Phosphoinositide phospholipase C

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phospholipase c-like protein

Species:

Leishmania mexicana

UniProt:

E9B168_LEIMU

TriTrypDb:

LmxM.29.2950

Length:

737

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B168

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B168

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	7
GO:0007165	signal transduction	2	7
GO:0008152	metabolic process	1	7
GO:0009056	catabolic process	2	7
GO:0009987	cellular process	1	7
GO:0016042	lipid catabolic process	4	7
GO:0035556	intracellular signal transduction	3	7
GO:0044238	primary metabolic process	2	7
GO:0050789	regulation of biological process	2	7
GO:0050794	regulation of cellular process	3	7
GO:0065007	biological regulation	1	7
GO:0071704	organic substance metabolic process	2	7
GO:1901575	organic substance catabolic process	3	7
GO:0048015	phosphatidylinositol-mediated signaling	5	1
GO:0048017	inositol lipid-mediated signaling	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004435	phosphatidylinositol phospholipase C activity	7	7
GO:0004620	phospholipase activity	5	7
GO:0004629	phospholipase C activity	6	7
GO:0005488	binding	1	7
GO:0005509	calcium ion binding	5	7
GO:0008081	phosphoric diester hydrolase activity	5	7
GO:0016298	lipase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0042578	phosphoric ester hydrolase activity	4	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	185	189	PF00656	0.189
CLV_C14_Caspase3-7	348	352	PF00656	0.464
CLV_C14_Caspase3-7	456	460	PF00656	0.754
CLV_NRD_NRD_1	195	197	PF00675	0.450
CLV_NRD_NRD_1	37	39	PF00675	0.431
CLV_NRD_NRD_1	376	378	PF00675	0.345
CLV_NRD_NRD_1	47	49	PF00675	0.457
CLV_NRD_NRD_1	64	66	PF00675	0.585
CLV_NRD_NRD_1	91	93	PF00675	0.376
CLV_PCSK_KEX2_1	332	334	PF00082	0.396
CLV_PCSK_KEX2_1	37	39	PF00082	0.438
CLV_PCSK_KEX2_1	376	378	PF00082	0.396
CLV_PCSK_KEX2_1	41	43	PF00082	0.502
CLV_PCSK_KEX2_1	46	48	PF00082	0.452
CLV_PCSK_KEX2_1	639	641	PF00082	0.464
CLV_PCSK_KEX2_1	68	70	PF00082	0.495
CLV_PCSK_KEX2_1	91	93	PF00082	0.448
CLV_PCSK_PC1ET2_1	332	334	PF00082	0.189
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.567
CLV_PCSK_PC1ET2_1	639	641	PF00082	0.464
CLV_PCSK_PC1ET2_1	68	70	PF00082	0.443
CLV_PCSK_PC7_1	37	43	PF00082	0.549
CLV_PCSK_SKI1_1	225	229	PF00082	0.428
CLV_PCSK_SKI1_1	332	336	PF00082	0.307
CLV_PCSK_SKI1_1	37	41	PF00082	0.488
CLV_PCSK_SKI1_1	377	381	PF00082	0.396
CLV_PCSK_SKI1_1	408	412	PF00082	0.460
