CNNM transmembrane domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function DUF21, putative

Species:

Leishmania mexicana

UniProt:

E9B177_LEIMU

TriTrypDb:

LmxM.29.3030

Length:

501

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9B177

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B177

Function

Biological processes
Term	Name	Level	Count
GO:0010960	magnesium ion homeostasis	8	11
GO:0042592	homeostatic process	3	11
GO:0048878	chemical homeostasis	4	11
GO:0050801	monoatomic ion homeostasis	5	11
GO:0055065	obsolete metal ion homeostasis	7	11
GO:0055080	monoatomic cation homeostasis	6	11
GO:0065007	biological regulation	1	11
GO:0065008	regulation of biological quality	2	11
GO:0072507	obsolete divalent inorganic cation homeostasis	7	11
GO:0098771	inorganic ion homeostasis	6	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	289	291	PF00675	0.535
CLV_NRD_NRD_1	386	388	PF00675	0.549
CLV_NRD_NRD_1	425	427	PF00675	0.608
CLV_PCSK_KEX2_1	289	291	PF00082	0.492
CLV_PCSK_KEX2_1	386	388	PF00082	0.550
CLV_PCSK_KEX2_1	405	407	PF00082	0.602
CLV_PCSK_PC1ET2_1	405	407	PF00082	0.648
CLV_PCSK_SKI1_1	321	325	PF00082	0.500
CLV_PCSK_SKI1_1	48	52	PF00082	0.239
CLV_PCSK_SKI1_1	67	71	PF00082	0.131
CLV_Separin_Metazoa	322	326	PF03568	0.269
DEG_APCC_DBOX_1	172	180	PF00400	0.242
DEG_APCC_DBOX_1	47	55	PF00400	0.442
DEG_Nend_UBRbox_2	1	3	PF02207	0.476
DEG_SPOP_SBC_1	470	474	PF00917	0.347
DEG_SPOP_SBC_1	53	57	PF00917	0.506
DOC_CKS1_1	374	379	PF01111	0.290
DOC_MAPK_gen_1	289	297	PF00069	0.266
DOC_MAPK_gen_1	386	394	PF00069	0.332
DOC_MAPK_gen_1	405	412	PF00069	0.496
DOC_MAPK_MEF2A_6	289	297	PF00069	0.365
DOC_MAPK_MEF2A_6	405	412	PF00069	0.472
DOC_PP4_FxxP_1	306	309	PF00568	0.334
DOC_USP7_MATH_1	133	137	PF00917	0.289
DOC_USP7_MATH_1	313	317	PF00917	0.388
DOC_USP7_MATH_1	470	474	PF00917	0.370
DOC_WW_Pin1_4	373	378	PF00397	0.415
DOC_WW_Pin1_4	444	449	PF00397	0.514
DOC_WW_Pin1_4	451	456	PF00397	0.517
DOC_WW_Pin1_4	56	61	PF00397	0.467
LIG_14-3-3_CanoR_1	314	320	PF00244	0.305
LIG_14-3-3_CanoR_1	52	60	PF00244	0.442
LIG_BRCT_BRCA1_1	302	306	PF00533	0.338
LIG_Clathr_ClatBox_1	43	47	PF01394	0.411
LIG_CtBP_PxDLS_1	409	413	PF00389	0.333
LIG_EH1_1	290	298	PF00400	0.342
LIG_EVH1_2	456	460	PF00568	0.362
LIG_FHA_1	104	110	PF00498	0.169
LIG_FHA_1	111	117	PF00498	0.125
LIG_FHA_1	147	153	PF00498	0.257
LIG_FHA_1	240	246	PF00498	0.311
LIG_FHA_1	402	408	PF00498	0.475
LIG_FHA_1	412	418	PF00498	0.509
LIG_FHA_1	445	451	PF00498	0.517
LIG_FHA_1	470	476	PF00498	0.535
LIG_FHA_1	91	97	PF00498	0.307
LIG_FHA_2	191	197	PF00498	0.534
LIG_FHA_2	214	220	PF00498	0.401
LIG_FHA_2	249	255	PF00498	0.297
LIG_FHA_2	359	365	PF00498	0.254
LIG_FHA_2	377	383	PF00498	0.450
LIG_FHA_2	486	492	PF00498	0.409
LIG_FHA_2	57	63	PF00498	0.506
LIG_FHA_2	98	104	PF00498	0.292
LIG_LIR_Apic_2	303	309	PF02991	0.399
LIG_LIR_Gen_1	275	285	PF02991	0.362
LIG_LIR_Gen_1	334	343	PF02991	0.367
LIG_LIR_Gen_1	47	54	PF02991	0.442
LIG_LIR_Gen_1	99	110	PF02991	0.215
LIG_LIR_Nem_3	275	281	PF02991	0.371
LIG_LIR_Nem_3	331	336	PF02991	0.304
LIG_LIR_Nem_3	459	463	PF02991	0.400
LIG_LIR_Nem_3	47	53	PF02991	0.424
LIG_LIR_Nem_3	99	105	PF02991	0.215
LIG_MAD2	52	60	PF02301	0.467
LIG_NBox_RRM_1	138	148	PF00076	0.310
LIG_PCNA_yPIPBox_3	386	395	PF02747	0.327
LIG_PTB_Apo_2	84	91	PF02174	0.379
LIG_Rb_pABgroove_1	96	104	PF01858	0.353
LIG_SH2_CRK	278	282	PF00017	0.262
LIG_SH2_NCK_1	278	282	PF00017	0.262
LIG_SH2_SRC	350	353	PF00017	0.299
LIG_SH2_STAP1	333	337	PF00017	0.326
LIG_SH2_STAT5	137	140	PF00017	0.379
