TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B1C1_LEIMU

TriTrypDb:

LmxM.29.3450

Length:

401

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B1C1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1C1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.290
CLV_C14_Caspase3-7	161	165	PF00656	0.381
CLV_MEL_PAP_1	60	66	PF00089	0.447
CLV_NRD_NRD_1	140	142	PF00675	0.476
CLV_NRD_NRD_1	187	189	PF00675	0.447
CLV_NRD_NRD_1	198	200	PF00675	0.514
CLV_NRD_NRD_1	243	245	PF00675	0.290
CLV_NRD_NRD_1	95	97	PF00675	0.277
CLV_PCSK_KEX2_1	15	17	PF00082	0.535
CLV_PCSK_KEX2_1	243	245	PF00082	0.281
CLV_PCSK_KEX2_1	268	270	PF00082	0.482
CLV_PCSK_KEX2_1	95	97	PF00082	0.282
CLV_PCSK_PC1ET2_1	15	17	PF00082	0.589
CLV_PCSK_PC1ET2_1	268	270	PF00082	0.448
CLV_PCSK_SKI1_1	188	192	PF00082	0.399
CLV_PCSK_SKI1_1	211	215	PF00082	0.441
CLV_PCSK_SKI1_1	251	255	PF00082	0.435
CLV_PCSK_SKI1_1	376	380	PF00082	0.478
CLV_PCSK_SKI1_1	49	53	PF00082	0.325
CLV_PCSK_SKI1_1	96	100	PF00082	0.254
DEG_APCC_DBOX_1	187	195	PF00400	0.470
DEG_SCF_FBW7_1	341	348	PF00400	0.377
DOC_CDC14_PxL_1	1	9	PF14671	0.257
DOC_CYCLIN_RxL_1	46	55	PF00134	0.377
DOC_PP2B_LxvP_1	59	62	PF13499	0.397
DOC_USP7_MATH_1	155	159	PF00917	0.412
DOC_USP7_MATH_1	384	388	PF00917	0.466
DOC_USP7_MATH_1	62	66	PF00917	0.465
DOC_USP7_UBL2_3	236	240	PF12436	0.457
DOC_WW_Pin1_4	34	39	PF00397	0.426
DOC_WW_Pin1_4	341	346	PF00397	0.440
LIG_14-3-3_CanoR_1	243	252	PF00244	0.464
LIG_14-3-3_CanoR_1	259	266	PF00244	0.345
LIG_14-3-3_CanoR_1	30	36	PF00244	0.510
LIG_14-3-3_CanoR_1	54	60	PF00244	0.496
LIG_Actin_WH2_2	175	190	PF00022	0.219
LIG_APCC_ABBA_1	17	22	PF00400	0.438
LIG_APCC_ABBAyCdc20_2	16	22	PF00400	0.415
LIG_BIR_II_1	1	5	PF00653	0.453
LIG_BRCT_BRCA1_1	396	400	PF00533	0.457
LIG_CtBP_PxDLS_1	363	367	PF00389	0.306
LIG_FHA_1	166	172	PF00498	0.442
LIG_FHA_1	240	246	PF00498	0.409
LIG_FHA_1	307	313	PF00498	0.437
LIG_FHA_1	341	347	PF00498	0.425
LIG_FHA_1	348	354	PF00498	0.430
LIG_FHA_1	56	62	PF00498	0.350
LIG_FHA_1	82	88	PF00498	0.334
LIG_FHA_2	24	30	PF00498	0.412
LIG_FHA_2	274	280	PF00498	0.473
LIG_FHA_2	342	348	PF00498	0.489
LIG_FHA_2	83	89	PF00498	0.405
LIG_LIR_Gen_1	164	174	PF02991	0.390
LIG_LIR_Gen_1	270	278	PF02991	0.462
LIG_LIR_Gen_1	84	94	PF02991	0.271
LIG_LIR_Nem_3	164	169	PF02991	0.306
LIG_LIR_Nem_3	183	187	PF02991	0.357
LIG_LIR_Nem_3	270	274	PF02991	0.488
LIG_LIR_Nem_3	318	322	PF02991	0.367
LIG_LIR_Nem_3	84	89	PF02991	0.271
LIG_MAD2	30	38	PF02301	0.448
LIG_MYND_3	4	8	PF01753	0.227
LIG_NRBOX	213	219	PF00104	0.429
LIG_PDZ_Class_2	396	401	PF00595	0.508
LIG_SH2_CRK	123	127	PF00017	0.303
LIG_SH2_NCK_1	123	127	PF00017	0.445
LIG_SH2_STAT5	144	147	PF00017	0.430
LIG_SH2_STAT5	285	288	PF00017	0.570