CLV_PCSK_SKI1_1	69	73	PF00082	0.484
CLV_PCSK_SKI1_1	91	95	PF00082	0.589
DEG_APCC_DBOX_1	407	415	PF00400	0.464
DEG_SPOP_SBC_1	379	383	PF00917	0.189
DOC_CKS1_1	425	430	PF01111	0.464
DOC_CYCLIN_RxL_1	511	519	PF00134	0.396
DOC_CYCLIN_yClb5_NLxxxL_5	21	30	PF00134	0.554
DOC_MAPK_gen_1	108	117	PF00069	0.554
DOC_MAPK_gen_1	176	184	PF00069	0.507
DOC_MAPK_gen_1	46	52	PF00069	0.504
DOC_MAPK_gen_1	65	74	PF00069	0.283
DOC_MAPK_MEF2A_6	177	186	PF00069	0.409
DOC_MAPK_MEF2A_6	670	679	PF00069	0.396
DOC_PP1_RVXF_1	267	273	PF00149	0.382
DOC_PP1_RVXF_1	363	369	PF00149	0.396
DOC_USP7_MATH_1	264	268	PF00917	0.317
DOC_USP7_MATH_1	470	474	PF00917	0.747
DOC_USP7_MATH_1	618	622	PF00917	0.396
DOC_USP7_MATH_1	666	670	PF00917	0.464
DOC_USP7_MATH_1	687	691	PF00917	0.464
DOC_USP7_MATH_1	720	724	PF00917	0.541
DOC_USP7_UBL2_3	434	438	PF12436	0.450
DOC_USP7_UBL2_3	62	66	PF12436	0.524
DOC_WW_Pin1_4	380	385	PF00397	0.396
DOC_WW_Pin1_4	424	429	PF00397	0.343
DOC_WW_Pin1_4	600	605	PF00397	0.488
LIG_14-3-3_CanoR_1	269	279	PF00244	0.444
LIG_14-3-3_CanoR_1	29	35	PF00244	0.520
LIG_14-3-3_CanoR_1	377	387	PF00244	0.396
LIG_14-3-3_CanoR_1	464	472	PF00244	0.493
LIG_14-3-3_CanoR_1	47	53	PF00244	0.483
LIG_14-3-3_CanoR_1	483	489	PF00244	0.459
LIG_14-3-3_CanoR_1	646	650	PF00244	0.189
LIG_Actin_WH2_2	687	704	PF00022	0.396
LIG_APCC_ABBA_1	71	76	PF00400	0.423
LIG_BIR_III_2	499	503	PF00653	0.396
LIG_BIR_III_4	199	203	PF00653	0.396
LIG_BRCT_BRCA1_1	722	726	PF00533	0.223
LIG_CtBP_PxDLS_1	428	432	PF00389	0.189
LIG_deltaCOP1_diTrp_1	236	243	PF00928	0.469
LIG_EVH1_1	10	14	PF00568	0.525
LIG_FHA_1	150	156	PF00498	0.537
LIG_FHA_1	190	196	PF00498	0.261
LIG_FHA_1	211	217	PF00498	0.471
LIG_FHA_1	292	298	PF00498	0.478
LIG_FHA_1	299	305	PF00498	0.327
LIG_FHA_1	361	367	PF00498	0.343
LIG_FHA_1	604	610	PF00498	0.396
LIG_FHA_1	645	651	PF00498	0.345
LIG_FHA_1	660	666	PF00498	0.351
LIG_FHA_1	674	680	PF00498	0.242
LIG_FHA_1	97	103	PF00498	0.458
LIG_FHA_2	14	20	PF00498	0.497
LIG_FHA_2	217	223	PF00498	0.436
LIG_FHA_2	237	243	PF00498	0.413
LIG_FHA_2	393	399	PF00498	0.407
LIG_FHA_2	415	421	PF00498	0.483
LIG_FHA_2	564	570	PF00498	0.396
LIG_FHA_2	683	689	PF00498	0.278
LIG_FHA_2	7	13	PF00498	0.549
LIG_FHA_2	79	85	PF00498	0.558
LIG_IBAR_NPY_1	656	658	PF08397	0.464
LIG_LIR_Gen_1	125	134	PF02991	0.513
LIG_LIR_Gen_1	209	218	PF02991	0.379
LIG_LIR_Gen_1	242	249	PF02991	0.400
LIG_LIR_Gen_1	256	264	PF02991	0.444
LIG_LIR_Gen_1	271	280	PF02991	0.184
LIG_LIR_Gen_1	630	637	PF02991	0.341
