Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B195_LEIMU

TriTrypDb:

LmxM.29.3210

Length:

884

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 1, no: 15
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B195

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B195

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	4
GO:0003824	catalytic activity	1	4
GO:0016853	isomerase activity	2	4
GO:0016859	cis-trans isomerase activity	3	4
GO:0140096	catalytic activity, acting on a protein	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	155	159	PF00656	0.613
CLV_C14_Caspase3-7	257	261	PF00656	0.593
CLV_NRD_NRD_1	232	234	PF00675	0.572
CLV_NRD_NRD_1	316	318	PF00675	0.527
CLV_NRD_NRD_1	483	485	PF00675	0.448
CLV_NRD_NRD_1	627	629	PF00675	0.531
CLV_PCSK_FUR_1	213	217	PF00082	0.498
CLV_PCSK_KEX2_1	215	217	PF00082	0.401
CLV_PCSK_KEX2_1	232	234	PF00082	0.572
CLV_PCSK_KEX2_1	316	318	PF00082	0.543
CLV_PCSK_KEX2_1	327	329	PF00082	0.554
CLV_PCSK_KEX2_1	364	366	PF00082	0.529
CLV_PCSK_KEX2_1	483	485	PF00082	0.455
CLV_PCSK_KEX2_1	627	629	PF00082	0.546
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.440
CLV_PCSK_PC1ET2_1	327	329	PF00082	0.664
CLV_PCSK_PC1ET2_1	364	366	PF00082	0.612
CLV_PCSK_SKI1_1	134	138	PF00082	0.409
CLV_PCSK_SKI1_1	246	250	PF00082	0.611
CLV_PCSK_SKI1_1	358	362	PF00082	0.500
CLV_PCSK_SKI1_1	364	368	PF00082	0.505
CLV_PCSK_SKI1_1	381	385	PF00082	0.548
CLV_PCSK_SKI1_1	397	401	PF00082	0.538
CLV_PCSK_SKI1_1	433	437	PF00082	0.272
CLV_PCSK_SKI1_1	484	488	PF00082	0.455
CLV_PCSK_SKI1_1	542	546	PF00082	0.513
CLV_PCSK_SKI1_1	627	631	PF00082	0.566
CLV_PCSK_SKI1_1	767	771	PF00082	0.702
CLV_Separin_Metazoa	229	233	PF03568	0.307
DEG_APCC_DBOX_1	315	323	PF00400	0.554
DEG_APCC_KENBOX_2	130	134	PF00400	0.457
DOC_CKS1_1	819	824	PF01111	0.483
DOC_CYCLIN_RxL_1	430	440	PF00134	0.266
DOC_CYCLIN_RxL_1	481	489	PF00134	0.495
DOC_CYCLIN_yClb3_PxF_3	742	748	PF00134	0.710
DOC_CYCLIN_yCln2_LP_2	208	214	PF00134	0.243
DOC_CYCLIN_yCln2_LP_2	744	750	PF00134	0.629
DOC_CYCLIN_yCln2_LP_2	769	775	PF00134	0.601
DOC_MAPK_gen_1	129	138	PF00069	0.545
DOC_MAPK_gen_1	246	256	PF00069	0.606
DOC_MAPK_gen_1	448	456	PF00069	0.459
DOC_MAPK_HePTP_8	212	224	PF00069	0.501
DOC_MAPK_MEF2A_6	191	200	PF00069	0.450
DOC_MAPK_MEF2A_6	215	224	PF00069	0.459
DOC_MAPK_MEF2A_6	450	458	PF00069	0.566
