RF_PROK_I domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RF-1 domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B1C8_LEIMU

TriTrypDb:

LmxM.29.3540

Length:

456

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B1C8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1C8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	3
GO:0003747	translation release factor activity	5	3
GO:0005488	binding	1	3
GO:0008079	translation termination factor activity	4	3
GO:0008135	translation factor activity, RNA binding	3	3
GO:0045182	translation regulator activity	1	3
GO:0090079	translation regulator activity, nucleic acid binding	2	3
GO:0097159	organic cyclic compound binding	2	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	62	66	PF00656	0.595
CLV_NRD_NRD_1	137	139	PF00675	0.511
CLV_NRD_NRD_1	165	167	PF00675	0.395
CLV_NRD_NRD_1	2	4	PF00675	0.746
CLV_NRD_NRD_1	200	202	PF00675	0.498
CLV_NRD_NRD_1	221	223	PF00675	0.643
CLV_NRD_NRD_1	37	39	PF00675	0.593
CLV_NRD_NRD_1	437	439	PF00675	0.551
CLV_NRD_NRD_1	88	90	PF00675	0.471
CLV_PCSK_FUR_1	194	198	PF00082	0.528
CLV_PCSK_FUR_1	89	93	PF00082	0.555
CLV_PCSK_KEX2_1	137	139	PF00082	0.511
CLV_PCSK_KEX2_1	165	167	PF00082	0.410
CLV_PCSK_KEX2_1	196	198	PF00082	0.481
CLV_PCSK_KEX2_1	199	201	PF00082	0.478
CLV_PCSK_KEX2_1	2	4	PF00082	0.746
CLV_PCSK_KEX2_1	221	223	PF00082	0.608
CLV_PCSK_KEX2_1	32	34	PF00082	0.600
CLV_PCSK_KEX2_1	328	330	PF00082	0.502
CLV_PCSK_KEX2_1	36	38	PF00082	0.578
CLV_PCSK_KEX2_1	437	439	PF00082	0.549
CLV_PCSK_KEX2_1	88	90	PF00082	0.476
CLV_PCSK_KEX2_1	91	93	PF00082	0.522
CLV_PCSK_PC1ET2_1	32	34	PF00082	0.641
CLV_PCSK_PC1ET2_1	328	330	PF00082	0.351
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.613
CLV_PCSK_PC7_1	194	200	PF00082	0.505
CLV_PCSK_PC7_1	33	39	PF00082	0.572
CLV_PCSK_SKI1_1	112	116	PF00082	0.419
CLV_PCSK_SKI1_1	169	173	PF00082	0.390
CLV_PCSK_SKI1_1	272	276	PF00082	0.490
CLV_PCSK_SKI1_1	3	7	PF00082	0.447
CLV_PCSK_SKI1_1	328	332	PF00082	0.494
CLV_PCSK_SKI1_1	355	359	PF00082	0.559
CLV_PCSK_SKI1_1	371	375	PF00082	0.461
DEG_APCC_DBOX_1	342	350	PF00400	0.629
DEG_APCC_DBOX_1	75	83	PF00400	0.440
DEG_Nend_UBRbox_1	1	4	PF02207	0.650
DEG_SPOP_SBC_1	283	287	PF00917	0.465
DOC_MAPK_gen_1	100	109	PF00069	0.583
DOC_MAPK_gen_1	154	163	PF00069	0.452
DOC_MAPK_gen_1	165	176	PF00069	0.357
DOC_MAPK_gen_1	218	228	PF00069	0.592
DOC_MAPK_gen_1	437	447	PF00069	0.668
