TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR repeat/Tetratricopeptide repeat, putative

Species:

Leishmania mexicana

UniProt:

E9B173_LEIMU

TriTrypDb:

LmxM.29.3010

Length:

847

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B173

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B173

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	260	264	PF00656	0.649
CLV_C14_Caspase3-7	315	319	PF00656	0.614
CLV_NRD_NRD_1	121	123	PF00675	0.359
CLV_NRD_NRD_1	127	129	PF00675	0.324
CLV_NRD_NRD_1	167	169	PF00675	0.583
CLV_NRD_NRD_1	172	174	PF00675	0.572
CLV_NRD_NRD_1	182	184	PF00675	0.604
CLV_NRD_NRD_1	254	256	PF00675	0.642
CLV_NRD_NRD_1	292	294	PF00675	0.706
CLV_NRD_NRD_1	421	423	PF00675	0.289
CLV_NRD_NRD_1	521	523	PF00675	0.304
CLV_NRD_NRD_1	691	693	PF00675	0.304
CLV_PCSK_FUR_1	170	174	PF00082	0.536
CLV_PCSK_KEX2_1	127	129	PF00082	0.311
CLV_PCSK_KEX2_1	167	169	PF00082	0.583
CLV_PCSK_KEX2_1	172	174	PF00082	0.572
CLV_PCSK_KEX2_1	182	184	PF00082	0.604
CLV_PCSK_KEX2_1	254	256	PF00082	0.652
CLV_PCSK_KEX2_1	292	294	PF00082	0.783
CLV_PCSK_KEX2_1	40	42	PF00082	0.500
CLV_PCSK_KEX2_1	420	422	PF00082	0.289
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.500
CLV_PCSK_PC7_1	168	174	PF00082	0.563
CLV_PCSK_SKI1_1	394	398	PF00082	0.649
CLV_PCSK_SKI1_1	444	448	PF00082	0.345
CLV_PCSK_SKI1_1	517	521	PF00082	0.439
CLV_PCSK_SKI1_1	543	547	PF00082	0.393
CLV_PCSK_SKI1_1	611	615	PF00082	0.229
CLV_PCSK_SKI1_1	811	815	PF00082	0.368
DEG_APCC_DBOX_1	102	110	PF00400	0.369
DEG_APCC_DBOX_1	189	197	PF00400	0.635
DEG_APCC_DBOX_1	796	804	PF00400	0.408
DEG_APCC_KENBOX_2	162	166	PF00400	0.520
DEG_SCF_FBW7_2	217	223	PF00400	0.668
DEG_SPOP_SBC_1	11	15	PF00917	0.613
DEG_SPOP_SBC_1	309	313	PF00917	0.592
DOC_CKS1_1	217	222	PF01111	0.669
DOC_CYCLIN_RxL_1	430	441	PF00134	0.292
DOC_MAPK_DCC_7	190	198	PF00069	0.655
DOC_MAPK_gen_1	190	198	PF00069	0.666
DOC_MAPK_gen_1	49	59	PF00069	0.373
DOC_MAPK_MEF2A_6	607	614	PF00069	0.443
DOC_MAPK_MEF2A_6	658	667	PF00069	0.304
DOC_MAPK_MEF2A_6	811	818	PF00069	0.385
DOC_MAPK_NFAT4_5	811	819	PF00069	0.391
DOC_PP1_RVXF_1	609	615	PF00149	0.431
DOC_PP1_RVXF_1	754	761	PF00149	0.369
DOC_USP7_MATH_1	11	15	PF00917	0.648
DOC_USP7_MATH_1	197	201	PF00917	0.609
DOC_USP7_MATH_1	234	238	PF00917	0.786
DOC_USP7_MATH_1	261	265	PF00917	0.590
DOC_USP7_MATH_1	267	271	PF00917	0.569
DOC_USP7_MATH_1	341	345	PF00917	0.537
DOC_USP7_UBL2_3	811	815	PF12436	0.352
DOC_WW_Pin1_4	208	213	PF00397	0.621
DOC_WW_Pin1_4	216	221	PF00397	0.619
DOC_WW_Pin1_4	235	240	PF00397	0.638
DOC_WW_Pin1_4	436	441	PF00397	0.304
DOC_WW_Pin1_4	489	494	PF00397	0.206
LIG_14-3-3_CanoR_1	103	113	PF00244	0.355