LIG_SH2_STAT5	284	287	PF00017	0.271
LIG_SH2_STAT5	336	339	PF00017	0.290
LIG_SH2_STAT5	384	387	PF00017	0.420
LIG_SH3_2	309	314	PF14604	0.247
LIG_SH3_2	453	458	PF14604	0.365
LIG_SH3_3	145	151	PF00018	0.268
LIG_SH3_3	306	312	PF00018	0.334
LIG_SH3_3	371	377	PF00018	0.438
LIG_SH3_3	450	456	PF00018	0.396
LIG_SH3_CIN85_PxpxPR_1	309	314	PF14604	0.239
LIG_SH3_CIN85_PxpxPR_1	453	458	PF14604	0.412
LIG_SUMO_SIM_anti_2	68	74	PF11976	0.451
LIG_SUMO_SIM_anti_2	79	85	PF11976	0.207
LIG_SUMO_SIM_par_1	108	113	PF11976	0.209
LIG_SUMO_SIM_par_1	294	300	PF11976	0.286
LIG_SUMO_SIM_par_1	358	364	PF11976	0.309
LIG_SUMO_SIM_par_1	390	396	PF11976	0.421
LIG_SUMO_SIM_par_1	408	415	PF11976	0.477
LIG_SUMO_SIM_par_1	93	100	PF11976	0.261
LIG_TYR_ITSM	274	281	PF00017	0.351
LIG_UBA3_1	69	74	PF00899	0.324
LIG_WW_3	311	315	PF00397	0.271
LIG_WW_3	455	459	PF00397	0.456
MOD_CDK_SPK_2	56	61	PF00069	0.379
MOD_CDK_SPxxK_3	451	458	PF00069	0.532
MOD_CDK_SPxxK_3	56	63	PF00069	0.324
MOD_CK1_1	13	19	PF00069	0.381
MOD_CK1_1	213	219	PF00069	0.632
MOD_CK1_1	241	247	PF00069	0.433
MOD_CK1_1	261	267	PF00069	0.211
MOD_CK1_1	3	9	PF00069	0.567
MOD_CK1_1	300	306	PF00069	0.476
MOD_CK1_1	316	322	PF00069	0.416
MOD_CK1_1	411	417	PF00069	0.550
MOD_CK1_1	471	477	PF00069	0.756
MOD_CK1_1	478	484	PF00069	0.672
MOD_CK2_1	190	196	PF00069	0.696
MOD_CK2_1	213	219	PF00069	0.512
MOD_CK2_1	248	254	PF00069	0.442
MOD_CK2_1	316	322	PF00069	0.551
MOD_CK2_1	376	382	PF00069	0.529
MOD_CK2_1	485	491	PF00069	0.706
MOD_CK2_1	56	62	PF00069	0.289
MOD_GlcNHglycan	212	215	PF01048	0.745
MOD_GlcNHglycan	24	27	PF01048	0.319
MOD_GlcNHglycan	351	355	PF01048	0.526
MOD_GlcNHglycan	482	485	PF01048	0.705
MOD_GSK3_1	10	17	PF00069	0.542
MOD_GSK3_1	146	153	PF00069	0.246
MOD_GSK3_1	257	264	PF00069	0.428
MOD_GSK3_1	272	279	PF00069	0.415
MOD_GSK3_1	300	307	PF00069	0.483
MOD_GSK3_1	324	331	PF00069	0.321
MOD_GSK3_1	408	415	PF00069	0.728
MOD_GSK3_1	436	443	PF00069	0.572
MOD_GSK3_1	469	476	PF00069	0.630
MOD_GSK3_1	52	59	PF00069	0.264
MOD_NEK2_1	1	6	PF00069	0.764
MOD_NEK2_1	108	113	PF00069	0.146
MOD_NEK2_1	14	19	PF00069	0.387
MOD_NEK2_1	195	200	PF00069	0.569
MOD_NEK2_1	20	25	PF00069	0.140
MOD_NEK2_1	257	262	PF00069	0.447
MOD_NEK2_1	304	309	PF00069	0.385
MOD_NEK2_1	401	406	PF00069	0.516
MOD_NEK2_1	412	417	PF00069	0.600
MOD_NEK2_1	468	473	PF00069	0.501
MOD_NEK2_1	475	480	PF00069	0.492
MOD_NEK2_1	54	59	PF00069	0.264
MOD_NEK2_1	90	95	PF00069	0.287
MOD_NEK2_1	97	102	PF00069	0.287
MOD_PIKK_1	14	20	PF00454	0.386
MOD_PIKK_1	304	310	PF00454	0.434
MOD_PKA_2	226	232	PF00069	0.458
MOD_PKA_2	266	272	PF00069	0.492
MOD_PKA_2	313	319	PF00069	0.436
MOD_PKA_2	324	330	PF00069	0.361
MOD_Plk_1	103	109	PF00069	0.343
MOD_Plk_1	189	195	PF00069	0.651
MOD_Plk_1	218	224	PF00069	0.438
MOD_Plk_1	316	322	PF00069	0.513
MOD_Plk_1	328	334	PF00069	0.340
MOD_Plk_2-3	190	196	PF00069	0.563
MOD_Plk_4	133	139	PF00069	0.293
MOD_Plk_4	190	196	PF00069	0.672
MOD_Plk_4	266	272	PF00069	0.390
MOD_Plk_4	297	303	PF00069	0.311
MOD_Plk_4	328	334	PF00069	0.324
MOD_Plk_4	365	371	PF00069	0.292
MOD_Plk_4	436	442	PF00069	0.623
MOD_Plk_4	65	71	PF00069	0.351
MOD_Plk_4	97	103	PF00069	0.359
MOD_ProDKin_1	373	379	PF00069	0.533
MOD_ProDKin_1	444	450	PF00069	0.672
MOD_ProDKin_1	451	457	PF00069	0.673
MOD_ProDKin_1	56	62	PF00069	0.324
MOD_SUMO_rev_2	228	234	PF00179	0.477
MOD_SUMO_rev_2	479	488	PF00179	0.539
TRG_DiLeu_BaEn_1	104	109	PF01217	0.324
TRG_ENDOCYTIC_2	278	281	PF00928	0.327
TRG_ENDOCYTIC_2	336	339	PF00928	0.351
TRG_ER_diArg_1	385	387	PF00400	0.544

