LeishMANIAdb
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Crinkler (CRN)

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Crinkler (CRN)
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B176_LEIMU
TriTrypDb:
LmxM.29.3025
Length:
95

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B176
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B176

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 36 38 PF00675 0.550
CLV_PCSK_SKI1_1 82 86 PF00082 0.703
DEG_APCC_DBOX_1 36 44 PF00400 0.691
DEG_Nend_UBRbox_2 1 3 PF02207 0.702
DOC_PP4_FxxP_1 60 63 PF00568 0.620
DOC_USP7_MATH_1 47 51 PF00917 0.719
LIG_14-3-3_CanoR_1 37 41 PF00244 0.599
LIG_14-3-3_CanoR_1 46 52 PF00244 0.496
LIG_LIR_Apic_2 59 63 PF02991 0.746
LIG_LIR_Gen_1 4 14 PF02991 0.672
LIG_LIR_Nem_3 4 10 PF02991 0.542
LIG_NRBOX 39 45 PF00104 0.697
LIG_SH3_3 22 28 PF00018 0.662
LIG_SH3_3 50 56 PF00018 0.723
LIG_SH3_3 74 80 PF00018 0.655
MOD_CK1_1 18 24 PF00069 0.524
MOD_GlcNHglycan 71 74 PF01048 0.486
MOD_NEK2_1 1 6 PF00069 0.574
MOD_NEK2_1 10 15 PF00069 0.644
MOD_NEK2_2 47 52 PF00069 0.722
MOD_PKA_2 36 42 PF00069 0.688
MOD_Plk_4 18 24 PF00069 0.621
MOD_SUMO_rev_2 13 21 PF00179 0.608
TRG_ENDOCYTIC_2 33 36 PF00928 0.548

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S7X3R6 Leishmania donovani 95% 100%
A4HIN6 Leishmania braziliensis 97% 100%
A4I5Y3 Leishmania infantum 95% 100%
Q4Q6Y8 Leishmania major 97% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS