Putative casein kinase 1 isoform 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

casein kinase 1 isoform 2, putative

Species:

Leishmania mexicana

UniProt:

E9B1C3_LEIMU

TriTrypDb:

LmxM.29.3470

Length:

393

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

E9B1C3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1C3

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016310	phosphorylation	5	12
GO:0019538	protein metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:0006810	transport	3	1
GO:0006897	endocytosis	5	1
GO:0007165	signal transduction	2	1
GO:0016192	vesicle-mediated transport	4	1
GO:0018105	peptidyl-serine phosphorylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018209	peptidyl-serine modification	6	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004672	protein kinase activity	3	12
GO:0004674	protein serine/threonine kinase activity	4	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	328	332	PF00656	0.601
CLV_NRD_NRD_1	126	128	PF00675	0.307
CLV_NRD_NRD_1	220	222	PF00675	0.354
CLV_PCSK_FUR_1	21	25	PF00082	0.714
CLV_PCSK_KEX2_1	220	222	PF00082	0.354
CLV_PCSK_KEX2_1	23	25	PF00082	0.653
CLV_PCSK_KEX2_1	248	250	PF00082	0.404
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.664
CLV_PCSK_PC1ET2_1	248	250	PF00082	0.404
CLV_PCSK_SKI1_1	156	160	PF00082	0.351
CLV_PCSK_SKI1_1	199	203	PF00082	0.328
CLV_PCSK_SKI1_1	257	261	PF00082	0.506
CLV_PCSK_SKI1_1	372	376	PF00082	0.659
DEG_APCC_DBOX_1	220	228	PF00400	0.370
DEG_Nend_UBRbox_3	1	3	PF02207	0.602
DOC_CYCLIN_RxL_1	281	291	PF00134	0.439
DOC_CYCLIN_RxL_1	369	377	PF00134	0.656
DOC_MAPK_gen_1	21	30	PF00069	0.674
DOC_MAPK_gen_1	245	253	PF00069	0.445
DOC_MAPK_MEF2A_6	132	141	PF00069	0.411
DOC_PP1_RVXF_1	247	254	PF00149	0.414
DOC_PP1_RVXF_1	282	289	PF00149	0.432
DOC_SPAK_OSR1_1	33	37	PF12202	0.411
DOC_USP7_MATH_1	235	239	PF00917	0.210
DOC_USP7_MATH_1	332	336	PF00917	0.722
DOC_USP7_MATH_1	344	348	PF00917	0.763
DOC_USP7_UBL2_3	128	132	PF12436	0.411
DOC_WW_Pin1_4	243	248	PF00397	0.465
DOC_WW_Pin1_4	261	266	PF00397	0.350
LIG_BIR_III_4	331	335	PF00653	0.744
LIG_BRCT_BRCA1_1	284	288	PF00533	0.477
LIG_BRCT_BRCA1_1	357	361	PF00533	0.711
LIG_FHA_1	105	111	PF00498	0.456
LIG_FHA_1	281	287	PF00498	0.503
LIG_FHA_1	355	361	PF00498	0.742
LIG_FHA_1	89	95	PF00498	0.419
LIG_GBD_Chelix_1	173	181	PF00786	0.475
LIG_LIR_Gen_1	105	114	PF02991	0.375
LIG_LIR_Gen_1	250	259	PF02991	0.477
LIG_LIR_Gen_1	313	324	PF02991	0.548
LIG_LIR_Nem_3	204	210	PF02991	0.370
LIG_LIR_Nem_3	238	244	PF02991	0.342
LIG_LIR_Nem_3	250	256	PF02991	0.502
LIG_LIR_Nem_3	313	319	PF02991	0.508
LIG_LIR_Nem_3	385	389	PF02991	0.649
LIG_LIR_Nem_3	47	52	PF02991	0.371
LIG_PCNA_PIPBox_1	380	389	PF02747	0.504
LIG_PDZ_Class_3	388	393	PF00595	0.687
LIG_Pex14_2	45	49	PF04695	0.389
LIG_PTB_Apo_2	373	380	PF02174	0.703
LIG_PTB_Apo_2	76	83	PF02174	0.501