DOC_MAPK_gen_1	76	84	PF00069	0.492
DOC_MAPK_HePTP_8	151	163	PF00069	0.495
DOC_MAPK_MEF2A_6	154	163	PF00069	0.463
DOC_MAPK_MEF2A_6	169	176	PF00069	0.321
DOC_MAPK_MEF2A_6	383	391	PF00069	0.517
DOC_MAPK_MEF2A_6	437	445	PF00069	0.534
DOC_MAPK_NFAT4_5	169	177	PF00069	0.427
DOC_USP7_MATH_1	234	238	PF00917	0.584
DOC_USP7_MATH_1	274	278	PF00917	0.557
DOC_USP7_MATH_1	304	308	PF00917	0.317
DOC_USP7_MATH_1	316	320	PF00917	0.572
DOC_USP7_MATH_1	351	355	PF00917	0.630
DOC_USP7_MATH_1	416	420	PF00917	0.652
DOC_WW_Pin1_4	230	235	PF00397	0.561
DOC_WW_Pin1_4	396	401	PF00397	0.457
LIG_14-3-3_CanoR_1	137	147	PF00244	0.493
LIG_14-3-3_CanoR_1	200	206	PF00244	0.524
LIG_14-3-3_CanoR_1	329	338	PF00244	0.484
LIG_14-3-3_CanoR_1	341	347	PF00244	0.533
LIG_14-3-3_CanoR_1	380	390	PF00244	0.499
LIG_14-3-3_CanoR_1	9	13	PF00244	0.616
LIG_Actin_WH2_2	330	345	PF00022	0.519
LIG_BRCT_BRCA1_1	105	109	PF00533	0.414
LIG_BRCT_BRCA1_1	9	13	PF00533	0.746
LIG_BRCT_BRCA1_2	105	111	PF00533	0.506
LIG_FHA_1	139	145	PF00498	0.421
LIG_FHA_1	253	259	PF00498	0.422
LIG_FHA_2	14	20	PF00498	0.722
LIG_FHA_2	284	290	PF00498	0.555
LIG_LIR_Apic_2	102	108	PF02991	0.581
LIG_LIR_Gen_1	332	342	PF02991	0.509
LIG_LIR_Gen_1	68	75	PF02991	0.355
LIG_LIR_Nem_3	102	107	PF02991	0.581
LIG_LIR_Nem_3	156	161	PF02991	0.424
LIG_LIR_Nem_3	332	337	PF02991	0.514
LIG_LIR_Nem_3	384	389	PF02991	0.431
LIG_LIR_Nem_3	68	73	PF02991	0.407
LIG_Pex14_1	386	390	PF04695	0.482
LIG_Pex14_2	158	162	PF04695	0.429
LIG_Pex14_2	334	338	PF04695	0.374
LIG_REV1ctd_RIR_1	112	120	PF16727	0.425
LIG_REV1ctd_RIR_1	406	415	PF16727	0.429
LIG_RPA_C_Fungi	160	172	PF08784	0.472
LIG_RPA_C_Insects	160	175	PF08784	0.512
LIG_SH2_CRK	105	109	PF00017	0.499
LIG_SH2_CRK	390	394	PF00017	0.490
LIG_SH2_NCK_1	105	109	PF00017	0.534
LIG_SH2_SRC	303	306	PF00017	0.529
LIG_SH2_STAT5	113	116	PF00017	0.387
LIG_SH2_STAT5	207	210	PF00017	0.589
LIG_SH2_STAT5	297	300	PF00017	0.364
LIG_SUMO_SIM_anti_2	77	83	PF11976	0.429
LIG_TYR_ITSM	100	107	PF00017	0.598
LIG_UBA3_1	81	90	PF00899	0.527
MOD_CDK_SPxxK_3	396	403	PF00069	0.461
MOD_CK1_1	11	17	PF00069	0.719
MOD_CK1_1	99	105	PF00069	0.574
MOD_CK2_1	304	310	PF00069	0.364
MOD_CK2_1	389	395	PF00069	0.491
MOD_CK2_1	449	455	PF00069	0.600
MOD_GlcNHglycan	148	151	PF01048	0.475
MOD_GlcNHglycan	236	239	PF01048	0.568
MOD_GlcNHglycan	276	279	PF01048	0.551
MOD_GlcNHglycan	418	421	PF01048	0.576
MOD_GlcNHglycan	61	64	PF01048	0.607