DOC_MAPK_NFAT4_5	453	461	PF00069	0.555
DOC_MAPK_RevD_3	220	234	PF00069	0.439
DOC_PP1_RVXF_1	431	437	PF00149	0.473
DOC_PP1_RVXF_1	851	857	PF00149	0.742
DOC_PP2B_LxvP_1	208	211	PF13499	0.222
DOC_PP2B_LxvP_1	744	747	PF13499	0.724
DOC_PP2B_LxvP_1	816	819	PF13499	0.635
DOC_PP4_FxxP_1	177	180	PF00568	0.529
DOC_USP7_MATH_1	118	122	PF00917	0.458
DOC_USP7_MATH_1	273	277	PF00917	0.760
DOC_USP7_MATH_1	695	699	PF00917	0.553
DOC_USP7_MATH_1	795	799	PF00917	0.677
DOC_WW_Pin1_4	61	66	PF00397	0.307
DOC_WW_Pin1_4	768	773	PF00397	0.433
DOC_WW_Pin1_4	789	794	PF00397	0.643
DOC_WW_Pin1_4	797	802	PF00397	0.615
DOC_WW_Pin1_4	818	823	PF00397	0.635
DOC_WW_Pin1_4	846	851	PF00397	0.593
LIG_14-3-3_CanoR_1	443	448	PF00244	0.455
LIG_14-3-3_CanoR_1	455	459	PF00244	0.485
LIG_14-3-3_CanoR_1	565	571	PF00244	0.597
LIG_14-3-3_CanoR_1	627	636	PF00244	0.547
LIG_Actin_WH2_2	298	315	PF00022	0.598
LIG_Actin_WH2_2	440	457	PF00022	0.480
LIG_Actin_WH2_2	494	510	PF00022	0.504
LIG_AP2alpha_2	703	705	PF02296	0.549
LIG_BRCT_BRCA1_1	274	278	PF00533	0.447
LIG_BRCT_BRCA1_1	90	94	PF00533	0.335
LIG_Clathr_ClatBox_1	435	439	PF01394	0.258
LIG_EH1_1	344	352	PF00400	0.505
LIG_eIF4E_1	345	351	PF01652	0.525
LIG_FHA_1	117	123	PF00498	0.470
LIG_FHA_1	307	313	PF00498	0.543
LIG_FHA_1	387	393	PF00498	0.482
LIG_FHA_1	439	445	PF00498	0.542
LIG_FHA_1	44	50	PF00498	0.433
LIG_FHA_1	455	461	PF00498	0.384
LIG_FHA_1	510	516	PF00498	0.496
LIG_FHA_1	525	531	PF00498	0.424
LIG_FHA_1	58	64	PF00498	0.278
LIG_FHA_1	628	634	PF00498	0.516
LIG_FHA_1	764	770	PF00498	0.644
LIG_FHA_1	8	14	PF00498	0.425
LIG_FHA_1	840	846	PF00498	0.790
LIG_FHA_2	24	30	PF00498	0.529
LIG_FHA_2	255	261	PF00498	0.643
LIG_FHA_2	313	319	PF00498	0.612
LIG_FHA_2	389	395	PF00498	0.508
LIG_FHA_2	459	465	PF00498	0.510
LIG_FHA_2	517	523	PF00498	0.478
LIG_FHA_2	650	656	PF00498	0.577
LIG_FHA_2	79	85	PF00498	0.491
LIG_IRF3_LxIS_1	268	275	PF10401	0.448
LIG_LIR_Apic_2	733	738	PF02991	0.676
LIG_LIR_Gen_1	293	301	PF02991	0.594
LIG_LIR_Gen_1	524	530	PF02991	0.544
LIG_LIR_Gen_1	667	676	PF02991	0.507
LIG_LIR_Gen_1	76	85	PF02991	0.370
LIG_LIR_Gen_1	8	17	PF02991	0.457
LIG_LIR_Nem_3	26	30	PF02991	0.341
LIG_LIR_Nem_3	293	298	PF02991	0.581
LIG_LIR_Nem_3	524	529	PF02991	0.545
LIG_LIR_Nem_3	667	672	PF02991	0.557
LIG_LIR_Nem_3	701	705	PF02991	0.645
LIG_LIR_Nem_3	76	82	PF02991	0.371
LIG_LIR_Nem_3	8	12	PF02991	0.458
