Translocon-associated protein subunit beta

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Translocon-associated protein beta (TRAPB), putative

Species:

Leishmania mexicana

UniProt:

E9B189_LEIMU

TriTrypDb:

LmxM.29.3150

Length:

212

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 10, no: 1
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9B189

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B189

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	90	94	PF00656	0.280
CLV_NRD_NRD_1	128	130	PF00675	0.491
CLV_NRD_NRD_1	207	209	PF00675	0.390
CLV_PCSK_SKI1_1	129	133	PF00082	0.510
CLV_PCSK_SKI1_1	171	175	PF00082	0.641
CLV_PCSK_SKI1_1	5	9	PF00082	0.602
DEG_APCC_DBOX_1	128	136	PF00400	0.291
DOC_CDC14_PxL_1	182	190	PF14671	0.308
DOC_CKS1_1	100	105	PF01111	0.162
DOC_MAPK_gen_1	195	203	PF00069	0.486
DOC_MAPK_MEF2A_6	197	205	PF00069	0.437
DOC_MAPK_MEF2A_6	5	12	PF00069	0.505
DOC_MAPK_NFAT4_5	5	13	PF00069	0.487
DOC_PP1_RVXF_1	82	89	PF00149	0.162
DOC_WW_Pin1_4	62	67	PF00397	0.273
DOC_WW_Pin1_4	99	104	PF00397	0.262
LIG_14-3-3_CanoR_1	154	160	PF00244	0.316
LIG_14-3-3_CanoR_1	195	205	PF00244	0.580
LIG_BIR_II_1	1	5	PF00653	0.579
LIG_BRCT_BRCA1_1	64	68	PF00533	0.286
LIG_BRCT_BRCA1_1	84	88	PF00533	0.145
LIG_FHA_1	115	121	PF00498	0.257
LIG_FHA_1	175	181	PF00498	0.315
LIG_FHA_2	40	46	PF00498	0.339
LIG_IRF3_LxIS_1	66	73	PF10401	0.162
LIG_LIR_Gen_1	163	173	PF02991	0.325
LIG_LIR_Gen_1	176	187	PF02991	0.318
LIG_LIR_Gen_1	18	28	PF02991	0.408
LIG_LIR_Nem_3	150	156	PF02991	0.351
LIG_LIR_Nem_3	163	168	PF02991	0.310
LIG_LIR_Nem_3	176	182	PF02991	0.295
LIG_LIR_Nem_3	18	24	PF02991	0.408
LIG_LIR_Nem_3	85	91	PF02991	0.332
LIG_LRP6_Inhibitor_1	131	137	PF00058	0.540
LIG_MYND_1	186	190	PF01753	0.308
LIG_NRBOX	3	9	PF00104	0.442
LIG_SH2_PTP2	179	182	PF00017	0.400
LIG_SH2_STAP1	109	113	PF00017	0.318
LIG_SH2_STAT5	172	175	PF00017	0.336
LIG_SH2_STAT5	179	182	PF00017	0.289
LIG_SH2_STAT5	191	194	PF00017	0.427
LIG_SUMO_SIM_anti_2	199	205	PF11976	0.497
LIG_SUMO_SIM_anti_2	51	58	PF11976	0.302
LIG_SUMO_SIM_par_1	155	161	PF11976	0.284
LIG_SUMO_SIM_par_1	54	60	PF11976	0.307
MOD_CK1_1	158	164	PF00069	0.356
MOD_CK1_1	39	45	PF00069	0.365
MOD_CK1_1	80	86	PF00069	0.372
MOD_CK2_1	109	115	PF00069	0.394
MOD_CK2_1	48	54	PF00069	0.385
MOD_GSK3_1	11	18	PF00069	0.575
MOD_GSK3_1	36	43	PF00069	0.329
MOD_GSK3_1	87	94	PF00069	0.292
MOD_NEK2_1	15	20	PF00069	0.546
MOD_NEK2_1	36	41	PF00069	0.294
MOD_Plk_1	114	120	PF00069	0.356
MOD_Plk_1	149	155	PF00069	0.482
MOD_Plk_1	174	180	PF00069	0.417
MOD_Plk_4	11	17	PF00069	0.543
MOD_ProDKin_1	62	68	PF00069	0.325
MOD_ProDKin_1	99	105	PF00069	0.308
MOD_SUMO_rev_2	65	73	PF00179	0.169
TRG_DiLeu_BaEn_1	200	205	PF01217	0.531
TRG_DiLeu_BaLyEn_6	31	36	PF01217	0.310
TRG_ENDOCYTIC_2	165	168	PF00928	0.383
TRG_ENDOCYTIC_2	179	182	PF00928	0.328
TRG_ER_diArg_1	205	208	PF00400	0.471
TRG_Pf-PMV_PEXEL_1	171	175	PF00026	0.544

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC54	Leptomonas seymouri	79%	100%
A0A0S4JI19	Bodo saltans	47%	100%
A0A1X0P213	Trypanosomatidae	55%	100%
A0A3R7RRG4	Trypanosoma rangeli	52%	100%
A0A3S7X3S9	Leishmania donovani	94%	100%
A4HIP9	Leishmania braziliensis	85%	100%
A4I662	Leishmania infantum	94%	100%
C9ZRC0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
Q4Q6X5	Leishmania major	93%	100%
V5B7D0	Trypanosoma cruzi	52%	100%