Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B196_LEIMU

TriTrypDb:

LmxM.29.3220

Length:

379

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B196

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B196

PDB structure(s): 7ane_ai

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.502
CLV_C14_Caspase3-7	242	246	PF00656	0.497
CLV_NRD_NRD_1	282	284	PF00675	0.460
CLV_NRD_NRD_1	298	300	PF00675	0.316
CLV_NRD_NRD_1	329	331	PF00675	0.525
CLV_PCSK_KEX2_1	284	286	PF00082	0.487
CLV_PCSK_KEX2_1	298	300	PF00082	0.320
CLV_PCSK_KEX2_1	329	331	PF00082	0.525
CLV_PCSK_PC1ET2_1	284	286	PF00082	0.547
CLV_PCSK_SKI1_1	116	120	PF00082	0.389
CLV_PCSK_SKI1_1	228	232	PF00082	0.413
CLV_PCSK_SKI1_1	314	318	PF00082	0.355
CLV_PCSK_SKI1_1	329	333	PF00082	0.393
CLV_PCSK_SKI1_1	48	52	PF00082	0.470
CLV_PCSK_SKI1_1	6	10	PF00082	0.423
CLV_PCSK_SKI1_1	68	72	PF00082	0.223
DEG_Nend_Nbox_1	1	3	PF02207	0.489
DEG_SPOP_SBC_1	323	327	PF00917	0.447
DOC_CYCLIN_RxL_1	54	65	PF00134	0.463
DOC_CYCLIN_yCln2_LP_2	317	320	PF00134	0.359
DOC_MAPK_DCC_7	344	352	PF00069	0.544
DOC_MAPK_gen_1	113	122	PF00069	0.425
DOC_MAPK_gen_1	298	306	PF00069	0.421
DOC_MAPK_gen_1	310	318	PF00069	0.384
DOC_MAPK_HePTP_8	296	308	PF00069	0.451
DOC_MAPK_MEF2A_6	116	124	PF00069	0.430
DOC_MAPK_MEF2A_6	299	308	PF00069	0.456
DOC_MAPK_MEF2A_6	344	352	PF00069	0.458
DOC_PP1_RVXF_1	100	106	PF00149	0.433
DOC_PP2B_LxvP_1	304	307	PF13499	0.414
DOC_PP2B_LxvP_1	316	319	PF13499	0.336
DOC_PP4_FxxP_1	35	38	PF00568	0.490
DOC_SPAK_OSR1_1	208	212	PF12202	0.497
DOC_USP7_UBL2_3	102	106	PF12436	0.542
DOC_WW_Pin1_4	336	341	PF00397	0.479
DOC_WW_Pin1_4	81	86	PF00397	0.544
LIG_14-3-3_CanoR_1	298	303	PF00244	0.440
LIG_14-3-3_CanoR_1	329	338	PF00244	0.472
LIG_DLG_GKlike_1	298	306	PF00625	0.440
LIG_EH_1	170	174	PF12763	0.429
LIG_eIF4E_1	184	190	PF01652	0.512
LIG_FHA_1	160	166	PF00498	0.479
LIG_FHA_1	288	294	PF00498	0.566
LIG_FHA_1	330	336	PF00498	0.459
LIG_FHA_1	56	62	PF00498	0.366
LIG_FHA_2	14	20	PF00498	0.494
LIG_FHA_2	145	151	PF00498	0.453
LIG_FHA_2	237	243	PF00498	0.535
LIG_FHA_2	368	374	PF00498	0.435
LIG_Integrin_isoDGR_2	226	228	PF01839	0.619
LIG_LIR_Apic_2	254	260	PF02991	0.543
LIG_LIR_Apic_2	34	38	PF02991	0.496
LIG_LIR_Gen_1	117	125	PF02991	0.397
LIG_LIR_Gen_1	149	160	PF02991	0.508
LIG_LIR_Gen_1	261	270	PF02991	0.372
LIG_LIR_Gen_1	361	371	PF02991	0.423
LIG_LIR_Gen_1	373	379	PF02991	0.443
LIG_LIR_Nem_3	117	122	PF02991	0.384
LIG_LIR_Nem_3	149	155	PF02991	0.411
LIG_LIR_Nem_3	182	187	PF02991	0.493
LIG_LIR_Nem_3	192	196	PF02991	0.341
LIG_LIR_Nem_3	261	265	PF02991	0.367
LIG_LIR_Nem_3	361	367	PF02991	0.435
LIG_LIR_Nem_3	373	379	PF02991	0.423
LIG_LYPXL_yS_3	184	187	PF13949	0.392
LIG_MYND_1	39	43	PF01753	0.528
LIG_PDZ_Class_2	374	379	PF00595	0.440
