Putative calmodulin-related protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

calmodulin-related protein, putative

Species:

Leishmania mexicana

UniProt:

E9B1B1_LEIMU

TriTrypDb:

LmxM.29.3360

Length:

725

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

E9B1B1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1B1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0005509	calcium ion binding	5	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	138	142	PF00656	0.340
CLV_C14_Caspase3-7	338	342	PF00656	0.444
CLV_C14_Caspase3-7	601	605	PF00656	0.505
CLV_C14_Caspase3-7	9	13	PF00656	0.694
CLV_NRD_NRD_1	421	423	PF00675	0.778
CLV_NRD_NRD_1	500	502	PF00675	0.573
CLV_NRD_NRD_1	568	570	PF00675	0.505
CLV_NRD_NRD_1	698	700	PF00675	0.600
CLV_PCSK_KEX2_1	421	423	PF00082	0.778
CLV_PCSK_KEX2_1	5	7	PF00082	0.716
CLV_PCSK_KEX2_1	698	700	PF00082	0.600
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.716
CLV_PCSK_SKI1_1	214	218	PF00082	0.684
CLV_PCSK_SKI1_1	220	224	PF00082	0.628
CLV_PCSK_SKI1_1	231	235	PF00082	0.310
CLV_PCSK_SKI1_1	294	298	PF00082	0.525
CLV_PCSK_SKI1_1	332	336	PF00082	0.408
CLV_PCSK_SKI1_1	355	359	PF00082	0.477
CLV_PCSK_SKI1_1	709	713	PF00082	0.576
DEG_APCC_DBOX_1	293	301	PF00400	0.577
DEG_APCC_DBOX_1	349	357	PF00400	0.485
DEG_APCC_DBOX_1	70	78	PF00400	0.395
DEG_SCF_FBW7_1	622	627	PF00400	0.735
DOC_ANK_TNKS_1	398	405	PF00023	0.600
DOC_CYCLIN_RxL_1	355	363	PF00134	0.559
DOC_MAPK_gen_1	281	289	PF00069	0.347
DOC_MAPK_gen_1	546	554	PF00069	0.710
DOC_MAPK_gen_1	702	712	PF00069	0.593
DOC_MAPK_gen_1	83	91	PF00069	0.464
DOC_MAPK_MEF2A_6	170	177	PF00069	0.593
DOC_MAPK_MEF2A_6	298	307	PF00069	0.610
DOC_PP1_RVXF_1	356	362	PF00149	0.590
DOC_PP1_RVXF_1	707	713	PF00149	0.588
DOC_PP4_FxxP_1	497	500	PF00568	0.565
DOC_USP7_MATH_1	128	132	PF00917	0.548
DOC_USP7_MATH_1	257	261	PF00917	0.408
DOC_USP7_MATH_1	548	552	PF00917	0.532
DOC_USP7_MATH_1	562	566	PF00917	0.516
DOC_USP7_MATH_1	571	575	PF00917	0.579
DOC_USP7_MATH_1	624	628	PF00917	0.647
DOC_WW_Pin1_4	575	580	PF00397	0.692
DOC_WW_Pin1_4	582	587	PF00397	0.664
DOC_WW_Pin1_4	620	625	PF00397	0.761
DOC_WW_Pin1_4	689	694	PF00397	0.653
LIG_14-3-3_CanoR_1	120	126	PF00244	0.520
LIG_14-3-3_CanoR_1	220	229	PF00244	0.678
LIG_14-3-3_CanoR_1	391	395	PF00244	0.549
LIG_14-3-3_CanoR_1	422	432	PF00244	0.711
LIG_14-3-3_CanoR_1	539	548	PF00244	0.785
LIG_14-3-3_CanoR_1	549	553	PF00244	0.593