LIG_LIR_Nem_3	87	92	PF02991	0.396
LIG_MYND_1	742	746	PF01753	0.697
LIG_NRBOX	162	168	PF00104	0.479
LIG_NRBOX	430	436	PF00104	0.390
LIG_PCNA_PIPBox_1	379	388	PF02747	0.295
LIG_PCNA_yPIPBox_3	374	386	PF02747	0.294
LIG_PCNA_yPIPBox_3	686	694	PF02747	0.618
LIG_Pex14_1	90	94	PF04695	0.326
LIG_Pex14_2	145	149	PF04695	0.417
LIG_Rb_LxCxE_1	430	452	PF01857	0.328
LIG_SH2_CRK	30	34	PF00017	0.412
LIG_SH2_CRK	526	530	PF00017	0.460
LIG_SH2_CRK	669	673	PF00017	0.592
LIG_SH2_CRK	735	739	PF00017	0.656
LIG_SH2_NCK_1	735	739	PF00017	0.668
LIG_SH2_PTP2	227	230	PF00017	0.461
LIG_SH2_SRC	227	230	PF00017	0.461
LIG_SH2_SRC	559	562	PF00017	0.439
LIG_SH2_STAP1	477	481	PF00017	0.448
LIG_SH2_STAP1	526	530	PF00017	0.495
LIG_SH2_STAT5	227	230	PF00017	0.410
LIG_SH2_STAT5	526	529	PF00017	0.523
LIG_SH2_STAT5	57	60	PF00017	0.404
LIG_SH2_STAT5	79	82	PF00017	0.361
LIG_SH2_STAT5	863	866	PF00017	0.751
LIG_SH3_3	265	271	PF00018	0.735
LIG_SH3_3	740	746	PF00018	0.600
LIG_SH3_3	798	804	PF00018	0.618
LIG_SH3_3	806	812	PF00018	0.445
LIG_SH3_3	816	822	PF00018	0.640
LIG_SH3_3	851	857	PF00018	0.743
LIG_SUMO_SIM_par_1	270	276	PF11976	0.622
LIG_SUMO_SIM_par_1	456	462	PF11976	0.564
LIG_TRAF2_1	493	496	PF00917	0.490
LIG_TRAF2_1	656	659	PF00917	0.649
LIG_UBA3_1	207	215	PF00899	0.448
LIG_UBA3_1	470	476	PF00899	0.431
LIG_WRC_WIRS_1	17	22	PF05994	0.488
LIG_WRC_WIRS_1	79	84	PF05994	0.315
MOD_CDK_SPK_2	846	851	PF00069	0.753
MOD_CDK_SPxxK_3	846	853	PF00069	0.664
MOD_CK1_1	121	127	PF00069	0.503
MOD_CK1_1	153	159	PF00069	0.660
MOD_CK1_1	239	245	PF00069	0.599
MOD_CK1_1	288	294	PF00069	0.656
MOD_CK1_1	521	527	PF00069	0.552
MOD_CK1_1	760	766	PF00069	0.754
MOD_CK1_1	789	795	PF00069	0.666
MOD_CK1_1	834	840	PF00069	0.715
MOD_CK1_1	867	873	PF00069	0.598
MOD_CK2_1	16	22	PF00069	0.453
MOD_CK2_1	162	168	PF00069	0.528
MOD_CK2_1	23	29	PF00069	0.508
MOD_CK2_1	312	318	PF00069	0.585
MOD_CK2_1	388	394	PF00069	0.528
MOD_CK2_1	400	406	PF00069	0.438
MOD_CK2_1	458	464	PF00069	0.503
MOD_CK2_1	628	634	PF00069	0.585
MOD_CK2_1	649	655	PF00069	0.566
MOD_CK2_1	695	701	PF00069	0.563
MOD_CK2_1	709	715	PF00069	0.541
MOD_GlcNHglycan	275	278	PF01048	0.693
MOD_GlcNHglycan	282	285	PF01048	0.644
MOD_GlcNHglycan	287	290	PF01048	0.560
MOD_GlcNHglycan	332	335	PF01048	0.601
MOD_GlcNHglycan	4	7	PF01048	0.534
MOD_GlcNHglycan	401	405	PF01048	0.597
MOD_GlcNHglycan	566	569	PF01048	0.323
