ANK_REP_REGION domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ankyrin repeats (3 copies), putative

Species:

Leishmania mexicana

UniProt:

E9B1A1_LEIMU

TriTrypDb:

LmxM.29.3260

Length:

411

Annotations

LeishMANIAdb annotations

An expanding group of Kinetoplastid proteins. Some members of this group have a hydrophobic C-terminal segment that might help membrane attachment

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B1A1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B1A1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	183	187	PF00656	0.389
CLV_C14_Caspase3-7	266	270	PF00656	0.633
CLV_C14_Caspase3-7	325	329	PF00656	0.516
CLV_NRD_NRD_1	318	320	PF00675	0.407
CLV_NRD_NRD_1	32	34	PF00675	0.357
CLV_NRD_NRD_1	352	354	PF00675	0.475
CLV_NRD_NRD_1	396	398	PF00675	0.476
CLV_PCSK_FUR_1	316	320	PF00082	0.411
CLV_PCSK_KEX2_1	318	320	PF00082	0.411
CLV_PCSK_KEX2_1	32	34	PF00082	0.335
CLV_PCSK_KEX2_1	352	354	PF00082	0.396
CLV_PCSK_SKI1_1	13	17	PF00082	0.373
CLV_PCSK_SKI1_1	162	166	PF00082	0.363
CLV_PCSK_SKI1_1	302	306	PF00082	0.393
CLV_PCSK_SKI1_1	352	356	PF00082	0.471
CLV_PCSK_SKI1_1	36	40	PF00082	0.297
CLV_PCSK_SKI1_1	399	403	PF00082	0.527
CLV_PCSK_SKI1_1	404	408	PF00082	0.581
DEG_Nend_UBRbox_3	1	3	PF02207	0.555
DOC_CKS1_1	119	124	PF01111	0.321
DOC_CKS1_1	255	260	PF01111	0.341
DOC_MAPK_gen_1	32	41	PF00069	0.263
DOC_USP7_MATH_1	128	132	PF00917	0.259
DOC_USP7_MATH_1	184	188	PF00917	0.329
DOC_USP7_MATH_1	263	267	PF00917	0.443
DOC_USP7_UBL2_3	306	310	PF12436	0.438
DOC_USP7_UBL2_3	404	408	PF12436	0.546
DOC_WW_Pin1_4	118	123	PF00397	0.340
DOC_WW_Pin1_4	188	193	PF00397	0.244
DOC_WW_Pin1_4	254	259	PF00397	0.375
DOC_WW_Pin1_4	85	90	PF00397	0.244
LIG_14-3-3_CanoR_1	198	208	PF00244	0.188
LIG_14-3-3_CanoR_1	378	382	PF00244	0.432
LIG_BIR_III_2	189	193	PF00653	0.309
LIG_BRCT_BRCA1_1	119	123	PF00533	0.329
LIG_BRCT_BRCA1_1	34	38	PF00533	0.389
LIG_BRCT_BRCA1_1	350	354	PF00533	0.262
LIG_FHA_1	189	195	PF00498	0.291
LIG_FHA_1	341	347	PF00498	0.469
LIG_FHA_1	63	69	PF00498	0.313
LIG_FHA_2	307	313	PF00498	0.474
LIG_FHA_2	378	384	PF00498	0.532
LIG_FHA_2	64	70	PF00498	0.315
LIG_Integrin_RGD_1	232	234	PF01839	0.350
LIG_LIR_Apic_2	253	258	PF02991	0.424
LIG_LIR_Gen_1	35	45	PF02991	0.266
LIG_LIR_Nem_3	35	41	PF02991	0.266
LIG_NRP_CendR_1	408	411	PF00754	0.637
LIG_PCNA_PIPBox_1	201	210	PF02747	0.371
LIG_PCNA_yPIPBox_3	198	208	PF02747	0.371
LIG_PTB_Apo_2	249	256	PF02174	0.473
LIG_PTB_Phospho_1	249	255	PF10480	0.407
LIG_SH2_CRK	255	259	PF00017	0.373
LIG_SH2_SRC	381	384	PF00017	0.446
LIG_SH2_STAP1	381	385	PF00017	0.500
LIG_SH2_STAT5	207	210	PF00017	0.237
LIG_SH2_STAT5	299	302	PF00017	0.437
LIG_SH2_STAT5	70	73	PF00017	0.278
LIG_SH2_STAT5	98	101	PF00017	0.248
LIG_TRAF2_1	309	312	PF00917	0.449
MOD_CK2_1	306	312	PF00069	0.434
MOD_CK2_1	324	330	PF00069	0.458
MOD_CK2_1	377	383	PF00069	0.534
MOD_CK2_1	63	69	PF00069	0.371
MOD_GlcNHglycan	157	160	PF01048	0.246
MOD_GlcNHglycan	223	226	PF01048	0.405
MOD_GlcNHglycan	269	272	PF01048	0.543
MOD_GlcNHglycan	408	411	PF01048	0.597
MOD_GSK3_1	110	117	PF00069	0.308
MOD_GSK3_1	118	125	PF00069	0.343
MOD_GSK3_1	184	191	PF00069	0.309
MOD_GSK3_1	263	270	PF00069	0.608
MOD_GSK3_1	294	301	PF00069	0.538
MOD_GSK3_1	402	409	PF00069	0.507
MOD_N-GLC_1	289	294	PF02516	0.367
MOD_N-GLC_1	347	352	PF02516	0.418
MOD_N-GLC_1	63	68	PF02516	0.256
MOD_N-GLC_1	79	84	PF02516	0.284
MOD_NEK2_1	402	407	PF00069	0.456
MOD_PIKK_1	115	121	PF00454	0.533
MOD_PIKK_1	92	98	PF00454	0.250
MOD_PKA_1	294	300	PF00069	0.436
MOD_PKA_1	32	38	PF00069	0.309
MOD_PKA_2	139	145	PF00069	0.452
MOD_PKA_2	155	161	PF00069	0.194
MOD_PKA_2	169	175	PF00069	0.176
MOD_PKA_2	263	269	PF00069	0.522
MOD_PKA_2	32	38	PF00069	0.389
MOD_PKA_2	377	383	PF00069	0.431
MOD_Plk_1	110	116	PF00069	0.259
MOD_Plk_1	402	408	PF00069	0.470
MOD_Plk_1	63	69	PF00069	0.255
MOD_Plk_4	52	58	PF00069	0.237
MOD_ProDKin_1	118	124	PF00069	0.334
MOD_ProDKin_1	188	194	PF00069	0.244
MOD_ProDKin_1	254	260	PF00069	0.371
MOD_ProDKin_1	85	91	PF00069	0.244
TRG_DiLeu_BaEn_1	274	279	PF01217	0.334
TRG_DiLeu_BaLyEn_6	189	194	PF01217	0.244
TRG_DiLeu_BaLyEn_6	246	251	PF01217	0.301
TRG_ER_diArg_1	31	33	PF00400	0.309
TRG_ER_diArg_1	316	319	PF00400	0.386
TRG_ER_diArg_1	352	354	PF00400	0.438
TRG_Pf-PMV_PEXEL_1	173	177	PF00026	0.295
TRG_Pf-PMV_PEXEL_1	249	253	PF00026	0.336
TRG_Pf-PMV_PEXEL_1	32	37	PF00026	0.369