LIG_LIR_Nem_3	209	214	PF02991	0.379
LIG_LIR_Nem_3	242	246	PF02991	0.404
LIG_LIR_Nem_3	256	262	PF02991	0.444
LIG_LIR_Nem_3	271	275	PF02991	0.191
LIG_LIR_Nem_3	382	388	PF02991	0.341
LIG_LIR_Nem_3	630	635	PF02991	0.395
LIG_LIR_Nem_3	703	708	PF02991	0.512
LIG_MAD2	434	442	PF02301	0.343
LIG_MYND_1	282	286	PF01753	0.479
LIG_NRBOX	477	483	PF00104	0.596
LIG_PCNA_yPIPBox_3	469	482	PF02747	0.680
LIG_Pex14_1	113	117	PF04695	0.439
LIG_Pex14_1	439	443	PF04695	0.300
LIG_Pex14_1	659	663	PF04695	0.343
LIG_Pex14_2	211	215	PF04695	0.396
LIG_SH2_CRK	705	709	PF00017	0.395
LIG_SH2_NCK_1	443	447	PF00017	0.407
LIG_SH2_PTP2	632	635	PF00017	0.396
LIG_SH2_STAT3	503	506	PF00017	0.396
LIG_SH2_STAT5	278	281	PF00017	0.502
LIG_SH2_STAT5	307	310	PF00017	0.343
LIG_SH2_STAT5	316	319	PF00017	0.343
LIG_SH2_STAT5	426	429	PF00017	0.396
LIG_SH2_STAT5	504	507	PF00017	0.338
LIG_SH2_STAT5	508	511	PF00017	0.327
LIG_SH2_STAT5	586	589	PF00017	0.343
LIG_SH2_STAT5	592	595	PF00017	0.416
LIG_SH2_STAT5	632	635	PF00017	0.343
LIG_SH3_3	422	428	PF00018	0.189
LIG_SH3_3	584	590	PF00018	0.343
LIG_SH3_3	728	734	PF00018	0.551
LIG_SH3_3	8	14	PF00018	0.490
LIG_SH3_4	619	626	PF00018	0.464
LIG_SH3_4	62	69	PF00018	0.566
LIG_SH3_5	303	307	PF00018	0.464
LIG_SUMO_SIM_anti_2	608	613	PF11976	0.464
LIG_SUMO_SIM_anti_2	671	676	PF11976	0.360
LIG_SUMO_SIM_par_1	385	390	PF11976	0.349
LIG_SUMO_SIM_par_1	48	55	PF11976	0.562
LIG_SUMO_SIM_par_1	605	610	PF11976	0.464
LIG_SxIP_EBH_1	610	624	PF03271	0.396
LIG_TRAF2_1	16	19	PF00917	0.558
LIG_TRFH_1	278	282	PF08558	0.429
LIG_TRFH_1	586	590	PF08558	0.343
LIG_TYR_ITIM	441	446	PF00017	0.363
LIG_TYR_ITSM	701	708	PF00017	0.464
LIG_UBA3_1	190	197	PF00899	0.464
LIG_UBA3_1	258	266	PF00899	0.569
LIG_UBA3_1	410	419	PF00899	0.351
LIG_UBA3_1	577	582	PF00899	0.464
LIG_UBA3_1	73	82	PF00899	0.293
LIG_WRC_WIRS_1	228	233	PF05994	0.550
LIG_WRC_WIRS_1	660	665	PF05994	0.464
MOD_CK1_1	122	128	PF00069	0.508
MOD_CK1_1	312	318	PF00069	0.343
MOD_CK1_1	484	490	PF00069	0.429
MOD_CK1_1	51	57	PF00069	0.519
MOD_CK2_1	13	19	PF00069	0.476
MOD_CK2_1	216	222	PF00069	0.438
MOD_CK2_1	236	242	PF00069	0.401
MOD_CK2_1	323	329	PF00069	0.464
MOD_CK2_1	392	398	PF00069	0.407
MOD_CK2_1	427	433	PF00069	0.360
MOD_CK2_1	504	510	PF00069	0.377
MOD_CK2_1	687	693	PF00069	0.464
MOD_GlcNHglycan	121	124	PF01048	0.476
MOD_GlcNHglycan	141	144	PF01048	0.576
MOD_GlcNHglycan	199	203	PF01048	0.343
MOD_GlcNHglycan	265	269	PF01048	0.307
MOD_GlcNHglycan	317	320	PF01048	0.427
MOD_GlcNHglycan	471	475	PF01048	0.626
