Reverse transcriptase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

T-complex protein 11, putative

Species:

Leishmania mexicana

UniProt:

E9B1B7_LEIMU

TriTrypDb:

LmxM.29.3420

Length:

873

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B1B7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1B7

Function

Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	1
GO:0009987	cellular process	1	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	133	135	PF00675	0.480
CLV_NRD_NRD_1	169	171	PF00675	0.686
CLV_NRD_NRD_1	282	284	PF00675	0.508
CLV_NRD_NRD_1	316	318	PF00675	0.517
CLV_NRD_NRD_1	375	377	PF00675	0.721
CLV_NRD_NRD_1	401	403	PF00675	0.500
CLV_NRD_NRD_1	404	406	PF00675	0.470
CLV_NRD_NRD_1	606	608	PF00675	0.376
CLV_NRD_NRD_1	645	647	PF00675	0.370
CLV_NRD_NRD_1	711	713	PF00675	0.417
CLV_NRD_NRD_1	808	810	PF00675	0.350
CLV_NRD_NRD_1	92	94	PF00675	0.434
CLV_PCSK_FUR_1	402	406	PF00082	0.558
CLV_PCSK_KEX2_1	121	123	PF00082	0.624
CLV_PCSK_KEX2_1	133	135	PF00082	0.420
CLV_PCSK_KEX2_1	292	294	PF00082	0.502
CLV_PCSK_KEX2_1	315	317	PF00082	0.529
CLV_PCSK_KEX2_1	374	376	PF00082	0.736
CLV_PCSK_KEX2_1	403	405	PF00082	0.473
CLV_PCSK_KEX2_1	645	647	PF00082	0.368
CLV_PCSK_KEX2_1	711	713	PF00082	0.417
CLV_PCSK_KEX2_1	808	810	PF00082	0.308
CLV_PCSK_KEX2_1	91	93	PF00082	0.453
CLV_PCSK_PC1ET2_1	121	123	PF00082	0.550
CLV_PCSK_PC1ET2_1	292	294	PF00082	0.502
CLV_PCSK_PC1ET2_1	315	317	PF00082	0.529
CLV_PCSK_PC1ET2_1	403	405	PF00082	0.569
CLV_PCSK_SKI1_1	133	137	PF00082	0.492
CLV_PCSK_SKI1_1	189	193	PF00082	0.502
CLV_PCSK_SKI1_1	196	200	PF00082	0.515
CLV_PCSK_SKI1_1	227	231	PF00082	0.484
CLV_PCSK_SKI1_1	292	296	PF00082	0.560
CLV_PCSK_SKI1_1	411	415	PF00082	0.430
CLV_PCSK_SKI1_1	531	535	PF00082	0.451
CLV_PCSK_SKI1_1	648	652	PF00082	0.334
CLV_PCSK_SKI1_1	712	716	PF00082	0.368
CLV_PCSK_SKI1_1	808	812	PF00082	0.311
CLV_PCSK_SKI1_1	843	847	PF00082	0.299
CLV_PCSK_SKI1_1	858	862	PF00082	0.244
DEG_APCC_DBOX_1	188	196	PF00400	0.490
DEG_APCC_DBOX_1	807	815	PF00400	0.350
DEG_APCC_DBOX_1	857	865	PF00400	0.417
DEG_APCC_DBOX_1	90	98	PF00400	0.410
DEG_SCF_FBW7_1	52	58	PF00400	0.459
DEG_SPOP_SBC_1	359	363	PF00917	0.782
DOC_CKS1_1	332	337	PF01111	0.774
DOC_CKS1_1	52	57	PF01111	0.577
DOC_CYCLIN_RxL_1	186	193	PF00134	0.503
DOC_MAPK_DCC_7	820	830	PF00069	0.372
DOC_MAPK_DCC_7	858	866	PF00069	0.451
DOC_MAPK_gen_1	121	129	PF00069	0.698
DOC_MAPK_gen_1	607	615	PF00069	0.451
DOC_MAPK_gen_1	645	653	PF00069	0.334
DOC_MAPK_gen_1	808	816	PF00069	0.247