LIG_14-3-3_CanoR_1	16	26	PF00244	0.573
LIG_14-3-3_CanoR_1	172	181	PF00244	0.664
LIG_14-3-3_CanoR_1	182	191	PF00244	0.599
LIG_14-3-3_CanoR_1	214	220	PF00244	0.600
LIG_14-3-3_CanoR_1	398	407	PF00244	0.534
LIG_14-3-3_CanoR_1	475	485	PF00244	0.369
LIG_14-3-3_CanoR_1	653	658	PF00244	0.304
LIG_14-3-3_CanoR_1	728	732	PF00244	0.317
LIG_14-3-3_CanoR_1	756	761	PF00244	0.336
LIG_14-3-3_CanoR_1	91	98	PF00244	0.336
LIG_Actin_WH2_2	25	42	PF00022	0.403
LIG_Actin_WH2_2	796	813	PF00022	0.389
LIG_APCC_ABBA_1	729	734	PF00400	0.350
LIG_APCC_ABBAyCdc20_2	728	734	PF00400	0.353
LIG_BRCT_BRCA1_1	294	298	PF00533	0.650
LIG_EH_1	475	479	PF12763	0.369
LIG_FHA_1	115	121	PF00498	0.369
LIG_FHA_1	285	291	PF00498	0.609
LIG_FHA_1	3	9	PF00498	0.601
LIG_FHA_1	311	317	PF00498	0.619
LIG_FHA_1	334	340	PF00498	0.647
LIG_FHA_1	34	40	PF00498	0.485
LIG_FHA_1	361	367	PF00498	0.572
LIG_FHA_1	431	437	PF00498	0.304
LIG_FHA_1	458	464	PF00498	0.357
LIG_FHA_1	46	52	PF00498	0.338
LIG_FHA_1	465	471	PF00498	0.316
LIG_FHA_1	499	505	PF00498	0.304
LIG_FHA_1	533	539	PF00498	0.348
LIG_FHA_1	635	641	PF00498	0.307
LIG_FHA_1	703	709	PF00498	0.338
LIG_FHA_1	714	720	PF00498	0.403
LIG_FHA_1	738	744	PF00498	0.374
LIG_FHA_1	772	778	PF00498	0.304
LIG_FHA_1	793	799	PF00498	0.378
LIG_FHA_1	805	811	PF00498	0.377
LIG_FHA_1	91	97	PF00498	0.347
LIG_LIR_Gen_1	115	124	PF02991	0.369
LIG_LIR_Gen_1	141	152	PF02991	0.397
LIG_LIR_Gen_1	702	712	PF02991	0.205
LIG_LIR_Gen_1	738	747	PF02991	0.378
LIG_LIR_Nem_3	115	119	PF02991	0.308
LIG_LIR_Nem_3	141	147	PF02991	0.397
LIG_LIR_Nem_3	441	446	PF02991	0.373
LIG_LIR_Nem_3	702	707	PF02991	0.293
LIG_LIR_Nem_3	738	742	PF02991	0.357
LIG_LYPXL_SIV_4	723	731	PF13949	0.352
LIG_MYND_1	191	195	PF01753	0.628
LIG_MYND_1	24	28	PF01753	0.536
LIG_NRBOX	46	52	PF00104	0.450
LIG_PCNA_PIPBox_1	404	413	PF02747	0.421
LIG_Pex14_2	443	447	PF04695	0.304
LIG_PTB_Apo_2	405	412	PF02174	0.417
LIG_PTB_Apo_2	445	452	PF02174	0.304
LIG_PTB_Apo_2	513	520	PF02174	0.304
LIG_PTB_Apo_2	649	656	PF02174	0.289
LIG_PTB_Apo_2	683	690	PF02174	0.289
LIG_PTB_Apo_2	718	725	PF02174	0.347
LIG_PTB_Phospho_1	405	411	PF10480	0.426
LIG_PTB_Phospho_1	649	655	PF10480	0.289
LIG_PTB_Phospho_1	718	724	PF10480	0.370
LIG_REV1ctd_RIR_1	511	521	PF16727	0.311
LIG_RPA_C_Fungi	580	592	PF08784	0.277
LIG_RPA_C_Fungi	682	694	PF08784	0.289
LIG_SH2_CRK	623	627	PF00017	0.304
LIG_SH2_CRK	704	708	PF00017	0.239
LIG_SH2_CRK	98	102	PF00017	0.346
LIG_SH2_GRB2like	582	585	PF00017	0.304
LIG_SH2_GRB2like	684	687	PF00017	0.334
LIG_SH2_NCK_1	131	135	PF00017	0.304
LIG_SH2_NCK_1	549	553	PF00017	0.341
LIG_SH2_PTP2	56	59	PF00017	0.383
