Sushi domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B167_LEIMU

TriTrypDb:

LmxM.29.2940

Length:

337

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 12, no: 0
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B167

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B167

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	144	146	PF00675	0.306
CLV_NRD_NRD_1	280	282	PF00675	0.472
CLV_NRD_NRD_1	297	299	PF00675	0.497
CLV_NRD_NRD_1	50	52	PF00675	0.462
CLV_PCSK_FUR_1	51	55	PF00082	0.460
CLV_PCSK_KEX2_1	144	146	PF00082	0.306
CLV_PCSK_KEX2_1	297	299	PF00082	0.482
CLV_PCSK_KEX2_1	53	55	PF00082	0.425
CLV_PCSK_PC1ET2_1	53	55	PF00082	0.464
CLV_PCSK_SKI1_1	298	302	PF00082	0.459
CLV_PCSK_SKI1_1	58	62	PF00082	0.367
DEG_APCC_DBOX_1	305	313	PF00400	0.401
DEG_APCC_DBOX_1	53	61	PF00400	0.377
DEG_APCC_KENBOX_2	315	319	PF00400	0.444
DEG_Nend_Nbox_1	1	3	PF02207	0.614
DOC_CYCLIN_yClb1_LxF_4	309	315	PF00134	0.543
DOC_CYCLIN_yClb5_NLxxxL_5	53	61	PF00134	0.378
DOC_MAPK_gen_1	281	289	PF00069	0.456
DOC_MAPK_gen_1	51	59	PF00069	0.387
DOC_MAPK_MEF2A_6	281	289	PF00069	0.396
DOC_MAPK_MEF2A_6	51	59	PF00069	0.364
DOC_MAPK_NFAT4_5	52	60	PF00069	0.494
DOC_PP1_RVXF_1	235	241	PF00149	0.507
DOC_USP7_MATH_1	135	139	PF00917	0.579
DOC_USP7_MATH_1	161	165	PF00917	0.419
DOC_USP7_MATH_1	190	194	PF00917	0.597
DOC_USP7_MATH_1	29	33	PF00917	0.479
DOC_WW_Pin1_4	238	243	PF00397	0.485
DOC_WW_Pin1_4	273	278	PF00397	0.316
LIG_14-3-3_CanoR_1	126	131	PF00244	0.412
LIG_14-3-3_CanoR_1	144	153	PF00244	0.482
LIG_14-3-3_CanoR_1	298	308	PF00244	0.566
LIG_FHA_1	109	115	PF00498	0.525
LIG_FHA_1	146	152	PF00498	0.455
LIG_FHA_1	284	290	PF00498	0.428
LIG_FHA_1	33	39	PF00498	0.448
LIG_FHA_2	105	111	PF00498	0.446
LIG_FHA_2	61	67	PF00498	0.512
LIG_LIR_Gen_1	124	135	PF02991	0.253
LIG_LIR_Gen_1	256	265	PF02991	0.511
LIG_LIR_Gen_1	91	101	PF02991	0.321
LIG_LIR_Nem_3	124	130	PF02991	0.250
LIG_LIR_Nem_3	256	261	PF02991	0.515
LIG_LIR_Nem_3	286	291	PF02991	0.369
LIG_LIR_Nem_3	80	86	PF02991	0.373
LIG_LIR_Nem_3	91	96	PF02991	0.264
LIG_Pex14_1	288	292	PF04695	0.316
LIG_PTB_Apo_2	178	185	PF02174	0.482
LIG_PTB_Apo_2	196	203	PF02174	0.306
LIG_PTB_Phospho_1	196	202	PF10480	0.510
LIG_SH2_CRK	202	206	PF00017	0.400
LIG_SH2_CRK	258	262	PF00017	0.535
LIG_SH2_NCK_1	258	262	PF00017	0.490
LIG_SH2_SRC	202	205	PF00017	0.344
LIG_SH2_STAT5	127	130	PF00017	0.329
LIG_SH2_STAT5	186	189	PF00017	0.410
LIG_SH2_STAT5	258	261	PF00017	0.479
LIG_SH2_STAT5	311	314	PF00017	0.588
