Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B1C0_LEIMU

TriTrypDb:

LmxM.29.3445

Length:

143

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9B1C0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1C0

Function

Biological processes
Term	Name	Level	Count
GO:0000394	RNA splicing, via endonucleolytic cleavage and ligation	8	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation	9	2
GO:0006396	RNA processing	6	2
GO:0006399	tRNA metabolic process	7	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008033	tRNA processing	8	2
GO:0008152	metabolic process	1	2
GO:0008380	RNA splicing	7	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034660	ncRNA metabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000213	tRNA-intron endonuclease activity	6	1
GO:0003676	nucleic acid binding	3	2
GO:0003824	catalytic activity	1	1
GO:0004518	nuclease activity	4	1
GO:0004519	endonuclease activity	5	1
GO:0004521	RNA endonuclease activity	5	1
GO:0004540	RNA nuclease activity	4	1
GO:0004549	tRNA-specific ribonuclease activity	5	1
GO:0005488	binding	1	2
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016892	RNA endonuclease activity, producing 3'-phosphomonoesters	6	1
GO:0016894	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters	6	1
GO:0097159	organic cyclic compound binding	2	2
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140101	catalytic activity, acting on a tRNA	4	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	85	89	PF00656	0.466
CLV_NRD_NRD_1	121	123	PF00675	0.375
CLV_NRD_NRD_1	72	74	PF00675	0.467
CLV_NRD_NRD_1	9	11	PF00675	0.534
CLV_PCSK_KEX2_1	11	13	PF00082	0.560
CLV_PCSK_KEX2_1	72	74	PF00082	0.467
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.699
CLV_PCSK_SKI1_1	42	46	PF00082	0.409
DOC_CYCLIN_RxL_1	39	46	PF00134	0.263
DOC_PP4_FxxP_1	102	105	PF00568	0.622
DOC_USP7_MATH_1	25	29	PF00917	0.736
DOC_USP7_MATH_1	52	56	PF00917	0.364
DOC_USP7_MATH_2	13	19	PF00917	0.558
DOC_WW_Pin1_4	101	106	PF00397	0.429
DOC_WW_Pin1_4	50	55	PF00397	0.552
LIG_14-3-3_CanoR_1	116	126	PF00244	0.358
LIG_14-3-3_CanoR_1	42	48	PF00244	0.285
LIG_FHA_1	69	75	PF00498	0.336
LIG_FHA_1	82	88	PF00498	0.430
LIG_FHA_2	128	134	PF00498	0.280
LIG_LIR_Apic_2	100	105	PF02991	0.618
LIG_LIR_Gen_1	3	9	PF02991	0.701
LIG_LIR_Nem_3	3	7	PF02991	0.664
LIG_NRBOX	39	45	PF00104	0.352
LIG_SH2_STAP1	139	143	PF00017	0.489
LIG_SH2_STAT5	139	142	PF00017	0.437
LIG_SH2_STAT5	4	7	PF00017	0.670
LIG_SUMO_SIM_anti_2	107	113	PF11976	0.441
LIG_SUMO_SIM_anti_2	3	9	PF11976	0.573
MOD_CDC14_SPxK_1	53	56	PF00782	0.450
MOD_CDK_SPxK_1	50	56	PF00069	0.454
MOD_CK1_1	104	110	PF00069	0.483
MOD_CK1_1	38	44	PF00069	0.409
MOD_CK2_1	127	133	PF00069	0.273
MOD_CK2_1	63	69	PF00069	0.418
MOD_GlcNHglycan	106	109	PF01048	0.448
MOD_GlcNHglycan	22	25	PF01048	0.604
MOD_GlcNHglycan	27	30	PF01048	0.537
MOD_GSK3_1	122	129	PF00069	0.427
MOD_GSK3_1	15	22	PF00069	0.682
MOD_GSK3_1	27	34	PF00069	0.638
MOD_GSK3_1	52	59	PF00069	0.571
MOD_GSK3_1	83	90	PF00069	0.493
MOD_N-GLC_2	119	121	PF02516	0.423
MOD_NEK2_1	126	131	PF00069	0.321
MOD_NEK2_1	137	142	PF00069	0.399
MOD_NEK2_1	43	48	PF00069	0.484
MOD_NMyristoyl	1	7	PF02799	0.585
MOD_OFUCOSY	115	121	PF10250	0.353
MOD_PKA_1	122	128	PF00069	0.408
MOD_PKA_2	20	26	PF00069	0.509
MOD_Plk_2-3	15	21	PF00069	0.528
MOD_Plk_2-3	83	89	PF00069	0.452
MOD_Plk_4	107	113	PF00069	0.437
MOD_Plk_4	122	128	PF00069	0.436
MOD_Plk_4	3	9	PF00069	0.700
MOD_ProDKin_1	101	107	PF00069	0.424
MOD_ProDKin_1	50	56	PF00069	0.548
TRG_DiLeu_BaLyEn_6	39	44	PF01217	0.256
TRG_ENDOCYTIC_2	4	7	PF00928	0.686
TRG_ER_diArg_1	72	74	PF00400	0.349
TRG_ER_diArg_1	9	12	PF00400	0.528
TRG_NLS_MonoExtC_3	9	14	PF00514	0.577

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4G2	Leptomonas seymouri	55%	91%
A0A3S7X3W7	Leishmania donovani	93%	100%
A4HIT3	Leishmania braziliensis	80%	100%
A4I635	Leishmania infantum	93%	100%
C9ZRF4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	89%
Q4Q6U4	Leishmania major	90%	100%