MOD_GSK3_1	153	160	PF00069	0.416
MOD_GSK3_1	230	237	PF00069	0.586
MOD_GSK3_1	367	374	PF00069	0.449
MOD_GSK3_1	412	419	PF00069	0.594
MOD_GSK3_1	445	452	PF00069	0.724
MOD_GSK3_1	7	14	PF00069	0.694
MOD_GSK3_1	91	98	PF00069	0.651
MOD_GSK3_1	99	106	PF00069	0.589
MOD_N-GLC_1	374	379	PF02516	0.574
MOD_NEK2_1	13	18	PF00069	0.617
MOD_NEK2_1	342	347	PF00069	0.417
MOD_NEK2_1	381	386	PF00069	0.364
MOD_PIKK_1	238	244	PF00454	0.586
MOD_PK_1	103	109	PF00069	0.567
MOD_PKA_1	32	38	PF00069	0.581
MOD_PKA_1	59	65	PF00069	0.608
MOD_PKA_1	91	97	PF00069	0.654
MOD_PKA_2	217	223	PF00069	0.557
MOD_PKA_2	32	38	PF00069	0.584
MOD_PKA_2	342	348	PF00069	0.459
MOD_PKA_2	436	442	PF00069	0.561
MOD_PKA_2	8	14	PF00069	0.683
MOD_PKA_2	91	97	PF00069	0.601
MOD_PKB_1	199	207	PF00069	0.562
MOD_PKB_1	369	377	PF00069	0.400
MOD_Plk_1	121	127	PF00069	0.484
MOD_Plk_1	351	357	PF00069	0.585
MOD_Plk_2-3	284	290	PF00069	0.511
MOD_Plk_4	157	163	PF00069	0.418
MOD_Plk_4	8	14	PF00069	0.716
MOD_ProDKin_1	230	236	PF00069	0.564
MOD_ProDKin_1	396	402	PF00069	0.454
MOD_SUMO_for_1	409	412	PF00179	0.528
MOD_SUMO_rev_2	106	114	PF00179	0.480
MOD_SUMO_rev_2	62	69	PF00179	0.557
TRG_DiLeu_BaEn_1	247	252	PF01217	0.349
TRG_DiLeu_BaEn_4	121	127	PF01217	0.605
TRG_DiLeu_BaLyEn_6	289	294	PF01217	0.458
TRG_DiLeu_BaLyEn_6	80	85	PF01217	0.543
TRG_ENDOCYTIC_2	104	107	PF00928	0.510
TRG_ENDOCYTIC_2	390	393	PF00928	0.454
TRG_ENDOCYTIC_2	70	73	PF00928	0.555
TRG_ER_diArg_1	1	3	PF00400	0.702
TRG_ER_diArg_1	137	139	PF00400	0.527
TRG_ER_diArg_1	189	192	PF00400	0.477
TRG_ER_diArg_1	196	199	PF00400	0.491
TRG_ER_diArg_1	200	203	PF00400	0.499
TRG_ER_diArg_1	340	343	PF00400	0.337
TRG_ER_diArg_1	36	38	PF00400	0.591
TRG_ER_diArg_1	369	372	PF00400	0.424
TRG_ER_diArg_1	436	438	PF00400	0.546
TRG_ER_diArg_1	45	48	PF00400	0.508
TRG_NLS_MonoCore_2	88	93	PF00514	0.599
TRG_NLS_MonoExtC_3	89	95	PF00514	0.624
TRG_NLS_MonoExtN_4	88	94	PF00514	0.613
TRG_Pf-PMV_PEXEL_1	83	87	PF00026	0.537

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ29	Leptomonas seymouri	61%	98%
A0A0S4JPR1	Bodo saltans	32%	84%
A0A1X0P2E4	Trypanosomatidae	39%	97%
A0A3R7MQL4	Trypanosoma rangeli	42%	95%
A0A3S7X3Z9	Leishmania donovani	91%	100%
A4HIU0	Leishmania braziliensis	81%	100%
A4I645	Leishmania infantum	91%	100%
C9ZRG6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	97%
Q4Q6T4	Leishmania major	92%	100%
V5BX14	Trypanosoma cruzi	41%	94%