DOC_MAPK_gen_1	88	97	PF00069	0.403
DOC_MAPK_MEF2A_6	809	818	PF00069	0.169
DOC_MAPK_MEF2A_6	858	866	PF00069	0.451
DOC_MAPK_RevD_3	697	712	PF00069	0.372
DOC_PIKK_1	38	46	PF02985	0.284
DOC_PP1_RVXF_1	609	616	PF00149	0.315
DOC_PP1_RVXF_1	622	629	PF00149	0.426
DOC_PP1_RVXF_1	680	687	PF00149	0.289
DOC_PP1_RVXF_1	807	814	PF00149	0.289
DOC_PP2B_LxvP_1	603	606	PF13499	0.350
DOC_USP7_MATH_1	174	178	PF00917	0.677
DOC_USP7_MATH_1	234	238	PF00917	0.629
DOC_USP7_MATH_1	246	250	PF00917	0.540
DOC_USP7_MATH_1	254	258	PF00917	0.447
DOC_USP7_MATH_1	323	327	PF00917	0.515
DOC_USP7_MATH_1	367	371	PF00917	0.694
DOC_USP7_MATH_1	537	541	PF00917	0.431
DOC_USP7_MATH_1	55	59	PF00917	0.331
DOC_USP7_MATH_1	636	640	PF00917	0.312
DOC_USP7_MATH_1	704	708	PF00917	0.463
DOC_USP7_MATH_1	717	721	PF00917	0.338
DOC_WW_Pin1_4	162	167	PF00397	0.766
DOC_WW_Pin1_4	19	24	PF00397	0.521
DOC_WW_Pin1_4	201	206	PF00397	0.562
DOC_WW_Pin1_4	240	245	PF00397	0.643
DOC_WW_Pin1_4	250	255	PF00397	0.451
DOC_WW_Pin1_4	324	329	PF00397	0.649
DOC_WW_Pin1_4	331	336	PF00397	0.701
DOC_WW_Pin1_4	360	365	PF00397	0.705
DOC_WW_Pin1_4	455	460	PF00397	0.368
DOC_WW_Pin1_4	51	56	PF00397	0.524
DOC_WW_Pin1_4	525	530	PF00397	0.417
DOC_WW_Pin1_4	547	552	PF00397	0.334
LIG_14-3-3_CanoR_1	133	138	PF00244	0.507
LIG_14-3-3_CanoR_1	26	36	PF00244	0.643
LIG_14-3-3_CanoR_1	272	276	PF00244	0.571
LIG_14-3-3_CanoR_1	293	299	PF00244	0.498
LIG_14-3-3_CanoR_1	304	311	PF00244	0.438
LIG_14-3-3_CanoR_1	390	395	PF00244	0.503
LIG_14-3-3_CanoR_1	538	546	PF00244	0.409
LIG_14-3-3_CanoR_1	624	629	PF00244	0.267
LIG_14-3-3_CanoR_1	724	734	PF00244	0.374
LIG_14-3-3_CanoR_1	820	828	PF00244	0.302
LIG_Actin_WH2_2	644	662	PF00022	0.299
LIG_Actin_WH2_2	731	746	PF00022	0.338
LIG_Actin_WH2_2	90	105	PF00022	0.361
LIG_BIR_II_1	1	5	PF00653	0.713
LIG_BIR_III_4	6	10	PF00653	0.605
LIG_BRCT_BRCA1_1	611	615	PF00533	0.289
LIG_Clathr_ClatBox_1	698	702	PF01394	0.417
LIG_EVH1_2	674	678	PF00568	0.417
LIG_FHA_1	139	145	PF00498	0.493
LIG_FHA_1	293	299	PF00498	0.544
LIG_FHA_1	325	331	PF00498	0.683
LIG_FHA_1	548	554	PF00498	0.417
LIG_FHA_1	653	659	PF00498	0.350
LIG_FHA_1	694	700	PF00498	0.344
LIG_FHA_1	820	826	PF00498	0.331
LIG_FHA_1	830	836	PF00498	0.241
LIG_FHA_1	867	873	PF00498	0.671
LIG_FHA_2	1	7	PF00498	0.718
LIG_FHA_2	156	162	PF00498	0.544
LIG_FHA_2	272	278	PF00498	0.560
LIG_FHA_2	305	311	PF00498	0.481
LIG_FHA_2	343	349	PF00498	0.680
LIG_FHA_2	425	431	PF00498	0.335
LIG_FHA_2	442	448	PF00498	0.392
LIG_FHA_2	639	645	PF00498	0.289