LIG_14-3-3_CanoR_1	598	607	PF00244	0.643
LIG_14-3-3_CanoR_1	636	641	PF00244	0.656
LIG_14-3-3_CanoR_1	88	98	PF00244	0.499
LIG_Actin_WH2_2	19	37	PF00022	0.500
LIG_AP2alpha_1	361	365	PF02296	0.461
LIG_APCC_ABBA_1	334	339	PF00400	0.444
LIG_BIR_II_1	1	5	PF00653	0.733
LIG_BIR_III_2	363	367	PF00653	0.592
LIG_BIR_III_4	256	260	PF00653	0.429
LIG_BRCT_BRCA1_1	44	48	PF00533	0.485
LIG_FHA_1	153	159	PF00498	0.549
LIG_FHA_1	376	382	PF00498	0.543
LIG_FHA_1	633	639	PF00498	0.408
LIG_FHA_1	652	658	PF00498	0.539
LIG_FHA_1	90	96	PF00498	0.504
LIG_FHA_2	120	126	PF00498	0.513
LIG_FHA_2	136	142	PF00498	0.344
LIG_FHA_2	205	211	PF00498	0.618
LIG_FHA_2	221	227	PF00498	0.439
LIG_FHA_2	259	265	PF00498	0.384
LIG_FHA_2	286	292	PF00498	0.344
LIG_FHA_2	440	446	PF00498	0.506
LIG_LIR_Apic_2	155	159	PF02991	0.603
LIG_LIR_Apic_2	207	211	PF02991	0.639
LIG_LIR_Apic_2	72	76	PF02991	0.468
LIG_LIR_Gen_1	131	137	PF02991	0.485
LIG_LIR_Gen_1	232	238	PF02991	0.356
LIG_LIR_Gen_1	242	251	PF02991	0.325
LIG_LIR_Gen_1	36	44	PF02991	0.344
LIG_LIR_Gen_1	714	723	PF02991	0.441
LIG_LIR_Nem_3	131	136	PF02991	0.344
LIG_LIR_Nem_3	160	164	PF02991	0.558
LIG_LIR_Nem_3	166	172	PF02991	0.483
LIG_LIR_Nem_3	232	237	PF02991	0.356
LIG_LIR_Nem_3	242	247	PF02991	0.325
LIG_LIR_Nem_3	248	254	PF02991	0.302
LIG_LIR_Nem_3	363	368	PF02991	0.367
LIG_LIR_Nem_3	65	70	PF02991	0.476
LIG_LIR_Nem_3	662	666	PF02991	0.486
LIG_LIR_Nem_3	675	680	PF02991	0.536
LIG_LIR_Nem_3	697	703	PF02991	0.557
LIG_LIR_Nem_3	714	718	PF02991	0.302
LIG_MAD2	358	366	PF02301	0.612
LIG_PCNA_TLS_4	391	398	PF02747	0.448
LIG_PCNA_yPIPBox_3	281	293	PF02747	0.408
LIG_Pex14_2	292	296	PF04695	0.344
LIG_Pex14_2	361	365	PF04695	0.461
LIG_Pex14_2	397	401	PF04695	0.473
LIG_Pex14_2	711	715	PF04695	0.573
LIG_Pex14_2	94	98	PF04695	0.435
LIG_PTB_Apo_2	705	712	PF02174	0.315
LIG_SH2_SRC	208	211	PF00017	0.597
LIG_SH2_STAT5	156	159	PF00017	0.645
LIG_SH2_STAT5	208	211	PF00017	0.597
LIG_SH2_STAT5	479	482	PF00017	0.523
LIG_SH2_STAT5	671	674	PF00017	0.432
LIG_SH2_STAT5	73	76	PF00017	0.460
LIG_SH3_1	156	162	PF00018	0.593
LIG_SH3_1	529	535	PF00018	0.503
LIG_SH3_3	156	162	PF00018	0.609
LIG_SH3_3	404	410	PF00018	0.645
LIG_SH3_3	477	483	PF00018	0.602
LIG_SH3_3	529	535	PF00018	0.503
LIG_SH3_3	556	562	PF00018	0.748
LIG_SUMO_SIM_anti_2	171	177	PF11976	0.491
LIG_SUMO_SIM_anti_2	445	451	PF11976	0.434
LIG_SUMO_SIM_par_1	186	192	PF11976	0.592
LIG_SUMO_SIM_par_1	634	642	PF11976	0.586
LIG_TRAF2_1	122	125	PF00917	0.526
LIG_TRAF2_1	196	199	PF00917	0.461
LIG_TRAF2_1	27	30	PF00917	0.510
LIG_TRAF2_1	393	396	PF00917	0.621
LIG_TRAF2_1	50	53	PF00917	0.485
LIG_TRAF2_1	518	521	PF00917	0.483
LIG_TRFH_1	687	691	PF08558	0.628
LIG_WRC_WIRS_1	293	298	PF05994	0.607
LIG_WRC_WIRS_1	398	403	PF05994	0.603
LIG_WRC_WIRS_1	643	648	PF05994	0.595
MOD_CDK_SPK_2	575	580	PF00069	0.730
MOD_CK1_1	131	137	PF00069	0.476
MOD_CK1_1	279	285	PF00069	0.408
MOD_CK1_1	375	381	PF00069	0.495
MOD_CK1_1	424	430	PF00069	0.722
MOD_CK1_1	540	546	PF00069	0.782
MOD_CK1_1	565	571	PF00069	0.746
MOD_CK1_1	575	581	PF00069	0.615
MOD_CK1_1	599	605	PF00069	0.754
MOD_CK1_1	704	710	PF00069	0.578
MOD_CK2_1	119	125	PF00069	0.522
MOD_CK2_1	186	192	PF00069	0.487
MOD_CK2_1	193	199	PF00069	0.415
MOD_CK2_1	204	210	PF00069	0.421
MOD_CK2_1	220	226	PF00069	0.448
MOD_CK2_1	390	396	PF00069	0.550
MOD_CK2_1	397	403	PF00069	0.579
MOD_CK2_1	47	53	PF00069	0.444
MOD_CK2_1	552	558	PF00069	0.791
MOD_CK2_1	628	634	PF00069	0.762
MOD_CK2_1	636	642	PF00069	0.546
MOD_CK2_1	689	695	PF00069	0.574
MOD_CK2_1	87	93	PF00069	0.453
MOD_GlcNHglycan	123	129	PF01048	0.601
MOD_GlcNHglycan	178	181	PF01048	0.475
MOD_GlcNHglycan	283	286	PF01048	0.444
MOD_GlcNHglycan	326	329	PF01048	0.539
MOD_GlcNHglycan	403	407	PF01048	0.626
MOD_GlcNHglycan	433	436	PF01048	0.726
MOD_GlcNHglycan	472	475	PF01048	0.540
MOD_GlcNHglycan	508	511	PF01048	0.636
MOD_GlcNHglycan	554	557	PF01048	0.498
MOD_GlcNHglycan	626	629	PF01048	0.686
MOD_GSK3_1	124	131	PF00069	0.620
MOD_GSK3_1	18	25	PF00069	0.553
MOD_GSK3_1	259	266	PF00069	0.387
MOD_GSK3_1	275	282	PF00069	0.322
MOD_GSK3_1	371	378	PF00069	0.505
MOD_GSK3_1	537	544	PF00069	0.727
MOD_GSK3_1	548	555	PF00069	0.669
MOD_GSK3_1	571	578	PF00069	0.786
MOD_GSK3_1	596	603	PF00069	0.738
MOD_GSK3_1	605	612	PF00069	0.696
MOD_GSK3_1	620	627	PF00069	0.671
MOD_GSK3_1	628	635	PF00069	0.772
MOD_GSK3_1	647	654	PF00069	0.562
MOD_N-GLC_1	131	136	PF02516	0.272
MOD_N-GLC_1	162	167	PF02516	0.366
MOD_N-GLC_1	214	219	PF02516	0.455
MOD_N-GLC_2	111	113	PF02516	0.541
MOD_NEK2_1	1	6	PF00069	0.674
MOD_NEK2_1	11	16	PF00069	0.573
MOD_NEK2_1	193	198	PF00069	0.452
MOD_NEK2_1	292	297	PF00069	0.600
MOD_NEK2_1	34	39	PF00069	0.485
MOD_NEK2_1	372	377	PF00069	0.524
MOD_NEK2_1	397	402	PF00069	0.580
MOD_NEK2_1	431	436	PF00069	0.764
MOD_NEK2_1	506	511	PF00069	0.543
MOD_NEK2_1	538	543	PF00069	0.793