LIG_SH2_SRC	561	564	PF00017	0.304
LIG_SH2_STAP1	131	135	PF00017	0.304
LIG_SH2_STAP1	150	154	PF00017	0.304
LIG_SH2_STAP1	35	39	PF00017	0.405
LIG_SH2_STAP1	432	436	PF00017	0.304
LIG_SH2_STAP1	459	463	PF00017	0.340
LIG_SH2_STAP1	466	470	PF00017	0.273
LIG_SH2_STAP1	527	531	PF00017	0.340
LIG_SH2_STAP1	534	538	PF00017	0.273
LIG_SH2_STAP1	561	565	PF00017	0.340
LIG_SH2_STAP1	568	572	PF00017	0.273
LIG_SH2_STAP1	629	633	PF00017	0.304
LIG_SH2_STAP1	670	674	PF00017	0.319
LIG_SH2_STAP1	684	688	PF00017	0.333
LIG_SH2_STAP1	697	701	PF00017	0.238
LIG_SH2_STAP1	704	708	PF00017	0.183
LIG_SH2_STAP1	739	743	PF00017	0.373
LIG_SH2_STAT3	411	414	PF00017	0.369
LIG_SH2_STAT5	35	38	PF00017	0.473
LIG_SH2_STAT5	411	414	PF00017	0.544
LIG_SH2_STAT5	432	435	PF00017	0.352
LIG_SH2_STAT5	459	462	PF00017	0.357
LIG_SH2_STAT5	466	469	PF00017	0.316
LIG_SH2_STAT5	534	537	PF00017	0.338
LIG_SH2_STAT5	553	556	PF00017	0.484
LIG_SH2_STAT5	56	59	PF00017	0.383
LIG_SH2_STAT5	655	658	PF00017	0.289
LIG_SH2_STAT5	684	687	PF00017	0.389
LIG_SH2_STAT5	704	707	PF00017	0.236
LIG_SH2_STAT5	724	727	PF00017	0.294
LIG_SH2_STAT5	739	742	PF00017	0.452
LIG_SH3_1	778	784	PF00018	0.369
LIG_SH3_3	200	206	PF00018	0.708
LIG_SH3_3	21	27	PF00018	0.491
LIG_SH3_3	228	234	PF00018	0.560
LIG_SH3_3	471	477	PF00018	0.369
LIG_SH3_3	778	784	PF00018	0.369
LIG_TYR_ITIM	621	626	PF00017	0.304
LIG_TYR_ITIM	96	101	PF00017	0.346
MOD_CDC14_SPxK_1	211	214	PF00782	0.661
MOD_CDC14_SPxK_1	492	495	PF00782	0.206
MOD_CDK_SPxK_1	208	214	PF00069	0.659
MOD_CDK_SPxK_1	489	495	PF00069	0.206
MOD_CK1_1	15	21	PF00069	0.556
MOD_CK1_1	241	247	PF00069	0.655
MOD_CK1_1	259	265	PF00069	0.520
MOD_CK1_1	272	278	PF00069	0.566
MOD_CK1_1	299	305	PF00069	0.712
MOD_CK1_1	308	314	PF00069	0.581
MOD_CK1_1	342	348	PF00069	0.664
MOD_CK1_1	368	374	PF00069	0.580
MOD_CK1_1	390	396	PF00069	0.653
MOD_CK1_1	4	10	PF00069	0.602
MOD_CK1_1	789	795	PF00069	0.381
MOD_CK2_1	254	260	PF00069	0.642
MOD_CK2_1	308	314	PF00069	0.609
MOD_CK2_1	342	348	PF00069	0.592
MOD_CK2_1	727	733	PF00069	0.269
MOD_Cter_Amidation	252	255	PF01082	0.586
MOD_Cter_Amidation	290	293	PF01082	0.731
MOD_GlcNHglycan	185	188	PF01048	0.564
MOD_GlcNHglycan	251	254	PF01048	0.619
MOD_GlcNHglycan	256	259	PF01048	0.638
MOD_GlcNHglycan	263	266	PF01048	0.640
MOD_GlcNHglycan	271	274	PF01048	0.532
MOD_GlcNHglycan	329	334	PF01048	0.636
MOD_GlcNHglycan	603	606	PF01048	0.241
MOD_GlcNHglycan	63	66	PF01048	0.366
MOD_GlcNHglycan	669	673	PF01048	0.495
MOD_GlcNHglycan	823	826	PF01048	0.357
MOD_GSK3_1	11	18	PF00069	0.574
MOD_GSK3_1	2	9	PF00069	0.651
MOD_GSK3_1	204	211	PF00069	0.668
MOD_GSK3_1	215	222	PF00069	0.790
MOD_GSK3_1	234	241	PF00069	0.676