LIG_FHA_2	663	669	PF00498	0.417
LIG_FHA_2	689	695	PF00498	0.334
LIG_FHA_2	777	783	PF00498	0.297
LIG_FHA_2	794	800	PF00498	0.255
LIG_LIR_Apic_2	331	335	PF02991	0.708
LIG_LIR_Gen_1	309	318	PF02991	0.535
LIG_LIR_Gen_1	491	500	PF02991	0.381
LIG_LIR_Gen_1	627	636	PF02991	0.169
LIG_LIR_Gen_1	668	678	PF02991	0.370
LIG_LIR_Gen_1	800	811	PF02991	0.311
LIG_LIR_Nem_3	220	225	PF02991	0.349
LIG_LIR_Nem_3	309	314	PF02991	0.523
LIG_LIR_Nem_3	491	495	PF02991	0.298
LIG_LIR_Nem_3	497	501	PF02991	0.250
LIG_LIR_Nem_3	627	631	PF02991	0.169
LIG_LIR_Nem_3	668	673	PF02991	0.288
LIG_LIR_Nem_3	800	806	PF02991	0.311
LIG_LIR_Nem_3	856	860	PF02991	0.281
LIG_MYND_1	379	383	PF01753	0.553
LIG_MYND_1	482	486	PF01753	0.302
LIG_NRBOX	464	470	PF00104	0.417
LIG_NRBOX	696	702	PF00104	0.289
LIG_PCNA_yPIPBox_3	711	723	PF02747	0.169
LIG_Pex14_2	142	146	PF04695	0.484
LIG_Pex14_2	561	565	PF04695	0.310
LIG_Pex14_2	615	619	PF04695	0.350
LIG_SH2_CRK	299	303	PF00017	0.474
LIG_SH2_CRK	332	336	PF00017	0.710
LIG_SH2_NCK_1	332	336	PF00017	0.710
LIG_SH2_PTP2	113	116	PF00017	0.634
LIG_SH2_STAP1	225	229	PF00017	0.463
LIG_SH2_STAP1	419	423	PF00017	0.392
LIG_SH2_STAT3	225	228	PF00017	0.524
LIG_SH2_STAT5	113	116	PF00017	0.657
LIG_SH2_STAT5	147	150	PF00017	0.511
LIG_SH2_STAT5	210	213	PF00017	0.578
LIG_SH2_STAT5	386	389	PF00017	0.544
LIG_SH2_STAT5	408	411	PF00017	0.481
LIG_SH2_STAT5	594	597	PF00017	0.323
LIG_SH2_STAT5	679	682	PF00017	0.308
LIG_SH2_STAT5	803	806	PF00017	0.308
LIG_SH3_1	376	382	PF00018	0.594
LIG_SH3_1	429	435	PF00018	0.302
LIG_SH3_3	376	382	PF00018	0.540
LIG_SH3_3	429	435	PF00018	0.427
LIG_SH3_3	49	55	PF00018	0.512
LIG_SH3_3	628	634	PF00018	0.302
LIG_SH3_3	668	674	PF00018	0.350
LIG_SH3_3	849	855	PF00018	0.328
LIG_SUMO_SIM_anti_2	655	661	PF11976	0.414
LIG_SUMO_SIM_anti_2	696	702	PF11976	0.292
LIG_SUMO_SIM_anti_2	815	820	PF11976	0.169
LIG_SUMO_SIM_par_1	467	474	PF11976	0.403
LIG_SUMO_SIM_par_1	696	702	PF11976	0.291
LIG_TRAF2_1	641	644	PF00917	0.346
LIG_TRAF2_1	691	694	PF00917	0.289
LIG_TYR_ITIM	297	302	PF00017	0.474
LIG_UBA3_1	104	111	PF00899	0.469
LIG_WRC_WIRS_1	803	808	PF05994	0.310
LIG_WW_3	165	169	PF00397	0.531
LIG_WW_3	480	484	PF00397	0.400
MOD_CDC14_SPxK_1	528	531	PF00782	0.417
MOD_CDK_SPK_2	19	24	PF00069	0.476
MOD_CDK_SPK_2	240	245	PF00069	0.595
MOD_CDK_SPK_2	324	329	PF00069	0.649
MOD_CDK_SPxK_1	162	168	PF00069	0.503
MOD_CDK_SPxK_1	525	531	PF00069	0.417
MOD_CDK_SPxxK_3	19	26	PF00069	0.474
MOD_CK1_1	150	156	PF00069	0.639
MOD_CK1_1	169	175	PF00069	0.590
