DUF2817 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2817), putative

Species:

Leishmania mexicana

UniProt:

E9B171_LEIMU

TriTrypDb:

LmxM.29.2990

Length:

408

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 7
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9B171

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B171

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	149	151	PF00675	0.560
CLV_NRD_NRD_1	247	249	PF00675	0.445
CLV_NRD_NRD_1	291	293	PF00675	0.542
CLV_NRD_NRD_1	77	79	PF00675	0.431
CLV_NRD_NRD_1	93	95	PF00675	0.608
CLV_PCSK_KEX2_1	149	151	PF00082	0.560
CLV_PCSK_KEX2_1	219	221	PF00082	0.510
CLV_PCSK_KEX2_1	385	387	PF00082	0.557
CLV_PCSK_KEX2_1	390	392	PF00082	0.606
CLV_PCSK_KEX2_1	77	79	PF00082	0.573
CLV_PCSK_KEX2_1	93	95	PF00082	0.480
CLV_PCSK_PC1ET2_1	219	221	PF00082	0.560
CLV_PCSK_PC1ET2_1	385	387	PF00082	0.557
CLV_PCSK_PC1ET2_1	390	392	PF00082	0.606
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.504
CLV_PCSK_PC7_1	386	392	PF00082	0.548
CLV_PCSK_SKI1_1	185	189	PF00082	0.573
CLV_PCSK_SKI1_1	199	203	PF00082	0.457
CLV_PCSK_SKI1_1	248	252	PF00082	0.515
CLV_PCSK_SKI1_1	292	296	PF00082	0.525
CLV_PCSK_SKI1_1	374	378	PF00082	0.525
CLV_PCSK_SKI1_1	385	389	PF00082	0.525
DEG_MDM2_SWIB_1	396	403	PF02201	0.385
DOC_CYCLIN_RxL_1	345	353	PF00134	0.190
DOC_MAPK_gen_1	290	300	PF00069	0.190
DOC_MAPK_gen_1	390	396	PF00069	0.373
DOC_MAPK_gen_1	93	100	PF00069	0.305
DOC_MAPK_MEF2A_6	292	300	PF00069	0.245
DOC_PP2B_LxvP_1	187	190	PF13499	0.327
DOC_USP7_UBL2_3	93	97	PF12436	0.360
LIG_14-3-3_CanoR_1	160	168	PF00244	0.325
LIG_14-3-3_CanoR_1	386	390	PF00244	0.357
LIG_BIR_II_1	1	5	PF00653	0.664
LIG_BRCT_BRCA1_1	132	136	PF00533	0.297
LIG_BRCT_BRCA1_1	3	7	PF00533	0.628
LIG_BRCT_BRCA1_1	392	396	PF00533	0.416
LIG_Clathr_ClatBox_1	19	23	PF01394	0.357
LIG_eIF4E_1	181	187	PF01652	0.190
LIG_FHA_1	103	109	PF00498	0.352
LIG_FHA_1	15	21	PF00498	0.351
LIG_FHA_1	259	265	PF00498	0.342
LIG_FHA_1	277	283	PF00498	0.201
LIG_FHA_1	36	42	PF00498	0.434
LIG_FHA_2	273	279	PF00498	0.302
LIG_IBAR_NPY_1	141	143	PF08397	0.194
LIG_KLC1_Yacidic_2	262	267	PF13176	0.398
LIG_LIR_Apic_2	224	230	PF02991	0.325
LIG_LIR_Gen_1	10	20	PF02991	0.405
LIG_LIR_Gen_1	165	173	PF02991	0.396
LIG_LIR_Gen_1	198	207	PF02991	0.309
LIG_LIR_Gen_1	262	272	PF02991	0.327
LIG_LIR_Nem_3	10	15	PF02991	0.405
LIG_LIR_Nem_3	165	171	PF02991	0.304
LIG_LIR_Nem_3	198	203	PF02991	0.309
LIG_LIR_Nem_3	262	268	PF02991	0.327
LIG_LIR_Nem_3	336	341	PF02991	0.325
LIG_PDZ_Class_1	403	408	PF00595	0.415
LIG_Pex14_2	396	400	PF04695	0.348
LIG_PTB_Apo_2	339	346	PF02174	0.388
LIG_PTB_Apo_2	351	358	PF02174	0.312
LIG_PTB_Phospho_1	351	357	PF10480	0.353
LIG_Rb_LxCxE_1	38	57	PF01857	0.389
LIG_SH2_CRK	200	204	PF00017	0.248
LIG_SH2_GRB2like	181	184	PF00017	0.190
