Putative serine/threonine-protein kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine/threonine-protein kinase, putative

Species:

Leishmania mexicana

UniProt:

E9B1D2_LEIMU

TriTrypDb:

LmxM.29.3580

Length:

748

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B1D2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1D2

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016310	phosphorylation	5	12
GO:0019538	protein metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:0000245	spliceosomal complex assembly	7	1
GO:0007165	signal transduction	2	1
GO:0016043	cellular component organization	3	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0035556	intracellular signal transduction	3	1
GO:0043933	protein-containing complex organization	4	1
GO:0050684	regulation of mRNA processing	7	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0065007	biological regulation	1	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1903311	regulation of mRNA metabolic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004672	protein kinase activity	3	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0004674	protein serine/threonine kinase activity	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.656
CLV_C14_Caspase3-7	370	374	PF00656	0.767
CLV_C14_Caspase3-7	587	591	PF00656	0.665
CLV_NRD_NRD_1	142	144	PF00675	0.414
CLV_NRD_NRD_1	25	27	PF00675	0.654
CLV_NRD_NRD_1	337	339	PF00675	0.446
CLV_NRD_NRD_1	347	349	PF00675	0.489
CLV_PCSK_KEX2_1	25	27	PF00082	0.604
CLV_PCSK_KEX2_1	336	338	PF00082	0.467
CLV_PCSK_KEX2_1	609	611	PF00082	0.692
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.604
CLV_PCSK_PC1ET2_1	609	611	PF00082	0.722
CLV_PCSK_SKI1_1	161	165	PF00082	0.298
CLV_PCSK_SKI1_1	26	30	PF00082	0.682
CLV_PCSK_SKI1_1	272	276	PF00082	0.279
CLV_PCSK_SKI1_1	329	333	PF00082	0.524
CLV_PCSK_SKI1_1	349	353	PF00082	0.615
CLV_PCSK_SKI1_1	406	410	PF00082	0.264
CLV_PCSK_SKI1_1	499	503	PF00082	0.281
CLV_PCSK_SKI1_1	522	526	PF00082	0.353
CLV_PCSK_SKI1_1	641	645	PF00082	0.427
CLV_PCSK_SKI1_1	9	13	PF00082	0.733
DEG_APCC_DBOX_1	271	279	PF00400	0.279
DEG_SCF_FBW7_1	297	304	PF00400	0.357
DOC_ANK_TNKS_1	107	114	PF00023	0.667
DOC_CKS1_1	298	303	PF01111	0.357
DOC_CKS1_1	428	433	PF01111	0.256
DOC_MAPK_gen_1	182	190	PF00069	0.326
DOC_MAPK_gen_1	415	424	PF00069	0.264
DOC_MAPK_HePTP_8	412	424	PF00069	0.264
DOC_MAPK_MEF2A_6	415	424	PF00069	0.264
DOC_PP1_RVXF_1	162	169	PF00149	0.264