MOD_GlcNHglycan	697	700	PF01048	0.541
MOD_GlcNHglycan	711	714	PF01048	0.634
MOD_GlcNHglycan	759	762	PF01048	0.660
MOD_GlcNHglycan	788	791	PF01048	0.492
MOD_GlcNHglycan	797	800	PF01048	0.779
MOD_GlcNHglycan	866	869	PF01048	0.778
MOD_GSK3_1	150	157	PF00069	0.544
MOD_GSK3_1	16	23	PF00069	0.507
MOD_GSK3_1	175	182	PF00069	0.544
MOD_GSK3_1	235	242	PF00069	0.681
MOD_GSK3_1	330	337	PF00069	0.635
MOD_GSK3_1	438	445	PF00069	0.544
MOD_GSK3_1	454	461	PF00069	0.373
MOD_GSK3_1	57	64	PF00069	0.336
MOD_GSK3_1	628	635	PF00069	0.524
MOD_GSK3_1	644	651	PF00069	0.512
MOD_GSK3_1	7	14	PF00069	0.540
MOD_GSK3_1	779	786	PF00069	0.662
MOD_GSK3_1	84	91	PF00069	0.448
MOD_N-GLC_1	153	158	PF02516	0.594
MOD_N-GLC_1	42	47	PF02516	0.531
MOD_N-GLC_2	223	225	PF02516	0.484
MOD_NEK2_1	20	25	PF00069	0.486
MOD_NEK2_1	254	259	PF00069	0.761
MOD_NEK2_1	272	277	PF00069	0.521
MOD_NEK2_1	285	290	PF00069	0.688
MOD_NEK2_1	306	311	PF00069	0.579
MOD_NEK2_1	312	317	PF00069	0.564
MOD_NEK2_1	37	42	PF00069	0.512
MOD_NEK2_1	385	390	PF00069	0.467
MOD_NEK2_1	400	405	PF00069	0.465
MOD_NEK2_1	414	419	PF00069	0.312
MOD_NEK2_1	438	443	PF00069	0.553
MOD_NEK2_1	454	459	PF00069	0.463
MOD_NEK2_1	486	491	PF00069	0.478
MOD_NEK2_1	507	512	PF00069	0.558
MOD_NEK2_1	636	641	PF00069	0.566
MOD_NEK2_1	644	649	PF00069	0.512
MOD_NEK2_1	781	786	PF00069	0.695
MOD_NEK2_1	864	869	PF00069	0.724
MOD_NEK2_2	78	83	PF00069	0.390
MOD_PIKK_1	239	245	PF00454	0.717
MOD_PIKK_1	306	312	PF00454	0.606
MOD_PIKK_1	414	420	PF00454	0.538
MOD_PIKK_1	502	508	PF00454	0.540
MOD_PIKK_1	509	515	PF00454	0.514
MOD_PIKK_1	524	530	PF00454	0.430
MOD_PIKK_1	628	634	PF00454	0.486
MOD_PIKK_1	649	655	PF00454	0.591
MOD_PIKK_1	682	688	PF00454	0.586
MOD_PIKK_1	831	837	PF00454	0.772
MOD_PKA_1	627	633	PF00069	0.610
MOD_PKA_2	312	318	PF00069	0.577
MOD_PKA_2	330	336	PF00069	0.467
MOD_PKA_2	442	448	PF00069	0.523
MOD_PKA_2	454	460	PF00069	0.482
MOD_PKA_2	564	570	PF00069	0.591
MOD_PKA_2	627	633	PF00069	0.585
MOD_Plk_1	343	349	PF00069	0.459
MOD_Plk_1	42	48	PF00069	0.423
MOD_Plk_1	438	444	PF00069	0.521
MOD_Plk_1	502	508	PF00069	0.545
MOD_Plk_1	521	527	PF00069	0.431
MOD_Plk_1	636	642	PF00069	0.465
MOD_Plk_1	7	13	PF00069	0.515
MOD_Plk_1	84	90	PF00069	0.510
MOD_Plk_2-3	168	174	PF00069	0.493
MOD_Plk_2-3	475	481	PF00069	0.542
MOD_Plk_4	11	17	PF00069	0.209
MOD_Plk_4	118	124	PF00069	0.424
MOD_Plk_4	162	168	PF00069	0.530