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1M9	Leptomonas seymouri	26%	100%
A0A0N1I470	Leptomonas seymouri	66%	98%
A0A0N1PDI6	Leptomonas seymouri	24%	83%
A0A0S4IPA6	Bodo saltans	40%	100%
A0A0S4JSF9	Bodo saltans	22%	93%
A0A1X0NRR8	Trypanosomatidae	24%	100%
A0A1X0P1F1	Trypanosomatidae	48%	100%
A0A1X0PAL3	Trypanosomatidae	26%	89%
A0A3Q8IC75	Leishmania donovani	91%	100%
A0A3Q8IL77	Leishmania donovani	25%	82%
A0A3Q8ITK0	Leishmania donovani	26%	100%
A0A3R7LBY6	Trypanosoma rangeli	45%	100%
A0A422NS01	Trypanosoma rangeli	24%	89%
A4HAY2	Leishmania braziliensis	23%	85%
A4HIN7	Leishmania braziliensis	78%	99%
A4HKU5	Leishmania braziliensis	25%	100%
A4I5Y4	Leishmania infantum	91%	100%
A4I8C4	Leishmania infantum	27%	100%
A4IA41	Leishmania infantum	25%	82%
C9ZM59	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	89%
D0A017	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	68%
E9B383	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B555	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	82%
Q12296	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	71%
Q4Q2T0	Leishmania major	25%	82%
Q4Q4X2	Leishmania major	26%	100%
Q4Q6Y7	Leishmania major	93%	100%
Q4V3C7	Arabidopsis thaliana	31%	100%
Q67XQ0	Arabidopsis thaliana	31%	100%
Q8RY60	Arabidopsis thaliana	29%	95%
Q8VZI2	Arabidopsis thaliana	28%	100%
Q9LTD8	Arabidopsis thaliana	28%	100%
Q9USJ3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	74%
V5BKR5	Trypanosoma cruzi	25%	87%
V5DM70	Trypanosoma cruzi	25%	100%
V5DNW3	Trypanosoma cruzi	47%	100%