LIG_PTB_Phospho_1	76	82	PF10480	0.501
LIG_RPA_C_Fungi	328	340	PF08784	0.718
LIG_SH2_CRK	82	86	PF00017	0.337
LIG_SH2_PTP2	207	210	PF00017	0.411
LIG_SH2_SRC	147	150	PF00017	0.475
LIG_SH2_SRC	195	198	PF00017	0.501
LIG_SH2_STAP1	106	110	PF00017	0.475
LIG_SH2_STAP1	282	286	PF00017	0.434
LIG_SH2_STAP1	294	298	PF00017	0.368
LIG_SH2_STAP1	312	316	PF00017	0.549
LIG_SH2_STAT3	272	275	PF00017	0.485
LIG_SH2_STAT3	314	317	PF00017	0.511
LIG_SH2_STAT5	106	109	PF00017	0.444
LIG_SH2_STAT5	147	150	PF00017	0.427
LIG_SH2_STAT5	153	156	PF00017	0.392
LIG_SH2_STAT5	175	178	PF00017	0.354
LIG_SH2_STAT5	207	210	PF00017	0.354
LIG_SH2_STAT5	229	232	PF00017	0.350
LIG_SH2_STAT5	233	236	PF00017	0.359
LIG_SH2_STAT5	279	282	PF00017	0.424
LIG_SH2_STAT5	296	299	PF00017	0.341
LIG_SH2_STAT5	314	317	PF00017	0.516
LIG_SH2_STAT5	99	102	PF00017	0.467
LIG_SH3_3	89	95	PF00018	0.347
LIG_SUMO_SIM_anti_2	107	112	PF11976	0.501
LIG_SUMO_SIM_par_1	105	112	PF11976	0.479
LIG_UBA3_1	121	128	PF00899	0.269
MOD_CDC14_SPxK_1	246	249	PF00782	0.475
MOD_CDK_SPK_2	243	248	PF00069	0.475
MOD_CDK_SPxK_1	243	249	PF00069	0.475
MOD_CK1_1	130	136	PF00069	0.374
MOD_CK1_1	209	215	PF00069	0.389
MOD_CK1_1	303	309	PF00069	0.273
MOD_CK1_1	335	341	PF00069	0.747
MOD_CK2_1	261	267	PF00069	0.480
MOD_CK2_1	319	325	PF00069	0.575
MOD_GlcNHglycan	302	305	PF01048	0.542
MOD_GlcNHglycan	327	330	PF01048	0.672
MOD_GlcNHglycan	334	337	PF01048	0.705
MOD_GlcNHglycan	341	344	PF01048	0.729
MOD_GlcNHglycan	364	367	PF01048	0.736
MOD_GlcNHglycan	55	58	PF01048	0.391
MOD_GSK3_1	197	204	PF00069	0.411
MOD_GSK3_1	299	306	PF00069	0.359
MOD_GSK3_1	335	342	PF00069	0.782
MOD_GSK3_1	350	357	PF00069	0.688
MOD_GSK3_1	370	377	PF00069	0.742
MOD_N-GLC_2	86	88	PF02516	0.411
MOD_NEK2_1	1	6	PF00069	0.780
MOD_NEK2_1	201	206	PF00069	0.354
MOD_NEK2_1	300	305	PF00069	0.462
MOD_NEK2_1	339	344	PF00069	0.804
MOD_NEK2_1	355	360	PF00069	0.730
MOD_NEK2_1	370	375	PF00069	0.492
MOD_PK_1	127	133	PF00069	0.324
MOD_PK_1	206	212	PF00069	0.370
MOD_PKA_1	127	133	PF00069	0.349
MOD_PKA_2	185	191	PF00069	0.416
MOD_PKA_2	235	241	PF00069	0.282
MOD_PKA_2	332	338	PF00069	0.713
MOD_PKA_2	339	345	PF00069	0.738
MOD_Plk_1	104	110	PF00069	0.491
MOD_Plk_1	292	298	PF00069	0.415
MOD_Plk_4	104	110	PF00069	0.411
MOD_Plk_4	225	231	PF00069	0.442
MOD_Plk_4	356	362	PF00069	0.730
MOD_Plk_4	370	376	PF00069	0.661
MOD_Plk_4	94	100	PF00069	0.430
MOD_ProDKin_1	243	249	PF00069	0.465
MOD_ProDKin_1	261	267	PF00069	0.352
MOD_SUMO_for_1	158	161	PF00179	0.411
MOD_SUMO_for_1	62	65	PF00179	0.354
MOD_SUMO_rev_2	254	262	PF00179	0.490
MOD_SUMO_rev_2	320	329	PF00179	0.661
TRG_ENDOCYTIC_2	106	109	PF00928	0.365
TRG_ENDOCYTIC_2	207	210	PF00928	0.354
TRG_ENDOCYTIC_2	316	319	PF00928	0.499
TRG_ENDOCYTIC_2	386	389	PF00928	0.648
TRG_ENDOCYTIC_2	82	85	PF00928	0.354
TRG_Pf-PMV_PEXEL_1	214	218	PF00026	0.421
TRG_Pf-PMV_PEXEL_1	284	289	PF00026	0.429