MOD_Plk_4	730	736	PF00069	0.639
MOD_ProDKin_1	61	67	PF00069	0.305
MOD_ProDKin_1	768	774	PF00069	0.434
MOD_ProDKin_1	789	795	PF00069	0.637
MOD_ProDKin_1	797	803	PF00069	0.618
MOD_ProDKin_1	818	824	PF00069	0.647
MOD_ProDKin_1	846	852	PF00069	0.590
MOD_SUMO_for_1	449	452	PF00179	0.443
MOD_SUMO_for_1	517	520	PF00179	0.570
MOD_SUMO_rev_2	126	136	PF00179	0.535
MOD_SUMO_rev_2	394	399	PF00179	0.475
TRG_DiLeu_BaEn_1	250	255	PF01217	0.590
TRG_DiLeu_BaEn_1	293	298	PF01217	0.564
TRG_DiLeu_BaEn_4	451	457	PF01217	0.579
TRG_DiLeu_BaEn_4	496	502	PF01217	0.432
TRG_DiLeu_BaLyEn_6	203	208	PF01217	0.443
TRG_DiLeu_BaLyEn_6	430	435	PF01217	0.482
TRG_DiLeu_BaLyEn_6	466	471	PF01217	0.427
TRG_DiLeu_BaLyEn_6	671	676	PF01217	0.580
TRG_DiLeu_BaLyEn_6	811	816	PF01217	0.426
TRG_ENDOCYTIC_2	227	230	PF00928	0.401
TRG_ENDOCYTIC_2	30	33	PF00928	0.391
TRG_ENDOCYTIC_2	526	529	PF00928	0.488
TRG_ENDOCYTIC_2	669	672	PF00928	0.597
TRG_ENDOCYTIC_2	79	82	PF00928	0.313
TRG_ENDOCYTIC_2	89	92	PF00928	0.296
TRG_ER_diArg_1	231	233	PF00400	0.460
TRG_ER_diArg_1	627	629	PF00400	0.549
TRG_ER_diArg_1	850	853	PF00400	0.643
TRG_NLS_MonoExtC_3	356	362	PF00514	0.443
TRG_NLS_MonoExtN_4	213	219	PF00514	0.537
TRG_Pf-PMV_PEXEL_1	365	370	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	390	394	PF00026	0.584
TRG_Pf-PMV_PEXEL_1	412	416	PF00026	0.433
TRG_Pf-PMV_PEXEL_1	469	474	PF00026	0.578
TRG_Pf-PMV_PEXEL_1	484	488	PF00026	0.372
TRG_Pf-PMV_PEXEL_1	499	503	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	542	546	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	627	632	PF00026	0.506
TRG_Pf-PMV_PEXEL_1	642	646	PF00026	0.527
TRG_Pf-PMV_PEXEL_1	862	866	PF00026	0.654

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD41	Leptomonas seymouri	63%	100%
A0A0S4JFL0	Bodo saltans	24%	71%
A0A1X0P1A9	Trypanosomatidae	37%	87%
A0A1X0P287	Trypanosomatidae	25%	78%
A0A3S7X3W0	Leishmania donovani	94%	100%
A0A422NMN4	Trypanosoma rangeli	24%	80%
A0A422P0Y3	Trypanosoma rangeli	38%	88%
A4HIQ9	Leishmania braziliensis	81%	100%
A4I604	Leishmania infantum	93%	100%
C9ZQI4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	70%
C9ZRC6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9B0F5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	67%
Q4Q6W9	Leishmania major	94%	100%
V5BCD0	Trypanosoma cruzi	23%	79%
V5BMS4	Trypanosoma cruzi	37%	93%