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVX1	Leptomonas seymouri	75%	100%
A0A0S4IZB7	Bodo saltans	24%	74%
A0A0S4J2H9	Bodo saltans	27%	72%
A0A0S4KFJ4	Bodo saltans	51%	100%
A0A1X0P1M7	Trypanosomatidae	52%	100%
A0A3Q8IFT3	Leishmania donovani	26%	100%
A0A3R7KWY8	Trypanosoma rangeli	54%	100%
A0A3S7X3U4	Leishmania donovani	95%	100%
A4H9M0	Leishmania braziliensis	23%	100%
A4HHC0	Leishmania braziliensis	26%	100%
A4HIR5	Leishmania braziliensis	84%	100%
A4I610	Leishmania infantum	95%	100%
A4IAC2	Leishmania infantum	26%	100%
A6NK59	Homo sapiens	27%	70%
A6QPE7	Bos taurus	29%	100%
C9ZRD5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
D0A5C3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
D3J162	Medicago truncatula	26%	76%
E9ALW3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9B5E5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
P0C927	Rattus norvegicus	25%	69%
Q08DV6	Bos taurus	27%	78%
Q3V096	Mus musculus	23%	78%
Q4JHE0	Oryza sativa subsp. japonica	22%	98%
Q4Q2I8	Leishmania major	27%	100%
Q4Q6W3	Leishmania major	95%	100%
Q4ULZ2	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	24%	100%
Q63369	Rattus norvegicus	28%	79%
Q6P6B7	Homo sapiens	24%	100%
Q9J569	Fowlpox virus (strain NVSL)	26%	68%
Q9J5H9	Fowlpox virus (strain NVSL)	26%	71%
V5BMS1	Trypanosoma cruzi	54%	100%