MOD_CK1_1	177	183	PF00069	0.551
MOD_CK1_1	217	223	PF00069	0.368
MOD_CK1_1	249	255	PF00069	0.766
MOD_CK1_1	257	263	PF00069	0.390
MOD_CK1_1	57	63	PF00069	0.618
MOD_CK1_1	627	633	PF00069	0.436
MOD_CK1_1	865	871	PF00069	0.624
MOD_CK2_1	234	240	PF00069	0.643
MOD_CK2_1	271	277	PF00069	0.590
MOD_CK2_1	29	35	PF00069	0.516
MOD_CK2_1	304	310	PF00069	0.505
MOD_CK2_1	342	348	PF00069	0.603
MOD_CK2_1	367	373	PF00069	0.565
MOD_CK2_1	441	447	PF00069	0.406
MOD_CK2_1	638	644	PF00069	0.305
MOD_CK2_1	688	694	PF00069	0.334
MOD_CK2_1	778	784	PF00069	0.251
MOD_CK2_1	793	799	PF00069	0.342
MOD_CK2_1	853	859	PF00069	0.403
MOD_GlcNHglycan	152	155	PF01048	0.384
MOD_GlcNHglycan	171	174	PF01048	0.725
MOD_GlcNHglycan	179	182	PF01048	0.514
MOD_GlcNHglycan	219	222	PF01048	0.413
MOD_GlcNHglycan	236	239	PF01048	0.711
MOD_GlcNHglycan	539	542	PF01048	0.441
MOD_GlcNHglycan	599	602	PF01048	0.440
MOD_GlcNHglycan	660	663	PF01048	0.288
MOD_GlcNHglycan	719	722	PF01048	0.432
MOD_GSK3_1	162	169	PF00069	0.583
MOD_GSK3_1	177	184	PF00069	0.442
MOD_GSK3_1	210	217	PF00069	0.472
MOD_GSK3_1	236	243	PF00069	0.694
MOD_GSK3_1	246	253	PF00069	0.749
MOD_GSK3_1	266	273	PF00069	0.369
MOD_GSK3_1	300	307	PF00069	0.480
MOD_GSK3_1	450	457	PF00069	0.350
MOD_GSK3_1	51	58	PF00069	0.524
MOD_GSK3_1	64	71	PF00069	0.455
MOD_GSK3_1	658	665	PF00069	0.364
MOD_GSK3_1	725	732	PF00069	0.311
MOD_GSK3_1	776	783	PF00069	0.355
MOD_GSK3_1	784	791	PF00069	0.300
MOD_GSK3_1	862	869	PF00069	0.507
MOD_N-GLC_1	342	347	PF02516	0.600
MOD_N-GLC_1	455	460	PF02516	0.368
MOD_N-GLC_1	510	515	PF02516	0.381
MOD_N-GLC_1	583	588	PF02516	0.350
MOD_NEK2_1	214	219	PF00069	0.350
MOD_NEK2_1	223	228	PF00069	0.383
MOD_NEK2_1	626	631	PF00069	0.350
MOD_NEK2_1	658	663	PF00069	0.293
MOD_NEK2_1	74	79	PF00069	0.457
MOD_NEK2_1	743	748	PF00069	0.294
MOD_NEK2_1	750	755	PF00069	0.296
MOD_NEK2_1	866	871	PF00069	0.507
MOD_NEK2_2	254	259	PF00069	0.432
MOD_PIKK_1	128	134	PF00454	0.606
MOD_PIKK_1	147	153	PF00454	0.598
MOD_PIKK_1	441	447	PF00454	0.467
MOD_PIKK_1	725	731	PF00454	0.440
MOD_PIKK_1	750	756	PF00454	0.378
MOD_PK_1	93	99	PF00069	0.414
MOD_PKA_1	133	139	PF00069	0.467
MOD_PKA_1	292	298	PF00069	0.463
MOD_PKA_2	133	139	PF00069	0.467
MOD_PKA_2	169	175	PF00069	0.628
MOD_PKA_2	177	183	PF00069	0.444
MOD_PKA_2	27	33	PF00069	0.624
MOD_PKA_2	271	277	PF00069	0.605
MOD_PKA_2	292	298	PF00069	0.493
MOD_PKA_2	300	306	PF00069	0.381
MOD_PKA_2	537	543	PF00069	0.374
MOD_PKA_2	788	794	PF00069	0.386
MOD_PKA_2	819	825	PF00069	0.302