MOD_GSK3_1	249	256	PF00069	0.570
MOD_GSK3_1	292	299	PF00069	0.684
MOD_GSK3_1	304	311	PF00069	0.556
MOD_GSK3_1	329	336	PF00069	0.658
MOD_GSK3_1	360	367	PF00069	0.602
MOD_GSK3_1	383	390	PF00069	0.649
MOD_GSK3_1	394	401	PF00069	0.569
MOD_GSK3_1	532	539	PF00069	0.329
MOD_GSK3_1	782	789	PF00069	0.452
MOD_LATS_1	515	521	PF00433	0.289
MOD_LATS_1	651	657	PF00433	0.304
MOD_N-GLC_1	304	309	PF02516	0.640
MOD_N-GLC_1	368	373	PF02516	0.535
MOD_N-GLC_1	457	462	PF02516	0.334
MOD_NEK2_1	1	6	PF00069	0.623
MOD_NEK2_1	249	254	PF00069	0.685
MOD_NEK2_1	317	322	PF00069	0.650
MOD_NEK2_2	670	675	PF00069	0.309
MOD_NEK2_2	727	732	PF00069	0.267
MOD_PIKK_1	104	110	PF00454	0.377
MOD_PIKK_1	238	244	PF00454	0.630
MOD_PIKK_1	292	298	PF00454	0.635
MOD_PIKK_1	517	523	PF00454	0.289
MOD_PKA_1	254	260	PF00069	0.636
MOD_PKA_1	292	298	PF00069	0.691
MOD_PKA_1	40	46	PF00069	0.360
MOD_PKA_2	104	110	PF00069	0.353
MOD_PKA_2	15	21	PF00069	0.621
MOD_PKA_2	253	259	PF00069	0.618
MOD_PKA_2	292	298	PF00069	0.691
MOD_PKA_2	33	39	PF00069	0.385
MOD_PKA_2	40	46	PF00069	0.463
MOD_PKA_2	727	733	PF00069	0.409
MOD_PKA_2	792	798	PF00069	0.369
MOD_PKA_2	90	96	PF00069	0.339
MOD_PKB_1	183	191	PF00069	0.655
MOD_Plk_1	304	310	PF00069	0.652
MOD_Plk_1	329	335	PF00069	0.622
MOD_Plk_4	312	318	PF00069	0.646
MOD_Plk_4	727	733	PF00069	0.400
MOD_Plk_4	786	792	PF00069	0.417
MOD_ProDKin_1	208	214	PF00069	0.624
MOD_ProDKin_1	216	222	PF00069	0.619
MOD_ProDKin_1	235	241	PF00069	0.638
MOD_ProDKin_1	436	442	PF00069	0.304
MOD_ProDKin_1	489	495	PF00069	0.206
MOD_SUMO_rev_2	486	492	PF00179	0.318
MOD_SUMO_rev_2	539	545	PF00179	0.334
MOD_SUMO_rev_2	808	813	PF00179	0.393
TRG_DiLeu_BaLyEn_6	402	407	PF01217	0.495
TRG_DiLeu_BaLyEn_6	46	51	PF01217	0.452
TRG_DiLeu_BaLyEn_6	836	841	PF01217	0.395
TRG_ENDOCYTIC_2	35	38	PF00928	0.392
TRG_ENDOCYTIC_2	56	59	PF00928	0.383
TRG_ENDOCYTIC_2	623	626	PF00928	0.304
TRG_ENDOCYTIC_2	657	660	PF00928	0.306
TRG_ENDOCYTIC_2	704	707	PF00928	0.239
TRG_ENDOCYTIC_2	739	742	PF00928	0.364
TRG_ENDOCYTIC_2	98	101	PF00928	0.349
TRG_ER_diArg_1	103	106	PF00400	0.433
TRG_ER_diArg_1	166	168	PF00400	0.554
TRG_ER_diArg_1	181	183	PF00400	0.614
TRG_ER_diArg_1	189	192	PF00400	0.587
TRG_ER_diArg_1	420	422	PF00400	0.290
TRG_Pf-PMV_PEXEL_1	461	465	PF00026	0.369
TRG_Pf-PMV_PEXEL_1	619	624	PF00026	0.409
TRG_Pf-PMV_PEXEL_1	706	710	PF00026	0.369
TRG_Pf-PMV_PEXEL_1	839	843	PF00026	0.416

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXB6	Leptomonas seymouri	57%	98%
A0A3S7X3S0	Leishmania donovani	90%	100%
A4HIN3	Leishmania braziliensis	74%	100%
A4I5Y0	Leishmania infantum	90%	100%
Q4Q6Z1	Leishmania major	88%	100%