Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B1A8_LEIMU

TriTrypDb:

LmxM.29.3330

Length:

390

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B1A8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1A8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	180	182	PF00675	0.735
CLV_NRD_NRD_1	282	284	PF00675	0.449
CLV_NRD_NRD_1	382	384	PF00675	0.578
CLV_NRD_NRD_1	385	387	PF00675	0.537
CLV_NRD_NRD_1	8	10	PF00675	0.621
CLV_PCSK_FUR_1	380	384	PF00082	0.575
CLV_PCSK_KEX2_1	128	130	PF00082	0.684
CLV_PCSK_KEX2_1	179	181	PF00082	0.725
CLV_PCSK_KEX2_1	202	204	PF00082	0.601
CLV_PCSK_KEX2_1	282	284	PF00082	0.498
CLV_PCSK_KEX2_1	382	384	PF00082	0.578
CLV_PCSK_KEX2_1	385	387	PF00082	0.537
CLV_PCSK_KEX2_1	8	10	PF00082	0.685
CLV_PCSK_PC1ET2_1	128	130	PF00082	0.632
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.641
CLV_PCSK_PC1ET2_1	202	204	PF00082	0.590
CLV_PCSK_SKI1_1	245	249	PF00082	0.514
CLV_PCSK_SKI1_1	3	7	PF00082	0.598
CLV_PCSK_SKI1_1	302	306	PF00082	0.625
CLV_PCSK_SKI1_1	386	390	PF00082	0.505
DEG_Nend_UBRbox_3	1	3	PF02207	0.591
DOC_CKS1_1	197	202	PF01111	0.590
DOC_PP1_RVXF_1	178	185	PF00149	0.485
DOC_PP1_RVXF_1	249	256	PF00149	0.588
DOC_PP2B_LxvP_1	170	173	PF13499	0.483
DOC_PP2B_LxvP_1	305	308	PF13499	0.625
DOC_PP2B_PxIxI_1	17	23	PF00149	0.469
DOC_PP4_FxxP_1	357	360	PF00568	0.521
DOC_PP4_FxxP_1	65	68	PF00568	0.583
DOC_USP7_MATH_1	105	109	PF00917	0.663
DOC_USP7_MATH_1	132	136	PF00917	0.622
DOC_USP7_MATH_1	141	145	PF00917	0.731
DOC_USP7_MATH_1	219	223	PF00917	0.646
DOC_USP7_MATH_1	230	234	PF00917	0.633
DOC_USP7_MATH_1	257	261	PF00917	0.621
DOC_USP7_MATH_1	66	70	PF00917	0.637
DOC_USP7_MATH_1	92	96	PF00917	0.599
DOC_USP7_UBL2_3	302	306	PF12436	0.625
DOC_WW_Pin1_4	14	19	PF00397	0.470
DOC_WW_Pin1_4	196	201	PF00397	0.558
DOC_WW_Pin1_4	267	272	PF00397	0.542
DOC_WW_Pin1_4	338	343	PF00397	0.634
DOC_WW_Pin1_4	70	75	PF00397	0.662
LIG_14-3-3_CanoR_1	203	208	PF00244	0.620
LIG_14-3-3_CanoR_1	276	285	PF00244	0.488
LIG_14-3-3_CanoR_1	324	328	PF00244	0.617
LIG_14-3-3_CterR_2	385	390	PF00244	0.555
LIG_BRCT_BRCA1_1	259	263	PF00533	0.520
LIG_BRCT_BRCA1_1	353	357	PF00533	0.513
LIG_FHA_1	15	21	PF00498	0.521
LIG_FHA_1	226	232	PF00498	0.519
LIG_FHA_1	318	324	PF00498	0.517
LIG_FHA_1	341	347	PF00498	0.546
LIG_FHA_1	43	49	PF00498	0.641
LIG_FHA_2	360	366	PF00498	0.472
LIG_LIR_Apic_2	354	360	PF02991	0.501
LIG_LIR_Apic_2	63	68	PF02991	0.572
LIG_LIR_Gen_1	187	197	PF02991	0.502
LIG_LIR_Gen_1	53	64	PF02991	0.582
LIG_LIR_Nem_3	187	192	PF02991	0.521
LIG_LIR_Nem_3	53	59	PF02991	0.568
LIG_PCNA_yPIPBox_3	35	48	PF02747	0.534
LIG_PTB_Apo_2	372	379	PF02174	0.611
LIG_PTB_Phospho_1	372	378	PF10480	0.610
LIG_SH2_CRK	56	60	PF00017	0.554
LIG_SH2_STAT3	97	100	PF00017	0.479
LIG_SH2_STAT5	26	29	PF00017	0.455
LIG_SH2_STAT5	267	270	PF00017	0.486
LIG_SH2_STAT5	363	366	PF00017	0.570