LIG_SH2_GRB2like	37	40	PF00017	0.371
LIG_SH2_NCK_1	314	318	PF00017	0.398
LIG_SH2_PTP2	265	268	PF00017	0.315
LIG_SH2_SRC	181	184	PF00017	0.239
LIG_SH2_SRC	265	268	PF00017	0.385
LIG_SH2_SRC	364	367	PF00017	0.317
LIG_SH2_STAP1	37	41	PF00017	0.493
LIG_SH2_STAP1	48	52	PF00017	0.338
LIG_SH2_STAT5	111	114	PF00017	0.300
LIG_SH2_STAT5	162	165	PF00017	0.360
LIG_SH2_STAT5	204	207	PF00017	0.327
LIG_SH2_STAT5	265	268	PF00017	0.398
LIG_SH2_STAT5	364	367	PF00017	0.301
LIG_SH2_STAT5	37	40	PF00017	0.395
LIG_SH2_STAT5	402	405	PF00017	0.361
LIG_SH3_2	190	195	PF14604	0.360
LIG_SH3_3	187	193	PF00018	0.334
LIG_SH3_3	373	379	PF00018	0.342
LIG_SUMO_SIM_anti_2	243	248	PF11976	0.325
LIG_SUMO_SIM_par_1	12	17	PF11976	0.391
LIG_SUMO_SIM_par_1	185	191	PF11976	0.242
LIG_TRAF2_1	164	167	PF00917	0.398
LIG_TRAF2_1	26	29	PF00917	0.404
LIG_TRAF2_1	284	287	PF00917	0.342
LIG_TRAF2_1	334	337	PF00917	0.190
LIG_WW_3	192	196	PF00397	0.360
MOD_CK1_1	308	314	PF00069	0.350
MOD_CK2_1	161	167	PF00069	0.371
MOD_CK2_1	281	287	PF00069	0.326
MOD_CMANNOS	397	400	PF00535	0.625
MOD_Cter_Amidation	91	94	PF01082	0.560
MOD_GlcNHglycan	102	105	PF01048	0.531
MOD_GlcNHglycan	113	116	PF01048	0.522
MOD_GlcNHglycan	307	310	PF01048	0.530
MOD_GlcNHglycan	9	12	PF01048	0.422
MOD_GSK3_1	272	279	PF00069	0.312
MOD_GSK3_1	300	307	PF00069	0.356
MOD_N-GLC_1	124	129	PF02516	0.501
MOD_N-GLC_1	35	40	PF02516	0.580
MOD_NEK2_1	218	223	PF00069	0.195
MOD_NEK2_1	27	32	PF00069	0.370
MOD_NEK2_1	403	408	PF00069	0.415
MOD_NEK2_1	7	12	PF00069	0.395
MOD_NEK2_1	99	104	PF00069	0.388
MOD_PIKK_1	282	288	PF00454	0.348
MOD_PIKK_1	300	306	PF00454	0.236
MOD_PK_1	242	248	PF00069	0.398
MOD_PK_1	390	396	PF00069	0.373
MOD_PKA_1	385	391	PF00069	0.357
MOD_PKA_2	360	366	PF00069	0.360
MOD_PKA_2	385	391	PF00069	0.357
MOD_Plk_1	124	130	PF00069	0.360
MOD_Plk_4	130	136	PF00069	0.301
MOD_Plk_4	27	33	PF00069	0.443
MOD_Plk_4	276	282	PF00069	0.344
MOD_Plk_4	360	366	PF00069	0.322
MOD_Plk_4	368	374	PF00069	0.306
MOD_SUMO_rev_2	238	244	PF00179	0.371
TRG_DiLeu_BaEn_1	182	187	PF01217	0.190
TRG_DiLeu_BaEn_4	153	159	PF01217	0.346
TRG_DiLeu_LyEn_5	182	187	PF01217	0.190
TRG_ENDOCYTIC_2	181	184	PF00928	0.301
TRG_ENDOCYTIC_2	200	203	PF00928	0.301
TRG_ENDOCYTIC_2	265	268	PF00928	0.398
TRG_ER_diArg_1	148	150	PF00400	0.360
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.522
TRG_Pf-PMV_PEXEL_1	249	253	PF00026	0.390
TRG_Pf-PMV_PEXEL_1	322	326	PF00026	0.390
TRG_Pf-PMV_PEXEL_1	348	353	PF00026	0.390

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKP4	Leptomonas seymouri	69%	100%
A0A1X0P1D9	Trypanosomatidae	49%	100%
A0A3Q8II59	Leishmania donovani	91%	100%
A4HIN1	Leishmania braziliensis	80%	100%
A4I5X8	Leishmania infantum	91%	100%
C9ZRA5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
Q4Q6Z3	Leishmania major	91%	100%