LIG_SH3_3	194	200	PF00018	0.518
LIG_SH3_3	229	235	PF00018	0.541
LIG_SH3_3	93	99	PF00018	0.201
LIG_SUMO_SIM_par_1	171	176	PF11976	0.322
LIG_TRAF2_1	107	110	PF00917	0.297
LIG_WRC_WIRS_1	311	316	PF05994	0.567
LIG_WRC_WIRS_1	90	95	PF05994	0.465
MOD_CK1_1	136	142	PF00069	0.403
MOD_CK1_1	147	153	PF00069	0.329
MOD_CK1_1	256	262	PF00069	0.493
MOD_CK1_1	32	38	PF00069	0.531
MOD_CK1_1	91	97	PF00069	0.489
MOD_CK2_1	104	110	PF00069	0.428
MOD_CK2_1	273	279	PF00069	0.567
MOD_CK2_1	60	66	PF00069	0.506
MOD_Cter_Amidation	295	298	PF01082	0.274
MOD_GlcNHglycan	302	305	PF01048	0.376
MOD_GSK3_1	100	107	PF00069	0.361
MOD_GSK3_1	113	120	PF00069	0.345
MOD_GSK3_1	283	290	PF00069	0.368
MOD_GSK3_1	29	36	PF00069	0.451
MOD_N-GLC_1	136	141	PF02516	0.443
MOD_N-GLC_1	155	160	PF02516	0.560
MOD_N-GLC_1	207	212	PF02516	0.577
MOD_N-GLC_1	67	72	PF02516	0.574
MOD_N-GLC_2	218	220	PF02516	0.377
MOD_NEK2_1	1	6	PF00069	0.575
MOD_NEK2_1	100	105	PF00069	0.344
MOD_NEK2_1	133	138	PF00069	0.436
MOD_NEK2_1	283	288	PF00069	0.485
MOD_NEK2_1	60	65	PF00069	0.391
MOD_PIKK_1	70	76	PF00454	0.555
MOD_PK_1	126	132	PF00069	0.377
MOD_PKA_1	144	150	PF00069	0.269
MOD_PKA_2	144	150	PF00069	0.269
MOD_Plk_1	136	142	PF00069	0.483
MOD_Plk_1	207	213	PF00069	0.564
MOD_Plk_1	67	73	PF00069	0.530
MOD_Plk_2-3	117	123	PF00069	0.380
MOD_Plk_4	126	132	PF00069	0.370
MOD_Plk_4	136	142	PF00069	0.407
MOD_Plk_4	147	153	PF00069	0.420
MOD_Plk_4	168	174	PF00069	0.327
MOD_Plk_4	192	198	PF00069	0.499
MOD_Plk_4	207	213	PF00069	0.611
MOD_Plk_4	228	234	PF00069	0.562
MOD_Plk_4	253	259	PF00069	0.468
MOD_Plk_4	283	289	PF00069	0.353
MOD_Plk_4	310	316	PF00069	0.510
MOD_Plk_4	326	332	PF00069	0.517
MOD_ProDKin_1	238	244	PF00069	0.483
MOD_ProDKin_1	273	279	PF00069	0.317
TRG_ENDOCYTIC_2	127	130	PF00928	0.359
TRG_ENDOCYTIC_2	202	205	PF00928	0.586
TRG_ENDOCYTIC_2	258	261	PF00928	0.479
TRG_ENDOCYTIC_2	311	314	PF00928	0.458
TRG_ER_diArg_1	144	146	PF00400	0.306
TRG_NLS_MonoCore_2	50	55	PF00514	0.406
TRG_NLS_MonoExtN_4	51	56	PF00514	0.372

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4A9	Leptomonas seymouri	46%	94%
A0A0S4IU13	Bodo saltans	23%	100%
A0A1X0P1Q5	Trypanosomatidae	21%	100%
A0A1X0P2Z8	Trypanosomatidae	39%	88%
A0A3R7LKG2	Trypanosoma rangeli	40%	100%
A0A3S7X3Q6	Leishmania donovani	87%	99%
A4HIM8	Leishmania braziliensis	65%	100%
A4I5X3	Leishmania infantum	87%	99%
B6DTB5	Bodo saltans	30%	100%
C9ZR98	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
Q4Q6Z8	Leishmania major	87%	100%