DOC_PP4_FxxP_1	30	33	PF00568	0.724
DOC_PP4_FxxP_1	312	315	PF00568	0.500
DOC_PP4_FxxP_1	530	533	PF00568	0.264
DOC_USP7_MATH_1	301	305	PF00917	0.464
DOC_USP7_MATH_1	33	37	PF00917	0.714
DOC_USP7_MATH_1	467	471	PF00917	0.414
DOC_USP7_MATH_1	618	622	PF00917	0.599
DOC_USP7_UBL2_3	12	16	PF12436	0.624
DOC_USP7_UBL2_3	23	27	PF12436	0.677
DOC_USP7_UBL2_3	329	333	PF12436	0.487
DOC_USP7_UBL2_3	5	9	PF12436	0.629
DOC_USP7_UBL2_3	521	525	PF12436	0.280
DOC_WW_Pin1_4	297	302	PF00397	0.324
DOC_WW_Pin1_4	427	432	PF00397	0.267
DOC_WW_Pin1_4	541	546	PF00397	0.426
LIG_14-3-3_CanoR_1	320	328	PF00244	0.659
LIG_14-3-3_CanoR_1	348	352	PF00244	0.703
LIG_14-3-3_CanoR_1	671	680	PF00244	0.547
LIG_APCC_ABBA_1	243	248	PF00400	0.279
LIG_BRCT_BRCA1_1	620	624	PF00533	0.669
LIG_Clathr_ClatBox_1	275	279	PF01394	0.279
LIG_CtBP_PxDLS_1	477	481	PF00389	0.279
LIG_deltaCOP1_diTrp_1	382	390	PF00928	0.593
LIG_deltaCOP1_diTrp_1	433	442	PF00928	0.314
LIG_EH1_1	302	310	PF00400	0.430
LIG_eIF4E_1	202	208	PF01652	0.264
LIG_FHA_1	171	177	PF00498	0.264
LIG_FHA_1	32	38	PF00498	0.609
LIG_FHA_1	407	413	PF00498	0.264
LIG_FHA_1	675	681	PF00498	0.604
LIG_FHA_2	125	131	PF00498	0.616
LIG_FHA_2	132	138	PF00498	0.491
LIG_FHA_2	322	328	PF00498	0.640
LIG_FHA_2	379	385	PF00498	0.558
LIG_FHA_2	428	434	PF00498	0.266
LIG_FHA_2	587	593	PF00498	0.698
LIG_FHA_2	634	640	PF00498	0.515
LIG_FHA_2	642	648	PF00498	0.417
LIG_FHA_2	69	75	PF00498	0.468
LIG_FHA_2	734	740	PF00498	0.661
LIG_Integrin_RGD_1	362	364	PF01839	0.645
LIG_LIR_Apic_2	414	420	PF02991	0.264
LIG_LIR_Apic_2	426	431	PF02991	0.264
LIG_LIR_Apic_2	529	533	PF02991	0.279
LIG_LIR_Gen_1	183	190	PF02991	0.279
LIG_LIR_Gen_1	199	208	PF02991	0.235
LIG_LIR_Gen_1	388	398	PF02991	0.357
LIG_LIR_Nem_3	158	163	PF02991	0.273
LIG_LIR_Nem_3	199	205	PF02991	0.291
LIG_LIR_Nem_3	258	262	PF02991	0.345
LIG_LIR_Nem_3	388	393	PF02991	0.482
LIG_LIR_Nem_3	404	408	PF02991	0.188
LIG_LIR_Nem_3	484	490	PF02991	0.377
LIG_LIR_Nem_3	503	509	PF02991	0.208
LIG_LIR_Nem_3	553	558	PF02991	0.386
LIG_LIR_Nem_3	560	566	PF02991	0.432
LIG_MAD2	715	723	PF02301	0.538
LIG_MYND_3	532	536	PF01753	0.256
LIG_Pex14_2	171	175	PF04695	0.264
LIG_PTB_Apo_2	154	161	PF02174	0.420
LIG_PTB_Apo_2	631	638	PF02174	0.549
LIG_PTB_Phospho_1	154	160	PF10480	0.424
LIG_PTB_Phospho_1	631	637	PF10480	0.554
LIG_Rb_pABgroove_1	237	245	PF01858	0.326
LIG_SH2_CRK	160	164	PF00017	0.330
LIG_SH2_CRK	259	263	PF00017	0.264
LIG_SH2_CRK	340	344	PF00017	0.426