MOD_GlcNHglycan	596	599	PF01048	0.486
MOD_GlcNHglycan	612	615	PF01048	0.169
MOD_GlcNHglycan	685	688	PF01048	0.471
MOD_GSK3_1	2	9	PF00069	0.685
MOD_GSK3_1	264	271	PF00069	0.295
MOD_GSK3_1	308	315	PF00069	0.343
MOD_GSK3_1	393	400	PF00069	0.396
MOD_GSK3_1	504	511	PF00069	0.464
MOD_GSK3_1	537	544	PF00069	0.403
MOD_GSK3_1	547	554	PF00069	0.343
MOD_GSK3_1	603	610	PF00069	0.464
MOD_GSK3_1	640	647	PF00069	0.354
MOD_GSK3_1	683	690	PF00069	0.471
MOD_N-GLC_1	309	314	PF02516	0.364
MOD_NEK2_1	227	232	PF00069	0.526
MOD_NEK2_1	258	263	PF00069	0.526
MOD_NEK2_1	30	35	PF00069	0.578
MOD_NEK2_1	308	313	PF00069	0.361
MOD_NEK2_1	322	327	PF00069	0.396
MOD_NEK2_1	414	419	PF00069	0.464
MOD_NEK2_1	453	458	PF00069	0.752
MOD_NEK2_1	481	486	PF00069	0.482
MOD_NEK2_1	516	521	PF00069	0.325
MOD_NEK2_1	612	617	PF00069	0.396
MOD_NEK2_1	726	731	PF00069	0.254
MOD_NEK2_2	32	37	PF00069	0.299
MOD_PIKK_1	216	222	PF00454	0.546
MOD_PIKK_1	270	276	PF00454	0.510
MOD_PIKK_1	323	329	PF00454	0.339
MOD_PIKK_1	462	468	PF00454	0.730
MOD_PIKK_1	612	618	PF00454	0.396
MOD_PKA_1	37	43	PF00069	0.544
MOD_PKA_2	268	274	PF00069	0.462
MOD_PKA_2	361	367	PF00069	0.396
MOD_PKA_2	37	43	PF00069	0.574
MOD_PKA_2	64	70	PF00069	0.383
MOD_PKA_2	645	651	PF00069	0.189
MOD_PKB_1	46	54	PF00069	0.478
MOD_Plk_1	147	153	PF00069	0.481
MOD_Plk_1	209	215	PF00069	0.464
MOD_Plk_1	397	403	PF00069	0.464
MOD_Plk_1	687	693	PF00069	0.418
MOD_Plk_4	122	128	PF00069	0.455
MOD_Plk_4	210	216	PF00069	0.477
MOD_Plk_4	258	264	PF00069	0.517
MOD_Plk_4	312	318	PF00069	0.330
MOD_Plk_4	397	403	PF00069	0.464
MOD_Plk_4	504	510	PF00069	0.464
MOD_Plk_4	607	613	PF00069	0.483
MOD_Plk_4	645	651	PF00069	0.369
MOD_Plk_4	720	726	PF00069	0.526
MOD_ProDKin_1	380	386	PF00069	0.396
MOD_ProDKin_1	424	430	PF00069	0.343
MOD_ProDKin_1	600	606	PF00069	0.485
MOD_SUMO_for_1	14	17	PF00179	0.403
MOD_SUMO_rev_2	163	170	PF00179	0.480
MOD_SUMO_rev_2	171	178	PF00179	0.423
MOD_SUMO_rev_2	51	59	PF00179	0.549
TRG_DiLeu_BaEn_2	241	247	PF01217	0.392
TRG_ENDOCYTIC_2	443	446	PF00928	0.397
TRG_ENDOCYTIC_2	632	635	PF00928	0.343
TRG_ENDOCYTIC_2	705	708	PF00928	0.382
TRG_ER_diArg_1	36	38	PF00400	0.463
TRG_ER_diArg_1	375	377	PF00400	0.396
TRG_ER_diArg_1	45	48	PF00400	0.531
TRG_ER_diArg_1	90	92	PF00400	0.317
TRG_NES_CRM1_1	207	220	PF08389	0.464
TRG_NES_CRM1_1	405	420	PF08389	0.271
TRG_NLS_Bipartite_1	47	69	PF00514	0.595
TRG_NLS_MonoExtC_3	64	69	PF00514	0.642
TRG_NLS_MonoExtN_4	62	69	PF00514	0.647
TRG_Pf-PMV_PEXEL_1	75	79	PF00026	0.506

