Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B188_LEIMU

TriTrypDb:

LmxM.29.3140

Length:

235

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B188

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B188

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	160	162	PF00675	0.524
CLV_NRD_NRD_1	216	218	PF00675	0.563
CLV_NRD_NRD_1	88	90	PF00675	0.540
CLV_PCSK_KEX2_1	160	162	PF00082	0.549
CLV_PCSK_KEX2_1	215	217	PF00082	0.565
CLV_PCSK_KEX2_1	88	90	PF00082	0.549
CLV_PCSK_PC7_1	156	162	PF00082	0.537
CLV_PCSK_SKI1_1	174	178	PF00082	0.546
DOC_CKS1_1	46	51	PF01111	0.531
DOC_PP4_FxxP_1	147	150	PF00568	0.644
DOC_USP7_MATH_1	183	187	PF00917	0.524
DOC_USP7_MATH_1	229	233	PF00917	0.364
DOC_USP7_MATH_1	99	103	PF00917	0.727
DOC_WW_Pin1_4	177	182	PF00397	0.611
DOC_WW_Pin1_4	24	29	PF00397	0.596
DOC_WW_Pin1_4	45	50	PF00397	0.532
DOC_WW_Pin1_4	73	78	PF00397	0.639
LIG_14-3-3_CanoR_1	139	147	PF00244	0.527
LIG_14-3-3_CanoR_1	202	207	PF00244	0.534
LIG_14-3-3_CanoR_1	98	108	PF00244	0.721
LIG_BIR_II_1	1	5	PF00653	0.645
LIG_BRCT_BRCA1_1	50	54	PF00533	0.785
LIG_Clathr_ClatBox_1	62	66	PF01394	0.685
LIG_FHA_2	74	80	PF00498	0.658
LIG_GBD_Chelix_1	187	195	PF00786	0.679
LIG_LIR_Gen_1	182	191	PF02991	0.551
LIG_LIR_Gen_1	33	43	PF02991	0.648
LIG_LIR_Nem_3	182	187	PF02991	0.550
LIG_LIR_Nem_3	33	39	PF02991	0.597
LIG_LYPXL_SIV_4	183	191	PF13949	0.575
LIG_PCNA_yPIPBox_3	112	120	PF02747	0.585
LIG_PDZ_Class_2	230	235	PF00595	0.557
LIG_Pex14_1	204	208	PF04695	0.625
LIG_SH2_CRK	184	188	PF00017	0.560
LIG_SH2_STAP1	184	188	PF00017	0.574
LIG_SH2_STAT5	146	149	PF00017	0.528
LIG_SH2_STAT5	208	211	PF00017	0.577
LIG_SUMO_SIM_par_1	15	23	PF11976	0.683
LIG_TRFH_1	177	181	PF08558	0.617
LIG_UBA3_1	162	168	PF00899	0.521
MOD_CDK_SPK_2	45	50	PF00069	0.532
MOD_CK1_1	107	113	PF00069	0.675
MOD_CK1_1	20	26	PF00069	0.693
MOD_CK1_1	211	217	PF00069	0.582
MOD_CK1_1	35	41	PF00069	0.664
MOD_CK2_1	73	79	PF00069	0.633
MOD_GlcNHglycan	1	4	PF01048	0.546
MOD_GlcNHglycan	109	112	PF01048	0.672
MOD_GlcNHglycan	142	145	PF01048	0.592
MOD_GlcNHglycan	229	232	PF01048	0.544
MOD_GSK3_1	1	8	PF00069	0.612
MOD_GSK3_1	121	128	PF00069	0.702
MOD_GSK3_1	20	27	PF00069	0.706
MOD_GSK3_1	34	41	PF00069	0.689
MOD_GSK3_1	48	55	PF00069	0.694
MOD_N-GLC_1	23	28	PF02516	0.704
MOD_N-GLC_1	99	104	PF02516	0.723
MOD_NEK2_1	1	6	PF00069	0.574
MOD_NEK2_1	227	232	PF00069	0.547
MOD_NEK2_1	32	37	PF00069	0.653
MOD_NEK2_2	229	234	PF00069	0.373
MOD_PKA_2	104	110	PF00069	0.595
MOD_PKA_2	121	127	PF00069	0.598
MOD_PKA_2	151	157	PF00069	0.558
MOD_Plk_1	125	131	PF00069	0.631
MOD_Plk_1	32	38	PF00069	0.582
MOD_Plk_4	1	7	PF00069	0.631
MOD_Plk_4	104	110	PF00069	0.571
MOD_Plk_4	183	189	PF00069	0.523
MOD_Plk_4	190	196	PF00069	0.528
MOD_Plk_4	229	235	PF00069	0.410
MOD_ProDKin_1	177	183	PF00069	0.604
MOD_ProDKin_1	24	30	PF00069	0.594
MOD_ProDKin_1	45	51	PF00069	0.531
MOD_ProDKin_1	73	79	PF00069	0.635
MOD_SUMO_rev_2	118	127	PF00179	0.690
TRG_DiLeu_BaEn_4	9	15	PF01217	0.718
TRG_ENDOCYTIC_2	184	187	PF00928	0.555
TRG_ER_diArg_1	159	161	PF00400	0.537
TRG_ER_diArg_1	215	217	PF00400	0.565
TRG_ER_diArg_1	88	91	PF00400	0.621

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXB3	Leptomonas seymouri	72%	100%
A0A3S7X3W4	Leishmania donovani	91%	100%
A4HIP8	Leishmania braziliensis	74%	100%
A4I663	Leishmania infantum	91%	100%
Q4Q6X6	Leishmania major	90%	100%