LIG_SH2_CRK	428	432	PF00017	0.256
LIG_SH2_CRK	563	567	PF00017	0.546
LIG_SH2_GRB2like	491	494	PF00017	0.348
LIG_SH2_NCK_1	197	201	PF00017	0.279
LIG_SH2_NCK_1	598	602	PF00017	0.710
LIG_SH2_SRC	202	205	PF00017	0.264
LIG_SH2_STAP1	131	135	PF00017	0.565
LIG_SH2_STAP1	197	201	PF00017	0.288
LIG_SH2_STAT5	170	173	PF00017	0.264
LIG_SH2_STAT5	228	231	PF00017	0.298
LIG_SH2_STAT5	637	640	PF00017	0.525
LIG_SUMO_SIM_anti_2	283	290	PF11976	0.279
LIG_SUMO_SIM_anti_2	304	310	PF11976	0.485
LIG_SUMO_SIM_anti_2	462	471	PF11976	0.264
LIG_SUMO_SIM_par_1	248	255	PF11976	0.264
LIG_SUMO_SIM_par_1	429	436	PF11976	0.256
LIG_TRAF2_1	344	347	PF00917	0.583
LIG_TRAF2_1	71	74	PF00917	0.459
LIG_TRAF2_1	736	739	PF00917	0.623
LIG_TYR_ITIM	504	509	PF00017	0.409
LIG_UBA3_1	305	310	PF00899	0.402
MOD_CDK_SPK_2	297	302	PF00069	0.279
MOD_CK1_1	124	130	PF00069	0.483
MOD_CK1_1	193	199	PF00069	0.409
MOD_CK1_1	304	310	PF00069	0.521
MOD_CK1_1	35	41	PF00069	0.654
MOD_CK1_1	376	382	PF00069	0.717
MOD_CK1_1	401	407	PF00069	0.264
MOD_CK1_1	591	597	PF00069	0.659
MOD_CK1_1	600	606	PF00069	0.707
MOD_CK1_1	608	614	PF00069	0.624
MOD_CK1_1	674	680	PF00069	0.574
MOD_CK2_1	106	112	PF00069	0.714
MOD_CK2_1	131	137	PF00069	0.543
MOD_CK2_1	16	22	PF00069	0.628
MOD_CK2_1	193	199	PF00069	0.409
MOD_CK2_1	249	255	PF00069	0.281
MOD_CK2_1	378	384	PF00069	0.597
MOD_CK2_1	457	463	PF00069	0.303
MOD_CK2_1	570	576	PF00069	0.588
MOD_CK2_1	578	584	PF00069	0.643
MOD_CK2_1	633	639	PF00069	0.551
MOD_CK2_1	68	74	PF00069	0.514
MOD_CK2_1	733	739	PF00069	0.661
MOD_CMANNOS	175	178	PF00535	0.264
MOD_GlcNHglycan	123	126	PF01048	0.507
MOD_GlcNHglycan	192	195	PF01048	0.264
MOD_GlcNHglycan	570	575	PF01048	0.639
MOD_GlcNHglycan	576	581	PF01048	0.652
MOD_GlcNHglycan	599	602	PF01048	0.682
MOD_GSK3_1	102	109	PF00069	0.735
MOD_GSK3_1	12	19	PF00069	0.736
MOD_GSK3_1	297	304	PF00069	0.393
MOD_GSK3_1	31	38	PF00069	0.689
MOD_GSK3_1	327	334	PF00069	0.534
MOD_GSK3_1	588	595	PF00069	0.681
MOD_GSK3_1	596	603	PF00069	0.668
MOD_GSK3_1	674	681	PF00069	0.579
MOD_GSK3_1	703	710	PF00069	0.713
MOD_N-GLC_1	234	239	PF02516	0.327
MOD_N-GLC_1	633	638	PF02516	0.547
MOD_N-GLC_2	219	221	PF02516	0.390
MOD_N-GLC_2	400	402	PF02516	0.264
MOD_NEK2_1	1	6	PF00069	0.725
MOD_NEK2_1	229	234	PF00069	0.302
MOD_NEK2_1	331	336	PF00069	0.459
MOD_NEK2_1	398	403	PF00069	0.264
MOD_NEK2_1	633	638	PF00069	0.547
MOD_NEK2_1	82	87	PF00069	0.661
MOD_PIKK_1	331	337	PF00454	0.474
MOD_PIKK_1	592	598	PF00454	0.615
