RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein 42 (RNA-binding motif protein 42), putative

Species:

Leishmania mexicana

UniProt:

E9B183_LEIMU

TriTrypDb:

LmxM.29.3090

Length:

332

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

E9B183

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B183

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	1
GO:0003729	mRNA binding	5	1
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	248	250	PF00675	0.742
CLV_PCSK_KEX2_1	242	244	PF00082	0.750
CLV_PCSK_PC1ET2_1	242	244	PF00082	0.750
CLV_PCSK_SKI1_1	18	22	PF00082	0.504
CLV_PCSK_SKI1_1	258	262	PF00082	0.485
CLV_PCSK_SKI1_1	273	277	PF00082	0.496
CLV_PCSK_SKI1_1	32	36	PF00082	0.501
DEG_APCC_DBOX_1	272	280	PF00400	0.573
DEG_SCF_FBW7_1	187	194	PF00400	0.527
DOC_CYCLIN_RxL_1	239	248	PF00134	0.511
DOC_PP1_RVXF_1	256	262	PF00149	0.493
DOC_USP7_MATH_1	177	181	PF00917	0.687
DOC_USP7_MATH_1	191	195	PF00917	0.689
DOC_WW_Pin1_4	128	133	PF00397	0.598
DOC_WW_Pin1_4	137	142	PF00397	0.584
DOC_WW_Pin1_4	187	192	PF00397	0.613
LIG_14-3-3_CanoR_1	287	296	PF00244	0.475
LIG_14-3-3_CanoR_1	32	37	PF00244	0.522
LIG_APCC_ABBA_1	303	308	PF00400	0.610
LIG_APCC_ABBAyCdc20_2	292	298	PF00400	0.536
LIG_APCC_ABBAyCdc20_2	302	308	PF00400	0.568
LIG_BIR_II_1	1	5	PF00653	0.546
LIG_BIR_III_3	1	5	PF00653	0.546
LIG_FHA_1	262	268	PF00498	0.656
LIG_FHA_1	33	39	PF00498	0.441
LIG_FHA_2	101	107	PF00498	0.503
LIG_FHA_2	266	272	PF00498	0.538
LIG_FHA_2	35	41	PF00498	0.422
LIG_IRF3_LxIS_1	41	46	PF10401	0.569
LIG_LIR_Gen_1	198	207	PF02991	0.592
LIG_LIR_Nem_3	198	202	PF02991	0.565
LIG_LIR_Nem_3	50	55	PF02991	0.507
LIG_Pex14_2	11	15	PF04695	0.396
LIG_SH2_CRK	80	84	PF00017	0.428
LIG_SH2_CRK	99	103	PF00017	0.223
LIG_SH2_PTP2	52	55	PF00017	0.566
LIG_SH2_SRC	52	55	PF00017	0.566
LIG_SH2_STAT5	118	121	PF00017	0.426
LIG_SH2_STAT5	52	55	PF00017	0.566
LIG_SH3_3	129	135	PF00018	0.636
LIG_SH3_3	155	161	PF00018	0.752
LIG_SUMO_SIM_par_1	34	40	PF11976	0.483
LIG_TRAF2_1	167	170	PF00917	0.807
LIG_TRAF2_1	180	183	PF00917	0.689
LIG_TRAF2_1	268	271	PF00917	0.428
LIG_WRC_WIRS_1	105	110	PF05994	0.587
MOD_CK1_1	137	143	PF00069	0.650
MOD_CK1_1	198	204	PF00069	0.615
MOD_CK2_1	100	106	PF00069	0.503
MOD_CK2_1	177	183	PF00069	0.679
MOD_CK2_1	265	271	PF00069	0.510
MOD_Cter_Amidation	223	226	PF01082	0.814
MOD_GlcNHglycan	204	207	PF01048	0.496
MOD_GlcNHglycan	279	282	PF01048	0.538
MOD_GlcNHglycan	289	292	PF01048	0.394
MOD_GSK3_1	100	107	PF00069	0.506
MOD_GSK3_1	187	194	PF00069	0.760
MOD_GSK3_1	198	205	PF00069	0.583
MOD_GSK3_1	261	268	PF00069	0.601
MOD_GSK3_1	60	67	PF00069	0.516
MOD_N-GLC_1	261	266	PF02516	0.603
MOD_N-GLC_1	287	292	PF02516	0.490
MOD_NEK2_1	108	113	PF00069	0.645
MOD_NEK2_1	202	207	PF00069	0.463
MOD_NEK2_1	260	265	PF00069	0.641
MOD_NEK2_1	64	69	PF00069	0.531
MOD_PK_1	70	76	PF00069	0.524
MOD_PKA_1	225	231	PF00069	0.747
MOD_PKA_1	249	255	PF00069	0.760
MOD_PKB_1	247	255	PF00069	0.768
MOD_PKB_1	68	76	PF00069	0.579
MOD_Plk_4	198	204	PF00069	0.657
MOD_Plk_4	321	327	PF00069	0.526
MOD_Plk_4	48	54	PF00069	0.491
MOD_ProDKin_1	128	134	PF00069	0.607
MOD_ProDKin_1	137	143	PF00069	0.585
MOD_ProDKin_1	187	193	PF00069	0.609
MOD_SUMO_for_1	163	166	PF00179	0.827
MOD_SUMO_rev_2	179	188	PF00179	0.784
TRG_ENDOCYTIC_2	52	55	PF00928	0.566
TRG_ENDOCYTIC_2	80	83	PF00928	0.431
TRG_ENDOCYTIC_2	98	101	PF00928	0.399
TRG_ER_diArg_1	326	329	PF00400	0.555
TRG_ER_diArg_1	68	71	PF00400	0.587

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL25	Leptomonas seymouri	64%	96%
A0A3R7N1J6	Trypanosoma rangeli	38%	86%
A0A3S5H7N8	Leishmania donovani	92%	100%
A4HIP3	Leishmania braziliensis	83%	100%
A4I5Z0	Leishmania infantum	93%	100%
Q4Q6Y1	Leishmania major	91%	100%
V5BX42	Trypanosoma cruzi	37%	80%