MOD_PKB_1	91	99	PF00069	0.540
MOD_Plk_1	531	537	PF00069	0.338
MOD_Plk_1	583	589	PF00069	0.451
MOD_Plk_1	693	699	PF00069	0.309
MOD_Plk_1	767	773	PF00069	0.329
MOD_Plk_2-3	236	242	PF00069	0.577
MOD_Plk_4	138	144	PF00069	0.515
MOD_Plk_4	210	216	PF00069	0.478
MOD_Plk_4	271	277	PF00069	0.574
MOD_Plk_4	531	537	PF00069	0.302
MOD_Plk_4	693	699	PF00069	0.322
MOD_Plk_4	704	710	PF00069	0.257
MOD_Plk_4	743	749	PF00069	0.278
MOD_ProDKin_1	162	168	PF00069	0.767
MOD_ProDKin_1	19	25	PF00069	0.521
MOD_ProDKin_1	201	207	PF00069	0.565
MOD_ProDKin_1	240	246	PF00069	0.644
MOD_ProDKin_1	250	256	PF00069	0.448
MOD_ProDKin_1	324	330	PF00069	0.652
MOD_ProDKin_1	331	337	PF00069	0.702
MOD_ProDKin_1	360	366	PF00069	0.706
MOD_ProDKin_1	455	461	PF00069	0.368
MOD_ProDKin_1	51	57	PF00069	0.520
MOD_ProDKin_1	525	531	PF00069	0.417
MOD_ProDKin_1	547	553	PF00069	0.334
MOD_SUMO_for_1	229	232	PF00179	0.560
MOD_SUMO_rev_2	285	294	PF00179	0.516
MOD_SUMO_rev_2	406	415	PF00179	0.553
TRG_DiLeu_BaEn_1	694	699	PF01217	0.289
TRG_DiLeu_BaLyEn_6	100	105	PF01217	0.444
TRG_ENDOCYTIC_2	299	302	PF00928	0.469
TRG_ENDOCYTIC_2	419	422	PF00928	0.425
TRG_ENDOCYTIC_2	803	806	PF00928	0.274
TRG_ENDOCYTIC_2	857	860	PF00928	0.286
TRG_ER_diArg_1	133	135	PF00400	0.518
TRG_ER_diArg_1	167	170	PF00400	0.506
TRG_ER_diArg_1	26	29	PF00400	0.663
TRG_ER_diArg_1	316	318	PF00400	0.601
TRG_ER_diArg_1	374	376	PF00400	0.635
TRG_ER_diArg_1	402	405	PF00400	0.518
TRG_ER_diArg_1	482	485	PF00400	0.291
TRG_ER_diArg_1	486	489	PF00400	0.290
TRG_ER_diArg_1	645	648	PF00400	0.417
TRG_ER_diArg_1	808	810	PF00400	0.350
TRG_ER_diArg_1	91	93	PF00400	0.515
TRG_NES_CRM1_1	38	51	PF08389	0.462
TRG_NES_CRM1_1	837	851	PF08389	0.169
TRG_Pf-PMV_PEXEL_1	189	193	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	316	320	PF00026	0.427
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.476
TRG_Pf-PMV_PEXEL_1	407	412	PF00026	0.585
TRG_Pf-PMV_PEXEL_1	569	573	PF00026	0.274
TRG_Pf-PMV_PEXEL_1	618	622	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	724	729	PF00026	0.356

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ54	Leptomonas seymouri	63%	100%
A0A0S4JLJ6	Bodo saltans	29%	91%
A0A1X0P1B7	Trypanosomatidae	38%	100%
A0A3S7X411	Leishmania donovani	93%	100%
A0A422NMF0	Trypanosoma rangeli	38%	100%
A4HIT0	Leishmania braziliensis	84%	100%
A4I632	Leishmania infantum	93%	100%
C9ZRF0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
Q4Q6U7	Leishmania major	92%	100%
V5B765	Trypanosoma cruzi	37%	100%