MOD_PIKK_1	69	75	PF00454	0.517
MOD_PIKK_1	704	710	PF00454	0.755
MOD_PKA_1	16	22	PF00069	0.764
MOD_PKA_2	347	353	PF00069	0.704
MOD_PKA_2	41	47	PF00069	0.660
MOD_PKA_2	517	523	PF00069	0.167
MOD_PKA_2	678	684	PF00069	0.687
MOD_Plk_1	633	639	PF00069	0.501
MOD_Plk_2-3	578	584	PF00069	0.608
MOD_Plk_2-3	586	592	PF00069	0.817
MOD_Plk_4	170	176	PF00069	0.264
MOD_Plk_4	249	255	PF00069	0.280
MOD_Plk_4	301	307	PF00069	0.455
MOD_Plk_4	347	353	PF00069	0.540
MOD_Plk_4	647	653	PF00069	0.593
MOD_ProDKin_1	297	303	PF00069	0.324
MOD_ProDKin_1	427	433	PF00069	0.267
MOD_ProDKin_1	541	547	PF00069	0.426
MOD_SUMO_for_1	291	294	PF00179	0.264
MOD_SUMO_rev_2	198	208	PF00179	0.282
MOD_SUMO_rev_2	285	293	PF00179	0.279
MOD_SUMO_rev_2	325	331	PF00179	0.492
MOD_SUMO_rev_2	346	351	PF00179	0.531
MOD_SUMO_rev_2	354	361	PF00179	0.554
MOD_SUMO_rev_2	55	63	PF00179	0.666
MOD_SUMO_rev_2	599	608	PF00179	0.636
TRG_DiLeu_BaEn_1	347	352	PF01217	0.595
TRG_DiLeu_BaEn_1	668	673	PF01217	0.448
TRG_DiLeu_BaEn_2	525	531	PF01217	0.279
TRG_DiLeu_BaEn_4	628	634	PF01217	0.562
TRG_DiLeu_BaEn_4	675	681	PF01217	0.656
TRG_DiLeu_LyEn_5	668	673	PF01217	0.492
TRG_ENDOCYTIC_2	147	150	PF00928	0.354
TRG_ENDOCYTIC_2	160	163	PF00928	0.264
TRG_ENDOCYTIC_2	185	188	PF00928	0.291
TRG_ENDOCYTIC_2	202	205	PF00928	0.198
TRG_ENDOCYTIC_2	259	262	PF00928	0.314
TRG_ENDOCYTIC_2	340	343	PF00928	0.477
TRG_ENDOCYTIC_2	405	408	PF00928	0.268
TRG_ENDOCYTIC_2	506	509	PF00928	0.409
TRG_ENDOCYTIC_2	563	566	PF00928	0.474
TRG_ER_diArg_1	336	338	PF00400	0.502
TRG_ER_diArg_1	516	519	PF00400	0.167
TRG_NLS_Bipartite_1	16	30	PF00514	0.688
TRG_NLS_MonoExtC_3	24	29	PF00514	0.680
TRG_NLS_MonoExtC_3	520	525	PF00514	0.322
TRG_NLS_MonoExtN_4	23	30	PF00514	0.684
TRG_NLS_MonoExtN_4	518	525	PF00514	0.322
TRG_NLS_MonoExtN_4	607	613	PF00514	0.519
TRG_Pf-PMV_PEXEL_1	206	210	PF00026	0.279
TRG_Pf-PMV_PEXEL_1	499	503	PF00026	0.279
TRG_Pf-PMV_PEXEL_1	612	617	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	671	675	PF00026	0.517

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1H8	Leptomonas seymouri	82%	100%
A0A0S4JMD1	Bodo saltans	55%	97%
A0A1X0P1B0	Trypanosomatidae	58%	100%
A0A3R7KF70	Trypanosoma rangeli	59%	100%
A0A3S7X404	Leishmania donovani	92%	100%
A4HIU4	Leishmania braziliensis	83%	99%
A4I649	Leishmania infantum	92%	100%
C9ZRG9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
Q4Q6T0	Leishmania major	94%	100%
V5B752	Trypanosoma cruzi	61%	100%