MOD_NEK2_1	573	578	PF00069	0.793
MOD_NEK2_1	607	612	PF00069	0.658
MOD_NEK2_2	285	290	PF00069	0.194
MOD_PIKK_1	263	269	PF00454	0.349
MOD_PIKK_1	573	579	PF00454	0.733
MOD_PIKK_1	596	602	PF00454	0.747
MOD_PIKK_1	609	615	PF00454	0.630
MOD_PK_1	415	421	PF00069	0.645
MOD_PK_1	636	642	PF00069	0.594
MOD_PKA_1	421	427	PF00069	0.773
MOD_PKA_2	119	125	PF00069	0.522
MOD_PKA_2	276	282	PF00069	0.408
MOD_PKA_2	34	40	PF00069	0.466
MOD_PKA_2	390	396	PF00069	0.561
MOD_PKA_2	42	48	PF00069	0.414
MOD_PKA_2	421	427	PF00069	0.773
MOD_PKA_2	525	531	PF00069	0.758
MOD_PKA_2	538	544	PF00069	0.747
MOD_PKA_2	548	554	PF00069	0.583
MOD_PKA_2	673	679	PF00069	0.560
MOD_PKA_2	701	707	PF00069	0.597
MOD_PKA_2	87	93	PF00069	0.510
MOD_Plk_1	124	130	PF00069	0.599
MOD_Plk_1	131	137	PF00069	0.429
MOD_Plk_1	225	231	PF00069	0.444
MOD_Plk_1	263	269	PF00069	0.344
MOD_Plk_1	617	623	PF00069	0.614
MOD_Plk_1	648	654	PF00069	0.576
MOD_Plk_2-3	339	345	PF00069	0.444
MOD_Plk_2-3	87	93	PF00069	0.538
MOD_Plk_4	171	177	PF00069	0.590
MOD_Plk_4	18	24	PF00069	0.577
MOD_Plk_4	204	210	PF00069	0.638
MOD_Plk_4	225	231	PF00069	0.422
MOD_Plk_4	34	40	PF00069	0.442
MOD_Plk_4	372	378	PF00069	0.514
MOD_Plk_4	548	554	PF00069	0.741
MOD_Plk_4	648	654	PF00069	0.576
MOD_ProDKin_1	575	581	PF00069	0.694
MOD_ProDKin_1	582	588	PF00069	0.663
MOD_ProDKin_1	620	626	PF00069	0.762
MOD_ProDKin_1	689	695	PF00069	0.649
TRG_DiLeu_BaEn_1	329	334	PF01217	0.560
TRG_DiLeu_BaEn_1	714	719	PF01217	0.522
TRG_DiLeu_BaEn_4	124	130	PF01217	0.499
TRG_DiLeu_BaEn_4	29	35	PF01217	0.475
TRG_ENDOCYTIC_2	251	254	PF00928	0.349
TRG_ENDOCYTIC_2	663	666	PF00928	0.591
TRG_ENDOCYTIC_2	681	684	PF00928	0.395
TRG_ENDOCYTIC_2	703	706	PF00928	0.536
TRG_ER_diArg_1	313	316	PF00400	0.563
TRG_ER_diArg_1	420	422	PF00400	0.709
TRG_ER_diArg_1	698	700	PF00400	0.600
TRG_ER_diArg_1	722	725	PF00400	0.496
TRG_NES_CRM1_1	267	280	PF08389	0.444
TRG_NES_CRM1_1	469	482	PF08389	0.614
TRG_Pf-PMV_PEXEL_1	214	218	PF00026	0.609
TRG_Pf-PMV_PEXEL_1	220	224	PF00026	0.610
TRG_Pf-PMV_PEXEL_1	24	29	PF00026	0.619
TRG_PTS1	722	725	PF00515	0.494

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB40	Leptomonas seymouri	57%	100%
A0A1X0P1B1	Trypanosomatidae	41%	100%
A0A3R7R5F4	Trypanosoma rangeli	40%	100%
A0A3S7X3V3	Leishmania donovani	92%	100%
A4HIS4	Leishmania braziliensis	71%	100%
A4I620	Leishmania infantum	92%	100%
Q4Q6V3	Leishmania major	91%	100%
V5BMR3	Trypanosoma cruzi	40%	100%