00400	0.620
LIG_BRCT_BRCA1_1	166	170	PF00533	0.785
LIG_deltaCOP1_diTrp_1	201	211	PF00928	0.735
LIG_FHA_1	130	136	PF00498	0.709
LIG_FHA_1	23	29	PF00498	0.687
LIG_FHA_1	300	306	PF00498	0.694
LIG_FHA_1	314	320	PF00498	0.591
LIG_FHA_1	35	41	PF00498	0.684
LIG_IRF3_LxIS_1	211	217	PF10401	0.472
LIG_LIR_Apic_2	153	159	PF02991	0.713
LIG_LIR_Apic_2	241	247	PF02991	0.792
LIG_LIR_Gen_1	167	178	PF02991	0.730
LIG_LIR_Gen_1	209	219	PF02991	0.466
LIG_LIR_Nem_3	167	173	PF02991	0.762
LIG_LIR_Nem_3	209	214	PF02991	0.566
LIG_MYND_1	64	68	PF01753	0.625
LIG_NRBOX	80	86	PF00104	0.620
LIG_PCNA_yPIPBox_3	72	85	PF02747	0.679
LIG_SH2_CRK	301	305	PF00017	0.698
LIG_SH2_CRK	320	324	PF00017	0.628
LIG_SH2_CRK	345	349	PF00017	0.764
LIG_SH2_NCK_1	233	237	PF00017	0.694
LIG_SH2_NCK_1	320	324	PF00017	0.650
LIG_SH2_NCK_1	345	349	PF00017	0.756
LIG_SH2_NCK_1	7	11	PF00017	0.664
LIG_SH2_SRC	345	348	PF00017	0.735
LIG_SH2_SRC	7	10	PF00017	0.663
LIG_SH2_STAP1	233	237	PF00017	0.736
LIG_SH2_STAT3	307	310	PF00017	0.696
LIG_SH2_STAT5	301	304	PF00017	0.700
LIG_SH3_1	360	366	PF00018	0.700
LIG_SH3_2	62	67	PF14604	0.799
LIG_SH3_3	115	121	PF00018	0.768
LIG_SH3_3	148	154	PF00018	0.656
LIG_SH3_3	254	260	PF00018	0.734
LIG_SH3_3	283	289	PF00018	0.701
LIG_SH3_3	309	315	PF00018	0.604
LIG_SH3_3	360	366	PF00018	0.622
LIG_SH3_3	59	65	PF00018	0.756
LIG_SH3_4	106	113	PF00018	0.728
LIG_SH3_4	218	225	PF00018	0.764
LIG_SUMO_SIM_anti_2	25	32	PF11976	0.684
LIG_TRAF2_1	93	96	PF00917	0.802
LIG_TRFH_1	211	215	PF08558	0.590
LIG_UBA3_1	213	218	PF00899	0.477
MOD_CDK_SPK_2	217	222	PF00069	0.764
MOD_CK1_1	152	158	PF00069	0.782
MOD_CK1_1	164	170	PF00069	0.627
MOD_CK1_1	217	223	PF00069	0.703
MOD_CK1_1	23	29	PF00069	0.687
MOD_CK1_1	235	241	PF00069	0.729
MOD_CK1_1	99	105	PF00069	0.771
MOD_CK2_1	225	231	PF00069	0.704
MOD_GlcNHglycan	101	104	PF01048	0.787
MOD_GlcNHglycan	111	114	PF01048	0.715
MOD_GlcNHglycan	121	124	PF01048	0.733
MOD_GlcNHglycan	126	129	PF01048	0.628
MOD_GlcNHglycan	163	166	PF01048	0.751
MOD_GlcNHglycan	234	237	PF01048	0.704
MOD_GlcNHglycan	241	244	PF01048	0.727
MOD_GlcNHglycan	282	285	PF01048	0.597
MOD_GSK3_1	160	167	PF00069	0.714
MOD_GSK3_1	22	29	PF00069	0.703
MOD_GSK3_1	235	242	PF00069	0.655
MOD_GSK3_1	243	250	PF00069	0.667
MOD_GSK3_1	261	268	PF00069	0.669
MOD_GSK3_1	269	276	PF00069	0.615
MOD_GSK3_1	51	58	PF00069	0.741
MOD_GSK3_1	95	102	PF00069	0.733
MOD_N-GLC_1	238	243	PF02516	0.709
MOD_NEK2_1	1	6	PF00069	0.601
MOD_NEK2_1	225	230	PF00069	0.726
MOD_NEK2_1	232	237	PF00069	0.656
MOD_NEK2_1	274	279	PF00069	0.712
MOD_NEK2_1	333	338	PF00069	0.732
MOD_PIKK_1	249	255	PF00454	0.729
MOD_PIKK_1	333	339	PF00454	0.627
MOD_PKA_2	225	231	PF00069	0.751
MOD_PKA_2	23	29	PF00069	0.687
MOD_Plk_1	191	197	PF00069	0.721
MOD_Plk_1	239	245	PF00069	0.711
MOD_Plk_1	26	32	PF00069	0.589
MOD_Plk_1	8	14	PF00069	0.700
MOD_Plk_4	26	32	PF00069	0.684
MOD_ProDKin_1	134	140	PF00069	0.738
MOD_ProDKin_1	217	223	PF00069	0.722
MOD_ProDKin_1	243	249	PF00069	0.819
MOD_ProDKin_1	256	262	PF00069	0.676
MOD_ProDKin_1	265	271	PF00069	0.624
MOD_ProDKin_1	287	293	PF00069	0.717
MOD_ProDKin_1	58	64	PF00069	0.755
MOD_SUMO_rev_2	152	162	PF00179	0.716

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGN6	Leptomonas seymouri	56%	98%
A0A3Q8IEJ9	Leishmania donovani	93%	100%
A0A422NME0	Trypanosoma rangeli	28%	99%
A4HIU8	Leishmania braziliensis	75%	98%
A4I653	Leishmania infantum	93%	100%
C9ZRH3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	96%
Q4Q6S6	Leishmania major	91%	100%
V5BX10	Trypanosoma cruzi	25%	99%