LIG_SH3_1	199	205	PF00018	0.433
LIG_SH3_3	199	205	PF00018	0.415
LIG_SH3_3	297	303	PF00018	0.385
LIG_SH3_3	351	357	PF00018	0.343
LIG_SUMO_SIM_par_1	167	172	PF11976	0.435
LIG_SUMO_SIM_par_1	295	302	PF11976	0.328
LIG_SUMO_SIM_par_1	308	314	PF11976	0.320
LIG_SUMO_SIM_par_1	320	326	PF11976	0.330
LIG_SUMO_SIM_par_1	360	367	PF11976	0.455
LIG_SUMO_SIM_par_1	49	55	PF11976	0.415
MOD_CK1_1	172	178	PF00069	0.446
MOD_CK1_1	34	40	PF00069	0.414
MOD_CK1_1	55	61	PF00069	0.466
MOD_CK2_1	23	29	PF00069	0.475
MOD_CK2_1	273	279	PF00069	0.475
MOD_CK2_1	341	347	PF00069	0.479
MOD_CK2_1	82	88	PF00069	0.405
MOD_Cter_Amidation	266	269	PF01082	0.407
MOD_GlcNHglycan	263	266	PF01048	0.475
MOD_GlcNHglycan	289	292	PF01048	0.548
MOD_GlcNHglycan	387	390	PF01048	0.501
MOD_GSK3_1	165	172	PF00069	0.369
MOD_GSK3_1	239	246	PF00069	0.515
MOD_GSK3_1	255	262	PF00069	0.275
MOD_GSK3_1	283	290	PF00069	0.515
MOD_GSK3_1	306	313	PF00069	0.383
MOD_GSK3_1	341	348	PF00069	0.402
MOD_N-GLC_1	20	25	PF02516	0.431
MOD_N-GLC_2	129	131	PF02516	0.481
MOD_NEK2_1	169	174	PF00069	0.424
MOD_NEK2_1	20	25	PF00069	0.499
MOD_NEK2_1	239	244	PF00069	0.431
MOD_NEK2_1	260	265	PF00069	0.513
MOD_NEK2_1	364	369	PF00069	0.440
MOD_NEK2_1	393	398	PF00069	0.525
MOD_NEK2_1	52	57	PF00069	0.439
MOD_NEK2_1	82	87	PF00069	0.147
MOD_PIKK_1	121	127	PF00454	0.372
MOD_PIKK_1	283	289	PF00454	0.530
MOD_PIKK_1	52	58	PF00454	0.375
MOD_PKA_1	243	249	PF00069	0.237
MOD_PKA_1	283	289	PF00069	0.568
MOD_PKA_2	243	249	PF00069	0.298
MOD_PKA_2	260	266	PF00069	0.508
MOD_PKA_2	327	333	PF00069	0.355
MOD_PKA_2	62	68	PF00069	0.451
MOD_PKB_1	259	267	PF00069	0.503
MOD_Plk_1	20	26	PF00069	0.429
MOD_Plk_1	364	370	PF00069	0.330
MOD_Plk_4	169	175	PF00069	0.449
MOD_Plk_4	213	219	PF00069	0.441
MOD_Plk_4	306	312	PF00069	0.384
MOD_Plk_4	55	61	PF00069	0.345
MOD_Plk_4	82	88	PF00069	0.363
MOD_ProDKin_1	34	40	PF00069	0.433
MOD_ProDKin_1	341	347	PF00069	0.436
MOD_SUMO_rev_2	8	17	PF00179	0.438
TRG_DiLeu_BaEn_4	361	367	PF01217	0.508
TRG_ENDOCYTIC_2	123	126	PF00928	0.304
TRG_ER_diArg_1	16	19	PF00400	0.516
TRG_ER_diArg_1	243	245	PF00400	0.297
TRG_ER_diArg_1	94	96	PF00400	0.323
TRG_Pf-PMV_PEXEL_1	243	247	PF00026	0.451

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P422	Leptomonas seymouri	75%	100%
A0A0S4JKF4	Bodo saltans	36%	95%
A0A1X0P1J7	Trypanosomatidae	41%	97%
A0A3Q8IF79	Leishmania donovani	97%	100%
A0A422NMP4	Trypanosoma rangeli	40%	97%
A4HIT4	Leishmania braziliensis	87%	100%
A4I636	Leishmania infantum	97%	100%
C9ZRF5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
Q0P5H9	Bos taurus	23%	91%
Q4Q6U3	Leishmania major	96%	100%
Q5BK48	Rattus norvegicus	24%	91%
Q8N0Z6	Homo sapiens	25%	91%
Q99LG4	Mus musculus	23%	91%
V5DNS8	Trypanosoma cruzi	46%	100%