LIG_Pex14_1	349	353	PF04695	0.395
LIG_Pex14_2	148	152	PF04695	0.393
LIG_SH2_SRC	322	325	PF00017	0.476
LIG_SH2_STAP1	353	357	PF00017	0.393
LIG_SH2_STAT5	179	182	PF00017	0.452
LIG_SH2_STAT5	24	27	PF00017	0.516
LIG_SH2_STAT5	264	267	PF00017	0.412
LIG_SH2_STAT5	322	325	PF00017	0.362
LIG_SH2_STAT5	364	367	PF00017	0.455
LIG_SH3_3	154	160	PF00018	0.558
LIG_SH3_3	217	223	PF00018	0.294
LIG_SUMO_SIM_anti_2	7	14	PF11976	0.515
LIG_TYR_ITIM	362	367	PF00017	0.515
LIG_UBA3_1	210	217	PF00899	0.498
LIG_WW_1	319	322	PF00397	0.379
MOD_CK1_1	236	242	PF00069	0.477
MOD_CK1_1	339	345	PF00069	0.536
MOD_CK1_1	84	90	PF00069	0.456
MOD_CK2_1	13	19	PF00069	0.477
MOD_CK2_1	144	150	PF00069	0.484
MOD_CK2_1	163	169	PF00069	0.460
MOD_CK2_1	339	345	PF00069	0.476
MOD_CK2_1	348	354	PF00069	0.415
MOD_CK2_1	367	373	PF00069	0.431
MOD_GlcNHglycan	199	202	PF01048	0.514
MOD_GlcNHglycan	233	236	PF01048	0.515
MOD_GSK3_1	159	166	PF00069	0.437
MOD_GSK3_1	218	225	PF00069	0.464
MOD_N-GLC_1	218	223	PF02516	0.398
MOD_NEK2_1	231	236	PF00069	0.491
MOD_NEK2_1	271	276	PF00069	0.506
MOD_NEK2_1	331	336	PF00069	0.541
MOD_NEK2_1	367	372	PF00069	0.424
MOD_NEK2_2	348	353	PF00069	0.503
MOD_PKA_1	298	304	PF00069	0.423
MOD_PKA_1	329	335	PF00069	0.514
MOD_PKA_2	202	208	PF00069	0.364
MOD_PKA_2	298	304	PF00069	0.422
MOD_PKA_2	329	335	PF00069	0.456
MOD_Plk_1	13	19	PF00069	0.412
MOD_Plk_1	252	258	PF00069	0.500
MOD_Plk_1	323	329	PF00069	0.514
MOD_Plk_1	367	373	PF00069	0.481
MOD_Plk_1	6	12	PF00069	0.618
MOD_Plk_2-3	13	19	PF00069	0.544
MOD_Plk_4	13	19	PF00069	0.539
MOD_Plk_4	20	26	PF00069	0.278
MOD_Plk_4	236	242	PF00069	0.472
MOD_Plk_4	252	258	PF00069	0.356
MOD_Plk_4	298	304	PF00069	0.423
MOD_Plk_4	331	337	PF00069	0.476
MOD_Plk_4	6	12	PF00069	0.604
MOD_ProDKin_1	336	342	PF00069	0.474
MOD_ProDKin_1	81	87	PF00069	0.540
MOD_SUMO_rev_2	65	70	PF00179	0.496
TRG_DiLeu_BaEn_4	98	104	PF01217	0.409
TRG_DiLeu_BaLyEn_6	128	133	PF01217	0.505
TRG_DiLeu_BaLyEn_6	36	41	PF01217	0.450
TRG_ENDOCYTIC_2	184	187	PF00928	0.370
TRG_ENDOCYTIC_2	364	367	PF00928	0.474
TRG_ENDOCYTIC_2	5	8	PF00928	0.578
TRG_ER_diArg_1	282	285	PF00400	0.417
TRG_ER_diArg_1	311	314	PF00400	0.377
TRG_ER_diArg_1	328	330	PF00400	0.403
TRG_NES_CRM1_1	134	145	PF08389	0.394
TRG_NES_CRM1_1	7	19	PF08389	0.578
TRG_Pf-PMV_PEXEL_1	329	333	PF00026	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1A9	Leptomonas seymouri	82%	91%
A0A0S4JLK9	Bodo saltans	50%	90%
A0A1X0P1F3	Trypanosomatidae	55%	98%
A0A3Q8IS88	Leishmania donovani	95%	100%
A0A422P0Y0	Trypanosoma rangeli	52%	93%
A4HIR0	Leishmania braziliensis	87%	100%
A4I605	Leishmania infantum	94%	100%
C9ZRC7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	93%
Q4Q6W8	Leishmania major	95%	100%
V5BMY6	Trypanosoma cruzi	55%	92%