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWX7	Leptomonas seymouri	35%	100%
A0A0N1I1N0	Leptomonas seymouri	62%	100%
A0A0N1IKD7	Leptomonas seymouri	32%	98%
A0A0S4ITT3	Bodo saltans	32%	84%
A0A0S4J9Y4	Bodo saltans	37%	100%
A0A0S4JUS2	Bodo saltans	35%	100%
A0A1X0P2K1	Trypanosomatidae	40%	100%
A0A3Q8IF05	Leishmania donovani	92%	100%
A0A3S7X8U7	Leishmania donovani	33%	100%
A0A422N571	Trypanosoma rangeli	36%	100%
A4HCK9	Leishmania braziliensis	34%	100%
A4HM43	Leishmania braziliensis	33%	100%
A4I027	Leishmania infantum	32%	94%
A4I5X4	Leishmania infantum	92%	100%
A4IAQ5	Leishmania infantum	32%	100%
A5D6R3	Danio rerio	36%	94%
D0A7A3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AEI1	Leishmania major	33%	100%
E9B5P2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
P10688	Rattus norvegicus	32%	97%
P10895	Bos taurus	33%	97%
P40977	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	82%
P51178	Homo sapiens	31%	97%
Q15111	Homo sapiens	28%	67%
Q1RML2	Bos taurus	31%	100%
Q2VRL0	Gallus gallus	33%	100%
Q32NH8	Xenopus laevis	32%	97%
Q39032	Arabidopsis thaliana	28%	100%
Q39033	Arabidopsis thaliana	29%	100%
Q3USB7	Mus musculus	27%	67%
Q4Q6Z7	Leishmania major	90%	100%
Q4QBH9	Leishmania major	31%	100%
Q56W08	Arabidopsis thaliana	27%	100%
Q5FX52	Rattus norvegicus	30%	100%
Q5RET0	Pongo abelii	33%	97%
Q62688	Rattus norvegicus	27%	67%
Q62711	Rattus norvegicus	34%	95%
Q7YRU3	Sus scrofa	30%	100%
Q86YW0	Homo sapiens	31%	100%
Q8GV43	Arabidopsis thaliana	28%	100%
Q8K2J0	Mus musculus	36%	94%
Q8K4D7	Mus musculus	30%	100%
Q8N3E9	Homo sapiens	37%	93%
Q8R3B1	Mus musculus	33%	97%
Q8SPR7	Sus scrofa	35%	95%
Q944C1	Arabidopsis thaliana	30%	100%
Q944C2	Arabidopsis thaliana	28%	100%
Q9BRC7	Homo sapiens	33%	97%
Q9LY51	Arabidopsis thaliana	30%	100%