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3F5	Leptomonas seymouri	44%	100%
A0A0N1HU44	Leptomonas seymouri	46%	100%
A0A0N1HU45	Leptomonas seymouri	72%	100%
A0A0N1I2H3	Leptomonas seymouri	38%	100%
A0A0N1IKB0	Leptomonas seymouri	33%	69%
A0A0S4IVY6	Bodo saltans	43%	95%
A0A0S4JA30	Bodo saltans	44%	100%
A0A0S4JCG2	Bodo saltans	24%	88%
A0A0S4JN06	Bodo saltans	52%	100%
A0A0S4JP58	Bodo saltans	48%	92%
A0A0S4JXJ0	Bodo saltans	40%	100%
A0A1X0NIT3	Trypanosomatidae	52%	100%
A0A1X0NXJ1	Trypanosomatidae	39%	100%
A0A1X0NZS9	Trypanosomatidae	44%	89%
A0A1X0P176	Trypanosomatidae	50%	100%
A0A3Q8IJ66	Leishmania donovani	49%	100%
A0A3Q8ISA0	Leishmania donovani	95%	100%
A0A3S7WNZ6	Leishmania donovani	37%	100%
A0A3S7WZA2	Leishmania donovani	41%	76%
A0A3S7X0V1	Leishmania donovani	31%	69%
A0A3S7X8X3	Leishmania donovani	47%	100%
A0A422MSV5	Trypanosoma rangeli	41%	100%
A0A422NL83	Trypanosoma rangeli	41%	99%
A4H436	Leishmania braziliensis	37%	100%
A4HCD7	Leishmania braziliensis	22%	92%
A4HEI6	Leishmania braziliensis	40%	76%
A4HFV0	Leishmania braziliensis	32%	70%
A4HIT6	Leishmania braziliensis	79%	99%
A4HMD0	Leishmania braziliensis	47%	100%
A4HMD1	Leishmania braziliensis	46%	100%
A4HSC0	Leishmania infantum	37%	100%
A4I1K4	Leishmania infantum	41%	76%
A4I2Y4	Leishmania infantum	31%	69%
A4I638	Leishmania infantum	95%	100%
A4IAZ7	Leishmania infantum	47%	100%
A4IAZ8	Leishmania infantum	49%	100%
A7E3X2	Bos taurus	46%	86%
B9VVJ6	Trypanosoma brucei brucei	52%	100%
C9ZK43	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	98%
C9ZNJ6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
C9ZNJ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
D0A1R2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
D3ZBE5	Rattus norvegicus	25%	100%
E9ADF5	Leishmania major	31%	70%
E9AKA2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9AZ78	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	69%
E9B5Y0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E9B5Y1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%
O15726	Plasmodium falciparum (isolate Dd2)	43%	100%
O57252	Vaccinia virus (strain Ankara)	27%	100%
O74135	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	45%	90%
O76324	Drosophila melanogaster	47%	89%
O96999	Leishmania major	37%	100%
P16913	Vaccinia virus (strain Western Reserve)	27%	100%
P20505	Vaccinia virus (strain Copenhagen)	27%	100%
P23291	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	43%	73%
P23292	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	43%	72%
P29295	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	47%	80%
P33800	Variola virus (isolate Human/India/Ind3/1967)	26%	100%
P34516	Caenorhabditis elegans	29%	100%
P35507	Bos taurus	42%	100%
P35508	Bos taurus	49%	95%
P35509	Bos taurus	47%	100%
P39962	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	39%	75%
P40230	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	42%	73%
P40233	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	44%	88%
P40234	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	44%	90%
