zf-CHCC domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B169_LEIMU

TriTrypDb:

LmxM.29.2960

Length:

225

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B169

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B169

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	10	14	PF00656	0.642
CLV_NRD_NRD_1	68	70	PF00675	0.557
CLV_PCSK_SKI1_1	188	192	PF00082	0.541
DEG_Nend_UBRbox_1	1	4	PF02207	0.564
DEG_SCF_FBW7_2	150	157	PF00400	0.651
DOC_MAPK_MEF2A_6	15	24	PF00069	0.625
DOC_PP1_RVXF_1	125	131	PF00149	0.424
DOC_PP1_RVXF_1	34	41	PF00149	0.527
DOC_PP2B_PxIxI_1	108	114	PF00149	0.419
DOC_PP4_FxxP_1	40	43	PF00568	0.529
DOC_USP7_MATH_2	25	31	PF00917	0.510
DOC_USP7_UBL2_3	199	203	PF12436	0.618
DOC_WW_Pin1_4	150	155	PF00397	0.516
DOC_WW_Pin1_4	171	176	PF00397	0.638
DOC_WW_Pin1_4	68	73	PF00397	0.562
LIG_BRCT_BRCA1_1	172	176	PF00533	0.505
LIG_FHA_1	2	8	PF00498	0.592
LIG_FHA_1	69	75	PF00498	0.565
LIG_FHA_2	133	139	PF00498	0.448
LIG_FHA_2	150	156	PF00498	0.515
LIG_FHA_2	50	56	PF00498	0.632
LIG_FHA_2	8	14	PF00498	0.661
LIG_LIR_Nem_3	4	8	PF02991	0.557
LIG_Pex14_2	5	9	PF04695	0.619
LIG_SH2_CRK	18	22	PF00017	0.532
LIG_SH2_CRK	187	191	PF00017	0.548
LIG_SH2_STAP1	28	32	PF00017	0.473
LIG_SH2_STAT5	48	51	PF00017	0.640
LIG_SH2_STAT5	76	79	PF00017	0.630
LIG_SH3_3	187	193	PF00018	0.539
LIG_SH3_3	19	25	PF00018	0.525
LIG_SH3_3	40	46	PF00018	0.534
LIG_SH3_3	84	90	PF00018	0.459
LIG_WRC_WIRS_1	8	13	PF05994	0.538
LIG_WW_1	20	23	PF00397	0.515
MOD_CK1_1	30	36	PF00069	0.528
MOD_CK2_1	131	137	PF00069	0.468
MOD_CK2_1	149	155	PF00069	0.407
MOD_CK2_1	214	220	PF00069	0.583
MOD_Cter_Amidation	67	70	PF01082	0.555
MOD_GlcNHglycan	216	219	PF01048	0.601
MOD_GSK3_1	149	156	PF00069	0.560
MOD_N-GLC_1	131	136	PF02516	0.414
MOD_N-GLC_1	74	79	PF02516	0.673
MOD_NEK2_1	1	6	PF00069	0.553
MOD_NEK2_1	38	43	PF00069	0.558
MOD_NEK2_1	7	12	PF00069	0.551
MOD_NEK2_1	74	79	PF00069	0.658
MOD_PKA_1	214	220	PF00069	0.583
MOD_PKA_2	30	36	PF00069	0.518
MOD_Plk_1	55	61	PF00069	0.594
MOD_ProDKin_1	150	156	PF00069	0.515
MOD_ProDKin_1	171	177	PF00069	0.640
MOD_ProDKin_1	68	74	PF00069	0.556
MOD_SUMO_rev_2	141	151	PF00179	0.495
MOD_SUMO_rev_2	173	182	PF00179	0.677
TRG_DiLeu_BaLyEn_6	3	8	PF01217	0.624
TRG_ENDOCYTIC_2	187	190	PF00928	0.592
TRG_ENDOCYTIC_2	23	26	PF00928	0.499

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4Q1	Leptomonas seymouri	80%	99%
A0A0S4ITD8	Bodo saltans	66%	96%
A0A1X0P1R4	Trypanosomatidae	78%	99%
A0A3S7X3U1	Leishmania donovani	98%	100%
A4HIM9	Leishmania braziliensis	92%	100%
A4I5X5	Leishmania infantum	98%	100%
C9ZR99	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	79%	95%
Q4Q6Z6	Leishmania major	96%	100%
V5BSK1	Trypanosoma cruzi	76%	100%