LIG_SH3_3	265	271	PF00018	0.553
LIG_SH3_3	341	347	PF00018	0.516
LIG_SH3_3	71	77	PF00018	0.641
LIG_SH3_4	302	309	PF00018	0.490
LIG_SH3_5	374	378	PF00018	0.612
LIG_SUMO_SIM_anti_2	45	53	PF11976	0.427
LIG_SUMO_SIM_par_1	45	53	PF11976	0.461
LIG_TRFH_1	189	193	PF08558	0.473
LIG_TYR_ITIM	54	59	PF00017	0.541
MOD_CDC14_SPxK_1	270	273	PF00782	0.534
MOD_CDK_SPxK_1	196	202	PF00069	0.561
MOD_CDK_SPxK_1	267	273	PF00069	0.542
MOD_CDK_SPxxK_3	196	203	PF00069	0.564
MOD_CK1_1	114	120	PF00069	0.659
MOD_CK1_1	144	150	PF00069	0.639
MOD_CK1_1	288	294	PF00069	0.570
MOD_CK1_1	84	90	PF00069	0.671
MOD_CK2_1	114	120	PF00069	0.672
MOD_CK2_1	219	225	PF00069	0.650
MOD_CK2_1	266	272	PF00069	0.522
MOD_Cter_Amidation	200	203	PF01082	0.643
MOD_GlcNHglycan	113	116	PF01048	0.617
MOD_GlcNHglycan	122	125	PF01048	0.583
MOD_GlcNHglycan	129	132	PF01048	0.557
MOD_GlcNHglycan	134	137	PF01048	0.644
MOD_GlcNHglycan	143	146	PF01048	0.607
MOD_GlcNHglycan	214	217	PF01048	0.683
MOD_GlcNHglycan	290	293	PF01048	0.555
MOD_GlcNHglycan	62	65	PF01048	0.589
MOD_GlcNHglycan	84	87	PF01048	0.555
MOD_GSK3_1	111	118	PF00069	0.719
MOD_GSK3_1	127	134	PF00069	0.644
MOD_GSK3_1	206	213	PF00069	0.758
MOD_GSK3_1	219	226	PF00069	0.567
MOD_GSK3_1	66	73	PF00069	0.662
MOD_GSK3_1	78	85	PF00069	0.547
MOD_GSK3_1	99	106	PF00069	0.624
MOD_LATS_1	384	390	PF00433	0.557
MOD_N-GLC_1	285	290	PF02516	0.440
MOD_N-GLC_1	81	86	PF02516	0.625
MOD_NEK2_1	111	116	PF00069	0.697
MOD_NEK2_1	277	282	PF00069	0.435
MOD_NEK2_1	376	381	PF00069	0.574
MOD_NEK2_1	4	9	PF00069	0.623
MOD_NEK2_2	351	356	PF00069	0.510
MOD_PIKK_1	277	283	PF00454	0.486
MOD_PIKK_1	42	48	PF00454	0.597
MOD_PKA_1	211	217	PF00069	0.698
MOD_PKA_2	323	329	PF00069	0.618
MOD_PKA_2	351	357	PF00069	0.543
MOD_Plk_1	285	291	PF00069	0.371
MOD_Plk_2-3	359	365	PF00069	0.469
MOD_Plk_4	106	112	PF00069	0.623
MOD_ProDKin_1	14	20	PF00069	0.469
MOD_ProDKin_1	196	202	PF00069	0.561
MOD_ProDKin_1	267	273	PF00069	0.542
MOD_ProDKin_1	338	344	PF00069	0.627
MOD_ProDKin_1	70	76	PF00069	0.659
MOD_SUMO_for_1	173	176	PF00179	0.591
MOD_SUMO_for_1	34	37	PF00179	0.561
MOD_SUMO_for_1	50	53	PF00179	0.560
MOD_SUMO_rev_2	120	130	PF00179	0.623
MOD_SUMO_rev_2	209	214	PF00179	0.704
TRG_DiLeu_BaLyEn_6	368	373	PF01217	0.598
TRG_ENDOCYTIC_2	189	192	PF00928	0.501
TRG_ENDOCYTIC_2	56	59	PF00928	0.550
TRG_ER_diArg_1	180	182	PF00400	0.579
TRG_ER_diArg_1	282	284	PF00400	0.499
TRG_ER_diArg_1	380	383	PF00400	0.568
TRG_ER_diArg_1	385	387	PF00400	0.541
TRG_NLS_MonoCore_2	201	206	PF00514	0.651
TRG_NLS_MonoExtN_4	178	183	PF00514	0.454
TRG_NLS_MonoExtN_4	200	206	PF00514	0.596

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU67	Leptomonas seymouri	48%	86%
A0A0S4JF36	Bodo saltans	25%	95%
A0A3Q8IFV3	Leishmania donovani	87%	100%
A4HIS1	Leishmania braziliensis	64%	98%
A4I617	Leishmania infantum	87%	100%
Q4Q6V6	Leishmania major	86%	100%