P40235	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	49%	100%
P40236	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	48%	98%
P42158	Arabidopsis thaliana	46%	87%
P42168	Caenorhabditis elegans	42%	100%
P48729	Homo sapiens	43%	100%
P48730	Homo sapiens	49%	95%
P49674	Homo sapiens	49%	94%
P54367	Drosophila melanogaster	46%	100%
P67827	Bos taurus	43%	100%
P67828	Oryctolagus cuniculus	43%	100%
P67829	Ovis aries	43%	100%
P67962	Gallus gallus	43%	100%
P67963	Xenopus laevis	43%	100%
P78368	Homo sapiens	46%	95%
P97633	Rattus norvegicus	43%	100%
P9WI62	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	25%	98%
P9WI63	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	25%	98%
Q06486	Rattus norvegicus	49%	95%
Q20471	Caenorhabditis elegans	48%	79%
Q32PI1	Bos taurus	28%	99%
Q39050	Arabidopsis thaliana	48%	86%
Q4Q6U1	Leishmania major	91%	100%
Q4Q9T3	Leishmania major	43%	78%
Q4R9A9	Macaca fascicularis	46%	100%
Q4V3C8	Arabidopsis thaliana	27%	81%
Q54DF7	Dictyostelium discoideum	36%	79%
Q556Y4	Dictyostelium discoideum	49%	92%
Q5BP74	Xenopus laevis	49%	95%
Q5PRD4	Danio rerio	46%	93%
Q5R4V3	Pongo abelii	46%	86%
Q5RC72	Pongo abelii	49%	95%
Q5XF24	Arabidopsis thaliana	48%	84%
Q5ZJS0	Gallus gallus	46%	86%
Q5ZLL1	Gallus gallus	48%	94%
Q62761	Rattus norvegicus	42%	100%
Q62762	Rattus norvegicus	46%	95%
Q62763	Rattus norvegicus	47%	88%
Q6K9N1	Oryza sativa subsp. japonica	49%	85%
Q6NRT0	Xenopus laevis	44%	85%
Q6P3K7	Danio rerio	49%	96%
Q6P647	Xenopus tropicalis	49%	95%
Q6QNL9	Eimeria tenella	47%	100%
Q6QNM1	Toxoplasma gondii	47%	100%
Q7RBX5	Plasmodium yoelii yoelii	44%	100%
Q7T2E3	Danio rerio	49%	98%
Q7TYY6	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	27%	98%
Q7ZUS1	Danio rerio	27%	92%
Q80X41	Mus musculus	29%	89%
Q86Y07	Homo sapiens	29%	77%
Q8BK63	Mus musculus	43%	100%
Q8BN21	Mus musculus	28%	78%
Q8BTH8	Mus musculus	46%	86%
Q8BVP5	Mus musculus	46%	95%
Q8C4X2	Mus musculus	43%	93%
Q8IHZ9	Plasmodium falciparum (isolate 3D7)	44%	100%
Q8LPI7	Arabidopsis thaliana	44%	95%
Q8LPJ1	Arabidopsis thaliana	45%	82%
Q8N752	Homo sapiens	43%	100%
Q8SQR2	Encephalitozoon cuniculi (strain GB-M1)	34%	100%
Q8SS96	Encephalitozoon cuniculi (strain GB-M1)	40%	100%
Q8TDX7	Homo sapiens	25%	100%
Q8VYK9	Arabidopsis thaliana	46%	90%
Q8WQ99	Caenorhabditis elegans	41%	97%
Q91FD5	Invertebrate iridescent virus 6	27%	96%
Q93Z18	Arabidopsis thaliana	43%	95%
Q95PZ9	Caenorhabditis elegans	30%	100%
Q99986	Homo sapiens	29%	99%
Q9CAI5	Arabidopsis thaliana	48%	85%
Q9DC28	Mus musculus	49%	95%
Q9ES74	Mus musculus	25%	100%
Q9FFH8	Arabidopsis thaliana	48%	83%
Q9HCP0	Homo sapiens	46%	93%
Q9J509	Fowlpox virus (strain NVSL)	28%	100%
Q9J523	Fowlpox virus (strain NVSL)	27%	100%
Q9JMK2	Mus musculus	49%	94%
Q9LSX4	Arabidopsis thaliana	47%	82%
Q9LW62	Arabidopsis thaliana	47%	89%
Q9NHE1	Leishmania major	45%	100%
Q9NHE2	Leishmania major	48%	100%
Q9XF67	Arabidopsis thaliana	29%	80%
Q9Y6M4	Homo sapiens	47%	88%
Q9ZUP4	Arabidopsis thaliana	49%	91%
Q9ZV15	Arabidopsis thaliana	24%	67%
Q9ZWB3	Arabidopsis thaliana	48%	83%
V5AIW9	Trypanosoma cruzi	42%	100%
V5BMQ3	Trypanosoma cruzi	61%	98%